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Protein

DNA-directed RNA polymerase subunit

Gene

L4R

Organism
Monkeypox virus
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates. Responsible for the transcription of early, intermediate and late genes.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotation, Transferase
Biological processTranscription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunitUniRule annotation (EC:2.7.7.6UniRule annotation)
Gene namesi
Name:L4RImported
ORF Names:MPXV-CAM1990_02-080Imported, MPXV-Congo_8-081Imported, MPXV-COP-082Imported, MPXV-GAB1988_001-081Imported, MPXV-Ikubi-080Imported, MPXV-Nig_SEV71_2_82-081Imported, MPXV-PCH-083Imported, MPXV-SL-082Imported, MPXV-UTC-077Imported, MPXV-W_Nigeria-081Imported, MPXV-WRAIR082Imported, MPXV_DRC_Yandongi_089Imported, MPXV_LIB1970_184_093Imported, MPXV_RCG2003_358_093Imported, MPXV_ROC_2010_032Imported, MPXV_SUD2005_01_089Imported, MPXV_USA2003_039_093Imported, MPXV_USA2003_044_093Imported, MPXV_ZAI1979_005_093Imported, MPXVgp088Imported
OrganismiMonkeypox virusImported
Taxonomic identifieri10244 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Virus hostiCynomys gunnisoni (Gunnison's prairie dog) [TaxID: 45479]
Cynomys leucurus (White-tailed prairie dog) [TaxID: 99825]
Cynomys ludovicianus (Black-tailed prairie dog) [TaxID: 45480]
Cynomys mexicanus (Mexican prairie dog) [TaxID: 99826]
Cynomys parvidens (Utah prairie dog) [TaxID: 99827]
Gliridae (dormice) [TaxID: 30650]
Heliosciurus ruwenzorii (Ruwenzori sun squirrel) [TaxID: 226685]
Homo sapiens (Human) [TaxID: 9606]
Mus musculus (Mouse) [TaxID: 10090]
Proteomesi
  • UP000126777 Componenti: Genome
  • UP000130227 Componenti: Genome
  • UP000158033 Componenti: Genome
  • UP000124163 Componenti: Genome
  • UP000117246 Componenti: Genome
  • UP000151462 Componenti: Genome
  • UP000104730 Componenti: Genome
  • UP000170119 Componenti: Genome
  • UP000172279 Componenti: Genome
  • UP000117086 Componenti: Genome
  • UP000127566 Componenti: Genome
  • UP000169092 Componenti: Genome
  • UP000155574 Componenti: Genome
  • UP000153809 Componenti: Genome
  • UP000150530 Componenti: Genome
  • UP000140016 Componenti: Genome
  • UP000141425 Componenti: Genome
  • UP000172985 Componenti: Genome
  • UP000116946 Componenti: Genome
  • UP000149280 Componenti: Genome
  • UP000102730 Componenti: Genome
  • UP000153264 Componenti: Genome
  • UP000133385 Componenti: Genome
  • UP000138604 Componenti: Genome
  • UP000102049 Componenti: Genome
  • UP000118284 Componenti: Genome
  • UP000151120 Componenti: Genome
  • UP000143488 Componenti: Genome
  • UP000099051 Componenti: Genome
  • UP000121251 Componenti: Genome
  • UP000099021 Componenti: Genome
  • UP000168391 Componenti: Genome
  • UP000143949 Componenti: Genome
  • UP000117231 Componenti: Genome
  • UP000133567 Componenti: Genome
  • UP000143786 Componenti: Genome
  • UP000151594 Componenti: Genome
  • UP000150603 Componenti: Genome
  • UP000154371 Componenti: Genome
  • UP000148165 Componenti: Genome
  • UP000112333 Componenti: Genome
  • UP000114038 Componenti: Genome
  • UP000170318 Componenti: Genome
  • UP000166832 Componenti: Genome
  • UP000113810 Componenti: Genome
  • UP000164300 Componenti: Genome
  • UP000100082 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • virion Source: UniProtKB-UniRule

