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Protein

DNA repair and recombination protein RadA

Gene

radA

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity).By similarity

Miscellaneous

The intein interrupts the ATP-binding site.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Endonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA recombination, Intron homing
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTKOD69014:G1G2A-1910-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair and recombination protein RadA
Cleaved into the following chain:
Gene namesi
Name:radA
Ordered Locus Names:TK1899
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000301641 – 149DNA repair and recombination protein RadA, 1st partSequence analysisAdd BLAST149
ChainiPRO_0000030165150 – 631Pko RadA inteinSequence analysisAdd BLAST482
ChainiPRO_0000030166632 – 836DNA repair and recombination protein RadA, 2nd partSequence analysisAdd BLAST205

Post-translational modificationi

This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.Curated

Keywords - PTMi

Autocatalytic cleavage, Protein splicing

Proteomic databases

PRIDEiQ5JET4

Interactioni

Protein-protein interaction databases

IntActiQ5JET4, 1 interactor
MINTiQ5JET4
STRINGi69014.TK1899

Structurei

3D structure databases

ProteinModelPortaliQ5JET4
SMRiQ5JET4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini285 – 410DOD-type homing endonucleaseAdd BLAST126

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00415 Archaea
arCOG03154 Archaea
COG0468 LUCA
COG1372 LUCA
HOGENOMiHOG000154068
InParanoidiQ5JET4
KOiK04483
OMAiSGKCFAK
OrthoDBiPOG093Z04YH

Family and domain databases

CDDicd01123 Rad51_DMC1_radA, 1 hit
Gene3Di3.10.28.10, 1 hit
HAMAPiMF_00348 RadA_arch, 1 hit
InterProiView protein in InterPro
IPR013632 DNA_recomb/repair_Rad51_C
IPR011938 DNA_recomb/repair_RadA
IPR010995 DNA_repair_Rad51/TF_NusA_a-hlx
IPR003586 Hint_dom_C
IPR003587 Hint_dom_N
IPR036844 Hint_dom_sf
IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
IPR027434 Homing_endonucl
IPR006142 INTEIN
IPR030934 Intein_C
IPR004042 Intein_endonuc
IPR006141 Intein_N
IPR004860 LAGLIDADG_2
IPR027417 P-loop_NTPase
IPR033925 Rad51_DMC1_RadA
IPR020588 RecA_ATP-bd
IPR020587 RecA_monomer-monomer_interface
PfamiView protein in Pfam
PF14528 LAGLIDADG_3, 1 hit
PF08423 Rad51, 2 hits
PRINTSiPR00379 INTEIN
SMARTiView protein in SMART
SM00278 HhH1, 2 hits
SM00305 HintC, 1 hit
SM00306 HintN, 1 hit
SUPFAMiSSF47794 SSF47794, 1 hit
SSF51294 SSF51294, 2 hits
SSF52540 SSF52540, 2 hits
SSF55608 SSF55608, 1 hit
TIGRFAMsiTIGR01443 intein_Cterm, 1 hit
TIGR01445 intein_Nterm, 1 hit
TIGR02236 recomb_radA, 1 hit
PROSITEiView protein in PROSITE
PS50818 INTEIN_C_TER, 1 hit
PS50819 INTEIN_ENDONUCLEASE, 1 hit
PS50817 INTEIN_N_TER, 1 hit
PS50162 RECA_2, 2 hits
PS50163 RECA_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5JET4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKKKVEDE VKELEEFEEL DVEESLSSSD KQSKPEKKIS ALEDLPGVGP
60 70 80 90 100
ATAEKLREAG YDTIEAIAVA SPLELKEIAG ISEGAALKII QAAREAANIG
110 120 130 140 150
TFMRADEYMK RRTTIGKIST GSKALDKLLG GGIETQAITE VFGEFGSGKC
160 170 180 190 200
FAKDTKVYYE NDTLVHFESI EDMYHKYASL GREVPFDNGY AVPLETVSVY
210 220 230 240 250
TFDPKTGEVK RTKASYIYRE KVEKLAEIRL SNGYLLRITL LHPVLVFRNG
260 270 280 290 300
LQWVPAGMIK PGDLIVGIRS VPANAATIEE SEAYFLGLFV AEGTSNPLSI
310 320 330 340 350
TTGSEELKDF IVSFIEDHDG YTPTVEVRRG LYRILFRKKT AEWLGELATS
360 370 380 390 400
NASTKVVPER VLNAGESAIA AFLAGYLDGD GYLTESIVEL VTKSRELADG
410 420 430 440 450
LVFLLKRLGI TPRISQKTIE GSVYYRIYIT GEDRKTFEKV LEKSRIKPGE
460 470 480 490 500
MNEGGVGRYP PALGKFLGKL YSEFRLPKRD NETAYHILTR SRNVWFTEKT
510 520 530 540 550
LSRIEEYFRE ALEKLSEARK ALEMGDKPEL PFPWTAITKY GFTDRQVANY
560 570 580 590 600
RTRGLPKRPE LKEKVVSALL KEIERLEGVA KLALETIELA RRLEFHEVSS
610 620 630 640 650
VEVVDYNDWV YDLVIPETHN FIAPNGLVLH NTQLAHTLAV MVQKPPEEGG
660 670 680 690 700
LGGSVIWIDT ENTFRPERIK QIAENRGLDP EETLKNIYVA RAFNSNHQML
710 720 730 740 750
LVEKAEEIIK EKAESDRPVK LLVVDSLMAH FRAEYVGRGT LAERQQKLAK
760 770 780 790 800
HLADLHRLAD LYDIAVFVTN QVQAKPDAFF GDPTRPVGGH ILAHSATLRV
810 820 830
YLRKGKAGKR VARLIDSPHL PEGEAVFRIT EKGVED
Length:836
Mass (Da):93,707
Last modified:February 15, 2005 - v1
Checksum:i57387B98C8317F04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA Translation: BAD86088.1
RefSeqiWP_011250850.1, NC_006624.1

Genome annotation databases

EnsemblBacteriaiBAD86088; BAD86088; TK1899
GeneIDi3233960
KEGGitko:TK1899
PATRICifig|69014.16.peg.1857

Similar proteinsi

Entry informationi

Entry nameiRADA_THEKO
AccessioniPrimary (citable) accession number: Q5JET4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Intein-containing proteins
    List of intein-containing protein entries
  2. SIMILARITY comments
    Index of protein domains and families

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