SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5J4W4

- MPK2_ORYSJ

UniProt

Q5J4W4 - MPK2_ORYSJ

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Mitogen-activated protein kinase 2
Gene
MPK2, Os08g0157000, LOC_Os08g06060, P0438H08.24
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei90 – 901ATP By similarity
Active sitei187 – 1871Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 759ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC
  3. protein tyrosine kinase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cortical microtubule organization Source: EnsemblPlants/Gramene
  2. hyperosmotic response Source: EnsemblPlants/Gramene
  3. hypotonic salinity response Source: EnsemblPlants/Gramene
  4. jasmonic acid and ethylene-dependent systemic resistance Source: EnsemblPlants/Gramene
  5. male meiosis cytokinesis Source: EnsemblPlants/Gramene
  6. pollen development Source: EnsemblPlants/Gramene
  7. response to abscisic acid Source: EnsemblPlants/Gramene
  8. response to cold Source: EnsemblPlants/Gramene
  9. response to fungus Source: EnsemblPlants/Gramene
  10. response to indolebutyric acid Source: EnsemblPlants/Gramene
  11. systemic acquired resistance, salicylic acid mediated signaling pathway Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_205014. CREB phosphorylation through the activation of Ras.
REACT_214549. Signalling to ERK5.
REACT_215626. ERK2 activation.
REACT_221522. ERKs are inactivated.
REACT_221537. ERK1 activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 2 (EC:2.7.11.24)
Short name:
MAP kinase 2
Gene namesi
Name:MPK2
Ordered Locus Names:Os08g0157000, LOC_Os08g06060
ORF Names:P0438H08.24
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 8

Organism-specific databases

GrameneiQ5J4W4.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: EnsemblPlants/Gramene
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Mitogen-activated protein kinase 2
PRO_0000239745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei221 – 2211Phosphotyrosine By similarity

Post-translational modificationi

The phosphorylation on Tyr-221 activates the enzyme By similarity. A conserved Thr, which must also be phosphorylated to activate the enzyme in closely related sequences, is replaced by Met-219 in this sequence.

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

By infection with rice blast fungus (M.grisea).1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ5J4W4.
SMRiQ5J4W4. Positions 49-391.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 347287Protein kinase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 4238Gly-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
KOiK04371.
OMAiWREALKF.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5J4W4-1 [UniParc]FASTAAdd to Basket

« Hide

MRMEGGGGGG HGHHGGGGGG HGHHGGIGGG EAQIKGTLTH GGRYVQYNVY    50
GNLFEVSSKY VPPIRPVGRG ACGIICAVVN AQTRQEVAIK KIGNAFDNQI 100
DAKRTLREIK LLRHMDHDNV ISIKDIIRPP RRENFNDVYI VYELMDTDLH 150
HLLRSNQPLT DDHCQYFLYQ VLRGLKYVHS ANVLHRDLRP SNLLLNAKCD 200
LKIGDFGLAR TTNETDFMME YVVTRWYRAP ELLLNCSEYT AAIDIWSVGC 250
ILGEIVTREP LFPGKDYVHQ LRLITELIGS PDDSSLGFLR SDNARRYVRS 300
LPQYPKQQFR ARFPTMSSGA MDLLERMLVF DPSKRITVDE ALCHPYLASL 350
HEIYDEPVCP APFSFDFEQP SLTEEDIKEI IWREALKFNP EPIH 394
Length:394
Mass (Da):44,585
Last modified:February 15, 2005 - v1
Checksum:iAC224C9134227481
GO

Sequence cautioni

The sequence BAC99508.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY506572 mRNA. Translation: AAS79349.1.
AP004460 Genomic DNA. Translation: BAC99508.1. Different initiation.
RefSeqiNP_001061028.2. NM_001067563.2.
UniGeneiOs.16795.

Genome annotation databases

EnsemblPlantsiOS08T0157000-00; OS08T0157000-00; OS08G0157000.
GeneIDi4344698.
KEGGiosa:4344698.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY506572 mRNA. Translation: AAS79349.1 .
AP004460 Genomic DNA. Translation: BAC99508.1 . Different initiation.
RefSeqi NP_001061028.2. NM_001067563.2.
UniGenei Os.16795.

3D structure databases

ProteinModelPortali Q5J4W4.
SMRi Q5J4W4. Positions 49-391.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS08T0157000-00 ; OS08T0157000-00 ; OS08G0157000 .
GeneIDi 4344698.
KEGGi osa:4344698.

Organism-specific databases

Gramenei Q5J4W4.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
KOi K04371.
OMAi WREALKF.

Enzyme and pathway databases

Reactomei REACT_205014. CREB phosphorylation through the activation of Ras.
REACT_214549. Signalling to ERK5.
REACT_215626. ERK2 activation.
REACT_221522. ERKs are inactivated.
REACT_221537. ERK1 activation.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel protein kinase OsMAPK-like involved in the developmental regulation for rice plants."
    Wang Y.D., Chen X., Ye Z.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. "Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
    Reyna N.S., Yang Y.
    Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, NOMENCLATURE.

Entry informationi

Entry nameiMPK2_ORYSJ
AccessioniPrimary (citable) accession number: Q5J4W4
Secondary accession number(s): Q6ZD93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: February 15, 2005
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi