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Q5JCS9

- B3GN3_MOUSE

UniProt

Q5JCS9 - B3GN3_MOUSE

Protein

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

Gene

B3gnt3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides.

    Catalytic activityi

    UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-(N-acetyl-D-glucosaminyl-(1->6))-N-acetyl-D-galactosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-(N-acetyl-D-glucosaminyl-(1->6))-N-acetyl-D-galactosaminyl-R.

    Pathwayi

    GO - Molecular functioni

    1. beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity Source: UniProtKB-EC
    2. galactosyltransferase activity Source: InterPro

    GO - Biological processi

    1. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_198517. O-linked glycosylation of mucins.
    REACT_198578. Keratan sulfate biosynthesis.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT31. Glycosyltransferase Family 31.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 (EC:2.4.1.146)
    Short name:
    BGnT-3
    Short name:
    Beta-1,3-Gn-T3
    Short name:
    Beta-1,3-N-acetylglucosaminyltransferase 3
    Short name:
    Beta3Gn-T3
    Alternative name(s):
    Core 1 extending beta-1,3-N-acetylglucosaminyltransferase
    Core1-beta3GlcNAcT
    Gene namesi
    Name:B3gnt3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:2152535. B3gnt3.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3PRO_0000219173Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ5JCS9.
    PaxDbiQ5JCS9.
    PRIDEiQ5JCS9.

    PTM databases

    PhosphoSiteiQ5JCS9.

    Expressioni

    Gene expression databases

    BgeeiQ5JCS9.
    GenevestigatoriQ5JCS9.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000034260.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5JCS9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 372341LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 31 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293830.
    GeneTreeiENSGT00740000115239.
    HOGENOMiHOG000232195.
    HOVERGENiHBG050653.
    InParanoidiQ5JCS9.
    KOiK07970.
    OMAiCAQPVFL.
    OrthoDBiEOG7BGHKT.
    PhylomeDBiQ5JCS9.
    TreeFamiTF318639.

    Family and domain databases

    InterProiIPR002659. Glyco_trans_31.
    [Graphical view]
    PANTHERiPTHR11214. PTHR11214. 1 hit.
    PfamiPF01762. Galactosyl_T. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5JCS9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLPRQSPYE ILLLVLVALL VLLLLLTSKS PPSCSAPERS KEPEDNPGWA    50
    TGHPRTHPAR CRANLSVSSH PDFAGLPLHV RDFLFYRHCR DFPVLREPRV 100
    TKCAEPVFLL LAIKSSPANY GRRQMLRTTW ARERRVRGAP LRRLFLVGSD 150
    RDPQQARKYN RLLELEAQKY GDILQWDFHD SFFNLTLKQV LFLEWQLTYC 200
    TNASFVLNGD DDVFAHTDNM VTYLQDHDPD QHLFVGHLIQ NVGPIRVPWS 250
    KYFIPALVMA EDRYPPYCGG GGFLLSRFTV AALRRAARVL PMFPIDDVFL 300
    GMCLQQQGLA PGTHSGVRTA GVFPPSPRVS SFDPCFYRDL LLVHRFLPFE 350
    MLLMWDALNQ PQLLCGRQSP AY 372
    Length:372
    Mass (Da):42,586
    Last modified:February 15, 2005 - v1
    Checksum:i484771C8054DE265
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti256 – 2561A → T in AAH26418. (PubMed:15489334)Curated
    Sequence conflicti283 – 2831L → I1 PublicationCurated
    Sequence conflicti283 – 2831L → I(PubMed:16141072)Curated
    Sequence conflicti295 – 2951I → V1 PublicationCurated
    Sequence conflicti295 – 2951I → V(PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY037785 mRNA. Translation: AAK68855.1.
    AY039028 mRNA. Translation: AAK72481.1.
    AK008674 mRNA. Translation: BAB25824.1.
    BC026418 mRNA. Translation: AAH26418.1.
    CCDSiCCDS22405.1.
    RefSeqiNP_082465.3. NM_028189.3.
    XP_006509815.1. XM_006509752.1.
    XP_006509816.1. XM_006509753.1.
    UniGeneiMm.290837.

    Genome annotation databases

    EnsembliENSMUST00000034260; ENSMUSP00000034260; ENSMUSG00000031803.
    GeneIDi72297.
    KEGGimmu:72297.
    UCSCiuc009mer.3. mouse.

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - GTase

    beta 3 GlcNAc-T III

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY037785 mRNA. Translation: AAK68855.1 .
    AY039028 mRNA. Translation: AAK72481.1 .
    AK008674 mRNA. Translation: BAB25824.1 .
    BC026418 mRNA. Translation: AAH26418.1 .
    CCDSi CCDS22405.1.
    RefSeqi NP_082465.3. NM_028189.3.
    XP_006509815.1. XM_006509752.1.
    XP_006509816.1. XM_006509753.1.
    UniGenei Mm.290837.

    3D structure databases

    ProteinModelPortali Q5JCS9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000034260.

    Protein family/group databases

    CAZyi GT31. Glycosyltransferase Family 31.

    PTM databases

    PhosphoSitei Q5JCS9.

    Proteomic databases

    MaxQBi Q5JCS9.
    PaxDbi Q5JCS9.
    PRIDEi Q5JCS9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034260 ; ENSMUSP00000034260 ; ENSMUSG00000031803 .
    GeneIDi 72297.
    KEGGi mmu:72297.
    UCSCi uc009mer.3. mouse.

    Organism-specific databases

    CTDi 10331.
    MGIi MGI:2152535. B3gnt3.

    Phylogenomic databases

    eggNOGi NOG293830.
    GeneTreei ENSGT00740000115239.
    HOGENOMi HOG000232195.
    HOVERGENi HBG050653.
    InParanoidi Q5JCS9.
    KOi K07970.
    OMAi CAQPVFL.
    OrthoDBi EOG7BGHKT.
    PhylomeDBi Q5JCS9.
    TreeFami TF318639.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    Reactomei REACT_198517. O-linked glycosylation of mucins.
    REACT_198578. Keratan sulfate biosynthesis.

    Miscellaneous databases

    NextBioi 335942.
    PROi Q5JCS9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5JCS9.
    Genevestigatori Q5JCS9.

    Family and domain databases

    InterProi IPR002659. Glyco_trans_31.
    [Graphical view ]
    PANTHERi PTHR11214. PTHR11214. 1 hit.
    Pfami PF01762. Galactosyl_T. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse beta1,3 N-acetylglucosaminyltransferase-3."
      Zhou D., Hennet T.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/Sv.
    2. "Core 1 beta-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT)."
      Yeh J.-C., Fukuda M.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Stomach.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiB3GN3_MOUSE
    AccessioniPrimary (citable) accession number: Q5JCS9
    Secondary accession number(s): Q8R0U2, Q9D7Z2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3