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Q5JEP3 (SYW_PYRKO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase
EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:TK1874
OrganismPyrococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Thermococcus kodakaraensis (strain KOD1)) [Reference proteome] [HAMAP]
Taxonomic identifier69014 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus ›

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136731

Regions

Motif81 – 899"HIGH" region HAMAP-Rule MF_00140
Motif252 – 2565"KMSKS" region HAMAP-Rule MF_00140

Sequences

Sequence LengthMass (Da)Tools
Q5JEP3 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 6C7FD1CF5263DCB2

FASTA38444,844
        10         20         30         40         50         60 
MDDFKVTPWD VEGVVDYNKL IEQFGTSPLT DELIEKTAEL TKSELPLFFR RRFFFSHRDY 

        70         80         90        100        110        120 
DKVLADYESG RGFFLYTGRG PSGPMHIGHI IPFFATKWLQ ENFDVNLYIQ ITDDEKFLFK 

       130        140        150        160        170        180 
EKLSFEDTKR WAYENILDII AVGFDPDKTF IFQNSEFTKI YEMALPIAKK INFSMARAVF 

       190        200        210        220        230        240 
GFNEQSKIGM IFYPAIQAAP TFFEKKRCLI PAAIDQDPYW RLQRDFAESL GYYKTAAIHS 

       250        260        270        280        290        300 
KFVPGLTSLE GKMSASKPET AVYLTDDPEE AGKKIWKFAL TGGQPTLKEQ REKGGNPEKC 

       310        320        330        340        350        360 
VVFKWFEIFF EPDDEKLMER YRACKAGELT CGQCKRELIE RVQKFLKEHQ KKRKEAEKKV 

       370        380 
EKFKYTGELA QEQWDKAIPE PLRT

« Hide

References

[1]"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006878 Genomic DNA. Translation: BAD86063.1.
RefSeqYP_184287.1. NC_006624.1.

3D structure databases

ProteinModelPortalQ5JEP3.
ModBaseSearch...

Protein-protein interaction databases

STRING69014.TK1874.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD86063; BAD86063; TK1874.
GeneID3235830.
KEGGtko:TK1874.

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000224742.
KOK01867.
OMAKTGGRET.
ProtClustDBPRK12285.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_A. Trp_tRNA_synth_A.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYW_PYRKO
AccessionPrimary (citable) accession number: Q5JEP3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

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