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Protein

Signal-induced proliferation-associated 1-like protein 2

Gene

Sipa1l2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-induced proliferation-associated 1-like protein 2
Short name:
SIPA1-like protein 2
Alternative name(s):
Serine-rich synapse-associated protein
Gene namesi
Name:Sipa1l2
Synonyms:Sersap2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306269. Sipa1l2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17221722Signal-induced proliferation-associated 1-like protein 2PRO_0000056751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei149 – 1491PhosphoserineCombined sources
Modified residuei380 – 3801PhosphoserineBy similarity
Modified residuei384 – 3841PhosphoserineBy similarity
Modified residuei1030 – 10301PhosphoserineBy similarity
Modified residuei1245 – 12451PhosphoserineCombined sources
Modified residuei1461 – 14611PhosphoserineCombined sources
Modified residuei1472 – 14721PhosphoserineBy similarity
Modified residuei1478 – 14781PhosphoserineCombined sources
Modified residuei1488 – 14881PhosphoserineCombined sources
Modified residuei1549 – 15491PhosphoserineCombined sources
Modified residuei1552 – 15521PhosphoserineBy similarity
Modified residuei1591 – 15911PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5JCS6.
PRIDEiQ5JCS6.

PTM databases

iPTMnetiQ5JCS6.
PhosphoSiteiQ5JCS6.

Interactioni

Protein-protein interaction databases

BioGridi262684. 1 interaction.
STRINGi10116.ENSRNOP00000026843.

Structurei

3D structure databases

ProteinModelPortaliQ5JCS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini596 – 813218Rap-GAPPROSITE-ProRule annotationAdd
BLAST
Domaini951 – 102777PDZPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1652 – 171261Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi58 – 647Poly-Gly
Compositional biasi819 – 8224Poly-Thr
Compositional biasi1126 – 11294Poly-Ser
Compositional biasi1322 – 136645Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 Rap-GAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3686. Eukaryota.
ENOG410XTIX. LUCA.
HOGENOMiHOG000154319.
HOVERGENiHBG056135.
InParanoidiQ5JCS6.
KOiK17702.
PhylomeDBiQ5JCS6.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR000331. Rap_GAP_dom.
IPR031203. SIPA1L2.
IPR021818. SIPA1L_C.
[Graphical view]
PANTHERiPTHR15711:SF7. PTHR15711:SF7. 3 hits.
PfamiPF02145. Rap_GAP. 1 hit.
PF11881. SPAR_C. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF111347. SSF111347. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50085. RAPGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JCS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDPRPSQAE KHKLGRAASK FKDPSRAMQS DDYFARKFKA INGSMGPATL
60 70 80 90 100
NTSSLSEGGG GGGGPANGTP AVPKMGVRAR VSEWPPKKDC SKDLACKTLW
110 120 130 140 150
ESRSQSSYES ATSIIQNGQN DQVDRQQEEQ LDLDFVEAKY TIGDIFVHSP
160 170 180 190 200
QRGLHPIRQR SNSDITISDI DTEDVLDQHA VNPNTGAALH REYGSTSSID
210 220 230 240 250
RQGLSGENVF AMLRGYRIES YDPKVTSSFG FPDFFPCDTA ISPSLHAAAQ
260 270 280 290 300
ISRGEFVRIS GLDYMDGGLL MGRDRDKPFK RRLKSESVET SLFRKLRTVK
310 320 330 340 350
SEHETFKFTS DLEEGRLDRG IRPWSCQRCF AHYDVQSILF NINEAMATRA
360 370 380 390 400
SVGKRKNITT GASAASQTPV PVGPAGGCES PLGSKEDLNA KENPDADEGD
410 420 430 440 450
GKSNDLVLSC PYFRNETGGE GDRRIALSRA NSASFSSGES CSFESSLSSH
460 470 480 490 500
CTNAGVSVLE VPRENQPIHR EKVKRYIIEH VDLGAYYYRK FFYGKEHQNY
510 520 530 540 550
FGIDENLGPV AVSIRREKVE DPREKEGSQF NYRVAFRTSE LTTLRGAILE
560 570 580 590 600
DAVPSTARHG TARGLPLKEV LEYVIPELSI PCLRQAANSP KVPEQLLKLD
610 620 630 640 650
EQGLSFQHKI GILYCKAGQS TEEEMYNNET AGPAFEEFLD LLGQRVRLKG
660 670 680 690 700
FSKYRAQLDN KTDSTGTHSL YTTYKDFELM FHVSTLLPYM PNNRQQLLRK
710 720 730 740 750
RHIGNDIVTI VFQEPGALPF TPKNIRSHFQ HVFVIVKVHN PCTENVCYSV
760 770 780 790 800
GVFRSKDVPP FVPPIPKGVT FPRTGVFRDF LLAKGINAEN AAHKSEKFRA
810 820 830 840 850
MATRTRHEYL KDLAENFVTT TTVDTSAKFS FITLGAKKKE RVKPRTDAHL
860 870 880 890 900
FSIGAIMWHV VARYFGQSAD IECLLGISNE FIMLIEKESK NVAFNCSCRD
910 920 930 940 950
VIGWTSGLVS IKIFYERGEC ILLSSVDNSS EDIREIVQRL VIVTRGCETV
960 970 980 990 1000
EMTLRRNGLG QLGFHVNFEG IVADVEPFGF AWKAGLRQGS RLVEICKVAV
1010 1020 1030 1040 1050
ATLTHEQMID LLRTSVTVKV VIIQPHEDGS PRRGCSELCR IPMVEYKLDS
1060 1070 1080 1090 1100
EGTPCEYKTP FRRNTTWHRV PTPALQPVSR ASPVPGTPDR LQCQPLLQQA
1110 1120 1130 1140 1150
QAAIPRSTSF DRKLPDGTRS SPSNQSSSSD PGPGGSGPWR PQVGYDGCPS
1160 1170 1180 1190 1200
PLLLEPQGPG SVECDGSGDH EDLMEVGRLP ETKWHGPPSK VLSSYKERAL
1210 1220 1230 1240 1250
QKDGSCKDSP NKLSHIGDKS CSSHSSSNTL SSNTSSNSDD KHFGSGDLMD
1260 1270 1280 1290 1300
PELLGLTYIK GASTDSGIDT TPCMPATILG PMHLTGSRSL IHSRAEQWAD
1310 1320 1330 1340 1350
AADVSGADED PAKMYTLHGY ASAISSSAAD GSMGDLSEVS SHSSGSHRSG
1360 1370 1380 1390 1400
SPSTHCSKST GSLDSSKVYI VTHSGGQQVP GAVAKPYHRQ GAANKYVIGW
1410 1420 1430 1440 1450
KKSEGSPPPE EPEVTECPRI YGEMDIMSTA SQHPAVVGDS VPEAQHVLSK
1460 1470 1480 1490 1500
DDFLKLMLPD SPLVEEGRRK FSFYGNLSPR RSLYRTLSDE SVCSNRRGSS
1510 1520 1530 1540 1550
FASSRSSILD QALPNDILFS TTPPYHSTLP PRTHPAPSMG SLRNEFWFSD
1560 1570 1580 1590 1600
GSLSDKSKCA DPGLMPLPDT AAGLDWSHLV DAARAFEGLD SDEELGLLCH
1610 1620 1630 1640 1650
HASYLDQRVA SFCTLTDLQH GQELEGAPEL SLCVDPTSGK EFMDTPGERS
1660 1670 1680 1690 1700
PSTLTGKVNQ LELILRQLQT DLRKEKQDKA VLQAEVQHLR QDNMRLQEES
1710 1720
QTATAQLRTF TEWFFSTIDK KV
Length:1,722
Mass (Da):189,653
Last modified:February 15, 2005 - v1
Checksum:i213DCA7DF7694167
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043227 mRNA. Translation: AAL02130.1.
RefSeqiNP_001009704.1. NM_001009704.1.
UniGeneiRn.44190.

Genome annotation databases

GeneIDi361442.
KEGGirno:361442.
UCSCiRGD:1306269. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043227 mRNA. Translation: AAL02130.1.
RefSeqiNP_001009704.1. NM_001009704.1.
UniGeneiRn.44190.

3D structure databases

ProteinModelPortaliQ5JCS6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi262684. 1 interaction.
STRINGi10116.ENSRNOP00000026843.

PTM databases

iPTMnetiQ5JCS6.
PhosphoSiteiQ5JCS6.

Proteomic databases

PaxDbiQ5JCS6.
PRIDEiQ5JCS6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi361442.
KEGGirno:361442.
UCSCiRGD:1306269. rat.

Organism-specific databases

CTDi57568.
RGDi1306269. Sipa1l2.

Phylogenomic databases

eggNOGiKOG3686. Eukaryota.
ENOG410XTIX. LUCA.
HOGENOMiHOG000154319.
HOVERGENiHBG056135.
InParanoidiQ5JCS6.
KOiK17702.
PhylomeDBiQ5JCS6.

Miscellaneous databases

PROiQ5JCS6.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR000331. Rap_GAP_dom.
IPR031203. SIPA1L2.
IPR021818. SIPA1L_C.
[Graphical view]
PANTHERiPTHR15711:SF7. PTHR15711:SF7. 3 hits.
PfamiPF02145. Rap_GAP. 1 hit.
PF11881. SPAR_C. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF111347. SSF111347. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50085. RAPGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel family of serine rich synapse associated proteins: SERSAPs."
    Boeckers T.M., Wendholt D., Bockmann J.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149; SER-1245; SER-1461; SER-1478; SER-1488 AND SER-1549, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSI1L2_RAT
AccessioniPrimary (citable) accession number: Q5JCS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: February 15, 2005
Last modified: June 8, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.