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Protein

Cannabinoid receptor 1

Gene

CNR1

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca2+ channel current (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Cannabinoid receptor 1
Short name:
CB-R
Short name:
CB1
Gene namesi
Name:CNR1
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 116ExtracellularSequence analysisAdd BLAST116
Transmembranei117 – 142Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini143 – 154CytoplasmicSequence analysisAdd BLAST12
Transmembranei155 – 175Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini176 – 187ExtracellularSequence analysisAdd BLAST12
Transmembranei188 – 212Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini213 – 232CytoplasmicSequence analysisAdd BLAST20
Transmembranei233 – 255Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini256 – 273ExtracellularSequence analysisAdd BLAST18
Transmembranei274 – 299Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini300 – 344CytoplasmicSequence analysisAdd BLAST45
Transmembranei345 – 365Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini366 – 377ExtracellularSequence analysisAdd BLAST12
Transmembranei378 – 399Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini400 – 472CytoplasmicSequence analysisAdd BLAST73

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693171 – 472Cannabinoid receptor 1Add BLAST472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi77N-linked (GlcNAc...)Sequence analysis1
Glycosylationi83N-linked (GlcNAc...)Sequence analysis1
Lipidationi415S-palmitoyl cysteineBy similarity1
Modified residuei425PhosphoserineBy similarity1
Modified residuei429PhosphoserineBy similarity1

Post-translational modificationi

Palmitoylation at Cys-415 is important for recruitment at both plasma membrane and lipid rafts.By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ5IS73.

Expressioni

Gene expression databases

BgeeiENSPTRG00000018411.

Interactioni

Subunit structurei

Interacts (via C-terminus) with CNRIP1.By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000055363.

Structurei

3D structure databases

ProteinModelPortaliQ5IS73.
SMRiQ5IS73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000049272.
HOVERGENiHBG051045.
InParanoidiQ5IS73.
KOiK04277.
OMAiVAFCVMW.
OrthoDBiEOG091G05O3.
TreeFamiTF330052.

Family and domain databases

InterProiIPR000810. Canbinoid_rcpt_1.
IPR002230. Cnbnoid_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037995. Cnoid_rcpt_1. 1 hit.
PRINTSiPR00522. CANABINOID1R.
PR00362. CANNABINOIDR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5IS73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL
60 70 80 90 100
TSFRGSPFQE KMTAGDNPQL VPADQVNITE FYNKSLSSFK ENEENIQCGE
110 120 130 140 150
NFMDIECFMV LNPSQQLAIA VLSLTLGTFT VLENLLVLCV ILHSRSLRCR
160 170 180 190 200
PSYHFIGSLA VADLLGSVIF VYSFIDFHVF HRKDSRNVFL FKLGGVTASF
210 220 230 240 250
TASVGSLFLT AIDRYISIHR PLAYKRIVTR PKAVVAFCLM WTIAIVIAVL
260 270 280 290 300
PLLGWNCEKL QSVCSDIFPH IDETYLMFWI GVTSVLLLFI VYAYMYILWK
310 320 330 340 350
AHSHAVRMIQ RGTQKSIIIH TSEDGKVQVT RPDQARMDIR LAKTLVLILV
360 370 380 390 400
VLIICWGPLL AIMVYDVFGK MNKLIKTVFA FCSMLCLLNS TVNPIIYALR
410 420 430 440 450
SKDLRHAFRS MFPSCEGTAQ PLDNSMGDSD CLHKHANNAA SVHRAAESCI
460 470
KSTVKIAKVT MSVSTDTSAE AL
Length:472
Mass (Da):52,858
Last modified:February 15, 2005 - v1
Checksum:i1D2E49061D12ABF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY665255 mRNA. Translation: AAV74293.1.
RefSeqiNP_001013035.1. NM_001013017.1.
XP_009449804.1. XM_009451529.2.
XP_009449805.1. XM_009451530.2.
XP_009449806.1. XM_009451531.2.
UniGeneiPtr.6364.

Genome annotation databases

EnsembliENSPTRT00000063819; ENSPTRP00000055363; ENSPTRG00000018411.
GeneIDi472066.
KEGGiptr:472066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY665255 mRNA. Translation: AAV74293.1.
RefSeqiNP_001013035.1. NM_001013017.1.
XP_009449804.1. XM_009451529.2.
XP_009449805.1. XM_009451530.2.
XP_009449806.1. XM_009451531.2.
UniGeneiPtr.6364.

3D structure databases

ProteinModelPortaliQ5IS73.
SMRiQ5IS73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000055363.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ5IS73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000063819; ENSPTRP00000055363; ENSPTRG00000018411.
GeneIDi472066.
KEGGiptr:472066.

Organism-specific databases

CTDi1268.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000049272.
HOVERGENiHBG051045.
InParanoidiQ5IS73.
KOiK04277.
OMAiVAFCVMW.
OrthoDBiEOG091G05O3.
TreeFamiTF330052.

Gene expression databases

BgeeiENSPTRG00000018411.

Family and domain databases

InterProiIPR000810. Canbinoid_rcpt_1.
IPR002230. Cnbnoid_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037995. Cnoid_rcpt_1. 1 hit.
PRINTSiPR00522. CANABINOID1R.
PR00362. CANNABINOIDR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNR1_PANTR
AccessioniPrimary (citable) accession number: Q5IS73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.