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Protein

DNA polymerase sliding clamp 2

Gene

pcn2

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciTKOD69014:GH72-593-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase sliding clamp 2UniRule annotation
Alternative name(s):
Proliferating cell nuclear antigen homolog 2UniRule annotation
Short name:
PCNA 2UniRule annotation
Gene namesi
Name:pcn2UniRule annotation
Ordered Locus Names:TK0582
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253DNA polymerase sliding clamp 2PRO_0000149209Add
BLAST

Interactioni

Subunit structurei

Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.UniRule annotation

Protein-protein interaction databases

DIPiDIP-59609N.
STRINGi69014.TK0582.

Structurei

Secondary structure

1
253
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86Combined sources
Helixi10 – 2112Combined sources
Beta strandi25 – 317Combined sources
Beta strandi33 – 419Combined sources
Beta strandi47 – 548Combined sources
Helixi55 – 573Combined sources
Beta strandi58 – 658Combined sources
Beta strandi67 – 726Combined sources
Helixi73 – 808Combined sources
Beta strandi88 – 936Combined sources
Beta strandi95 – 11420Combined sources
Beta strandi132 – 1376Combined sources
Helixi138 – 15114Combined sources
Beta strandi153 – 1597Combined sources
Beta strandi164 – 1696Combined sources
Beta strandi174 – 1796Combined sources
Beta strandi186 – 1949Combined sources
Beta strandi196 – 2016Combined sources
Helixi202 – 2098Combined sources
Beta strandi210 – 2123Combined sources
Beta strandi216 – 2227Combined sources
Beta strandi228 – 2347Combined sources
Turni235 – 2373Combined sources
Beta strandi238 – 2447Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LX2X-ray2.40A/B/C1-253[»]
ProteinModelPortaliQ5JFD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00488. Archaea.
COG0592. LUCA.
HOGENOMiHOG000222371.
InParanoidiQ5JFD3.
KOiK04802.
OMAiTIYLGNN.

Family and domain databases

HAMAPiMF_00317. DNApol_clamp_arch. 1 hit.
InterProiIPR000730. Pr_cel_nuc_antig.
IPR022649. Pr_cel_nuc_antig_C.
IPR022659. Pr_cel_nuc_antig_CS.
IPR022648. Pr_cel_nuc_antig_N.
[Graphical view]
PANTHERiPTHR11352. PTHR11352. 1 hit.
PfamiPF02747. PCNA_C. 1 hit.
PF00705. PCNA_N. 1 hit.
[Graphical view]
PRINTSiPR00339. PCNACYCLIN.
PROSITEiPS01251. PCNA_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JFD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFEIVFDSA REFESLIATL EKFFDEAVFQ VNMEGIQMRA IDPSRVVLVD
60 70 80 90 100
LNLPEMLFSK YSVESEEAIA FDLKRFLKVL KLARSRDTLV LRKGGENFLE
110 120 130 140 150
VGLLGDENTW FKLPLIDANT PEIEIPSLPW TVKAVVLAGA LKRAVKAAKL
160 170 180 190 200
VSDSIYFMAT PEKLTFKAEG NDSEVRTVLT MEDPGLLDLE HKMTKAKSAY
210 220 230 240 250
GVAYLEDILR SLADADEVII RFGFDIPLLL KYMVRDAGEV SFLIAPRVEE

GRS
Length:253
Mass (Da):28,447
Last modified:February 15, 2005 - v1
Checksum:i2460EF12BE490CAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD84771.1.
RefSeqiWP_011249537.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD84771; BAD84771; TK0582.
GeneIDi3235115.
KEGGitko:TK0582.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD84771.1.
RefSeqiWP_011249537.1. NC_006624.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LX2X-ray2.40A/B/C1-253[»]
ProteinModelPortaliQ5JFD3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59609N.
STRINGi69014.TK0582.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD84771; BAD84771; TK0582.
GeneIDi3235115.
KEGGitko:TK0582.

Phylogenomic databases

eggNOGiarCOG00488. Archaea.
COG0592. LUCA.
HOGENOMiHOG000222371.
InParanoidiQ5JFD3.
KOiK04802.
OMAiTIYLGNN.

Enzyme and pathway databases

BioCyciTKOD69014:GH72-593-MONOMER.

Family and domain databases

HAMAPiMF_00317. DNApol_clamp_arch. 1 hit.
InterProiIPR000730. Pr_cel_nuc_antig.
IPR022649. Pr_cel_nuc_antig_C.
IPR022659. Pr_cel_nuc_antig_CS.
IPR022648. Pr_cel_nuc_antig_N.
[Graphical view]
PANTHERiPTHR11352. PTHR11352. 1 hit.
PfamiPF02747. PCNA_C. 1 hit.
PF00705. PCNA_N. 1 hit.
[Graphical view]
PRINTSiPR00339. PCNACYCLIN.
PROSITEiPS01251. PCNA_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCNA2_THEKO
AccessioniPrimary (citable) accession number: Q5JFD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: November 11, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.