Q5JE49 (IF2A_PYRKO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Translation initiation factor 2 subunit alpha

Alternative name(s):
aIF2-alpha
eIF-2-alpha

Gene names

Name:	eif2a
Ordered Locus Names:	TK1100

Organism

Pyrococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Thermococcus kodakaraensis (strain KOD1)) [Reference proteome] [HAMAP]

Taxonomic identifier

69014 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus › Thermococcus kodakarensis

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA By similarity. HAMAP-Rule MF_00231
Subunit structure	Heterotrimer composed of an alpha, a beta and a gamma chain By similarity.
Sequence similarities	Belongs to the eIF-2-alpha family. Contains 1 S1 motif domain.

Ontologies

Keywords
Biological process	Protein biosynthesis
Ligand	RNA-binding
Molecular function	Initiation factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	eukaryotic translation initiation factor 2 complex Inferred from electronic annotation. Source: InterPro
Molecular_function	translation initiation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 275	275	Translation initiation factor 2 subunit alpha HAMAP-Rule MF_00231		PRO_0000137401
Regions
	Domain	12 – 83	72	S1 motif

Sequences

	Sequence		Length	Mass (Da)
	Q5JE49 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 52C9A8448C6DB0E3	FASTA	275	31,590
	10 20 30 40 50 60 MPRKAKEYPE EGEFVVATVK NIHPYGAFLT LDEYPGKEGF MHISEVAPTW VKNIRDYLKE 70 80 90 100 110 120 GQKIVAKVIR VDPEKGHIDL SLKRVNQQQR KAKLQEYKRA QKAENLLKMA AEKLGKDFET 130 140 150 160 170 180 AWREVWVPLE EEYGEVYAAF EDAAQNGMDV LKGLISDEWI EALKPIIEAY VEIPTVTIDA 190 200 210 220 230 240 EFEITVPKPN GIEIIKEALI KARDRANQEK DIEVKFSYQG APRYRIDITA PDYYKAEEVL 250 260 270 EDIAEEILRV IKEAGGEATL IRKEKRIKKV KKRGS

References

[1]

"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes." Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T. Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006878 Genomic DNA. Translation: BAD85289.1.
RefSeq	YP_183513.1. NC_006624.1.
3D structure databases
ProteinModelPortal	Q5JE49.
SMR	Q5JE49. Positions 5-265.
ModBase	Search...
Protein-protein interaction databases
STRING	69014.TK1100.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAD85289; BAD85289; TK1100.
GeneID	3233948.
KEGG	tko:TK1100.
Phylogenomic databases
eggNOG	COG1093.
HOGENOM	HOG000224965.
KO	K03237.
OMA	KDVNEHQ.
ProtClustDB	PRK03987.
Family and domain databases
Gene3D	1.10.150.190. 1 hit. 2.40.50.140. 1 hit. 3.30.70.1130. 1 hit.
HAMAP	MF_00231. eIF-2-alpha.
InterPro	IPR012340. NA-bd_OB-fold. IPR003029. Rbsml_prot_S1_RNA-bd_dom. IPR022967. RNA-binding_domain_S1. IPR022964. TIF2_asu_arc. IPR024055. TIF2_asu_C. IPR024054. TIF2_asu_middle. IPR011488. TIF_2_asu. [Graphical view]
Pfam	PF07541. EIF_2_alpha. 1 hit. PF00575. S1. 1 hit. [Graphical view]
SMART	SM00316. S1. 1 hit. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit. SSF110993. SSF110993. 1 hit. SSF116742. SSF116742. 1 hit.
PROSITE	PS50126. S1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IF2A_PYRKO

Accession

Primary (citable) accession number: Q5JE49

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	February 15, 2005
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program