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Protein

Glucagon-like peptide 2 receptor

Gene

Glp2r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-like peptide 2 receptor
Short name:
GLP-2 receptor
Short name:
GLP-2-R
Short name:
GLP-2R
Gene namesi
Name:Glp2r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2136733. Glp2r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 135135ExtracellularBy similarityAdd
BLAST
Transmembranei136 – 16025Helical; Name=1By similarityAdd
BLAST
Topological domaini161 – 17212CytoplasmicBy similarityAdd
BLAST
Transmembranei173 – 19725Helical; Name=2By similarityAdd
BLAST
Topological domaini198 – 22326ExtracellularBy similarityAdd
BLAST
Transmembranei224 – 24724Helical; Name=3By similarityAdd
BLAST
Topological domaini248 – 26114CytoplasmicBy similarityAdd
BLAST
Transmembranei262 – 28322Helical; Name=4By similarityAdd
BLAST
Topological domaini284 – 30118ExtracellularBy similarityAdd
BLAST
Transmembranei302 – 32423Helical; Name=5By similarityAdd
BLAST
Topological domaini325 – 34824CytoplasmicBy similarityAdd
BLAST
Transmembranei349 – 36719Helical; Name=6By similarityAdd
BLAST
Topological domaini368 – 37912ExtracellularBy similarityAdd
BLAST
Transmembranei380 – 40021Helical; Name=7By similarityAdd
BLAST
Topological domaini401 – 512112CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Glucagon-like peptide 2 receptorPRO_0000307111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 65By similarity
Disulfide bondi56 ↔ 97By similarity
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence analysis
Disulfide bondi78 ↔ 119By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5IXF8.
PRIDEiQ5IXF8.

Expressioni

Gene expression databases

BgeeiQ5IXF8.
CleanExiMM_GLP2R.
ExpressionAtlasiQ5IXF8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061560.

Structurei

3D structure databases

ProteinModelPortaliQ5IXF8.
SMRiQ5IXF8. Positions 29-121, 136-408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiQ5IXF8.
KOiK04582.
OMAiKCPKKLS.
PhylomeDBiQ5IXF8.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5IXF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRLWGPGTP FLALLLLVSI KQVTTGSLLE ETVQKWAQYK ETCLKDLLEK
60 70 80 90 100
PSGVFCNGTF DKYVCWPHSF PGNVSVPCPS YLPWWNKESP GRAYRHCLAQ
110 120 130 140 150
GTWQKQENST DTWQDESECS ENHSFKQNVD HYHHTLLSTL QLMYTVGYSL
160 170 180 190 200
SLISLFLALT LFLFLRKLHC TRNYIHMNLF ASFILRALVV LVKDMVFYNS
210 220 230 240 250
YSRRPDSESG WMSYLSEISA SCRSVQVLLH YFVGTNHLWL LVEGLYLHAL
260 270 280 290 300
LEPTVLPERR LWPKYLVVGW AFPMLFVIPW IFVRASLENT GCWAVNENKK
310 320 330 340 350
IWWIIRGPIL LCVTVNFFIF LKILKLLISK FRAHQMCFRD YKYRLAKSTL
360 370 380 390 400
LLILLMGVHE FLFTFFTDDQ VQGFSRLIRL FIQLTLSSFH GFLVALQYGF
410 420 430 440 450
ASREVKAELR KTWGRFLLAR HWGCRACVLG KNFRFLGKCS KKLSEGDGAE
460 470 480 490 500
TLQKLQSSGV SSHLTAGNLR DHGAQPHRGR GAWPRASSLS ESSEGDFTLA
510
NTMEEILEES EI
Length:512
Mass (Da):59,105
Last modified:October 2, 2007 - v2
Checksum:iB7CBEE79F0267867
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti263 – 2631P → H in AAT46060 (Ref. 1) Curated
Sequence conflicti459 – 4602GV → AF in AAT46060 (Ref. 1) Curated
Sequence conflicti485 – 4851R → L in AAT46060 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY605231 mRNA. Translation: AAT46060.1.
AL646097 Genomic DNA. Translation: CAI25249.1.
CCDSiCCDS24860.1.
RefSeqiNP_783612.2. NM_175681.3.
UniGeneiMm.118883.

Genome annotation databases

EnsembliENSMUST00000051765; ENSMUSP00000061560; ENSMUSG00000049928.
GeneIDi93896.
KEGGimmu:93896.
UCSCiuc007jna.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY605231 mRNA. Translation: AAT46060.1.
AL646097 Genomic DNA. Translation: CAI25249.1.
CCDSiCCDS24860.1.
RefSeqiNP_783612.2. NM_175681.3.
UniGeneiMm.118883.

3D structure databases

ProteinModelPortaliQ5IXF8.
SMRiQ5IXF8. Positions 29-121, 136-408.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061560.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ5IXF8.
PRIDEiQ5IXF8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051765; ENSMUSP00000061560; ENSMUSG00000049928.
GeneIDi93896.
KEGGimmu:93896.
UCSCiuc007jna.1. mouse.

Organism-specific databases

CTDi9340.
MGIiMGI:2136733. Glp2r.

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiQ5IXF8.
KOiK04582.
OMAiKCPKKLS.
PhylomeDBiQ5IXF8.
TreeFamiTF315710.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.

Miscellaneous databases

ChiTaRSiGlp2r. mouse.
NextBioi351847.
PROiQ5IXF8.
SOURCEiSearch...

Gene expression databases

BgeeiQ5IXF8.
CleanExiMM_GLP2R.
ExpressionAtlasiQ5IXF8. baseline and differential.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Murine glucagon-like peptide-2 receptor cDNA."
    Estall J.L., Drucker D.J.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Jejunum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiGLP2R_MOUSE
AccessioniPrimary (citable) accession number: Q5IXF8
Secondary accession number(s): Q5SU65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: May 11, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.