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Q5J4W4

- MPK2_ORYSJ

UniProt

Q5J4W4 - MPK2_ORYSJ

Protein

Mitogen-activated protein kinase 2

Gene

MPK2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei90 – 901ATPPROSITE-ProRule annotation
    Active sitei187 – 1871Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 759ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: UniProtKB-EC
    3. protein tyrosine kinase activity Source: InterPro

    GO - Biological processi

    1. cortical microtubule organization Source: EnsemblPlants/Gramene
    2. hyperosmotic response Source: EnsemblPlants/Gramene
    3. hypotonic salinity response Source: EnsemblPlants/Gramene
    4. jasmonic acid and ethylene-dependent systemic resistance Source: EnsemblPlants/Gramene
    5. male meiosis cytokinesis Source: EnsemblPlants/Gramene
    6. pollen development Source: EnsemblPlants/Gramene
    7. response to abscisic acid Source: EnsemblPlants/Gramene
    8. response to cold Source: EnsemblPlants/Gramene
    9. response to fungus Source: EnsemblPlants/Gramene
    10. response to indolebutyric acid Source: EnsemblPlants/Gramene
    11. systemic acquired resistance, salicylic acid mediated signaling pathway Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_205014. CREB phosphorylation through the activation of Ras.
    REACT_214549. Signalling to ERK5.
    REACT_215626. ERK2 activation.
    REACT_221522. ERKs are inactivated.
    REACT_221537. ERK1 activation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase 2 (EC:2.7.11.24)
    Short name:
    MAP kinase 2
    Gene namesi
    Name:MPK2
    Ordered Locus Names:Os08g0157000, LOC_Os08g06060
    ORF Names:P0438H08.24
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 8

    Organism-specific databases

    GrameneiQ5J4W4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: EnsemblPlants/Gramene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 394394Mitogen-activated protein kinase 2PRO_0000239745Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei221 – 2211PhosphotyrosineBy similarity

    Post-translational modificationi

    The phosphorylation on Tyr-221 activates the enzyme By similarity. A conserved Thr, which must also be phosphorylated to activate the enzyme in closely related sequences, is replaced by Met-219 in this sequence.By similarity

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Inductioni

    By infection with rice blast fungus (M.grisea).1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ5J4W4.
    SMRiQ5J4W4. Positions 49-391.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini61 – 347287Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi5 – 4238Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    KOiK04371.
    OMAiWREALKF.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5J4W4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRMEGGGGGG HGHHGGGGGG HGHHGGIGGG EAQIKGTLTH GGRYVQYNVY    50
    GNLFEVSSKY VPPIRPVGRG ACGIICAVVN AQTRQEVAIK KIGNAFDNQI 100
    DAKRTLREIK LLRHMDHDNV ISIKDIIRPP RRENFNDVYI VYELMDTDLH 150
    HLLRSNQPLT DDHCQYFLYQ VLRGLKYVHS ANVLHRDLRP SNLLLNAKCD 200
    LKIGDFGLAR TTNETDFMME YVVTRWYRAP ELLLNCSEYT AAIDIWSVGC 250
    ILGEIVTREP LFPGKDYVHQ LRLITELIGS PDDSSLGFLR SDNARRYVRS 300
    LPQYPKQQFR ARFPTMSSGA MDLLERMLVF DPSKRITVDE ALCHPYLASL 350
    HEIYDEPVCP APFSFDFEQP SLTEEDIKEI IWREALKFNP EPIH 394
    Length:394
    Mass (Da):44,585
    Last modified:February 15, 2005 - v1
    Checksum:iAC224C9134227481
    GO

    Sequence cautioni

    The sequence BAC99508.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY506572 mRNA. Translation: AAS79349.1.
    AP004460 Genomic DNA. Translation: BAC99508.1. Different initiation.
    RefSeqiNP_001061028.2. NM_001067563.2.
    UniGeneiOs.16795.

    Genome annotation databases

    EnsemblPlantsiOS08T0157000-00; OS08T0157000-00; OS08G0157000.
    GeneIDi4344698.
    KEGGiosa:4344698.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY506572 mRNA. Translation: AAS79349.1 .
    AP004460 Genomic DNA. Translation: BAC99508.1 . Different initiation.
    RefSeqi NP_001061028.2. NM_001067563.2.
    UniGenei Os.16795.

    3D structure databases

    ProteinModelPortali Q5J4W4.
    SMRi Q5J4W4. Positions 49-391.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS08T0157000-00 ; OS08T0157000-00 ; OS08G0157000 .
    GeneIDi 4344698.
    KEGGi osa:4344698.

    Organism-specific databases

    Gramenei Q5J4W4.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    KOi K04371.
    OMAi WREALKF.

    Enzyme and pathway databases

    Reactomei REACT_205014. CREB phosphorylation through the activation of Ras.
    REACT_214549. Signalling to ERK5.
    REACT_215626. ERK2 activation.
    REACT_221522. ERKs are inactivated.
    REACT_221537. ERK1 activation.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel protein kinase OsMAPK-like involved in the developmental regulation for rice plants."
      Wang Y.D., Chen X., Ye Z.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. "Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
      Reyna N.S., Yang Y.
      Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, NOMENCLATURE.

    Entry informationi

    Entry nameiMPK2_ORYSJ
    AccessioniPrimary (citable) accession number: Q5J4W4
    Secondary accession number(s): Q6ZD93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3