Reviewed, UniProtKB/Swiss-Prot Q5IS74 (TPP1_PANTR)

Names and origin

Protein names

Recommended name:
    Tripeptidyl-peptidase 1
      Short name=TPP-1
    EC=3.4.14.9
Alternative name(s):
    Tripeptidyl-peptidase I
      Short name=TPP-I
    Tripeptidyl aminopeptidase

Gene names

Name:	TPP1
Synonyms:	CLN2

Organism

Pan troglodytes (Chimpanzee)

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length	563 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus By similarity.
Catalytic activity	Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity.
Subcellular location	Lysosome By similarity. Melanosome By similarity.
Post-translational modification	Activated by autocatalytic proteolytical processing upon acidification By similarity.
Sequence similarities	Belongs to the peptidase S53 family.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Molecular function	Hydrolase Protease Serine protease
PTM	Glycoprotein Zymogen
Gene Ontology (GO)
Biological process	bone resorption Inferred from sequence or structural similarity. Source: UniProtKB nervous system development Inferred from sequence or structural similarity. Source: UniProtKB peptide catabolic process Inferred from sequence or structural similarity. Source: UniProtKB proteolysis Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	lysosome Inferred from sequence or structural similarity. Source: UniProtKB melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell soluble fraction Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	protein binding Inferred from sequence or structural similarity. Source: UniProtKB serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	By similarity
	Propeptide	20 – 195	176	Removed in mature form By similarity		PRO_0000027380
	Chain	196 – 563	368	Tripeptidyl-peptidase 1		PRO_0000027381
Sites
	Active site	272	1	Charge relay system By similarity
	Active site	276	1	Charge relay system By similarity
	Active site	475	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	210	1	N-linked (GlcNAc...) Potential
	Glycosylation	222	1	N-linked (GlcNAc...) Potential
	Glycosylation	286	1	N-linked (GlcNAc...) Potential
	Glycosylation	313	1	N-linked (GlcNAc...) Potential
	Glycosylation	443	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5IS74-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: F8B1991276E8F361	FASTA	563	61,295
	10 20 30 40 50 60 MGLQACLLGL FALILSGKCS YSPEPDQRRT LPPGWVSLGR ADPEEELSLT FALRQQNVER 70 80 90 100 110 120 LSELVQAVSD PSSPQYGKYL TLENVADLVR PSPLTLRTVQ KWLLAAGARK CHSVITQDFL 130 140 150 160 170 180 TCWLSIRQAE LLLPGAEFHH YVGGPTETHV VRSPHPYQLP QALAPHVDFV GGLHRFPPTS 190 200 210 220 230 240 SLRQRPEPQV TGTVGLHLGV TPSVIRKRYN LTSQDVGSGT SNNSQACAQF LEQYFHDSDL 250 260 270 280 290 300 AQFMRLFGGN FAHQASVARV VGQQGRGRAG IEASLDVQYL MSAGANISTW VYSSPGRHEG 310 320 330 340 350 360 QEPFLQWLML LSNESALPHV HTVSYGDDED SLSSAYIQRV NTELMKAAAR GLTLLFASGD 370 380 390 400 410 420 SGAGCWSVSG RHQFRPTFPA SSPYVTTVGG TSFQEPFLIT NEIVDYISGG GFSNVFPRPS 430 440 450 460 470 480 YQEEAVTKFL SSSPHLPPSS YFNASGRAYP DVAALSDGYW VVSNRVPIPW VSGTSASTPV 490 500 510 520 530 540 FGGILSLINE HRILSGRPPL GFLNPRLYQQ HGAGLFDVTR GCHESCLDEE VEGQGFCSGP 550 560 GWDPVTGWGT PNFPALLKTL LNP

References

[1]	"Accelerated evolution of nervous system genes in the origin of Homo sapiens." Dorus S., Vallender E.J., Evans P.D., Anderson J.R., Gilbert S.L., Mahowald M., Wyckoff G.J., Malcom C.M., Lahn B.T. Cell 119:1027-1040(2004) [PubMed: 15620360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY665254 mRNA. Translation: AAV74292.1.
RefSeq	NP_001013025.1.
3D structure databases
SMR	Q5IS74. Positions 198-561.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5IS74.
Protein family/group databases
MEROPS	S53.003.
Genome annotation databases
Ensembl	ENSPTRT00000006261; ENSPTRP00000005774; ENSPTRG00000003299; Pan troglodytes. [Genome view] ENSPTRT00000006262; ENSPTRP00000005775; ENSPTRG00000003299; Pan troglodytes. [Genome view]
GeneID	450999.
KEGG	ptr:450999.
Organism-specific databases
CTD	450999.
Phylogenomic databases
eggNOG	maNOG12815.
HOVERGEN	Q5IS74.
OMA	GWGTPNY.
Enzyme and pathway databases
BRENDA	3.4.14.9. 264977.
Family and domain databases
InterPro	IPR015366. Peptidase_S53_propep. IPR000209. Peptidase_S8/S53. IPR009020. Prot_inh_propept. [Graphical view]
Gene3D	G3DSA:3.40.50.200. Pept_S8_S53. 1 hit.
Pfam	PF00082. Peptidase_S8. 1 hit. PF09286. Pro-kuma_activ. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPP1_PANTR

Accession

Primary (citable) accession number: Q5IS74

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	February 15, 2005
Last modified:	January 19, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)