Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glyoxylate reductase

Gene

gyaR

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Glycolate + NAD+ = glyoxylate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei241UniRule annotation1
Active sitei270UniRule annotation1
Active sitei288Proton donorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi158 – 161NADPUniRule annotation4
Nucleotide bindingi180 – 182NADPUniRule annotation3
Nucleotide bindingi239 – 241NADPUniRule annotation3
Nucleotide bindingi288 – 290NADPUniRule annotation3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciTKOD69014:G1G2A-679-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxylate reductaseUniRule annotation (EC:1.1.1.26UniRule annotation)
Gene namesi
Name:gyaRUniRule annotation
Ordered Locus Names:TK0683
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000759501 – 333Glyoxylate reductaseAdd BLAST333

Proteomic databases

PRIDEiQ5JEZ2

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi69014.TK0683

Structurei

3D structure databases

ProteinModelPortaliQ5JEZ2
SMRiQ5JEZ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01755 Archaea
COG1052 LUCA
HOGENOMiHOG000136700
InParanoidiQ5JEZ2
KOiK00015
OMAiKWIAHNG
OrthoDBiPOG093Z0DW1

Family and domain databases

HAMAPiMF_00776 GyaR, 1 hit
InterProiView protein in InterPro
IPR006139 D-isomer_2_OHA_DH_cat_dom
IPR029753 D-isomer_DH_CS
IPR029752 D-isomer_DH_CS1
IPR006140 D-isomer_DH_NAD-bd
IPR023519 Glyoxylate_reductase_GyaR
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00389 2-Hacid_dh, 1 hit
PF02826 2-Hacid_dh_C, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00065 D_2_HYDROXYACID_DH_1, 1 hit
PS00671 D_2_HYDROXYACID_DH_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5JEZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPKVFITRA IPENGIEMLK EHFEVEVWPE EREIPREVLL KKVRDVDALV
60 70 80 90 100
TMLSERIDSE VFDAAPRLRI VANYAVGYDN IDVEEATRRG IYVTNTPDVL
110 120 130 140 150
TDATADFAWT LLLATARRLI EADHFTRSGE WKRRGIAWHP RWFLGYDVYG
160 170 180 190 200
KTIGIVGFGR IGQAVARRAR GFGMRILYYS RSRKPEAEKE LGAEFRSLED
210 220 230 240 250
LLRESDFVVL AVPLTKETQY MINEERLRLM KKTAILVNIA RGKVVDTKAL
260 270 280 290 300
MKALKEGWIA GAGLDVYEEE PYYNEELFSL KNVVLAPHIG SATYGAREGM
310 320 330
AELVARNLIA FKNGEVPPTL VNKEVVKVRK PGF
Length:333
Mass (Da):37,931
Last modified:February 15, 2005 - v1
Checksum:i5D836274189CC8D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA Translation: BAD84872.1
RefSeqiWP_011249634.1, NC_006624.1

Genome annotation databases

EnsemblBacteriaiBAD84872; BAD84872; TK0683
GeneIDi3234458
KEGGitko:TK0683
PATRICifig|69014.16.peg.664

Similar proteinsi

Entry informationi

Entry nameiGYAR_THEKO
AccessioniPrimary (citable) accession number: Q5JEZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health