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Q5JFX1 (AROB_PYRKO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:TK0267
OrganismPyrococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Thermococcus kodakaraensis (strain KOD1)) [Reference proteome] [HAMAP]
Taxonomic identifier69014 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus ›

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP-Rule MF_00110

Cofactor

NAD By similarity.

Divalent metal cations By similarity.

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP-Rule MF_00110

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: HAMAP

chorismate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3413413-dehydroquinate synthase HAMAP-Rule MF_00110
PRO_0000140820

Sequences

Sequence LengthMass (Da)Tools
Q5JFX1 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: AABE9497172A9897

FASTA34137,195
        10         20         30         40         50         60 
MEGLSFGPLS ILPSLAEELN PHRVAFLTNT TVERLWLEKA AEGIEEPIRI VIPDGEKYKS 

        70         80         90        100        110        120 
LETAVAIWKR LQEEGFTRKS LLIGLGGGVV TDIAGFVAST YMRGTLLGLV PTTLLAQVDA 

       130        140        150        160        170        180 
AIGGKTGVNF NGKNMIGTFY LPNFVLIAHE TLSTLPEEEI RNGLGEVAKY ALLDRKVYAL 

       190        200        210        220        230        240 
ARNFEGISET LIRECALFKV EVVEKDLGES GLRRILNLGH TAGHAIEKLS NYRIKHGLAV 

       250        260        270        280        290        300 
SMGLMVASKV GEELYGFDSG KTEELLKKLG LPTGHPFRAE EILEEMRLDK KAWYGRITFV 

       310        320        330        340 
IPVEIGDVVV EEVDEAVLKR ALEATRDDSG SGDCQKPGGS A

« Hide

References

[1]"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006878 Genomic DNA. Translation: BAD84456.1.
RefSeqYP_182680.1. NC_006624.1.

3D structure databases

ProteinModelPortalQ5JFX1.
ModBaseSearch...

Protein-protein interaction databases

STRING69014.TK0267.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD84456; BAD84456; TK0267.
GeneID3234241.
KEGGtko:TK0267.

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHOG000007970.
KOK01735.
OMANELISGM.
ProtClustDBPRK00002.

Enzyme and pathway databases

UniPathwayUPA00053; UER00085.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
PIRSFPIRSF001455. DHQ_synth. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_PYRKO
AccessionPrimary (citable) accession number: Q5JFX1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: February 15, 2005
Last modified: May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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