Q5JFN7 (PUR5_PYRKO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase
EC=6.3.3.1

Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase

Gene names

Name:	purM
Ordered Locus Names:	TK0208

Organism

Pyrococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Thermococcus kodakaraensis (strain KOD1))

Taxonomic identifier

69014 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741_A
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741_A
Subcellular location	Cytoplasm By similarity HAMAP MF_00741_A.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741_A		PRO_0000148288

Sequences

	Sequence		Length	Mass (Da)
	Q5JFN7 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 0FFA6F5DFBF89BD4	FASTA	334	36,429
	10 20 30 40 50 60 MLTYAQAGVD DEKTSRALKS IISLAKGTFE FRRGKLGEPA EDLGHYAALM DFGDFYLAIT 70 80 90 100 110 120 TDGVGTKVLV AEAVGKFDTI GIDMIAMNVN DLLCVGAEPV ALVDYLAVKE PDERVFEGIA 130 140 150 160 170 180 QGLYEGARQA GIAIVGGETA VMPDLINGFD LAGTAIGVVE KRKVITGKKI RPGDAVIGIK 190 200 210 220 230 240 SSGIHSNGLT LARKLLIPKY GLDYEYEGKK LWEWLLEPTR IYVKAVLELI ENVKVHGLAH 250 260 270 280 290 300 ITGGGLLNLK RLTSFGFSIE MPPIEGIFRL IYENGVPLEE MFRVFNMGVG MVAVVPREEK 310 320 330 EEALQLLNRH FESFELGKVV GEPGIRVENY GIKL

References

[1]

"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes." Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T. Genome Res. 15:352-363(2005) [PubMed: 15710748] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006878 Genomic DNA. Translation: BAD84397.1.
RefSeq	YP_182621.1. NC_006624.1.
3D structure databases
ProteinModelPortal	Q5JFN7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000006801; EBPYRP00000006582; EBPYRG00000006800.
GeneID	3235276.
GenomeReviews	Gene locus TK0208 in contig AP006878_GR.
KEGG	tko:TK0208.
NMPDR	fig|69014.3.peg.463.
Phylogenomic databases
eggNOG	arNOG04189.
GeneTree	EBGT00050000022555.
HOGENOM	HBG531222.
OMA	GIDMIAM.
PhylomeDB	Q5JFN7.
ProtClustDB	PRK05385.
Enzyme and pathway databases
BioCyc	TKOD69014:TK0208-MONOMER.
Family and domain databases
HAMAP	MF_00741_A. AIRS_A. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
KO	K01933.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. PurM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_PYRKO

Accession

Primary (citable) accession number: Q5JFN7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	February 15, 2005
Last modified:	December 14, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program