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Q5JFR5

- HISX_THEKO

UniProt

Q5JFR5 - HISX_THEKO

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei100 – 1001NADUniRule annotation
    Binding sitei182 – 1821NADUniRule annotation
    Binding sitei205 – 2051SubstrateUniRule annotation
    Metal bindingi227 – 2271ZincUniRule annotation
    Binding sitei227 – 2271SubstrateUniRule annotation
    Metal bindingi230 – 2301ZincUniRule annotation
    Binding sitei230 – 2301SubstrateUniRule annotation
    Active sitei275 – 2751Proton acceptorUniRule annotation
    Active sitei276 – 2761Proton acceptorUniRule annotation
    Binding sitei276 – 2761SubstrateUniRule annotation
    Metal bindingi309 – 3091ZincUniRule annotation
    Binding sitei309 – 3091SubstrateUniRule annotation
    Binding sitei363 – 3631SubstrateUniRule annotation
    Metal bindingi368 – 3681ZincUniRule annotation
    Binding sitei368 – 3681SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciTKOD69014:GH72-246-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:TK0244
    OrganismiThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
    Taxonomic identifieri69014 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000000536: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Histidinol dehydrogenasePRO_0000135904Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi69014.TK0244.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5JFR5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 2 hits.
    [Graphical view]
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5JFR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGLEEYVRE ILEDIRRRGL EALREYSERF DNYSGPFRVS EGEFEEAEEL    50
    VPEEDKRVIE ETMERLWEYH ARQFRDVELY IKRGSLYGLI YRPIGRIGIY 100
    VPGGKPLPST LMMVGIPARI AGVREIAVTT PPKDGKVNPY VLYVAKLLGI 150
    EEVYKLGGVG AIAAMAYGVG MRRVDKIFGP GNRFVNEAKR QVFGIVGIDS 200
    LAGPSEIAVI ADESADKDYV LADLLSQLEH GKDSKAWLLT TSRELADYCS 250
    REGIEVLLCR NLEECAEKAN EIAPEHLEII TENPEELVDL IENAGAIYLG 300
    PYTPVPAADY FLGVNHVLPT GGAARFSGVL TVMDFMKPIT LARVSREEFL 350
    AYRRLGMRLA EIEGMEAHRR SLEVRR 376
    Length:376
    Mass (Da):42,216
    Last modified:February 15, 2005 - v1
    Checksum:i3D3D163558E01B8A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006878 Genomic DNA. Translation: BAD84433.1.
    RefSeqiYP_182657.1. NC_006624.1.

    Genome annotation databases

    EnsemblBacteriaiBAD84433; BAD84433; TK0244.
    GeneIDi3234039.
    KEGGitko:TK0244.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006878 Genomic DNA. Translation: BAD84433.1 .
    RefSeqi YP_182657.1. NC_006624.1.

    3D structure databases

    ProteinModelPortali Q5JFR5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 69014.TK0244.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD84433 ; BAD84433 ; TK0244 .
    GeneIDi 3234039.
    KEGGi tko:TK0244.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci TKOD69014:GH72-246-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 2 hits.
    [Graphical view ]
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
      Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
      Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-918 / JCM 12380 / KOD1.

    Entry informationi

    Entry nameiHISX_THEKO
    AccessioniPrimary (citable) accession number: Q5JFR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3