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Q5JEY0

- DHYS_THEKO

UniProt

Q5JEY0 - DHYS_THEKO

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Protein

Probable deoxyhypusine synthase

Gene
dys, TK0671
Organism
Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue By similarity.UniRule annotation

Catalytic activityi

[eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.UniRule annotation

Cofactori

NAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei308 – 3081Nucleophile By similarity

GO - Molecular functioni

  1. deoxyhypusine synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. deoxyhypusine biosynthetic process from spermidine Source: UniProtKB-HAMAP
  2. peptidyl-lysine modification to peptidyl-hypusine Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Hypusine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciTKOD69014:GH72-682-MONOMER.
UniPathwayiUPA00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxyhypusine synthase (EC:2.5.1.46)
Short name:
DHS
Gene namesi
Name:dys
Ordered Locus Names:TK0671
OrganismiThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000000536: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Probable deoxyhypusine synthaseUniRule annotationPRO_0000134506Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi69014.TK0671.

Structurei

3D structure databases

ProteinModelPortaliQ5JEY0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1899.
HOGENOMiHOG000228838.
KOiK00809.
OMAiKRAGMII.

Family and domain databases

Gene3Di3.40.910.10. 1 hit.
HAMAPiMF_00153. DHS.
InterProiIPR022899. Deoxyhypus_synthase_arc.
IPR002773. Deoxyhypusine_synthase.
IPR029035. DHS-like_NAD/FAD-binding_dom.
[Graphical view]
PANTHERiPTHR11703. PTHR11703. 1 hit.
PfamiPF01916. DS. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
TIGRFAMsiTIGR00321. dhys. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5JEY0-1 [UniParc]FASTAAdd to Basket

« Hide

MTEPKDIVLK ESEEVEGIPI EGPWLDDVSS LEEVLDYYER IGFQATHLGK    50
AIEIWKKVEK RRAEGKEVRV FLGYTSNIIS SGLRELVAWL VKEGKIDVIV 100
TTAGGIEEDF IKALKPFILG DWHVNDALMR EKGINRIGNI FVPNDRYIEF 150
EKYMIPFFER VLEIEKERGK PLTASEFIYE LGRYMDEKLG KEKERSVIYW 200
AYKRNVPIFC PAITDGSIGD MLYFFKEERG DRELIIDIAN DIVKLNNLAV 250
TAKETASIIL GGSLPKHAII NANLFRGGTD YAIYITTAVP WDGSLSGAPP 300
SEGVSWGKIR AKADYVEIWA DATLVFPLLV WKVMKAP 337
Length:337
Mass (Da):38,214
Last modified:February 15, 2005 - v1
Checksum:i776B14C6D3BEBF36
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006878 Genomic DNA. Translation: BAD84860.1.
RefSeqiYP_183084.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD84860; BAD84860; TK0671.
GeneIDi3234536.
KEGGitko:TK0671.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006878 Genomic DNA. Translation: BAD84860.1 .
RefSeqi YP_183084.1. NC_006624.1.

3D structure databases

ProteinModelPortali Q5JEY0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 69014.TK0671.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD84860 ; BAD84860 ; TK0671 .
GeneIDi 3234536.
KEGGi tko:TK0671.

Phylogenomic databases

eggNOGi COG1899.
HOGENOMi HOG000228838.
KOi K00809.
OMAi KRAGMII.

Enzyme and pathway databases

UniPathwayi UPA00354 .
BioCyci TKOD69014:GH72-682-MONOMER.

Family and domain databases

Gene3Di 3.40.910.10. 1 hit.
HAMAPi MF_00153. DHS.
InterProi IPR022899. Deoxyhypus_synthase_arc.
IPR002773. Deoxyhypusine_synthase.
IPR029035. DHS-like_NAD/FAD-binding_dom.
[Graphical view ]
PANTHERi PTHR11703. PTHR11703. 1 hit.
Pfami PF01916. DS. 1 hit.
[Graphical view ]
SUPFAMi SSF52467. SSF52467. 1 hit.
TIGRFAMsi TIGR00321. dhys. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
    Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
    Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Entry informationi

Entry nameiDHYS_THEKO
AccessioniPrimary (citable) accession number: Q5JEY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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