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Q5IS74

- TPP1_PANTR

UniProt

Q5IS74 - TPP1_PANTR

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Protein
Tripeptidyl-peptidase 1
Gene
TPP1, CLN2
Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus By similarity.

Catalytic activityi

Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei272 – 2721Charge relay system By similarity
Active sitei276 – 2761Charge relay system By similarity
Active sitei475 – 4751Charge relay system By similarity
Metal bindingi517 – 5171Calcium By similarity
Metal bindingi518 – 5181Calcium; via carbonyl oxygen By similarity
Metal bindingi539 – 5391Calcium; via carbonyl oxygen By similarity
Metal bindingi541 – 5411Calcium; via carbonyl oxygen By similarity
Metal bindingi543 – 5431Calcium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. peptidase activity Source: UniProtKB
  3. serine-type endopeptidase activity Source: InterPro
  4. serine-type peptidase activity Source: UniProtKB
  5. tripeptidyl-peptidase activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. bone resorption Source: UniProtKB
  2. lysosome organization Source: Ensembl
  3. nervous system development Source: UniProtKB
  4. neuromuscular process controlling balance Source: Ensembl
  5. peptide catabolic process Source: UniProtKB
  6. proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

MEROPSiS53.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Tripeptidyl-peptidase 1 (EC:3.4.14.9)
Short name:
TPP-1
Alternative name(s):
Tripeptidyl aminopeptidase
Tripeptidyl-peptidase I
Short name:
TPP-I
Gene namesi
Name:TPP1
Synonyms:CLN2
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Chromosome 11

Subcellular locationi

Lysosome By similarity. Melanosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB
  2. melanosome Source: UniProtKB-SubCell
  3. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 By similarity
Add
BLAST
Propeptidei20 – 195176Removed in mature form By similarity
PRO_0000027380Add
BLAST
Chaini196 – 563368Tripeptidyl-peptidase 1
PRO_0000027381Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi111 ↔ 122 By similarity
Glycosylationi210 – 2101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi222 – 2221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi286 – 2861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi313 – 3131N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi365 ↔ 526 By similarity
Glycosylationi443 – 4431N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi522 ↔ 537 By similarity

Post-translational modificationi

Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity By similarity.

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, Zymogen

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000054786.

Structurei

3D structure databases

ProteinModelPortaliQ5IS74.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini199 – 563365Peptidase S53
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4934.
GeneTreeiENSGT00390000008684.
HOGENOMiHOG000171253.
HOVERGENiHBG004449.
KOiK01279.
OMAiCRVRSAR.
OrthoDBiEOG7RNJZW.
TreeFamiTF333497.

Family and domain databases

Gene3Di3.40.50.200. 1 hit.
InterProiIPR015366. Peptidase_S53_propep.
IPR000209. Peptidase_S8/S53_dom.
IPR009020. Prot_inh_propept.
[Graphical view]
PfamiPF00082. Peptidase_S8. 1 hit.
PF09286. Pro-kuma_activ. 1 hit.
[Graphical view]
SMARTiSM00944. Pro-kuma_activ. 1 hit.
[Graphical view]
SUPFAMiSSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS51695. SEDOLISIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5IS74-1 [UniParc]FASTAAdd to Basket

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MGLQACLLGL FALILSGKCS YSPEPDQRRT LPPGWVSLGR ADPEEELSLT    50
FALRQQNVER LSELVQAVSD PSSPQYGKYL TLENVADLVR PSPLTLRTVQ 100
KWLLAAGARK CHSVITQDFL TCWLSIRQAE LLLPGAEFHH YVGGPTETHV 150
VRSPHPYQLP QALAPHVDFV GGLHRFPPTS SLRQRPEPQV TGTVGLHLGV 200
TPSVIRKRYN LTSQDVGSGT SNNSQACAQF LEQYFHDSDL AQFMRLFGGN 250
FAHQASVARV VGQQGRGRAG IEASLDVQYL MSAGANISTW VYSSPGRHEG 300
QEPFLQWLML LSNESALPHV HTVSYGDDED SLSSAYIQRV NTELMKAAAR 350
GLTLLFASGD SGAGCWSVSG RHQFRPTFPA SSPYVTTVGG TSFQEPFLIT 400
NEIVDYISGG GFSNVFPRPS YQEEAVTKFL SSSPHLPPSS YFNASGRAYP 450
DVAALSDGYW VVSNRVPIPW VSGTSASTPV FGGILSLINE HRILSGRPPL 500
GFLNPRLYQQ HGAGLFDVTR GCHESCLDEE VEGQGFCSGP GWDPVTGWGT 550
PNFPALLKTL LNP 563
Length:563
Mass (Da):61,295
Last modified:February 15, 2005 - v1
Checksum:iF8B1991276E8F361
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY665254 mRNA. Translation: AAV74292.1.
RefSeqiNP_001013025.1. NM_001013007.1.
UniGeneiPtr.6178.

Genome annotation databases

EnsembliENSPTRT00000006261; ENSPTRP00000005774; ENSPTRG00000003299.
GeneIDi450999.
KEGGiptr:450999.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY665254 mRNA. Translation: AAV74292.1 .
RefSeqi NP_001013025.1. NM_001013007.1.
UniGenei Ptr.6178.

3D structure databases

ProteinModelPortali Q5IS74.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9598.ENSPTRP00000054786.

Protein family/group databases

MEROPSi S53.003.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPTRT00000006261 ; ENSPTRP00000005774 ; ENSPTRG00000003299 .
GeneIDi 450999.
KEGGi ptr:450999.

Organism-specific databases

CTDi 1200.

Phylogenomic databases

eggNOGi COG4934.
GeneTreei ENSGT00390000008684.
HOGENOMi HOG000171253.
HOVERGENi HBG004449.
KOi K01279.
OMAi CRVRSAR.
OrthoDBi EOG7RNJZW.
TreeFami TF333497.

Miscellaneous databases

NextBioi 20833675.

Family and domain databases

Gene3Di 3.40.50.200. 1 hit.
InterProi IPR015366. Peptidase_S53_propep.
IPR000209. Peptidase_S8/S53_dom.
IPR009020. Prot_inh_propept.
[Graphical view ]
Pfami PF00082. Peptidase_S8. 1 hit.
PF09286. Pro-kuma_activ. 1 hit.
[Graphical view ]
SMARTi SM00944. Pro-kuma_activ. 1 hit.
[Graphical view ]
SUPFAMi SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEi PS51695. SEDOLISIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Accelerated evolution of nervous system genes in the origin of Homo sapiens."
    Dorus S., Vallender E.J., Evans P.D., Anderson J.R., Gilbert S.L., Mahowald M., Wyckoff G.J., Malcom C.M., Lahn B.T.
    Cell 119:1027-1040(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTPP1_PANTR
AccessioniPrimary (citable) accession number: Q5IS74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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