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Q5JFR5

- HISX_THEKO

UniProt

Q5JFR5 - HISX_THEKO

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Protein

Histidinol dehydrogenase

Gene
hisD, TK0244
Organism
Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei100 – 1001NAD By similarity
Binding sitei182 – 1821NAD By similarity
Binding sitei205 – 2051Substrate By similarity
Metal bindingi227 – 2271Zinc By similarity
Binding sitei227 – 2271Substrate By similarity
Metal bindingi230 – 2301Zinc By similarity
Binding sitei230 – 2301Substrate By similarity
Active sitei275 – 2751Proton acceptor By similarity
Active sitei276 – 2761Proton acceptor By similarity
Binding sitei276 – 2761Substrate By similarity
Metal bindingi309 – 3091Zinc By similarity
Binding sitei309 – 3091Substrate By similarity
Binding sitei363 – 3631Substrate By similarity
Metal bindingi368 – 3681Zinc By similarity
Binding sitei368 – 3681Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciTKOD69014:GH72-246-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:TK0244
OrganismiThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000000536: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Histidinol dehydrogenaseUniRule annotationPRO_0000135904Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi69014.TK0244.

Structurei

3D structure databases

ProteinModelPortaliQ5JFR5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 2 hits.
[Graphical view]
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JFR5-1 [UniParc]FASTAAdd to Basket

« Hide

MKGLEEYVRE ILEDIRRRGL EALREYSERF DNYSGPFRVS EGEFEEAEEL    50
VPEEDKRVIE ETMERLWEYH ARQFRDVELY IKRGSLYGLI YRPIGRIGIY 100
VPGGKPLPST LMMVGIPARI AGVREIAVTT PPKDGKVNPY VLYVAKLLGI 150
EEVYKLGGVG AIAAMAYGVG MRRVDKIFGP GNRFVNEAKR QVFGIVGIDS 200
LAGPSEIAVI ADESADKDYV LADLLSQLEH GKDSKAWLLT TSRELADYCS 250
REGIEVLLCR NLEECAEKAN EIAPEHLEII TENPEELVDL IENAGAIYLG 300
PYTPVPAADY FLGVNHVLPT GGAARFSGVL TVMDFMKPIT LARVSREEFL 350
AYRRLGMRLA EIEGMEAHRR SLEVRR 376
Length:376
Mass (Da):42,216
Last modified:February 15, 2005 - v1
Checksum:i3D3D163558E01B8A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006878 Genomic DNA. Translation: BAD84433.1.
RefSeqiYP_182657.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD84433; BAD84433; TK0244.
GeneIDi3234039.
KEGGitko:TK0244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006878 Genomic DNA. Translation: BAD84433.1 .
RefSeqi YP_182657.1. NC_006624.1.

3D structure databases

ProteinModelPortali Q5JFR5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 69014.TK0244.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD84433 ; BAD84433 ; TK0244 .
GeneIDi 3234039.
KEGGi tko:TK0244.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci TKOD69014:GH72-246-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 2 hits.
[Graphical view ]
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
    Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
    Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Entry informationi

Entry nameiHISX_THEKO
AccessioniPrimary (citable) accession number: Q5JFR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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