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Q5J6J1

- SPCA_TRIRU

UniProt

Q5J6J1 - SPCA_TRIRU

Protein

Carboxypeptidase S1 homolog A

Gene

SCPA

Organism
Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Extracellular serine carboxypeptidase that contributes to pathogenicity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    pH dependencei

    Optimum pH is 4.5.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei238 – 2381PROSITE-ProRule annotation
    Active sitei458 – 4581PROSITE-ProRule annotation
    Binding sitei461 – 4611SubstrateBy similarity
    Active sitei516 – 5161PROSITE-ProRule annotation
    Binding sitei517 – 5171SubstrateBy similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Virulence

    Protein family/group databases

    MEROPSiS10.016.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase S1 homolog A (EC:3.4.16.6)
    Alternative name(s):
    Serine carboxypeptidase A
    Short name:
    SPCA
    Gene namesi
    Name:SCPA
    OrganismiTrichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)
    Taxonomic identifieri5551 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaemitosporic ArthrodermataceaeTrichophyton

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 629610Carboxypeptidase S1 homolog APRO_0000384117Add
    BLAST
    Propeptidei630 – 65223Removed in mature formSequence AnalysisPRO_0000384118Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 121By similarity
    Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi325 ↔ 361By similarity
    Disulfide bondi332 ↔ 354By similarity
    Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence Analysis
    Lipidationi629 – 6291GPI-anchor amidated glycineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ5J6J1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 2 hits.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5J6J1-1 [UniParc]FASTAAdd to Basket

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    MRFAASIAVA LPVIHAASAQ GFPPPVKGVT VVKSKFDENV KITYKENDIC    50
    ETTQGVRSFT GHVHLPPDND DFGVYRNYSI NTFFWFFEAR EDPKNAPLSI 100
    WLNGGPGSSS MIGLFQENGP CWVNEDSKST TNNSFSWNNK VNMLYIDQPN 150
    QVGFSYDVPT NITYSTINDT ISVADFSNGV PAQNLSTLVG TGSSQNPWAT 200
    ANNTVNAARS IWHFAQVWFQ EFPEHKPNNN KISIWTESYG GRYGPSFASY 250
    FQEQNEKIKN HTITEEGEMH ILNLDTLGII NGCIDLMFQA ESYAEFPYNN 300
    TYGIKAYTKE KRDAILHDIH RPDGCFDKVT KCREAAKEGD PHFYSNNATV 350
    NTICADANSA CDKYLMDPFQ ETNLGYYDIA HPLQDPFPPP FYKGFLSQSS 400
    VLSDMGSPVN FSQYAQAVGK SFHGVGDYAR PDVRGFTGDI AYLLESGVKV 450
    ALVYGDRDYI CNWFGGEQVS LGLNYTGTQD FHRAKYADVK VNSSYVGGVV 500
    RQHGNFSFTR VFEAGHEVPG YQPETALKIF ERIMFNKDIS TGEIDIAQKP 550
    DYGTTGTEST FHIKNDIPPS PEPTCYLLSA DGTCTPEQLN AIKDGTAVVE 600
    NYIIKSPAAS KGNPPPTTTS SPTAAPTAGS AMLKAPVAML AISALTVLAF 650
    FL 652
    Length:652
    Mass (Da):71,825
    Last modified:February 15, 2005 - v1
    Checksum:iB5D3E435BAC0A9C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY497023 Genomic DNA. Translation: AAS76667.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY497023 Genomic DNA. Translation: AAS76667.1 .

    3D structure databases

    ProteinModelPortali Q5J6J1.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.016.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 2 hits.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Trichophyton rubrum secreted and membrane-associated carboxypeptidases."
      Zaugg C., Jousson O., Lechenne B., Staib P., Monod M.
      Int. J. Med. Microbiol. 298:669-682(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.

    Entry informationi

    Entry nameiSPCA_TRIRU
    AccessioniPrimary (citable) accession number: Q5J6J1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3