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Q5J6J2

- SCPB_TRIRU

UniProt

Q5J6J2 - SCPB_TRIRU

Protein

Carboxypeptidase S1 homolog B

Gene

SCPB

Organism
Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Extracellular serine carboxypeptidase that contributes to pathogenicity.1 Publication

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    pH dependencei

    Optimum pH is 8.0.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei240 – 2401PROSITE-ProRule annotation
    Active sitei459 – 4591PROSITE-ProRule annotation
    Binding sitei462 – 4621SubstrateBy similarity
    Active sitei517 – 5171PROSITE-ProRule annotation
    Binding sitei518 – 5181SubstrateBy similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Virulence

    Protein family/group databases

    MEROPSiS10.016.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase S1 homolog B (EC:3.4.16.6)
    Alternative name(s):
    Serine carboxypeptidase B
    Short name:
    SPCB
    Gene namesi
    Name:SCPB
    OrganismiTrichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)
    Taxonomic identifieri5551 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaemitosporic ArthrodermataceaeTrichophyton

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 633612Carboxypeptidase S1 homolog BPRO_0000384123Add
    BLAST
    Propeptidei634 – 66229Removed in mature formSequence AnalysisPRO_0000384124Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi51 ↔ 123By similarity
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi328 ↔ 364By similarity
    Disulfide bondi335 ↔ 357By similarity
    Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi414 – 4141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi475 – 4751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi493 – 4931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi506 – 5061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi598 – 5981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi612 – 6121N-linked (GlcNAc...)Sequence Analysis
    Lipidationi633 – 6331GPI-anchor amidated glycineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Expressioni

    Inductioni

    Expression is strongly increased during growth on protein-rich medium.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ5J6J2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 2 hits.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5J6J2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSFCGVAAC LLTVAGHLAQ AQFPPKPEGV TVLESKFGSG ARITYKEPGL    50
    CETTEGVKSY AGYVHLPPGT LRDFGVEQDY PINTFFWFFE ARKDPENAPL 100
    GIWMNGGPGS SSMFGMMTEN GPCFVNADSN STRLNPHSWN NEVNMLYIDQ 150
    PVQVGLSYDT LANFTRNLVT DEITKLKPGE PIPEQNATFL VGTYASRNMN 200
    TTAHGTRHAA MALWHFAQVW FQEFPGYHPR NNKISIATES YGGRYGPAFT 250
    AFFEEQNQKI KNGTWKGHEG TMHVLHLDTL MIVNGCIDRL VQWPAYPQMA 300
    YNNTYSIEAV NASIHAGMLD ALYRDGGCRD KINHCRSLSS VFDPENLGIN 350
    STVNDVCKDA ETFCSNDVRD PYLKFSGRNY YDIGQLDPSP FPAPFYMAWL 400
    NQPHVQAALG VPLNWTQSND VVSTAFRAIG DYPRPGWLEN LAYLLENGIK 450
    VSLVYGDRDY ACNWFGGELS SLGINYTDTH EFHNAGYAGI QINSSYIGGQ 500
    VRQYGNLSFA RVYEAGHEVP SYQPETALQI FHRSLFNKDI ATGTKDTSSR 550
    MDGGKFYGTS GPADSFGFKN KPPPQHVHFC HILDTSTCTK EQIQSVENGT 600
    AAVRSWIIVD SNSTSLFPEV VGSGEPTPTP MPGGATTLSA HGFLYGVTLW 650
    AVIVVAVIEL AM 662
    Length:662
    Mass (Da):73,012
    Last modified:February 15, 2005 - v1
    Checksum:iB47308AB5BB82CCB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY497022 Genomic DNA. Translation: AAS76666.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY497022 Genomic DNA. Translation: AAS76666.1 .

    3D structure databases

    ProteinModelPortali Q5J6J2.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.016.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 2 hits.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Trichophyton rubrum secreted and membrane-associated carboxypeptidases."
      Zaugg C., Jousson O., Lechenne B., Staib P., Monod M.
      Int. J. Med. Microbiol. 298:669-682(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
    2. "Gene expression profiling in the human pathogenic dermatophyte Trichophyton rubrum during growth on proteins."
      Zaugg C., Monod M., Weber J., Harshman K., Pradervand S., Thomas J., Bueno M., Giddey K., Staib P.
      Eukaryot. Cell 8:241-250(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiSCPB_TRIRU
    AccessioniPrimary (citable) accession number: Q5J6J2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3