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Q5JE49 (IF2A_THEKO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor 2 subunit alpha
Alternative name(s):
aIF2-alpha
eIF-2-alpha
Gene names
Name:eif2a
Ordered Locus Names:TK1100
OrganismThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) [Reference proteome] [HAMAP]
Taxonomic identifier69014 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA By similarity. HAMAP-Rule MF_00231

Subunit structure

Heterotrimer composed of an alpha, a beta and a gamma chain By similarity.

Sequence similarities

Belongs to the eIF-2-alpha family.

Contains 1 S1 motif domain.

Ontologies

Keywords
   Biological processProtein biosynthesis
   LigandRNA-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componenteukaryotic translation initiation factor 2 complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functiontranslation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275Translation initiation factor 2 subunit alpha HAMAP-Rule MF_00231
PRO_0000137401

Regions

Domain12 – 8372S1 motif

Sequences

Sequence LengthMass (Da)Tools
Q5JE49 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 52C9A8448C6DB0E3

FASTA27531,590
        10         20         30         40         50         60 
MPRKAKEYPE EGEFVVATVK NIHPYGAFLT LDEYPGKEGF MHISEVAPTW VKNIRDYLKE 

        70         80         90        100        110        120 
GQKIVAKVIR VDPEKGHIDL SLKRVNQQQR KAKLQEYKRA QKAENLLKMA AEKLGKDFET 

       130        140        150        160        170        180 
AWREVWVPLE EEYGEVYAAF EDAAQNGMDV LKGLISDEWI EALKPIIEAY VEIPTVTIDA 

       190        200        210        220        230        240 
EFEITVPKPN GIEIIKEALI KARDRANQEK DIEVKFSYQG APRYRIDITA PDYYKAEEVL 

       250        260        270 
EDIAEEILRV IKEAGGEATL IRKEKRIKKV KKRGS 

« Hide

References

[1]"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006878 Genomic DNA. Translation: BAD85289.1.
RefSeqYP_183513.1. NC_006624.1.

3D structure databases

ProteinModelPortalQ5JE49.
SMRQ5JE49. Positions 5-265.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING69014.TK1100.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD85289; BAD85289; TK1100.
GeneID3233948.
KEGGtko:TK1100.

Phylogenomic databases

eggNOGCOG1093.
HOGENOMHOG000224965.
KOK03237.
OMAKDVNEHQ.
ProtClustDBPRK03987.

Enzyme and pathway databases

BioCycTKOD69014:GH72-1113-MONOMER.

Family and domain databases

Gene3D1.10.150.190. 1 hit.
2.40.50.140. 1 hit.
3.30.70.1130. 1 hit.
HAMAPMF_00231. eIF_2_alpha.
InterProIPR012340. NA-bd_OB-fold.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR022967. RNA-binding_domain_S1.
IPR022964. TIF2_asu_arc.
IPR024055. TIF2_asu_C.
IPR024054. TIF2_asu_middle.
IPR011488. TIF_2_asu.
[Graphical view]
PfamPF07541. EIF_2_alpha. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
SMARTSM00316. S1. 1 hit.
[Graphical view]
SUPFAMSSF110993. SSF110993. 1 hit.
SSF116742. SSF116742. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEPS50126. S1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2A_THEKO
AccessionPrimary (citable) accession number: Q5JE49
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: February 15, 2005
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries