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Q5JE49

- IF2A_THEKO

UniProt

Q5JE49 - IF2A_THEKO

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Protein

Translation initiation factor 2 subunit alpha

Gene

eif2a

Organism
Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.UniRule annotation

GO - Molecular functioni

  1. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciTKOD69014:GH72-1113-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit alphaUniRule annotation
Alternative name(s):
aIF2-alphaUniRule annotation
eIF-2-alphaUniRule annotation
Gene namesi
Name:eif2aUniRule annotation
Ordered Locus Names:TK1100
OrganismiThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000000536: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. eukaryotic translation initiation factor 2 complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Translation initiation factor 2 subunit alphaPRO_0000137401Add
BLAST

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.UniRule annotation

Protein-protein interaction databases

STRINGi69014.TK1100.

Structurei

3D structure databases

ProteinModelPortaliQ5JE49.
SMRiQ5JE49. Positions 5-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 8372S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the eIF-2-alpha family.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1093.
HOGENOMiHOG000224965.
InParanoidiQ5JE49.
KOiK03237.
OMAiIDAEFEI.

Family and domain databases

Gene3Di1.10.150.190. 1 hit.
2.40.50.140. 1 hit.
3.30.70.1130. 1 hit.
HAMAPiMF_00231. eIF_2_alpha.
InterProiIPR012340. NA-bd_OB-fold.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR022967. S1_dom.
IPR022964. TIF2_asu_arc.
IPR024055. TIF2_asu_C.
IPR024054. TIF2_asu_middle.
IPR011488. TIF_2_asu.
[Graphical view]
PfamiPF07541. EIF_2_alpha. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
SMARTiSM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF110993. SSF110993. 1 hit.
SSF116742. SSF116742. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEiPS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JE49-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRKAKEYPE EGEFVVATVK NIHPYGAFLT LDEYPGKEGF MHISEVAPTW
60 70 80 90 100
VKNIRDYLKE GQKIVAKVIR VDPEKGHIDL SLKRVNQQQR KAKLQEYKRA
110 120 130 140 150
QKAENLLKMA AEKLGKDFET AWREVWVPLE EEYGEVYAAF EDAAQNGMDV
160 170 180 190 200
LKGLISDEWI EALKPIIEAY VEIPTVTIDA EFEITVPKPN GIEIIKEALI
210 220 230 240 250
KARDRANQEK DIEVKFSYQG APRYRIDITA PDYYKAEEVL EDIAEEILRV
260 270
IKEAGGEATL IRKEKRIKKV KKRGS
Length:275
Mass (Da):31,590
Last modified:February 15, 2005 - v1
Checksum:i52C9A8448C6DB0E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006878 Genomic DNA. Translation: BAD85289.1.
RefSeqiYP_183513.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD85289; BAD85289; TK1100.
GeneIDi3233948.
KEGGitko:TK1100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006878 Genomic DNA. Translation: BAD85289.1 .
RefSeqi YP_183513.1. NC_006624.1.

3D structure databases

ProteinModelPortali Q5JE49.
SMRi Q5JE49. Positions 5-265.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 69014.TK1100.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD85289 ; BAD85289 ; TK1100 .
GeneIDi 3233948.
KEGGi tko:TK1100.

Phylogenomic databases

eggNOGi COG1093.
HOGENOMi HOG000224965.
InParanoidi Q5JE49.
KOi K03237.
OMAi IDAEFEI.

Enzyme and pathway databases

BioCyci TKOD69014:GH72-1113-MONOMER.

Family and domain databases

Gene3Di 1.10.150.190. 1 hit.
2.40.50.140. 1 hit.
3.30.70.1130. 1 hit.
HAMAPi MF_00231. eIF_2_alpha.
InterProi IPR012340. NA-bd_OB-fold.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR022967. S1_dom.
IPR022964. TIF2_asu_arc.
IPR024055. TIF2_asu_C.
IPR024054. TIF2_asu_middle.
IPR011488. TIF_2_asu.
[Graphical view ]
Pfami PF07541. EIF_2_alpha. 1 hit.
PF00575. S1. 1 hit.
[Graphical view ]
SMARTi SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF110993. SSF110993. 1 hit.
SSF116742. SSF116742. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEi PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
    Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
    Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Entry informationi

Entry nameiIF2A_THEKO
AccessioniPrimary (citable) accession number: Q5JE49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: February 15, 2005
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3