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Protein

tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 2

Gene

taw3-2

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-((3S)-(3-amino-3-carboxypropyl))-4-demethylwyosine(37) in tRNA(Phe) = S-adenosyl-L-homocysteine + 7-((3S)-(3-amino-3-carboxypropyl))wyosine(37) in tRNA(Phe).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciTKOD69014:G1G2A-1919-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 2UniRule annotation (EC:2.1.1.282UniRule annotation)
Alternative name(s):
tRNA wyosine derivatives biosynthesis protein Taw3 2UniRule annotation
Gene namesi
Name:taw3-2UniRule annotation
Ordered Locus Names:TK1907
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001571011 – 212tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 2Add BLAST212

Interactioni

Protein-protein interaction databases

STRINGi69014.TK1907

Structurei

3D structure databases

ProteinModelPortaliQ5JES6
SMRiQ5JES6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TYW3 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04156 Archaea
COG1590 LUCA
HOGENOMiHOG000222308
InParanoidiQ5JES6
KOiK15450
OMAiGFKYTTF
OrthoDBiPOG093Z0FD3

Family and domain databases

Gene3Di3.30.1960.10, 1 hit
HAMAPiMF_00266 TYW3_archaea, 1 hit
InterProiView protein in InterPro
IPR022908 Taw3
IPR003827 tRNA_yW-synthesising
IPR036602 tRNA_yW-synthesising-like_sf
PfamiView protein in Pfam
PF02676 TYW3, 1 hit
SUPFAMiSSF111278 SSF111278, 1 hit

Sequencei

Sequence statusi: Complete.

Q5JES6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAKREALQS LFTAMRDGKV DGDIIDLLLL INSIKGIYTT SSCSGRIGII
60 70 80 90 100
EEPALGAKPL SRWLIKVHRP IEFEEAKEAL KNAKEGIIFL KSQPPIFHVV
110 120 130 140 150
AEDLEKARKL HELGLASGFK YTTFKVISKR YLVEINATEY LTAPLGRDGR
160 170 180 190 200
VLVDDGYLRF AVEIGNEMLR RSKGRLPRLE ENFRRLREEL GTDELFYELV
210
EEYKIRENWE LP
Length:212
Mass (Da):24,351
Last modified:February 15, 2005 - v1
Checksum:iD3BDA2CB7D52F05B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA Translation: BAD86096.1
RefSeqiWP_011250858.1, NC_006624.1

Genome annotation databases

EnsemblBacteriaiBAD86096; BAD86096; TK1907
GeneIDi3234934
KEGGitko:TK1907
PATRICifig|69014.16.peg.1864

Similar proteinsi

Entry informationi

Entry nameiTYW32_THEKO
AccessioniPrimary (citable) accession number: Q5JES6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health