Q5ISC7 (Q5ISC7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Predicted NUP98/PRRX2 fusion protein EMBL AAV84357.1
Organism	Homo sapiens (Human) EMBL AAV84357.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	268 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus By similarity RuleBase RU000682.
Sequence similarities	Contains 1 homeobox DNA-binding domain. SAAS SAAS003654

Ontologies

Keywords
Cellular component	Nucleus RuleBase RU000682 SAAS SAAS003654
Domain	Homeobox RuleBase RU000682 SAAS SAAS003654
Ligand	DNA-binding RuleBase RU000682 SAAS SAAS003654
Molecular function	Developmental protein SAAS SAAS003654
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAV84357.1
	Non-terminal residue	268	1	EMBL AAV84357.1

Sequences

	Sequence		Length	Mass (Da)
	Q5ISC7 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: D613D91CDD6F1B5B	FASTA	268	28,114
	10 20 30 40 50 60 GVTQASQPGG LFGTATNTST GTAFGTGTGL FGQTNTGFGA VGSTLFGNNK LTTFGSSTTS 70 80 90 100 110 120 APSFGTTSGG LFGFGTNTSG NSIFGSKPAP GTLGTGLGAG FGTGECPSPG RGSAAKRKKK 130 140 150 160 170 180 QRRNRTTFNS SQLQALERVF ERTHYPDAFV REELARRVNL SEARVQVWFQ NRRAKFRRNE 190 200 210 220 230 240 RAMLASRSAS LLKSYSQEAA IEQPVAPRPT ALSPDYLSWT ASSPYSTVPP YSPGSSGPAT 250 260 PGVNMANSIA SLRLKAKEFS LHHSQVPT

References

[1]

"A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia." Gervais C., Mauvieux L., Perrusson N., Helias C., Struski S., Leymarie V., Lioure B., Lessard M. Leukemia 19:145-148(2005) [PubMed: 15496970] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY662674 mRNA. Translation: AAV84357.1.
3D structure databases
ProteinModelPortal	Q5ISC7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5ISC7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG021349.
Family and domain databases
InterPro	IPR003654. Homeo_OAR. IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. PF03826. OAR. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS50803. OAR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q5ISC7_HUMAN

Accession

Primary (citable) accession number: Q5ISC7

Entry history

Integrated into UniProtKB/TrEMBL:	February 15, 2005
Last sequence update:	February 15, 2005
Last modified:	July 27, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.