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Q5JE49

- IF2A_THEKO

UniProt

Q5JE49 - IF2A_THEKO

Protein

Translation initiation factor 2 subunit alpha

Gene

eif2a

Organism
Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.UniRule annotation

    GO - Molecular functioni

    1. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciTKOD69014:GH72-1113-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor 2 subunit alphaUniRule annotation
    Alternative name(s):
    aIF2-alphaUniRule annotation
    eIF-2-alphaUniRule annotation
    Gene namesi
    Name:eif2aUniRule annotation
    Ordered Locus Names:TK1100
    OrganismiThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
    Taxonomic identifieri69014 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000000536: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. eukaryotic translation initiation factor 2 complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 275275Translation initiation factor 2 subunit alphaPRO_0000137401Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotrimer composed of an alpha, a beta and a gamma chain.UniRule annotation

    Protein-protein interaction databases

    STRINGi69014.TK1100.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5JE49.
    SMRiQ5JE49. Positions 5-265.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 8372S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the eIF-2-alpha family.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1093.
    HOGENOMiHOG000224965.
    KOiK03237.
    OMAiIDAEFEI.

    Family and domain databases

    Gene3Di1.10.150.190. 1 hit.
    2.40.50.140. 1 hit.
    3.30.70.1130. 1 hit.
    HAMAPiMF_00231. eIF_2_alpha.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR022967. RNA-binding_domain_S1.
    IPR022964. TIF2_asu_arc.
    IPR024055. TIF2_asu_C.
    IPR024054. TIF2_asu_middle.
    IPR011488. TIF_2_asu.
    [Graphical view]
    PfamiPF07541. EIF_2_alpha. 1 hit.
    PF00575. S1. 1 hit.
    [Graphical view]
    SMARTiSM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF110993. SSF110993. 1 hit.
    SSF116742. SSF116742. 1 hit.
    SSF50249. SSF50249. 1 hit.
    PROSITEiPS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5JE49-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRKAKEYPE EGEFVVATVK NIHPYGAFLT LDEYPGKEGF MHISEVAPTW    50
    VKNIRDYLKE GQKIVAKVIR VDPEKGHIDL SLKRVNQQQR KAKLQEYKRA 100
    QKAENLLKMA AEKLGKDFET AWREVWVPLE EEYGEVYAAF EDAAQNGMDV 150
    LKGLISDEWI EALKPIIEAY VEIPTVTIDA EFEITVPKPN GIEIIKEALI 200
    KARDRANQEK DIEVKFSYQG APRYRIDITA PDYYKAEEVL EDIAEEILRV 250
    IKEAGGEATL IRKEKRIKKV KKRGS 275
    Length:275
    Mass (Da):31,590
    Last modified:February 15, 2005 - v1
    Checksum:i52C9A8448C6DB0E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006878 Genomic DNA. Translation: BAD85289.1.
    RefSeqiYP_183513.1. NC_006624.1.

    Genome annotation databases

    EnsemblBacteriaiBAD85289; BAD85289; TK1100.
    GeneIDi3233948.
    KEGGitko:TK1100.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006878 Genomic DNA. Translation: BAD85289.1 .
    RefSeqi YP_183513.1. NC_006624.1.

    3D structure databases

    ProteinModelPortali Q5JE49.
    SMRi Q5JE49. Positions 5-265.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 69014.TK1100.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD85289 ; BAD85289 ; TK1100 .
    GeneIDi 3233948.
    KEGGi tko:TK1100.

    Phylogenomic databases

    eggNOGi COG1093.
    HOGENOMi HOG000224965.
    KOi K03237.
    OMAi IDAEFEI.

    Enzyme and pathway databases

    BioCyci TKOD69014:GH72-1113-MONOMER.

    Family and domain databases

    Gene3Di 1.10.150.190. 1 hit.
    2.40.50.140. 1 hit.
    3.30.70.1130. 1 hit.
    HAMAPi MF_00231. eIF_2_alpha.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR022967. RNA-binding_domain_S1.
    IPR022964. TIF2_asu_arc.
    IPR024055. TIF2_asu_C.
    IPR024054. TIF2_asu_middle.
    IPR011488. TIF_2_asu.
    [Graphical view ]
    Pfami PF07541. EIF_2_alpha. 1 hit.
    PF00575. S1. 1 hit.
    [Graphical view ]
    SMARTi SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF110993. SSF110993. 1 hit.
    SSF116742. SSF116742. 1 hit.
    SSF50249. SSF50249. 1 hit.
    PROSITEi PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
      Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
      Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-918 / JCM 12380 / KOD1.

    Entry informationi

    Entry nameiIF2A_THEKO
    AccessioniPrimary (citable) accession number: Q5JE49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Translation initiation factors
      List of translation initiation factor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3