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Q5JEQ6

- MTAP_THEKO

UniProt

Q5JEQ6 - MTAP_THEKO

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Protein
S-methyl-5'-thioadenosine phosphorylase
Gene
mtnP, TK1895
Organism
Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates By similarity.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101Phosphate By similarity
Sitei163 – 1631Important for substrate specificity By similarity
Binding sitei180 – 1801Substrate; via amide nitrogen By similarity
Binding sitei181 – 1811Phosphate By similarity
Sitei215 – 2151Important for substrate specificity By similarity

GO - Molecular functioni

  1. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP
  2. phosphorylase activity Source: InterPro

GO - Biological processi

  1. L-methionine salvage from methylthioadenosine Source: UniProtKB-HAMAP
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciTKOD69014:GH72-1932-MONOMER.
UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylase (EC:2.4.2.28)
Alternative name(s):
5'-methylthioadenosine phosphorylase
Short name:
MTA phosphorylase
Short name:
MTAP
Gene namesi
Name:mtnP
Ordered Locus Names:TK1895
OrganismiThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000000536: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257S-methyl-5'-thioadenosine phosphorylaseUniRule annotation
PRO_0000415108Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer By similarity.UniRule annotation

Protein-protein interaction databases

IntActiQ5JEQ6. 1 interaction.
MINTiMINT-8377197.
STRINGi69014.TK1895.

Structurei

3D structure databases

ProteinModelPortaliQ5JEQ6.
SMRiQ5JEQ6. Positions 4-257.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 512Phosphate binding By similarity
Regioni83 – 842Phosphate binding By similarity
Regioni204 – 2063Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0005.
HOGENOMiHOG000228987.
KOiK00772.
OMAiDYTFYNG.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.
PROSITEiPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JEQ6-1 [UniParc]FASTAAdd to Basket

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MPRIGIIGGS GVYGVFEPKE TVKVHTPYGR PSAPVEIGEI EGVEVAFIPR    50
HGKHHEFPPH EVPYRANIWA LKELGVERVI GITAVGSLRE EYKPGDIVIT 100
DQFIDFTKKR DYTFYNGPRV AHVSMADPFC PEMRKIFYET AKELGFPVHE 150
KGTYVCIEGP RFSTRAESFM FRQFAHIIGM TLVPEVNLAR ELGMCYVNIA 200
TVTDYDVWAD KPVDAQEVLK VMAENNYKVQ ELLKKGIPKI PEERHCGCAD 250
VLKTMFV 257
Length:257
Mass (Da):29,076
Last modified:February 15, 2005 - v1
Checksum:iF2655D33A7EADFF5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006878 Genomic DNA. Translation: BAD86084.1.
RefSeqiYP_184308.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD86084; BAD86084; TK1895.
GeneIDi3235538.
KEGGitko:TK1895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006878 Genomic DNA. Translation: BAD86084.1 .
RefSeqi YP_184308.1. NC_006624.1.

3D structure databases

ProteinModelPortali Q5JEQ6.
SMRi Q5JEQ6. Positions 4-257.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q5JEQ6. 1 interaction.
MINTi MINT-8377197.
STRINGi 69014.TK1895.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD86084 ; BAD86084 ; TK1895 .
GeneIDi 3235538.
KEGGi tko:TK1895.

Phylogenomic databases

eggNOGi COG0005.
HOGENOMi HOG000228987.
KOi K00772.
OMAi DYTFYNG.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .
BioCyci TKOD69014:GH72-1932-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
PROSITEi PS01240. PNP_MTAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
    Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
    Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Entry informationi

Entry nameiMTAP_THEKO
AccessioniPrimary (citable) accession number: Q5JEQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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