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Protein

Beta-defensin 121

Gene

DEFB121

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has antibacterial activity.Curated

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 121
Alternative name(s):
Beta-defensin 21
Short name:
DEFB-21
Defensin, beta 121
Gene namesi
Name:DEFB121
Synonyms:DEFB21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:18101. DEFB121.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38497.

Polymorphism and mutation databases

BioMutaiDEFB121.
DMDMi61212937.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence analysisAdd
BLAST
Chaini16 – 7661Beta-defensin 121PRO_0000006991Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 50By similarity
Disulfide bondi30 ↔ 44By similarity
Disulfide bondi34 ↔ 51By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ5J5C9.
PRIDEiQ5J5C9.

Expressioni

Tissue specificityi

Abundant expression in the male reproductive tract only.1 Publication

Gene expression databases

BgeeiENSG00000204548.
CleanExiHS_DEFB121.
GenevisibleiQ5J5C9. HS.

Organism-specific databases

HPAiHPA045290.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SYNE4Q8N2053EBI-10244198,EBI-7131783

Protein-protein interaction databases

BioGridi128847. 9 interactions.
IntActiQ5J5C9. 1 interaction.
STRINGi9606.ENSP00000417128.

Structurei

3D structure databases

ProteinModelPortaliQ5J5C9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JKRC. Eukaryota.
ENOG41113KI. LUCA.
GeneTreeiENSGT00730000111628.
HOGENOMiHOG000246960.
HOVERGENiHBG097015.
InParanoidiQ5J5C9.
OMAiEVFHILC.
OrthoDBiEOG091G18PL.
PhylomeDBiQ5J5C9.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProDomiPD866254. PD866254. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5J5C9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLLLLLTV TLLLAQVTPV MKCWGKSGRC RTTCKESEVY YILCKTEAKC
60 70
CVDPKYVPVK PKLTDTNTSL ESTSAV
Length:76
Mass (Da):8,456
Last modified:February 15, 2005 - v1
Checksum:i1B80ECF2491B2E18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY501000 mRNA. Translation: AAS87294.1.
AL121751 Genomic DNA. No translation available.
BC130607 mRNA. Translation: AAI30608.1.
BC130609 mRNA. Translation: AAI30610.1.
CCDSiCCDS33456.1.
RefSeqiNP_001011878.1. NM_001011878.2.
UniGeneiHs.272294.

Genome annotation databases

EnsembliENST00000376314; ENSP00000417128; ENSG00000204548.
GeneIDi245934.
KEGGihsa:245934.
UCSCiuc002wvv.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY501000 mRNA. Translation: AAS87294.1.
AL121751 Genomic DNA. No translation available.
BC130607 mRNA. Translation: AAI30608.1.
BC130609 mRNA. Translation: AAI30610.1.
CCDSiCCDS33456.1.
RefSeqiNP_001011878.1. NM_001011878.2.
UniGeneiHs.272294.

3D structure databases

ProteinModelPortaliQ5J5C9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128847. 9 interactions.
IntActiQ5J5C9. 1 interaction.
STRINGi9606.ENSP00000417128.

Polymorphism and mutation databases

BioMutaiDEFB121.
DMDMi61212937.

Proteomic databases

PaxDbiQ5J5C9.
PRIDEiQ5J5C9.

Protocols and materials databases

DNASUi245934.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376314; ENSP00000417128; ENSG00000204548.
GeneIDi245934.
KEGGihsa:245934.
UCSCiuc002wvv.3. human.

Organism-specific databases

CTDi245934.
GeneCardsiDEFB121.
HGNCiHGNC:18101. DEFB121.
HPAiHPA045290.
MIMi616075. gene.
neXtProtiNX_Q5J5C9.
PharmGKBiPA38497.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JKRC. Eukaryota.
ENOG41113KI. LUCA.
GeneTreeiENSGT00730000111628.
HOGENOMiHOG000246960.
HOVERGENiHBG097015.
InParanoidiQ5J5C9.
OMAiEVFHILC.
OrthoDBiEOG091G18PL.
PhylomeDBiQ5J5C9.

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Miscellaneous databases

GenomeRNAii245934.
PROiQ5J5C9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204548.
CleanExiHS_DEFB121.
GenevisibleiQ5J5C9. HS.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProDomiPD866254. PD866254. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiDB121_HUMAN
AccessioniPrimary (citable) accession number: Q5J5C9
Secondary accession number(s): A1L4N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: February 15, 2005
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.