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Protein

Muscarinic acetylcholine receptor M5

Gene

CHRM5

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Muscarinic acetylcholine receptor M5
Gene namesi
Name:CHRM5
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularBy similarityAdd BLAST29
Transmembranei30 – 53Helical; Name=1By similarityAdd BLAST24
Topological domaini54 – 66CytoplasmicBy similarityAdd BLAST13
Transmembranei67 – 87Helical; Name=2By similarityAdd BLAST21
Topological domaini88 – 104ExtracellularBy similarityAdd BLAST17
Transmembranei105 – 126Helical; Name=3By similarityAdd BLAST22
Topological domaini127 – 146CytoplasmicBy similarityAdd BLAST20
Transmembranei147 – 169Helical; Name=4By similarityAdd BLAST23
Topological domaini170 – 191ExtracellularBy similarityAdd BLAST22
Transmembranei192 – 214Helical; Name=5By similarityAdd BLAST23
Topological domaini215 – 443CytoplasmicBy similarityAdd BLAST229
Transmembranei444 – 464Helical; Name=6By similarityAdd BLAST21
Topological domaini465 – 478ExtracellularBy similarityAdd BLAST14
Transmembranei479 – 498Helical; Name=7By similarityAdd BLAST20
Topological domaini499 – 532CytoplasmicBy similarityAdd BLAST34

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690451 – 532Muscarinic acetylcholine receptor M5Add BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi103 ↔ 183PROSITE-ProRule annotation
Modified residuei501PhosphothreonineSequence analysis1
Modified residuei505PhosphothreonineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5IS53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000231484.
HOVERGENiHBG105720.
InParanoidiQ5IS53.
KOiK04133.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000502. Musac_Ach_M5_rcpt.
IPR000995. Musac_Ach_rcpt.
[Graphical view]
PANTHERiPTHR24249:SF58. PTHR24249:SF58. 3 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00542. MUSCRINICM5R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5IS53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGDSYGNAT TINGTPVNHQ PLERHRLWEV ITIAAVTAVV SLITIVGNVL
60 70 80 90 100
VMISFKVNSQ LKTVNNYYLL SLACADLIIG IFSMNLYTTY ILMGRWALGS
110 120 130 140 150
LACDLWLALD YVASNASVMN LLVISFDRYF SITRPLTYRA KRTPKRAGIM
160 170 180 190 200
IGLAWLISFI LWAPAILCWQ YLVGKRTVPP DECQIQFLSE PTITFGTAIA
210 220 230 240 250
AFYIPVSVMT ILYCRIYRET EKRTKDLADL QGSVSVTKAE KRKPAHRALF
260 270 280 290 300
RSCFRCPRPT LVQRERNQAS RSSSHRSTSI TGKPSQATGP STNWAKAEEL
310 320 330 340 350
TTCSSYPSSE DEDKPATDPV LQVVYKSQGK ESPGEEFSAE EAEETFVKGQ
360 370 380 390 400
TDKNDCDSPD YFLSPAAAHR PKSQQCVAYK FQLVVKADGT QETNNGCHKV
410 420 430 440 450
KIMPCSFPVA KEPSTKGLSP NLSHQMTKRK RMVLVKERKA AQTLSAILLA
460 470 480 490 500
FIITWTPYNI MVLVSTFCDK CVPVALWHLG YWLCYVNSTV NPICYALCNR
510 520 530
TFRKTFKMLL LCQWKKKKVE EKLYWQGNSK LP
Length:532
Mass (Da):59,873
Last modified:February 15, 2005 - v1
Checksum:i4B09E40A3940A8F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY665275 mRNA. Translation: AAV74313.1.
RefSeqiNP_001012444.1. NM_001012442.1.
UniGeneiPtr.6367.

Genome annotation databases

GeneIDi503515.
KEGGiptr:503515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY665275 mRNA. Translation: AAV74313.1.
RefSeqiNP_001012444.1. NM_001012442.1.
UniGeneiPtr.6367.

3D structure databases

ProteinModelPortaliQ5IS53.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi503515.
KEGGiptr:503515.

Organism-specific databases

CTDi1133.

Phylogenomic databases

HOGENOMiHOG000231484.
HOVERGENiHBG105720.
InParanoidiQ5IS53.
KOiK04133.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000502. Musac_Ach_M5_rcpt.
IPR000995. Musac_Ach_rcpt.
[Graphical view]
PANTHERiPTHR24249:SF58. PTHR24249:SF58. 3 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00542. MUSCRINICM5R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACM5_PANTR
AccessioniPrimary (citable) accession number: Q5IS53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: February 15, 2005
Last modified: June 8, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.