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Q5JFR5 (HISX_THEKO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:TK0244
OrganismThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) [Reference proteome] [HAMAP]
Taxonomic identifier69014 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135904

Sites

Active site2751Proton acceptor By similarity
Active site2761Proton acceptor By similarity
Metal binding2271Zinc By similarity
Metal binding2301Zinc By similarity
Metal binding3091Zinc By similarity
Metal binding3681Zinc By similarity
Binding site1001NAD By similarity
Binding site1821NAD By similarity
Binding site2051Substrate By similarity
Binding site2271Substrate By similarity
Binding site2301Substrate By similarity
Binding site2761Substrate By similarity
Binding site3091Substrate By similarity
Binding site3631Substrate By similarity
Binding site3681Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5JFR5 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 3D3D163558E01B8A

FASTA37642,216
        10         20         30         40         50         60 
MKGLEEYVRE ILEDIRRRGL EALREYSERF DNYSGPFRVS EGEFEEAEEL VPEEDKRVIE 

        70         80         90        100        110        120 
ETMERLWEYH ARQFRDVELY IKRGSLYGLI YRPIGRIGIY VPGGKPLPST LMMVGIPARI 

       130        140        150        160        170        180 
AGVREIAVTT PPKDGKVNPY VLYVAKLLGI EEVYKLGGVG AIAAMAYGVG MRRVDKIFGP 

       190        200        210        220        230        240 
GNRFVNEAKR QVFGIVGIDS LAGPSEIAVI ADESADKDYV LADLLSQLEH GKDSKAWLLT 

       250        260        270        280        290        300 
TSRELADYCS REGIEVLLCR NLEECAEKAN EIAPEHLEII TENPEELVDL IENAGAIYLG 

       310        320        330        340        350        360 
PYTPVPAADY FLGVNHVLPT GGAARFSGVL TVMDFMKPIT LARVSREEFL AYRRLGMRLA 

       370 
EIEGMEAHRR SLEVRR 

« Hide

References

[1]"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006878 Genomic DNA. Translation: BAD84433.1.
RefSeqYP_182657.1. NC_006624.1.

3D structure databases

ProteinModelPortalQ5JFR5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING69014.TK0244.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD84433; BAD84433; TK0244.
GeneID3234039.
KEGGtko:TK0244.

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMAVCTPPDK.
ProtClustDBPRK00877.

Enzyme and pathway databases

BioCycTKOD69014:GH72-246-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 2 hits.
[Graphical view]
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_THEKO
AccessionPrimary (citable) accession number: Q5JFR5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways