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Q5J6J1

- SPCA_TRIRU

UniProt

Q5J6J1 - SPCA_TRIRU

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Protein
Carboxypeptidase S1 homolog A
Gene
SCPA
Organism
Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Extracellular serine carboxypeptidase that contributes to pathogenicity By similarity.1 Publication

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

pH dependencei

Optimum pH is 4.5.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei238 – 2381 By similarity
Active sitei458 – 4581 By similarity
Binding sitei461 – 4611Substrate By similarity
Active sitei516 – 5161 By similarity
Binding sitei517 – 5171Substrate By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Virulence

Protein family/group databases

MEROPSiS10.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase S1 homolog A (EC:3.4.16.6)
Alternative name(s):
Serine carboxypeptidase A
Short name:
SPCA
Gene namesi
Name:SCPA
OrganismiTrichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)
Taxonomic identifieri5551 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaemitosporic ArthrodermataceaeTrichophyton

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor Reviewed prediction

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 629610Carboxypeptidase S1 homolog A
PRO_0000384117Add
BLAST
Propeptidei630 – 65223Removed in mature form Reviewed prediction
PRO_0000384118Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 121 By similarity
Glycosylationi77 – 771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi132 – 1321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi168 – 1681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi184 – 1841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi202 – 2021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi260 – 2601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi299 – 2991N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi325 ↔ 361 By similarity
Disulfide bondi332 ↔ 354 By similarity
Glycosylationi347 – 3471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi410 – 4101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi474 – 4741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi492 – 4921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi505 – 5051N-linked (GlcNAc...) Reviewed prediction
Lipidationi629 – 6291GPI-anchor amidated glycine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5J6J1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5J6J1-1 [UniParc]FASTAAdd to Basket

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MRFAASIAVA LPVIHAASAQ GFPPPVKGVT VVKSKFDENV KITYKENDIC    50
ETTQGVRSFT GHVHLPPDND DFGVYRNYSI NTFFWFFEAR EDPKNAPLSI 100
WLNGGPGSSS MIGLFQENGP CWVNEDSKST TNNSFSWNNK VNMLYIDQPN 150
QVGFSYDVPT NITYSTINDT ISVADFSNGV PAQNLSTLVG TGSSQNPWAT 200
ANNTVNAARS IWHFAQVWFQ EFPEHKPNNN KISIWTESYG GRYGPSFASY 250
FQEQNEKIKN HTITEEGEMH ILNLDTLGII NGCIDLMFQA ESYAEFPYNN 300
TYGIKAYTKE KRDAILHDIH RPDGCFDKVT KCREAAKEGD PHFYSNNATV 350
NTICADANSA CDKYLMDPFQ ETNLGYYDIA HPLQDPFPPP FYKGFLSQSS 400
VLSDMGSPVN FSQYAQAVGK SFHGVGDYAR PDVRGFTGDI AYLLESGVKV 450
ALVYGDRDYI CNWFGGEQVS LGLNYTGTQD FHRAKYADVK VNSSYVGGVV 500
RQHGNFSFTR VFEAGHEVPG YQPETALKIF ERIMFNKDIS TGEIDIAQKP 550
DYGTTGTEST FHIKNDIPPS PEPTCYLLSA DGTCTPEQLN AIKDGTAVVE 600
NYIIKSPAAS KGNPPPTTTS SPTAAPTAGS AMLKAPVAML AISALTVLAF 650
FL 652
Length:652
Mass (Da):71,825
Last modified:February 15, 2005 - v1
Checksum:iB5D3E435BAC0A9C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY497023 Genomic DNA. Translation: AAS76667.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY497023 Genomic DNA. Translation: AAS76667.1 .

3D structure databases

ProteinModelPortali Q5J6J1.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 2 hits.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Trichophyton rubrum secreted and membrane-associated carboxypeptidases."
    Zaugg C., Jousson O., Lechenne B., Staib P., Monod M.
    Int. J. Med. Microbiol. 298:669-682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.

Entry informationi

Entry nameiSPCA_TRIRU
AccessioniPrimary (citable) accession number: Q5J6J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: February 15, 2005
Last modified: June 11, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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