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Protein

S-adenosylmethionine synthase

Gene

mat

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the formation of S-adenosylmethionine from methionine and ATP.UniRule annotation

Catalytic activityi

ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: S-adenosyl-L-methionine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. S-adenosylmethionine synthase (mat)
This subpathway is part of the pathway S-adenosyl-L-methionine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine, the pathway S-adenosyl-L-methionine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi139 – 144ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00315; UER00080.

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine synthaseUniRule annotation (EC:2.5.1.6UniRule annotation)
Short name:
AdoMet synthaseUniRule annotation
Alternative name(s):
Methionine adenosyltransferaseUniRule annotation
Gene namesi
Name:matUniRule annotation
Ordered Locus Names:TK0545
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001500391 – 405S-adenosylmethionine synthaseAdd BLAST405

Interactioni

Protein-protein interaction databases

STRINGi69014.TK0545.

Structurei

Secondary structure

1405
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 12Combined sources5
Helixi18 – 20Combined sources3
Beta strandi21 – 29Combined sources9
Helixi34 – 57Combined sources24
Beta strandi63 – 71Combined sources9
Beta strandi74 – 76Combined sources3
Beta strandi83 – 86Combined sources4
Beta strandi88 – 100Combined sources13
Helixi107 – 122Combined sources16
Turni128 – 130Combined sources3
Beta strandi131 – 136Combined sources6
Beta strandi139 – 143Combined sources5
Helixi145 – 154Combined sources10
Beta strandi165 – 170Combined sources6
Helixi174 – 186Combined sources13
Helixi189 – 194Combined sources6
Beta strandi198 – 209Combined sources12
Beta strandi212 – 222Combined sources11
Helixi223 – 225Combined sources3
Helixi229 – 250Combined sources22
Beta strandi255 – 259Combined sources5
Turni265 – 268Combined sources4
Beta strandi272 – 277Combined sources6
Helixi278 – 281Combined sources4
Turni313 – 315Combined sources3
Helixi317 – 335Combined sources19
Beta strandi339 – 347Combined sources9
Beta strandi358 – 366Combined sources9
Helixi372 – 374Combined sources3
Helixi376 – 388Combined sources13
Turni389 – 391Combined sources3
Helixi392 – 398Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4L4QX-ray2.00A/B/C/D1-405[»]
SMRiQ5JF22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AdoMet synthase 2 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01678. Archaea.
COG1812. LUCA.
HOGENOMiHOG000229842.
InParanoidiQ5JF22.
KOiK00789.
OMAiHNTDQVE.

Family and domain databases

HAMAPiMF_00136. S_AdoMet_synth2. 1 hit.
InterProiIPR027790. AdoMet_synthase_2_family.
IPR002795. S-AdoMet_synthetase_arc.
[Graphical view]
PfamiPF01941. AdoMet_Synthase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JF22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKVRNIVV EELVRTPVEM QKVELVERKG IGHPDSIADG IAEAVSRALS
60 70 80 90 100
REYVKRYGII LHHNTDQVEV VGGRAYPQFG GGEVIKPIYI LLSGRAVEMV
110 120 130 140 150
DREFFPVHEI ALKAAKDYLR KAVRHLDLEH HVIIDSRIGQ GSVDLVGVFN
160 170 180 190 200
KAKKNPIPLA NDTSFGVGYA PLSETEKIVL ETEKYLNSDE FKKKYPAVGE
210 220 230 240 250
DIKVMGLRKG DEIDLTIAAA IVDSEVDNPD DYMAVKEAIY EAAKGIVESH
260 270 280 290 300
TERPTNIYVN TADDPKEGIY YITVTGTSAE AGDDGSVGRG NRVNGLITPN
310 320 330 340 350
RHMSMEAAAG KNPVSHVGKI YNILSMLIAN DIAEQVEGVE EVYVRILSQI
360 370 380 390 400
GKPIDEPLVA SVQIIPKKGY SIDVLQKPAY EIADEWLANI TKIQKMILED

KVNVF
Length:405
Mass (Da):44,615
Last modified:February 15, 2005 - v1
Checksum:i13F0938F4ED2E6B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD84734.1.
RefSeqiWP_011249500.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD84734; BAD84734; TK0545.
GeneIDi3233990.
KEGGitko:TK0545.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD84734.1.
RefSeqiWP_011249500.1. NC_006624.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4L4QX-ray2.00A/B/C/D1-405[»]
SMRiQ5JF22.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi69014.TK0545.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD84734; BAD84734; TK0545.
GeneIDi3233990.
KEGGitko:TK0545.

Phylogenomic databases

eggNOGiarCOG01678. Archaea.
COG1812. LUCA.
HOGENOMiHOG000229842.
InParanoidiQ5JF22.
KOiK00789.
OMAiHNTDQVE.

Enzyme and pathway databases

UniPathwayiUPA00315; UER00080.

Family and domain databases

HAMAPiMF_00136. S_AdoMet_synth2. 1 hit.
InterProiIPR027790. AdoMet_synthase_2_family.
IPR002795. S-AdoMet_synthetase_arc.
[Graphical view]
PfamiPF01941. AdoMet_Synthase. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMETK_THEKO
AccessioniPrimary (citable) accession number: Q5JF22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: November 30, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.