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Q5JDN6

- PRNK_THEKO

UniProt

Q5JDN6 - PRNK_THEKO

Protein

Polyribonucleotide 5'-hydroxyl-kinase TK1956

Gene

TK1956

Organism
Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA By similarity.By similarity

    Catalytic activityi

    ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA.
    ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA.

    Cofactori

    Divalent cation.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi34 – 418ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTKOD69014:GH72-1995-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide 5'-hydroxyl-kinase TK1956 (EC:2.7.1.78)
    Alternative name(s):
    Polynucleotide kinase TK1956
    Gene namesi
    Ordered Locus Names:TK1956
    OrganismiThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
    Taxonomic identifieri69014 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000000536: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351Polyribonucleotide 5'-hydroxyl-kinase TK1956PRO_0000376018Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi69014.TK1956.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5JDN6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG1341.
    HOGENOMiHOG000074023.
    KOiK06947.
    OMAiFIGEITP.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR029007. MobB-typ_P-loop.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF03205. MobB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5JDN6-1 [UniParc]FASTAAdd to Basket

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    MNKARYTQDV PEDRIKLLES IASYNKPFTL MVVGGVDSGK STLITFLGNE    50
    LLSLGFKVAV VDSDVGQKGV LPPGTISLAI PEGPFESMSE LEGVAHYFVG 100
    TTAPSQFIGE MAVGVKRMVE IARNVADVVL IDTTGFVTGV GAEMKRLKAE 150
    LVKPDIIAVI HSGELSGLVK ALEPYGGVIE LAVSETVKRY PLEERRNLRA 200
    EKWRNYFRDS QLVEFSASEV AITGTSLFHG IPLNADENEL LEKAFGWLVV 250
    AGWKNKGYTV VKADVEKFPR AHSRELKAID FEKLSNLLVG LIDGEGLCMG 300
    VGVLKWINFS EGRLQILTPV RDLSGVREIR FGRIRVTEEG EELGLLRRDE 350
    L 351
    Length:351
    Mass (Da):38,564
    Last modified:February 15, 2005 - v1
    Checksum:i792F87FD047132AE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006878 Genomic DNA. Translation: BAD86145.1.
    RefSeqiYP_184369.1. NC_006624.1.

    Genome annotation databases

    EnsemblBacteriaiBAD86145; BAD86145; TK1956.
    GeneIDi3235264.
    KEGGitko:TK1956.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006878 Genomic DNA. Translation: BAD86145.1 .
    RefSeqi YP_184369.1. NC_006624.1.

    3D structure databases

    ProteinModelPortali Q5JDN6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 69014.TK1956.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD86145 ; BAD86145 ; TK1956 .
    GeneIDi 3235264.
    KEGGi tko:TK1956.

    Phylogenomic databases

    eggNOGi COG1341.
    HOGENOMi HOG000074023.
    KOi K06947.
    OMAi FIGEITP.

    Enzyme and pathway databases

    BioCyci TKOD69014:GH72-1995-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR029007. MobB-typ_P-loop.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF03205. MobB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
      Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
      Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-918 / JCM 12380 / KOD1.

    Entry informationi

    Entry nameiPRNK_THEKO
    AccessioniPrimary (citable) accession number: Q5JDN6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3