Q5JFV1 (AROD_PYRKO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	TK0266

Organism

Pyrococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Thermococcus kodakaraensis (strain KOD1))

Taxonomic identifier

69014 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_0000138836
Sites
	Active site	112	1	Proton acceptor By similarity
	Active site	139	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5JFV1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 4E25FA94159634A7	FASTA	213	24,014
	10 20 30 40 50 60 MIAGVVTARN PGEALEKIKT SKFNLYEVRL DSFESFEGLE VLGEYSKKLI FTPRRREEGG 70 80 90 100 110 120 IRPLDDGTRL SLYRRVMELK PAYVDVEFAS DIAQEVMELA KEKGVGVILS YHDFNGTPDF 130 140 150 160 170 180 GKLLTLLEDM EELEPEIIKI VTTANSPLDN LRVLRLYEHA ENLIAFCMGP LGRISRVFSA 190 200 210 QLAPFTYAPL EGEVAPGQLR AEELDRLRVM LFG

References

[1]

"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes." Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T. Genome Res. 15:352-363(2005) [PubMed: 15710748] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006878 Genomic DNA. Translation: BAD84455.1.
RefSeq	YP_182679.1. NC_006624.1.
3D structure databases
ProteinModelPortal	Q5JFV1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000007974; EBPYRP00000007755; EBPYRG00000007973.
GeneID	3234240.
GenomeReviews	Gene locus TK0266 in contig AP006878_GR.
KEGG	tko:TK0266.
NMPDR	fig|69014.3.peg.13.
Phylogenomic databases
eggNOG	arNOG12575.
GeneTree	EBGT00050000022269.
HOGENOM	HBG732926.
PhylomeDB	Q5JFV1.
ProtClustDB	PRK02412.
Enzyme and pathway databases
BioCyc	TKOD69014:TK0266-MONOMER.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_PYRKO

Accession

Primary (citable) accession number: Q5JFV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	February 15, 2005
Last modified:	November 16, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program