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Protein

D(3) dopamine receptor

Gene

DRD3

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei110AgonistBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
D(3) dopamine receptor
Alternative name(s):
Dopamine D3 receptor
Gene namesi
Name:DRD3
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularBy similarityAdd BLAST32
Transmembranei33 – 55Helical; Name=1By similarityAdd BLAST23
Topological domaini56 – 65CytoplasmicBy similarity10
Transmembranei66 – 88Helical; Name=2By similarityAdd BLAST23
Topological domaini89 – 104ExtracellularBy similarityAdd BLAST16
Transmembranei105 – 126Helical; Name=3By similarityAdd BLAST22
Topological domaini127 – 149CytoplasmicBy similarityAdd BLAST23
Transmembranei150 – 170Helical; Name=4By similarityAdd BLAST21
Topological domaini171 – 187ExtracellularBy similarityAdd BLAST17
Transmembranei188 – 212Helical; Name=5By similarityAdd BLAST25
Topological domaini213 – 329CytoplasmicBy similarityAdd BLAST117
Transmembranei330 – 351Helical; Name=6By similarityAdd BLAST22
Topological domaini352 – 366ExtracellularBy similarityAdd BLAST15
Transmembranei367 – 388Helical; Name=7By similarityAdd BLAST22
Topological domaini389 – 400CytoplasmicBy similarityAdd BLAST12

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693991 – 400D(3) dopamine receptorAdd BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi103 ↔ 181PROSITE-ProRule annotation
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi355 ↔ 358PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by GRK4.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5IS72.

Expressioni

Gene expression databases

BgeeiENSPTRG00000015241.

Interactioni

Subunit structurei

Interacts with CLIC6 (By similarity). Interacts with GRK4. Interacts with PALM. Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (By similarity).By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000026285.

Structurei

3D structure databases

ProteinModelPortaliQ5IS72.
SMRiQ5IS72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni189 – 196Agonist bindingBy similarity8
Regioni342 – 350Agonist bindingBy similarity9

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00890000139331.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ5IS72.
KOiK04146.
OMAiQNSQCIS.
OrthoDBiEOG091G06VI.
TreeFamiTF334382.

Family and domain databases

CDDicd15310. 7tmA_D3_dopamine_R. 1 hit.
InterProiView protein in InterPro
IPR001620. Dopamine_D3_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00568. DOPAMINED3R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5IS72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLSQLSGH LNYTCGAENS TGASQARPHA YYALSYCALI LAIVFGNGLV
60 70 80 90 100
CMAVLKERAL QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR
110 120 130 140 150
ICCDVFVTLD VMMCTASILN LCAISIDRYT AVVMPVHYQH GTGQSSCRRV
160 170 180 190 200
ALMITAVWVL AFAVSCPLLF GFNTTGDPTV CSISNPDFVI YSSVVSFYLP
210 220 230 240 250
FGVTVLVYAR IYMVLKQRRR KRILTRQNSQ CNSVRPGFPQ QTLSPDPAHL
260 270 280 290 300
ELKRYYSICQ DTALGGPGFQ ERGGELKREE KTRNSLSPTI APKLSLEVRK
310 320 330 340 350
LSNGRLSTSL KLGPLQPRGV PLREKKATQM VAIVLGAFIV CWLPFFLTHV
360 370 380 390 400
LNTHCQTCHV SPELYSATTW LGYVNSALNP VIYTTFNIEF RKAFLKILSC
Length:400
Mass (Da):44,237
Last modified:February 15, 2005 - v1
Checksum:i1F77A2B82B7FED9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY665256 mRNA. Translation: AAV74294.1.
RefSeqiNP_001029084.1. NM_001033912.1.
XP_009444264.1. XM_009445989.2.
UniGeneiPtr.6359.

Genome annotation databases

EnsembliENSPTRT00000028481; ENSPTRP00000026285; ENSPTRG00000015241.
GeneIDi470885.
KEGGiptr:470885.

Similar proteinsi

Entry informationi

Entry nameiDRD3_PANTR
AccessioniPrimary (citable) accession number: Q5IS72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: February 15, 2005
Last modified: October 25, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families