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Protein

DNA polymerase sliding clamp 2

Gene

pcn2

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase sliding clamp 2UniRule annotation
Alternative name(s):
Proliferating cell nuclear antigen homolog 2UniRule annotation
Short name:
PCNA 2UniRule annotation
Gene namesi
Name:pcn2UniRule annotation
Ordered Locus Names:TK0582
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001492091 – 253DNA polymerase sliding clamp 2Add BLAST253

Interactioni

Subunit structurei

Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.UniRule annotation

Protein-protein interaction databases

DIPiDIP-59609N.
STRINGi69014.TK0582.

Structurei

Secondary structure

1253
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Helixi10 – 21Combined sources12
Beta strandi25 – 31Combined sources7
Beta strandi33 – 41Combined sources9
Beta strandi47 – 54Combined sources8
Helixi55 – 57Combined sources3
Beta strandi58 – 65Combined sources8
Beta strandi67 – 72Combined sources6
Helixi73 – 80Combined sources8
Beta strandi88 – 93Combined sources6
Beta strandi95 – 114Combined sources20
Beta strandi132 – 137Combined sources6
Helixi138 – 151Combined sources14
Beta strandi153 – 159Combined sources7
Beta strandi164 – 169Combined sources6
Beta strandi174 – 179Combined sources6
Beta strandi186 – 194Combined sources9
Beta strandi196 – 201Combined sources6
Helixi202 – 209Combined sources8
Beta strandi210 – 212Combined sources3
Beta strandi216 – 222Combined sources7
Beta strandi228 – 234Combined sources7
Turni235 – 237Combined sources3
Beta strandi238 – 244Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LX2X-ray2.40A/B/C1-253[»]
ProteinModelPortaliQ5JFD3.
SMRiQ5JFD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00488. Archaea.
COG0592. LUCA.
HOGENOMiHOG000222371.
InParanoidiQ5JFD3.
KOiK04802.
OMAiTIYLGNN.

Family and domain databases

HAMAPiMF_00317. DNApol_clamp_arch. 1 hit.
InterProiIPR000730. Pr_cel_nuc_antig.
IPR022649. Pr_cel_nuc_antig_C.
IPR022659. Pr_cel_nuc_antig_CS.
IPR022648. Pr_cel_nuc_antig_N.
[Graphical view]
PANTHERiPTHR11352. PTHR11352. 1 hit.
PfamiPF02747. PCNA_C. 1 hit.
PF00705. PCNA_N. 1 hit.
[Graphical view]
PRINTSiPR00339. PCNACYCLIN.
PROSITEiPS01251. PCNA_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JFD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFEIVFDSA REFESLIATL EKFFDEAVFQ VNMEGIQMRA IDPSRVVLVD
60 70 80 90 100
LNLPEMLFSK YSVESEEAIA FDLKRFLKVL KLARSRDTLV LRKGGENFLE
110 120 130 140 150
VGLLGDENTW FKLPLIDANT PEIEIPSLPW TVKAVVLAGA LKRAVKAAKL
160 170 180 190 200
VSDSIYFMAT PEKLTFKAEG NDSEVRTVLT MEDPGLLDLE HKMTKAKSAY
210 220 230 240 250
GVAYLEDILR SLADADEVII RFGFDIPLLL KYMVRDAGEV SFLIAPRVEE

GRS
Length:253
Mass (Da):28,447
Last modified:February 15, 2005 - v1
Checksum:i2460EF12BE490CAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD84771.1.
RefSeqiWP_011249537.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD84771; BAD84771; TK0582.
GeneIDi3235115.
KEGGitko:TK0582.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD84771.1.
RefSeqiWP_011249537.1. NC_006624.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LX2X-ray2.40A/B/C1-253[»]
ProteinModelPortaliQ5JFD3.
SMRiQ5JFD3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59609N.
STRINGi69014.TK0582.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD84771; BAD84771; TK0582.
GeneIDi3235115.
KEGGitko:TK0582.

Phylogenomic databases

eggNOGiarCOG00488. Archaea.
COG0592. LUCA.
HOGENOMiHOG000222371.
InParanoidiQ5JFD3.
KOiK04802.
OMAiTIYLGNN.

Family and domain databases

HAMAPiMF_00317. DNApol_clamp_arch. 1 hit.
InterProiIPR000730. Pr_cel_nuc_antig.
IPR022649. Pr_cel_nuc_antig_C.
IPR022659. Pr_cel_nuc_antig_CS.
IPR022648. Pr_cel_nuc_antig_N.
[Graphical view]
PANTHERiPTHR11352. PTHR11352. 1 hit.
PfamiPF02747. PCNA_C. 1 hit.
PF00705. PCNA_N. 1 hit.
[Graphical view]
PRINTSiPR00339. PCNACYCLIN.
PROSITEiPS01251. PCNA_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCNA2_THEKO
AccessioniPrimary (citable) accession number: Q5JFD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.