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Q5JDN6

- PRNK_THEKO

UniProt

Q5JDN6 - PRNK_THEKO

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Protein

Polyribonucleotide 5'-hydroxyl-kinase TK1956

Gene

TK1956

Organism
Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA (By similarity).By similarity

Catalytic activityi

ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA.
ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA.

Cofactori

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 418ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTKOD69014:GH72-1995-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide 5'-hydroxyl-kinase TK1956 (EC:2.7.1.78)
Alternative name(s):
Polynucleotide kinase TK1956
Gene namesi
Ordered Locus Names:TK1956
OrganismiThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000000536: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Polyribonucleotide 5'-hydroxyl-kinase TK1956PRO_0000376018Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi69014.TK1956.

Structurei

3D structure databases

ProteinModelPortaliQ5JDN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1341.
HOGENOMiHOG000074023.
InParanoidiQ5JDN6.
KOiK06947.
OMAiFIGEITP.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR029007. MobB-typ_P-loop.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF03205. MobB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5JDN6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKARYTQDV PEDRIKLLES IASYNKPFTL MVVGGVDSGK STLITFLGNE
60 70 80 90 100
LLSLGFKVAV VDSDVGQKGV LPPGTISLAI PEGPFESMSE LEGVAHYFVG
110 120 130 140 150
TTAPSQFIGE MAVGVKRMVE IARNVADVVL IDTTGFVTGV GAEMKRLKAE
160 170 180 190 200
LVKPDIIAVI HSGELSGLVK ALEPYGGVIE LAVSETVKRY PLEERRNLRA
210 220 230 240 250
EKWRNYFRDS QLVEFSASEV AITGTSLFHG IPLNADENEL LEKAFGWLVV
260 270 280 290 300
AGWKNKGYTV VKADVEKFPR AHSRELKAID FEKLSNLLVG LIDGEGLCMG
310 320 330 340 350
VGVLKWINFS EGRLQILTPV RDLSGVREIR FGRIRVTEEG EELGLLRRDE

L
Length:351
Mass (Da):38,564
Last modified:February 15, 2005 - v1
Checksum:i792F87FD047132AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD86145.1.
RefSeqiYP_184369.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD86145; BAD86145; TK1956.
GeneIDi3235264.
KEGGitko:TK1956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD86145.1 .
RefSeqi YP_184369.1. NC_006624.1.

3D structure databases

ProteinModelPortali Q5JDN6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 69014.TK1956.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD86145 ; BAD86145 ; TK1956 .
GeneIDi 3235264.
KEGGi tko:TK1956.

Phylogenomic databases

eggNOGi COG1341.
HOGENOMi HOG000074023.
InParanoidi Q5JDN6.
KOi K06947.
OMAi FIGEITP.

Enzyme and pathway databases

BioCyci TKOD69014:GH72-1995-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR029007. MobB-typ_P-loop.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF03205. MobB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
    Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
    Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Entry informationi

Entry nameiPRNK_THEKO
AccessioniPrimary (citable) accession number: Q5JDN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: February 15, 2005
Last modified: November 26, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3