Reviewed, UniProtKB/Swiss-Prot Q5JDN6 (PRNK_PYRKO)

Names and origin

Protein names

Recommended name:
    Polyribonucleotide 5'-hydroxyl-kinase TK1956
    EC=2.7.1.78
Alternative name(s):
    Polynucleotide kinase TK1956

Gene names

Ordered Locus Names:

TK1956

Organism

Pyrococcus kodakaraensis (Thermococcus kodakaraensis) [Complete proteome] [HAMAP]

Taxonomic identifier

311400 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA By similarity.
Catalytic activity	ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA. ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA.
Cofactor	Divalent cation By similarity.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	Mo-molybdopterin cofactor biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity Inferred from electronic annotation. Source: EC GTP binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Polyribonucleotide 5'-hydroxyl-kinase TK1956		PRO_0000376018
Regions
	Nucleotide binding	34 – 41	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5JDN6-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 792F87FD047132AE	FASTA	351	38,564
	10 20 30 40 50 60 MNKARYTQDV PEDRIKLLES IASYNKPFTL MVVGGVDSGK STLITFLGNE LLSLGFKVAV 70 80 90 100 110 120 VDSDVGQKGV LPPGTISLAI PEGPFESMSE LEGVAHYFVG TTAPSQFIGE MAVGVKRMVE 130 140 150 160 170 180 IARNVADVVL IDTTGFVTGV GAEMKRLKAE LVKPDIIAVI HSGELSGLVK ALEPYGGVIE 190 200 210 220 230 240 LAVSETVKRY PLEERRNLRA EKWRNYFRDS QLVEFSASEV AITGTSLFHG IPLNADENEL 250 260 270 280 290 300 LEKAFGWLVV AGWKNKGYTV VKADVEKFPR AHSRELKAID FEKLSNLLVG LIDGEGLCMG 310 320 330 340 350 VGVLKWINFS EGRLQILTPV RDLSGVREIR FGRIRVTEEG EELGLLRRDE L

References

[1]

"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes." Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T. Genome Res. 15:352-363(2005) [PubMed: 15710748] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KOD1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006878 Genomic DNA. Translation: BAD86145.1.
RefSeq	YP_184369.1.
3D structure databases
SMR	Q5JDN6. Positions 29-321.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5JDN6.
Genome annotation databases
GeneID	3235264.
GenomeReviews	Gene locus TK1956 in contig AP006878_GR.
KEGG	tko:TK1956.
NMPDR	fig|69014.3.peg.1806.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG10593.
HOGENOM	HBG538965.
OMA	NDLGPPT.
Enzyme and pathway databases
BioCyc	TKOD69014:TK1956-MONOMER.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

PRNK_PYRKO

Accession

Primary (citable) accession number: Q5JDN6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 26, 2009
Last sequence update:	February 15, 2005
Last modified:	February 9, 2010
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)