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Q5JE39 (GLKA_PYRKO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ADP-dependent glucokinase
Short name=ADP-GK
Short name=ADPGK
EC=2.7.1.147
Gene names
Name:glkA
Ordered Locus Names:TK1110
OrganismPyrococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Thermococcus kodakaraensis (strain KOD1))
Taxonomic identifier69014 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor By similarity. HAMAP MF_00809

Catalytic activity

ADP + D-glucose = AMP + D-glucose 6-phosphate. HAMAP MF_00809

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00809

Pathway

Carbohydrate degradation; glycolysis. HAMAP MF_00809

Subunit structure

Monomer By similarity. HAMAP MF_00809

Subcellular location

Cytoplasm By similarity HAMAP MF_00809.

Sequence similarities

Belongs to the ADP-dependent glucokinase family.

Contains 1 ADPK (ADP-dependent kinase) domain.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
Glycolysis
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionADP-specific glucokinase activity

Inferred from electronic annotation. Source: EC

magnesium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453ADP-dependent glucokinase HAMAP MF_00809
PRO_0000184774

Regions

Domain1 – 453453ADPK
Nucleotide binding341 – 3433ADP By similarity
Nucleotide binding437 – 4415ADP By similarity

Sites

Active site4391Proton acceptor By similarity
Metal binding2651Magnesium By similarity
Metal binding2941Magnesium By similarity
Metal binding4391Magnesium By similarity
Binding site291Glucose By similarity
Binding site331Glucose By similarity
Binding site871Glucose By similarity
Binding site1121Glucose By similarity
Binding site1751Glucose By similarity
Binding site1961Glucose By similarity
Binding site2911ADP By similarity
Binding site3411ADP By similarity
Binding site3421ADP; via carbonyl oxygen By similarity
Binding site4281ADP; via carbonyl oxygen By similarity
Binding site4391ADP By similarity
Binding site4391Glucose By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5JE39 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 3C2A09D9DEDE8577

FASTA45350,735
        10         20         30         40         50         60 
MNWDGLYASA FERIRDNIGK VGNVLLAYNT NIDAIKYLER EDLERRIGAA GREEVLPYSE 

        70         80         90        100        110        120 
KLPKRIESVP QLLGSILWSI RRGKAAELFV ESCSTRFYMR RWGWDELRMG GQVGIMANLL 

       130        140        150        160        170        180 
GGVYGVPVIA HVPQLSRLQA ELFKDGPIYV PKVEGGKLKL VHPKEFKADE ENCIHYIYEF 

       190        200        210        220        230        240 
PRGFRVFDFE APRENRFIGS ADDYNTNVVI RPEFEEHFGE IAEKTELAII SGLQALTEGN 

       250        260        270        280        290        300 
YREPFETIKE HLDVLEGKGI PAHLEFAFTP DETVRKEILG VLGKFWSVGL NEVELASIMD 

       310        320        330        340        350        360 
VMGEKTLAEK LLAHDPVDPI VVTKAMLKLA EKTGVRRIHF HTYGYYLALT DYRGEFVRDA 

       370        380        390        400        410        420 
LLFAALAAAA KAKLGDVRNI DDVVKAMDVP VNEKAKGVEE ALTKEYGMEN GIAEVNGYQL 

       430        440        450 
AFIPTKIVAK PKSTVGIGDT ISSSAFVGEF ALR

« Hide

References

[1]"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
Genome Res. 15:352-363(2005) [PubMed: 15710748] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006878 Genomic DNA. Translation: BAD85299.1.
RefSeqYP_183523.1. NC_006624.1.

3D structure databases

ProteinModelPortalQ5JE39.
SMRQ5JE39. Positions 3-452.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBPYRT00000007350; EBPYRP00000007131; EBPYRG00000007349.
GeneID3234742.
GenomeReviewsGene locus TK1110 in contig AP006878_GR.
KEGGtko:TK1110.
NMPDRfig|69014.3.peg.1289.

Phylogenomic databases

eggNOGarNOG04149.
GeneTreeEBGT00050000022952.
HOGENOMHBG645711.
OMAIHYIYEF.
PhylomeDBQ5JE39.
ProtClustDBPRK14038.

Enzyme and pathway databases

BioCycTKOD69014:TK1110-MONOMER.

Family and domain databases

HAMAPMF_00809. ADP_glucokinase.
[Tree]
InterProIPR007666. ADP_PFK/GK.
IPR015990. ADP_PFK/GK_arc.
[Graphical view]
KOK00918.
PfamPF04587. ADP_PFK_GK. 1 hit.
[Graphical view]
PIRSFPIRSF015883. ADP-Pfk_glckin. 1 hit.
PROSITEPS51255. ADPK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLKA_PYRKO
AccessionPrimary (citable) accession number: Q5JE39
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: February 15, 2005
Last modified: December 14, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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