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Protein

Glyoxylate reductase

Gene

gyaR

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Glycolate + NAD+ = glyoxylate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei241UniRule annotation1
Active sitei270UniRule annotation1
Active sitei288Proton donorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi158 – 161NADPUniRule annotation4
Nucleotide bindingi180 – 182NADPUniRule annotation3
Nucleotide bindingi239 – 241NADPUniRule annotation3
Nucleotide bindingi288 – 290NADPUniRule annotation3

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxylate reductaseUniRule annotation (EC:1.1.1.26UniRule annotation)
Gene namesi
Name:gyaRUniRule annotation
Ordered Locus Names:TK0683
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000759501 – 333Glyoxylate reductaseAdd BLAST333

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi69014.TK0683.

Structurei

3D structure databases

ProteinModelPortaliQ5JEZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01755. Archaea.
COG1052. LUCA.
HOGENOMiHOG000136700.
InParanoidiQ5JEZ2.
KOiK00015.
OMAiKSIGPDW.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
HAMAPiMF_00776. GyaR. 1 hit.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR023519. Glyoxylate_reductase_GyaR.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JEZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPKVFITRA IPENGIEMLK EHFEVEVWPE EREIPREVLL KKVRDVDALV
60 70 80 90 100
TMLSERIDSE VFDAAPRLRI VANYAVGYDN IDVEEATRRG IYVTNTPDVL
110 120 130 140 150
TDATADFAWT LLLATARRLI EADHFTRSGE WKRRGIAWHP RWFLGYDVYG
160 170 180 190 200
KTIGIVGFGR IGQAVARRAR GFGMRILYYS RSRKPEAEKE LGAEFRSLED
210 220 230 240 250
LLRESDFVVL AVPLTKETQY MINEERLRLM KKTAILVNIA RGKVVDTKAL
260 270 280 290 300
MKALKEGWIA GAGLDVYEEE PYYNEELFSL KNVVLAPHIG SATYGAREGM
310 320 330
AELVARNLIA FKNGEVPPTL VNKEVVKVRK PGF
Length:333
Mass (Da):37,931
Last modified:February 15, 2005 - v1
Checksum:i5D836274189CC8D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD84872.1.
RefSeqiWP_011249634.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD84872; BAD84872; TK0683.
GeneIDi3234458.
KEGGitko:TK0683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD84872.1.
RefSeqiWP_011249634.1. NC_006624.1.

3D structure databases

ProteinModelPortaliQ5JEZ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi69014.TK0683.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD84872; BAD84872; TK0683.
GeneIDi3234458.
KEGGitko:TK0683.

Phylogenomic databases

eggNOGiarCOG01755. Archaea.
COG1052. LUCA.
HOGENOMiHOG000136700.
InParanoidiQ5JEZ2.
KOiK00015.
OMAiKSIGPDW.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
HAMAPiMF_00776. GyaR. 1 hit.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR023519. Glyoxylate_reductase_GyaR.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGYAR_THEKO
AccessioniPrimary (citable) accession number: Q5JEZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.