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotation, VirionUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the poxviridae DNA-directed RNA polymerase 22 kDa subunit family.UniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR007937. RNA_Pol_22kDa_poxvir.
PfamiView protein in Pfam
PF05273. Pox_RNA_Pol_22. 1 hit.
PIRSFiPIRSF000744. RPO22. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD011187. RNA_Pol_22kDa_poxvir. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5IXT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQYNVKYLA KILCLKTEIA RDPYAVINRN VLLRYTTDIE YNDLVTLITV
60 70 80 90 100
RHKIDSMKTV FQVFNESSIN YTPVDDDYGE PIIITSYLQK GHNKFPVNFL
110 120 130 140 150
YIDVVISDLF PSFVRLDTTE TNIVNSVLQT GDGKKTLRLP KMLETEIVVK
160 170 180
ILYRPNIPLK IVRFFRNNMV TGVEIADRSV ISVAD
Length:185
Mass (Da):21,342
Last modified:April 14, 2009 - v1
Checksum:iE4A289D674B3B9E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY603973 Genomic DNA. Translation: AAU01292.1.
AY741551 Genomic DNA. Translation: AAW67840.1.
AY753185 Genomic DNA. Translation: AAX09183.1.
DQ011153 Genomic DNA. Translation: AAY96887.1.
DQ011154 Genomic DNA. Translation: AAY97087.1.
DQ011155 Genomic DNA. Translation: AAY97288.1.
DQ011156 Genomic DNA. Translation: AAY97486.1.
DQ011157 Genomic DNA. Translation: AAY97685.1.
HM172544 Genomic DNA. Translation: ADK39113.1.
HQ857562 Genomic DNA. Translation: ADX22735.1.
HQ857563 Genomic DNA. Translation: ADX22931.1.
KC257459 Genomic DNA. Translation: AGF36644.1.
KC257460 Genomic DNA. Translation: AGF36851.1.
KC257461 Genomic DNA. Translation: AGF36992.1.
JX878407 Genomic DNA. Translation: AGR34449.1.
JX878408 Genomic DNA. Translation: AGR34639.1.
JX878409 Genomic DNA. Translation: AGR34830.1.
JX878410 Genomic DNA. Translation: AGR35021.1.
JX878411 Genomic DNA. Translation: AGR35212.1.
JX878412 Genomic DNA. Translation: AGR35403.1.
JX878413 Genomic DNA. Translation: AGR35594.1.
JX878414 Genomic DNA. Translation: AGR35785.1.
JX878415 Genomic DNA. Translation: AGR35976.1.
JX878416 Genomic DNA. Translation: AGR36167.1.
JX878417 Genomic DNA. Translation: AGR36358.1.
JX878418 Genomic DNA. Translation: AGR36549.1.
JX878419 Genomic DNA. Translation: AGR36740.1.
JX878420 Genomic DNA. Translation: AGR36931.1.
JX878421 Genomic DNA. Translation: AGR37122.1.
JX878422 Genomic DNA. Translation: AGR37313.1.
JX878423 Genomic DNA. Translation: AGR37504.1.
JX878424 Genomic DNA. Translation: AGR37694.1.
JX878425 Genomic DNA. Translation: AGR37884.1.
JX878426 Genomic DNA. Translation: AGR38074.1.
JX878427 Genomic DNA. Translation: AGR38265.1.
JX878428 Genomic DNA. Translation: AGR38456.1.
JX878429 Genomic DNA. Translation: AGR38647.1.
KJ642612 Genomic DNA. Translation: AIE40173.1.
KJ642613 Genomic DNA. Translation: AIE40351.1.
KJ642614 Genomic DNA. Translation: AIE40525.1.
KJ642615 Genomic DNA. Translation: AIE40701.1.
KJ642616 Genomic DNA. Translation: AIE40879.1.
KJ642617 Genomic DNA. Translation: AIE41055.1.
KJ642618 Genomic DNA. Translation: AIE41230.1.
