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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTKOD69014:G1G2A-1885-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:TK1874
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367311 – 384Tryptophan--tRNA ligaseAdd BLAST384

Interactioni

Protein-protein interaction databases

STRINGi69014.TK1874

Structurei

3D structure databases

ProteinModelPortaliQ5JEP3
SMRiQ5JEP3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 89"HIGH" region9
Motifi252 – 256"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01887 Archaea
COG0180 LUCA
HOGENOMiHOG000224742
InParanoidiQ5JEP3
KOiK01867
OMAiADILHPQ
OrthoDBiPOG093Z034D

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00140_A Trp_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR020653 Tryptophan-tRNA-ligase_arc
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q5JEP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDFKVTPWD VEGVVDYNKL IEQFGTSPLT DELIEKTAEL TKSELPLFFR
60 70 80 90 100
RRFFFSHRDY DKVLADYESG RGFFLYTGRG PSGPMHIGHI IPFFATKWLQ
110 120 130 140 150
ENFDVNLYIQ ITDDEKFLFK EKLSFEDTKR WAYENILDII AVGFDPDKTF
160 170 180 190 200
IFQNSEFTKI YEMALPIAKK INFSMARAVF GFNEQSKIGM IFYPAIQAAP
210 220 230 240 250
TFFEKKRCLI PAAIDQDPYW RLQRDFAESL GYYKTAAIHS KFVPGLTSLE
260 270 280 290 300
GKMSASKPET AVYLTDDPEE AGKKIWKFAL TGGQPTLKEQ REKGGNPEKC
310 320 330 340 350
VVFKWFEIFF EPDDEKLMER YRACKAGELT CGQCKRELIE RVQKFLKEHQ
360 370 380
KKRKEAEKKV EKFKYTGELA QEQWDKAIPE PLRT
Length:384
Mass (Da):44,844
Last modified:February 15, 2005 - v1
Checksum:i6C7FD1CF5263DCB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA Translation: BAD86063.1
RefSeqiWP_011250825.1, NC_006624.1

Genome annotation databases

EnsemblBacteriaiBAD86063; BAD86063; TK1874
GeneIDi3235830
KEGGitko:TK1874
PATRICifig|69014.16.peg.1832

Similar proteinsi

Entry informationi

Entry nameiSYW_THEKO
AccessioniPrimary (citable) accession number: Q5JEP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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