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Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei259PROSITE-ProRule annotation1
Active sitei451PROSITE-ProRule annotation1
Active sitei513PROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERitriru-q5j6j0. Carboxypeptidase_S10.
MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
Synonyms:ScpC
OrganismiTrichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)
Taxonomic identifieri5551 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000040748418 – 124By similarityAdd BLAST107
ChainiPRO_0000407485125 – 536Carboxypeptidase Y homolog AAdd BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi172 ↔ 412By similarity
Glycosylationi203N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi306 ↔ 320By similarity
Disulfide bondi330 ↔ 353By similarity
Disulfide bondi337 ↔ 346By similarity
Disulfide bondi375 ↔ 382By similarity
Glycosylationi502N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi559305.XP_003231165.1.

Structurei

3D structure databases

ProteinModelPortaliQ5J6J0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5J6J0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFFTTGLLA TAALAAAQEQ QVLQAEDGMG RAPLPDSSIF DETLQKFQSS
60 70 80 90 100
LEDGISHFWS EMKTNFKDYL PLISLPKKHT RRPDSEWDHV VRGADIESVW
110 120 130 140 150
VQGADGEKRR EIDGKLHNYD LRVKAVDPGV KQYSGYLDDN DADKHLFYWF
160 170 180 190 200
FESRNDPKND PVVLWLNGGP GCSSLTGLFL ELGPATIDKN LKVVSNPYSW
210 220 230 240 250
NSNASVIFLD QPVNVGFSYS GSSVSDTVAA GKDVYALLTL FFKQFPEYAT
260 270 280 290 300
QDFHISGESY AGHYIPVFAA EILSHKNTNI NLKSALIGNG LTDPLTQYPQ
310 320 330 340 350
YRPMACGEGG YPAVLDQGTC RSMDNSLERC LSLIETCYSS ESAWVCVPAA
360 370 380 390 400
MYCNSAILAP YQQTGMNPYD VRTKCEDMAS LCYPQLNAIT EWLNQKPVMQ
410 420 430 440 450
ALGVEVESYE SCNSGINRDF LFHGDWMKPY HRLVPSVLEK IPVLIYAGDA
460 470 480 490 500
DFICNWLGNK AWTEALEWPG HKKFAETKLE DLKIVDNKNK GKKIGQVKSS
510 520 530
GNFTFMRIFG AGHMVPLNQP EASLEFLNRW LRGEWH
Length:536
Mass (Da):60,099
Last modified:February 15, 2005 - v1
Checksum:i0AFB2B9200435C27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY497024 Genomic DNA. Translation: AAS76668.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY497024 Genomic DNA. Translation: AAS76668.1.

3D structure databases

ProteinModelPortaliQ5J6J0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi559305.XP_003231165.1.

Protein family/group databases

ESTHERitriru-q5j6j0. Carboxypeptidase_S10.
MEROPSiS10.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBPYA_TRIRU
AccessioniPrimary (citable) accession number: Q5J6J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: February 15, 2005
Last modified: October 5, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.