KJ642619 Genomic DNA. Translation: AIE41408.1.
KP849469 Genomic DNA. Translation: AKG51063.1.
KP849470 Genomic DNA. Translation: AKG51249.1.
KP849471 Genomic DNA. Translation: AKG51436.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY603973 Genomic DNA. Translation: AAU01292.1.
AY741551 Genomic DNA. Translation: AAW67840.1.
AY753185 Genomic DNA. Translation: AAX09183.1.
DQ011153 Genomic DNA. Translation: AAY96887.1.
DQ011154 Genomic DNA. Translation: AAY97087.1.
DQ011155 Genomic DNA. Translation: AAY97288.1.
DQ011156 Genomic DNA. Translation: AAY97486.1.
DQ011157 Genomic DNA. Translation: AAY97685.1.
HM172544 Genomic DNA. Translation: ADK39113.1.
HQ857562 Genomic DNA. Translation: ADX22735.1.
HQ857563 Genomic DNA. Translation: ADX22931.1.
KC257459 Genomic DNA. Translation: AGF36644.1.
KC257460 Genomic DNA. Translation: AGF36851.1.
KC257461 Genomic DNA. Translation: AGF36992.1.
JX878407 Genomic DNA. Translation: AGR34449.1.
JX878408 Genomic DNA. Translation: AGR34639.1.
JX878409 Genomic DNA. Translation: AGR34830.1.
JX878410 Genomic DNA. Translation: AGR35021.1.
JX878411 Genomic DNA. Translation: AGR35212.1.
JX878412 Genomic DNA. Translation: AGR35403.1.
JX878413 Genomic DNA. Translation: AGR35594.1.
JX878414 Genomic DNA. Translation: AGR35785.1.
JX878415 Genomic DNA. Translation: AGR35976.1.
JX878416 Genomic DNA. Translation: AGR36167.1.
JX878417 Genomic DNA. Translation: AGR36358.1.
JX878418 Genomic DNA. Translation: AGR36549.1.
JX878419 Genomic DNA. Translation: AGR36740.1.
JX878420 Genomic DNA. Translation: AGR36931.1.
JX878421 Genomic DNA. Translation: AGR37122.1.
JX878422 Genomic DNA. Translation: AGR37313.1.
JX878423 Genomic DNA. Translation: AGR37504.1.
JX878424 Genomic DNA. Translation: AGR37694.1.
JX878425 Genomic DNA. Translation: AGR37884.1.
JX878426 Genomic DNA. Translation: AGR38074.1.
JX878427 Genomic DNA. Translation: AGR38265.1.
JX878428 Genomic DNA. Translation: AGR38456.1.
JX878429 Genomic DNA. Translation: AGR38647.1.
KJ642612 Genomic DNA. Translation: AIE40173.1.
KJ642613 Genomic DNA. Translation: AIE40351.1.
KJ642614 Genomic DNA. Translation: AIE40525.1.
KJ642615 Genomic DNA. Translation: AIE40701.1.
KJ642616 Genomic DNA. Translation: AIE40879.1.
KJ642617 Genomic DNA. Translation: AIE41055.1.
KJ642618 Genomic DNA. Translation: AIE41230.1.
KJ642619 Genomic DNA. Translation: AIE41408.1.
KP849469 Genomic DNA. Translation: AKG51063.1.
KP849470 Genomic DNA. Translation: AKG51249.1.
KP849471 Genomic DNA. Translation: AKG51436.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR007937. RNA_Pol_22kDa_poxvir.
PfamiView protein in Pfam
PF05273. Pox_RNA_Pol_22. 1 hit.
PIRSFiPIRSF000744. RPO22. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD011187. RNA_Pol_22kDa_poxvir. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5IXT7_MONPV
AccessioniPrimary (citable) accession number: Q5IXT7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 14, 2009
Last sequence update: April 14, 2009
Last modified: May 10, 2017
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.