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Q5JEY0

- DHYS_THEKO

UniProt

Q5JEY0 - DHYS_THEKO

Protein

Probable deoxyhypusine synthase

Gene

dys

Organism
Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.UniRule annotation

    Catalytic activityi

    [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.UniRule annotation

    Cofactori

    NAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei308 – 3081NucleophileUniRule annotation

    GO - Molecular functioni

    1. deoxyhypusine synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyhypusine biosynthetic process from spermidine Source: UniProtKB-HAMAP
    2. peptidyl-lysine modification to peptidyl-hypusine Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Hypusine biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciTKOD69014:GH72-682-MONOMER.
    UniPathwayiUPA00354.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable deoxyhypusine synthaseUniRule annotation (EC:2.5.1.46UniRule annotation)
    Short name:
    DHSUniRule annotation
    Gene namesi
    Name:dysUniRule annotation
    Ordered Locus Names:TK0671
    OrganismiThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
    Taxonomic identifieri69014 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000000536: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337Probable deoxyhypusine synthasePRO_0000134506Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi69014.TK0671.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5JEY0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the deoxyhypusine synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1899.
    HOGENOMiHOG000228838.
    KOiK00809.
    OMAiKRAGMII.

    Family and domain databases

    Gene3Di3.40.910.10. 1 hit.
    HAMAPiMF_00153. DHS.
    InterProiIPR022899. Deoxyhypus_synthase_arc.
    IPR002773. Deoxyhypusine_synthase.
    IPR029035. DHS-like_NAD/FAD-binding_dom.
    [Graphical view]
    PANTHERiPTHR11703. PTHR11703. 1 hit.
    PfamiPF01916. DS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52467. SSF52467. 1 hit.
    TIGRFAMsiTIGR00321. dhys. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5JEY0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEPKDIVLK ESEEVEGIPI EGPWLDDVSS LEEVLDYYER IGFQATHLGK    50
    AIEIWKKVEK RRAEGKEVRV FLGYTSNIIS SGLRELVAWL VKEGKIDVIV 100
    TTAGGIEEDF IKALKPFILG DWHVNDALMR EKGINRIGNI FVPNDRYIEF 150
    EKYMIPFFER VLEIEKERGK PLTASEFIYE LGRYMDEKLG KEKERSVIYW 200
    AYKRNVPIFC PAITDGSIGD MLYFFKEERG DRELIIDIAN DIVKLNNLAV 250
    TAKETASIIL GGSLPKHAII NANLFRGGTD YAIYITTAVP WDGSLSGAPP 300
    SEGVSWGKIR AKADYVEIWA DATLVFPLLV WKVMKAP 337
    Length:337
    Mass (Da):38,214
    Last modified:February 15, 2005 - v1
    Checksum:i776B14C6D3BEBF36
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006878 Genomic DNA. Translation: BAD84860.1.
    RefSeqiYP_183084.1. NC_006624.1.

    Genome annotation databases

    EnsemblBacteriaiBAD84860; BAD84860; TK0671.
    GeneIDi3234536.
    KEGGitko:TK0671.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006878 Genomic DNA. Translation: BAD84860.1 .
    RefSeqi YP_183084.1. NC_006624.1.

    3D structure databases

    ProteinModelPortali Q5JEY0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 69014.TK0671.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD84860 ; BAD84860 ; TK0671 .
    GeneIDi 3234536.
    KEGGi tko:TK0671.

    Phylogenomic databases

    eggNOGi COG1899.
    HOGENOMi HOG000228838.
    KOi K00809.
    OMAi KRAGMII.

    Enzyme and pathway databases

    UniPathwayi UPA00354 .
    BioCyci TKOD69014:GH72-682-MONOMER.

    Family and domain databases

    Gene3Di 3.40.910.10. 1 hit.
    HAMAPi MF_00153. DHS.
    InterProi IPR022899. Deoxyhypus_synthase_arc.
    IPR002773. Deoxyhypusine_synthase.
    IPR029035. DHS-like_NAD/FAD-binding_dom.
    [Graphical view ]
    PANTHERi PTHR11703. PTHR11703. 1 hit.
    Pfami PF01916. DS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52467. SSF52467. 1 hit.
    TIGRFAMsi TIGR00321. dhys. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
      Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
      Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-918 / JCM 12380 / KOD1.

    Entry informationi

    Entry nameiDHYS_THEKO
    AccessioniPrimary (citable) accession number: Q5JEY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3