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Q5J6J1

- SPCA_TRIRU

UniProt

Q5J6J1 - SPCA_TRIRU

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Protein

Carboxypeptidase S1 homolog A

Gene

SCPA

Organism
Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Extracellular serine carboxypeptidase that contributes to pathogenicity.By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

pH dependencei

Optimum pH is 4.5.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei238 – 2381PROSITE-ProRule annotation
Active sitei458 – 4581PROSITE-ProRule annotation
Binding sitei461 – 4611SubstrateBy similarity
Active sitei516 – 5161PROSITE-ProRule annotation
Binding sitei517 – 5171SubstrateBy similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Virulence

Protein family/group databases

MEROPSiS10.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase S1 homolog A (EC:3.4.16.6)
Alternative name(s):
Serine carboxypeptidase A
Short name:
SPCA
Gene namesi
Name:SCPA
OrganismiTrichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)
Taxonomic identifieri5551 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 629610Carboxypeptidase S1 homolog APRO_0000384117Add
BLAST
Propeptidei630 – 65223Removed in mature formSequence AnalysisPRO_0000384118Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 121By similarity
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi325 ↔ 361By similarity
Disulfide bondi332 ↔ 354By similarity
Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence Analysis
Lipidationi629 – 6291GPI-anchor amidated glycineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5J6J1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5J6J1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRFAASIAVA LPVIHAASAQ GFPPPVKGVT VVKSKFDENV KITYKENDIC
60 70 80 90 100
ETTQGVRSFT GHVHLPPDND DFGVYRNYSI NTFFWFFEAR EDPKNAPLSI
110 120 130 140 150
WLNGGPGSSS MIGLFQENGP CWVNEDSKST TNNSFSWNNK VNMLYIDQPN
160 170 180 190 200
QVGFSYDVPT NITYSTINDT ISVADFSNGV PAQNLSTLVG TGSSQNPWAT
210 220 230 240 250
ANNTVNAARS IWHFAQVWFQ EFPEHKPNNN KISIWTESYG GRYGPSFASY
260 270 280 290 300
FQEQNEKIKN HTITEEGEMH ILNLDTLGII NGCIDLMFQA ESYAEFPYNN
310 320 330 340 350
TYGIKAYTKE KRDAILHDIH RPDGCFDKVT KCREAAKEGD PHFYSNNATV
360 370 380 390 400
NTICADANSA CDKYLMDPFQ ETNLGYYDIA HPLQDPFPPP FYKGFLSQSS
410 420 430 440 450
VLSDMGSPVN FSQYAQAVGK SFHGVGDYAR PDVRGFTGDI AYLLESGVKV
460 470 480 490 500
ALVYGDRDYI CNWFGGEQVS LGLNYTGTQD FHRAKYADVK VNSSYVGGVV
510 520 530 540 550
RQHGNFSFTR VFEAGHEVPG YQPETALKIF ERIMFNKDIS TGEIDIAQKP
560 570 580 590 600
DYGTTGTEST FHIKNDIPPS PEPTCYLLSA DGTCTPEQLN AIKDGTAVVE
610 620 630 640 650
NYIIKSPAAS KGNPPPTTTS SPTAAPTAGS AMLKAPVAML AISALTVLAF

FL
Length:652
Mass (Da):71,825
Last modified:February 15, 2005 - v1
Checksum:iB5D3E435BAC0A9C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY497023 Genomic DNA. Translation: AAS76667.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY497023 Genomic DNA. Translation: AAS76667.1 .

3D structure databases

ProteinModelPortali Q5J6J1.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 2 hits.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Trichophyton rubrum secreted and membrane-associated carboxypeptidases."
    Zaugg C., Jousson O., Lechenne B., Staib P., Monod M.
    Int. J. Med. Microbiol. 298:669-682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.

Entry informationi

Entry nameiSPCA_TRIRU
AccessioniPrimary (citable) accession number: Q5J6J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: February 15, 2005
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3