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Protein

Translation initiation factor 2 subunit alpha

Gene

eif2a

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit alphaUniRule annotation
Alternative name(s):
aIF2-alphaUniRule annotation
eIF-2-alphaUniRule annotation
Gene namesi
Name:eif2aUniRule annotation
Ordered Locus Names:TK1100
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001374011 – 275Translation initiation factor 2 subunit alphaAdd BLAST275

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.UniRule annotation

Protein-protein interaction databases

STRINGi69014.TK1100.

Structurei

3D structure databases

ProteinModelPortaliQ5JE49.
SMRiQ5JE49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 83S1 motifUniRule annotationAdd BLAST72

Sequence similaritiesi

Belongs to the eIF-2-alpha family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04107. Archaea.
COG1093. LUCA.
HOGENOMiHOG000224965.
InParanoidiQ5JE49.
KOiK03237.
OMAiKDVNEHQ.
OrthoDBiPOG093Z07K6.

Family and domain databases

Gene3Di1.10.150.190. 1 hit.
3.30.70.1130. 1 hit.
HAMAPiMF_00231. eIF_2_alpha. 1 hit.
InterProiView protein in InterPro
IPR012340. NA-bd_OB-fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
IPR022964. TIF2_asu_arc.
IPR024055. TIF2_asu_C.
IPR024054. TIF2_asu_middle.
IPR011488. TIF_2_asu.
PANTHERiPTHR10602. PTHR10602. 1 hit.
PfamiView protein in Pfam
PF07541. EIF_2_alpha. 1 hit.
PF00575. S1. 1 hit.
SMARTiView protein in SMART
SM00316. S1. 1 hit.
SUPFAMiSSF110993. SSF110993. 1 hit.
SSF116742. SSF116742. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEiView protein in PROSITE
PS50126. S1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5JE49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRKAKEYPE EGEFVVATVK NIHPYGAFLT LDEYPGKEGF MHISEVAPTW
60 70 80 90 100
VKNIRDYLKE GQKIVAKVIR VDPEKGHIDL SLKRVNQQQR KAKLQEYKRA
110 120 130 140 150
QKAENLLKMA AEKLGKDFET AWREVWVPLE EEYGEVYAAF EDAAQNGMDV
160 170 180 190 200
LKGLISDEWI EALKPIIEAY VEIPTVTIDA EFEITVPKPN GIEIIKEALI
210 220 230 240 250
KARDRANQEK DIEVKFSYQG APRYRIDITA PDYYKAEEVL EDIAEEILRV
260 270
IKEAGGEATL IRKEKRIKKV KKRGS
Length:275
Mass (Da):31,590
Last modified:February 15, 2005 - v1
Checksum:i52C9A8448C6DB0E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD85289.1.
RefSeqiWP_011250051.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD85289; BAD85289; TK1100.
GeneIDi3233948.
KEGGitko:TK1100.
PATRICifig|69014.16.peg.1076.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiIF2A_THEKO
AccessioniPrimary (citable) accession number: Q5JE49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: February 15, 2005
Last modified: June 7, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families