Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5JCS9 (B3GN3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

Short name=BGnT-3
Short name=Beta-1,3-Gn-T3
Short name=Beta-1,3-N-acetylglucosaminyltransferase 3
Short name=Beta3Gn-T3
EC=2.4.1.146
Alternative name(s):
Core 1 extending beta-1,3-N-acetylglucosaminyltransferase
Core1-beta3GlcNAcT
Gene names
Name:B3gnt3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides.

Catalytic activity

UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-(N-acetyl-D-glucosaminyl-(1->6))-N-acetyl-D-galactosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-(N-acetyl-D-glucosaminyl-(1->6))-N-acetyl-D-galactosaminyl-R.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatus membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the glycosyltransferase 31 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
PRO_0000219173

Regions

Topological domain1 – 1010Cytoplasmic Potential
Transmembrane11 – 3121Helical; Signal-anchor for type II membrane protein; Potential
Topological domain32 – 372341Lumenal Potential

Amino acid modifications

Glycosylation641N-linked (GlcNAc...) Potential
Glycosylation1841N-linked (GlcNAc...) Potential
Glycosylation2021N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2561A → T in AAH26418. Ref.4
Sequence conflict2831L → I Ref.1
Sequence conflict2831L → I Ref.3
Sequence conflict2951I → V Ref.1
Sequence conflict2951I → V Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q5JCS9 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 484771C8054DE265

FASTA37242,586
        10         20         30         40         50         60 
MRLPRQSPYE ILLLVLVALL VLLLLLTSKS PPSCSAPERS KEPEDNPGWA TGHPRTHPAR 

        70         80         90        100        110        120 
CRANLSVSSH PDFAGLPLHV RDFLFYRHCR DFPVLREPRV TKCAEPVFLL LAIKSSPANY 

       130        140        150        160        170        180 
GRRQMLRTTW ARERRVRGAP LRRLFLVGSD RDPQQARKYN RLLELEAQKY GDILQWDFHD 

       190        200        210        220        230        240 
SFFNLTLKQV LFLEWQLTYC TNASFVLNGD DDVFAHTDNM VTYLQDHDPD QHLFVGHLIQ 

       250        260        270        280        290        300 
NVGPIRVPWS KYFIPALVMA EDRYPPYCGG GGFLLSRFTV AALRRAARVL PMFPIDDVFL 

       310        320        330        340        350        360 
GMCLQQQGLA PGTHSGVRTA GVFPPSPRVS SFDPCFYRDL LLVHRFLPFE MLLMWDALNQ 

       370 
PQLLCGRQSP AY 

« Hide

References

« Hide 'large scale' references
[1]"Mouse beta1,3 N-acetylglucosaminyltransferase-3."
Zhou D., Hennet T.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/Sv.
[2]"Core 1 beta-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT)."
Yeh J.-C., Fukuda M.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Stomach.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY037785 mRNA. Translation: AAK68855.1.
AY039028 mRNA. Translation: AAK72481.1.
AK008674 mRNA. Translation: BAB25824.1.
BC026418 mRNA. Translation: AAH26418.1.
RefSeqNP_082465.3. NM_028189.3.
XP_006509815.1. XM_006509752.1.
XP_006509816.1. XM_006509753.1.
UniGeneMm.290837.

3D structure databases

ProteinModelPortalQ5JCS9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000034260.

Protein family/group databases

CAZyGT31. Glycosyltransferase Family 31.

PTM databases

PhosphoSiteQ5JCS9.

Proteomic databases

PaxDbQ5JCS9.
PRIDEQ5JCS9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034260; ENSMUSP00000034260; ENSMUSG00000031803.
GeneID72297.
KEGGmmu:72297.
UCSCuc009mer.3. mouse.

Organism-specific databases

CTD10331.
MGIMGI:2152535. B3gnt3.

Phylogenomic databases

eggNOGNOG293830.
GeneTreeENSGT00740000115239.
HOGENOMHOG000232195.
HOVERGENHBG050653.
InParanoidQ5JCS9.
KOK07970.
OMACAQPVFL.
OrthoDBEOG7BGHKT.
PhylomeDBQ5JCS9.
TreeFamTF318639.

Enzyme and pathway databases

UniPathwayUPA00378.

Gene expression databases

BgeeQ5JCS9.
GenevestigatorQ5JCS9.

Family and domain databases

InterProIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERPTHR11214. PTHR11214. 1 hit.
PfamPF01762. Galactosyl_T. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio335942.
PROQ5JCS9.
SOURCESearch...

Entry information

Entry nameB3GN3_MOUSE
AccessionPrimary (citable) accession number: Q5JCS9
Secondary accession number(s): Q8R0U2, Q9D7Z2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: February 15, 2005
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot