Kras

Functionⁱ

GO - Molecular functionⁱ

GDP binding Source: Ensembl
GMP binding Source: Ensembl
GTPase activity Source: InterPro
GTP binding Source: UniProtKB-KW
LRR domain binding Source: Ensembl
protein complex binding Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

cytokine-mediated signaling pathway Source: Ensembl
female pregnancy Source: Ensembl
liver development Source: Ensembl
positive regulation of cell proliferation Source: Ensembl
positive regulation of cellular senescence Source: Ensembl
positive regulation of gene expression Source: Ensembl
positive regulation of MAP kinase activity Source: Ensembl
positive regulation of NF-kappaB transcription factor activity Source: Ensembl
positive regulation of nitric-oxide synthase activity Source: Ensembl
regulation of protein stability Source: Ensembl
response to glucocorticoid Source: Ensembl
response to isolation stress Source: Ensembl
response to mineralocorticoid Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Ligand	GTP-bindingSAAS annotation, Nucleotide-binding

Ligand

GTP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Kras proteinImported Submitted name: Putative uncharacterized proteinImported Submitted name: V-Ki-ras2 Kirsten rat sarcoma viral oncogene homologImported Submitted name: p21BImported
Gene namesⁱ	Name:KrasImported Synonyms:Kras2Imported ORF Names:mCG_13312Imported
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:96680. Kras.

Subcellular locationⁱ

GO - Cellular componentⁱ

extrinsic component of cytoplasmic side of plasma membrane Source: Ensembl
focal adhesion Source: Ensembl
membrane raft Source: Ensembl
mitochondrion Source: Ensembl

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5J7N1.

MaxQBⁱ

Q5J7N1.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000030265.
ExpressionAtlasⁱ	Q5J7N1. baseline and differential.

Interactionⁱ

GO - Molecular functionⁱ

LRR domain binding Source: Ensembl
protein complex binding Source: Ensembl

Complete GO annotation...

Structureⁱ

3D structure databases

SMRⁱ	Q5J7N1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	KOG0395. Eukaryota. COG1100. LUCA.
HOVERGENⁱ	HBG009351.
KEGG Orthology (KO) More...KOⁱ	K07827.
OMAⁱ	QSWAVNM.

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR020849. Small_GTPase_Ras.
PANTHERⁱ	PTHR24070. PTHR24070. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071. Ras. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
TIGRFAMsⁱ	TIGR00231. small_GTP. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51421. RAS. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5J7N1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET 
        60         70         80         90        100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI 
       110        120        130        140        150
KRVKDSEDVP MVLVGNKCDL PSRTVDTKQA QELARSYGIP FIETSAKTRQ 
       160        170        180 
GVDDAFYTLV REIRKHKEKM SKDGKKKKKK SRTRCTVM

Length:188

Mass (Da):21,483

Last modified:May 10, 2005 - v1

Checksum:ⁱB0A542E8AD158F51

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC141051 mRNA. Translation: AAI41052.1. AY487807 mRNA. Translation: AAS58056.1. AK164065 mRNA. Translation: BAE37609.1. CH466572 Genomic DNA. Translation: EDL10686.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_067259.4. NM_021284.6.
UniGeneⁱ	Mm.383182.

Genome annotation databases

GeneIDⁱ	16653.
KEGGⁱ	mmu:16653.
UCSC genome browser More...UCSCⁱ	uc009erh.2. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC141051 mRNA. Translation: AAI41052.1. AY487807 mRNA. Translation: AAS58056.1. AK164065 mRNA. Translation: BAE37609.1. CH466572 Genomic DNA. Translation: EDL10686.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_067259.4. NM_021284.6.
UniGeneⁱ	Mm.383182.

3D structure databases

SMRⁱ	Q5J7N1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5J7N1.

MaxQBⁱ

Q5J7N1.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	16653.
KEGGⁱ	mmu:16653.
UCSC genome browser More...UCSCⁱ	uc009erh.2. mouse.

Organism-specific databases

CTDⁱ	3845.
MGIⁱ	MGI:96680. Kras.

Phylogenomic databases

eggNOGⁱ	KOG0395. Eukaryota. COG1100. LUCA.
HOVERGENⁱ	HBG009351.
KEGG Orthology (KO) More...KOⁱ	K07827.
OMAⁱ	QSWAVNM.

Miscellaneous databases

ChiTaRSⁱ	Kras. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030265.
ExpressionAtlasⁱ	Q5J7N1. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR020849. Small_GTPase_Ras.
PANTHERⁱ	PTHR24070. PTHR24070. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071. Ras. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
TIGRFAMsⁱ	TIGR00231. small_GTP. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51421. RAS. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5J7N1_MOUSE
Accessionⁱ	Q5J7N1Primary (citable) accession number: Q5J7N1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 10, 2005
	Last sequence update:	May 10, 2005
	Last modified:	July 5, 2017
	This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - Q5J7N1 (Q5J7N1_MOUSE)

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Kras protein

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5J7N1 (Q5J7N1_MOUSE)

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Kras protein

Kras

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