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Q5J6J2

- SCPB_TRIRU

UniProt

Q5J6J2 - SCPB_TRIRU

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Protein

Carboxypeptidase S1 homolog B

Gene
SCPB
Organism
Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Extracellular serine carboxypeptidase that contributes to pathogenicity.1 Publication

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

pH dependencei

Optimum pH is 8.0.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei240 – 2401 By similarity
Active sitei459 – 4591 By similarity
Binding sitei462 – 4621Substrate By similarity
Active sitei517 – 5171 By similarity
Binding sitei518 – 5181Substrate By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Virulence

Protein family/group databases

MEROPSiS10.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase S1 homolog B (EC:3.4.16.6)
Alternative name(s):
Serine carboxypeptidase B
Short name:
SPCB
Gene namesi
Name:SCPB
OrganismiTrichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)
Taxonomic identifieri5551 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaemitosporic ArthrodermataceaeTrichophyton

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor Reviewed prediction

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 633612Carboxypeptidase S1 homolog BPRO_0000384123Add
BLAST
Propeptidei634 – 66229Removed in mature form Reviewed predictionPRO_0000384124Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 123 By similarity
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi163 – 1631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi186 – 1861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi262 – 2621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi302 – 3021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi311 – 3111N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi328 ↔ 364 By similarity
Disulfide bondi335 ↔ 357 By similarity
Glycosylationi350 – 3501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi414 – 4141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi475 – 4751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi493 – 4931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi506 – 5061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi598 – 5981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi612 – 6121N-linked (GlcNAc...) Reviewed prediction
Lipidationi633 – 6331GPI-anchor amidated glycine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Expressioni

Inductioni

Expression is strongly increased during growth on protein-rich medium.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ5J6J2.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5J6J2-1 [UniParc]FASTAAdd to Basket

« Hide

MVSFCGVAAC LLTVAGHLAQ AQFPPKPEGV TVLESKFGSG ARITYKEPGL    50
CETTEGVKSY AGYVHLPPGT LRDFGVEQDY PINTFFWFFE ARKDPENAPL 100
GIWMNGGPGS SSMFGMMTEN GPCFVNADSN STRLNPHSWN NEVNMLYIDQ 150
PVQVGLSYDT LANFTRNLVT DEITKLKPGE PIPEQNATFL VGTYASRNMN 200
TTAHGTRHAA MALWHFAQVW FQEFPGYHPR NNKISIATES YGGRYGPAFT 250
AFFEEQNQKI KNGTWKGHEG TMHVLHLDTL MIVNGCIDRL VQWPAYPQMA 300
YNNTYSIEAV NASIHAGMLD ALYRDGGCRD KINHCRSLSS VFDPENLGIN 350
STVNDVCKDA ETFCSNDVRD PYLKFSGRNY YDIGQLDPSP FPAPFYMAWL 400
NQPHVQAALG VPLNWTQSND VVSTAFRAIG DYPRPGWLEN LAYLLENGIK 450
VSLVYGDRDY ACNWFGGELS SLGINYTDTH EFHNAGYAGI QINSSYIGGQ 500
VRQYGNLSFA RVYEAGHEVP SYQPETALQI FHRSLFNKDI ATGTKDTSSR 550
MDGGKFYGTS GPADSFGFKN KPPPQHVHFC HILDTSTCTK EQIQSVENGT 600
AAVRSWIIVD SNSTSLFPEV VGSGEPTPTP MPGGATTLSA HGFLYGVTLW 650
AVIVVAVIEL AM 662
Length:662
Mass (Da):73,012
Last modified:February 15, 2005 - v1
Checksum:iB47308AB5BB82CCB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY497022 Genomic DNA. Translation: AAS76666.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY497022 Genomic DNA. Translation: AAS76666.1 .

3D structure databases

ProteinModelPortali Q5J6J2.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 2 hits.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Trichophyton rubrum secreted and membrane-associated carboxypeptidases."
    Zaugg C., Jousson O., Lechenne B., Staib P., Monod M.
    Int. J. Med. Microbiol. 298:669-682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
  2. "Gene expression profiling in the human pathogenic dermatophyte Trichophyton rubrum during growth on proteins."
    Zaugg C., Monod M., Weber J., Harshman K., Pradervand S., Thomas J., Bueno M., Giddey K., Staib P.
    Eukaryot. Cell 8:241-250(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiSCPB_TRIRU
AccessioniPrimary (citable) accession number: Q5J6J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: February 15, 2005
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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