Unreviewed, UniProtKB/TrEMBL Q5ISC7 (Q5ISC7_HUMAN)

Names and origin

Protein names	Submitted name:     Predicted NUP98/PRRX2 fusion protein EMBL AAV84357.1
Organism	Homo sapiens (Human) EMBL AAV84357.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	268 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Nucleus. Spearmint SPM003654 NucleusBy similarity. RuleBase RU000682V4
Sequence similarities	Contains 1 homeobox DNA-binding domain. Spearmint SPM003654

Ontologies

Keywords
Cellular component	Nucleus RuleBase RU000682V4 Spearmint SPM000047
Domain	Homeobox RuleBase RU000682V4 Spearmint SPM000047
Ligand	DNA-binding RuleBase RU000682V4 Spearmint SPM000047
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAV84357.1
	Non-terminal residue	268	1	EMBL AAV84357.1

Sequences

	Sequence		Length	Mass (Da)
	Q5ISC7-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: D613D91CDD6F1B5B	FASTA	268	28,114
	10 20 30 40 50 60 GVTQASQPGG LFGTATNTST GTAFGTGTGL FGQTNTGFGA VGSTLFGNNK LTTFGSSTTS 70 80 90 100 110 120 APSFGTTSGG LFGFGTNTSG NSIFGSKPAP GTLGTGLGAG FGTGECPSPG RGSAAKRKKK 130 140 150 160 170 180 QRRNRTTFNS SQLQALERVF ERTHYPDAFV REELARRVNL SEARVQVWFQ NRRAKFRRNE 190 200 210 220 230 240 RAMLASRSAS LLKSYSQEAA IEQPVAPRPT ALSPDYLSWT ASSPYSTVPP YSPGSSGPAT 250 260 PGVNMANSIA SLRLKAKEFS LHHSQVPT

References

[1]	"A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia." Gervais C., Mauvieux L., Perrusson N., Helias C., Struski S., Leymarie V., Lioure B., Lessard M. Leukemia 19:145-148(2005) [PubMed: 15496970] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY662674 mRNA. Translation: AAV84357.1.
UniGene	Hs.660115
3D structure databases
SMR	Q5ISC7. Positions 120-178.
ModBase	Search...
Organism-specific databases
HGNC	HGNC:21338. PRRX2.
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q5ISC7.
Family and domain databases
InterPro	IPR003654. Homeo_OAR. IPR001356. Homeobox. IPR012287. Homeodomain-rel. IPR000047. HTH_lambrepressr. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. PF03826. OAR. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX. PR00031. HTHREPRESSR.
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS50803. OAR. 1 hit. [Graphical view]

Entry information

Entry name

Q5ISC7_HUMAN

Accession

Primary (citable) accession number: Q5ISC7

Entry history

Integrated into UniProtKB/TrEMBL:	February 15, 2005
Last sequence update:	February 15, 2005
Last modified:	September 23, 2008
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)