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Protein

Probable deoxyhypusine synthase

Gene

dys

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.UniRule annotation

Catalytic activityi

[eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.UniRule annotation

Cofactori

NAD(+)UniRule annotation

Pathway:ieIF5A hypusination

This protein is involved in the pathway eIF5A hypusination, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway eIF5A hypusination and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei308 – 3081NucleophileUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Hypusine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciTKOD69014:GH72-682-MONOMER.
UniPathwayiUPA00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxyhypusine synthaseUniRule annotation (EC:2.5.1.46UniRule annotation)
Short name:
DHSUniRule annotation
Gene namesi
Name:dysUniRule annotation
Ordered Locus Names:TK0671
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000000536 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Probable deoxyhypusine synthasePRO_0000134506Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi69014.TK0671.

Structurei

3D structure databases

ProteinModelPortaliQ5JEY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the deoxyhypusine synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1899.
HOGENOMiHOG000228838.
InParanoidiQ5JEY0.
KOiK00809.
OMAiEATACFP.

Family and domain databases

Gene3Di3.40.910.10. 1 hit.
HAMAPiMF_00153. DHS.
InterProiIPR022899. Deoxyhypus_synthase_arc.
IPR002773. Deoxyhypusine_synthase.
IPR029035. DHS-like_NAD/FAD-binding_dom.
[Graphical view]
PANTHERiPTHR11703. PTHR11703. 1 hit.
PfamiPF01916. DS. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
TIGRFAMsiTIGR00321. dhys. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5JEY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEPKDIVLK ESEEVEGIPI EGPWLDDVSS LEEVLDYYER IGFQATHLGK
60 70 80 90 100
AIEIWKKVEK RRAEGKEVRV FLGYTSNIIS SGLRELVAWL VKEGKIDVIV
110 120 130 140 150
TTAGGIEEDF IKALKPFILG DWHVNDALMR EKGINRIGNI FVPNDRYIEF
160 170 180 190 200
EKYMIPFFER VLEIEKERGK PLTASEFIYE LGRYMDEKLG KEKERSVIYW
210 220 230 240 250
AYKRNVPIFC PAITDGSIGD MLYFFKEERG DRELIIDIAN DIVKLNNLAV
260 270 280 290 300
TAKETASIIL GGSLPKHAII NANLFRGGTD YAIYITTAVP WDGSLSGAPP
310 320 330
SEGVSWGKIR AKADYVEIWA DATLVFPLLV WKVMKAP
Length:337
Mass (Da):38,214
Last modified:February 15, 2005 - v1
Checksum:i776B14C6D3BEBF36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD84860.1.
RefSeqiWP_011249622.1. NC_006624.1.
YP_183084.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD84860; BAD84860; TK0671.
GeneIDi3234536.
KEGGitko:TK0671.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD84860.1.
RefSeqiWP_011249622.1. NC_006624.1.
YP_183084.1. NC_006624.1.

3D structure databases

ProteinModelPortaliQ5JEY0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi69014.TK0671.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD84860; BAD84860; TK0671.
GeneIDi3234536.
KEGGitko:TK0671.

Phylogenomic databases

eggNOGiCOG1899.
HOGENOMiHOG000228838.
InParanoidiQ5JEY0.
KOiK00809.
OMAiEATACFP.

Enzyme and pathway databases

UniPathwayiUPA00354.
BioCyciTKOD69014:GH72-682-MONOMER.

Family and domain databases

Gene3Di3.40.910.10. 1 hit.
HAMAPiMF_00153. DHS.
InterProiIPR022899. Deoxyhypus_synthase_arc.
IPR002773. Deoxyhypusine_synthase.
IPR029035. DHS-like_NAD/FAD-binding_dom.
[Graphical view]
PANTHERiPTHR11703. PTHR11703. 1 hit.
PfamiPF01916. DS. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
TIGRFAMsiTIGR00321. dhys. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
    Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
    Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Entry informationi

Entry nameiDHYS_THEKO
AccessioniPrimary (citable) accession number: Q5JEY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: July 22, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.