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Q5JFR5

- HISX_THEKO

UniProt

Q5JFR5 - HISX_THEKO

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei100 – 1001NADUniRule annotation
Binding sitei182 – 1821NADUniRule annotation
Binding sitei205 – 2051SubstrateUniRule annotation
Metal bindingi227 – 2271ZincUniRule annotation
Binding sitei227 – 2271SubstrateUniRule annotation
Metal bindingi230 – 2301ZincUniRule annotation
Binding sitei230 – 2301SubstrateUniRule annotation
Active sitei275 – 2751Proton acceptorUniRule annotation
Active sitei276 – 2761Proton acceptorUniRule annotation
Binding sitei276 – 2761SubstrateUniRule annotation
Metal bindingi309 – 3091ZincUniRule annotation
Binding sitei309 – 3091SubstrateUniRule annotation
Binding sitei363 – 3631SubstrateUniRule annotation
Metal bindingi368 – 3681ZincUniRule annotation
Binding sitei368 – 3681SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciTKOD69014:GH72-246-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:TK0244
OrganismiThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000000536: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Histidinol dehydrogenasePRO_0000135904Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi69014.TK0244.

Structurei

3D structure databases

ProteinModelPortaliQ5JFR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
InParanoidiQ5JFR5.
KOiK00013.
OMAiYAAKLCG.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 2 hits.
[Graphical view]
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JFR5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKGLEEYVRE ILEDIRRRGL EALREYSERF DNYSGPFRVS EGEFEEAEEL
60 70 80 90 100
VPEEDKRVIE ETMERLWEYH ARQFRDVELY IKRGSLYGLI YRPIGRIGIY
110 120 130 140 150
VPGGKPLPST LMMVGIPARI AGVREIAVTT PPKDGKVNPY VLYVAKLLGI
160 170 180 190 200
EEVYKLGGVG AIAAMAYGVG MRRVDKIFGP GNRFVNEAKR QVFGIVGIDS
210 220 230 240 250
LAGPSEIAVI ADESADKDYV LADLLSQLEH GKDSKAWLLT TSRELADYCS
260 270 280 290 300
REGIEVLLCR NLEECAEKAN EIAPEHLEII TENPEELVDL IENAGAIYLG
310 320 330 340 350
PYTPVPAADY FLGVNHVLPT GGAARFSGVL TVMDFMKPIT LARVSREEFL
360 370
AYRRLGMRLA EIEGMEAHRR SLEVRR
Length:376
Mass (Da):42,216
Last modified:February 15, 2005 - v1
Checksum:i3D3D163558E01B8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD84433.1.
RefSeqiYP_182657.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD84433; BAD84433; TK0244.
GeneIDi3234039.
KEGGitko:TK0244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD84433.1 .
RefSeqi YP_182657.1. NC_006624.1.

3D structure databases

ProteinModelPortali Q5JFR5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 69014.TK0244.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD84433 ; BAD84433 ; TK0244 .
GeneIDi 3234039.
KEGGi tko:TK0244.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
InParanoidi Q5JFR5.
KOi K00013.
OMAi YAAKLCG.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci TKOD69014:GH72-246-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 2 hits.
[Graphical view ]
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
    Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
    Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Entry informationi

Entry nameiHISX_THEKO
AccessioniPrimary (citable) accession number: Q5JFR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: November 26, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3