Reviewed, UniProtKB/Swiss-Prot Q5JE15 (AOR_PYRKO)

Names and origin

Protein names

Recommended name:
    Tungsten-containing aldehyde ferredoxin oxidoreductase
    EC=1.2.7.5

Gene names

Name:	aor
Ordered Locus Names:	TK1066

Organism

Pyrococcus kodakaraensis (Thermococcus kodakaraensis) [Complete proteome] [HAMAP]

Taxonomic identifier

69014 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus

Protein attributes

Sequence length	605 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An aldehyde + H2O + 2 oxidized ferredoxin = an acid + 2 H+ + 2 reduced ferredoxin.
Cofactor	Binds 1 4Fe-4S cluster per subunit By similarity. Binds 1 tungstopterin cofactor per subunit By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the AOR/FOR family.

Ontologies

Keywords
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding Tungsten
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW aldehyde ferredoxin oxidoreductase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 605	605	Tungsten-containing aldehyde ferredoxin oxidoreductase		PRO_0000064608

Sequences

	Sequence		Length	Mass (Da)
	Q5JE15-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: CCDA95873B3AC062	FASTA	605	66,768
	10 20 30 40 50 60 MYGNWGRFLR VNLSTGEVKV EEYGEELAKK WLGSRGLAIY LLLKEMDPKA DPLGPENKLI 70 80 90 100 110 120 ITPGPLTGTS APTGGRYNVV TKSPQTGFIT MANSGGYFGA ELKFAGWDAI VVEGQSEKPV 130 140 150 160 170 180 YIYIKDDHVE IRDASHLWGK VVSETEAAIK KEIGSNKLHI ASIGPAGENL VKFAAIMNDG 190 200 210 220 230 240 HRAAGRAGVG AVMGSKKLKA IAVEGSKRVP IADKQKFMLV VREKINKLRN DPVAGGGLPK 250 260 270 280 290 300 YGTAVLVNII NENGLYPTRN FQTGVFEHAY EQSGEAMTAK YLIRNQPCYA CPIGCGRVNK 310 320 330 340 350 360 LPTLGVTEGP EYESIWALGA NLGINDLASI IEANHQCDEF GLDTISTGGT LAAAMELYEK 370 380 390 400 410 420 GYLTDDELGD APPFRWGNTE VLHYYIEKIA YRKDLGDKLA EGSYRFAEMY GHPEFSMSVK 430 440 450 460 470 480 KLELPAYDPR GAEGHGLGYA TNNRGGCHIK NYMISPEILG YPYKMDPHDI SDEKVKMLIL 490 500 510 520 530 540 FQDLSALIDA AGLCLFTTFG LGADDYRDML NAALGWDFST EDYLKIGERI WNAERLFNLK 550 560 570 580 590 600 AGLDPAKDET LPKRFLEEPM PEGPNKGHVV RLKEMLPRYY KLRGWTEDGR IPREKAEELG IAEFL

References

[1]

"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes." Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T. Genome Res. 15:352-363(2005) [PubMed: 15710748] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KOD1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006878 Genomic DNA. Translation: BAD85255.1.
RefSeq	YP_183479.1.
3D structure databases
SMR	Q5JE15. Positions 1-604.
ModBase	Search...
Genome annotation databases
GeneID	3233851.
GenomeReviews	Gene locus TK1066 in contig AP006878_GR.
KEGG	tko:TK1066.
NMPDR	fig|69014.3.peg.1189.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5JE15.
OMA	Q5JE15. CTIACGR.
Enzyme and pathway databases
BioCyc	TKOD69014:TK1066-MON.
BRENDA	1.2.7.5. 192130.
Family and domain databases
InterPro	IPR013985. Ald_Fedxn_OxRdtase_3. IPR013983. Ald_Fedxn_OxRdtase_N. IPR001203. OxRdtase_Ald_Fedxn_C. [Graphical view]
Gene3D	G3DSA:1.10.599.10. Oxred_Ald_Fedxn_3. 1 hit. G3DSA:3.60.9.10. Oxred_Ald_Fedxn_N. 1 hit.
Pfam	PF01314. AFOR_C. 1 hit. PF02730. AFOR_N. 1 hit. [Graphical view]
SMART	SM00790. AFOR_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AOR_PYRKO

Accession

Primary (citable) accession number: Q5JE15

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	February 15, 2005
Last modified:	June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)