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Q5IS52

- ACHA2_PANTR

UniProt

Q5IS52 - ACHA2_PANTR

Protein

Neuronal acetylcholine receptor subunit alpha-2

Gene

CHRNA2

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.By similarity

    GO - Molecular functioni

    1. acetylcholine-activated cation-selective channel activity Source: InterPro
    2. acetylcholine receptor activity Source: Ensembl

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuronal acetylcholine receptor subunit alpha-2
    Gene namesi
    Name:CHRNA2
    OrganismiPan troglodytes (Chimpanzee)
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Chromosome 8

    Subcellular locationi

    GO - Cellular componenti

    1. acetylcholine-gated channel complex Source: Ensembl
    2. cell junction Source: UniProtKB-KW
    3. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 529503Neuronal acetylcholine receptor subunit alpha-2PRO_0000000342Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi183 ↔ 197By similarity
    Glycosylationi235 – 2351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi247 ↔ 248Associated with receptor activationBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Alpha-2 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9598.ENSPTRP00000034420.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5IS52.
    SMRiQ5IS52. Positions 265-356.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 264238ExtracellularAdd
    BLAST
    Topological domaini353 – 502150CytoplasmicAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei265 – 28925HelicalSequence AnalysisAdd
    BLAST
    Transmembranei297 – 31519HelicalSequence AnalysisAdd
    BLAST
    Transmembranei331 – 35222HelicalSequence AnalysisAdd
    BLAST
    Transmembranei503 – 52119HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG290206.
    GeneTreeiENSGT00750000117277.
    HOGENOMiHOG000006756.
    HOVERGENiHBG003756.
    InParanoidiQ5IS52.
    KOiK04804.
    OMAiACAGHVA.
    OrthoDBiEOG72JWGV.
    TreeFamiTF315605.

    Family and domain databases

    Gene3Di1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProiIPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5IS52-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPSCPVFLS FTKLSLWWLL LTPAGGEEAK RPPPRAPGDP LSSPSPTALP    50
    QGGSHTETED RLFKHLFRGY NRWARPVPNT SDVVIVRFGL SIAQLIDVDE 100
    KNQMMTTNVW LKQEWSDYKL RWNPADFGNI TSLRVPSEMI WIPDIVLYNN 150
    ADGEFAVTHM TKAHLFSTGT VHWVPPAIYK SSCSIDVTFF PFDQQNCKMK 200
    FGSWTYDKAK IDLEQMEQTV DLKDYWESGE WAIVNATGTY NSKKYDCCAE 250
    IYPDVTYAFI IRRLPLFYTI NLIIPCLLIS CLTVLVFYLP SNCGEKITLC 300
    ISVLLSLTVF LLLITEIIPS TSLVIPLIGE YLLFTMIFVT LSIVITVFVL 350
    NVHHRSPSTH TMPHWVRGTL LGCVPRWLLM NRPPPPLELC HPLHLKLSPS 400
    YHWLESNVDA EEREVVVEEE DRWACAGHVA PSVGTLCSHG HLHSGASGPK 450
    AEALLQEGEL LLSPHMQKAL EGVHYIADHL RSEDADSSVK EDWKYVAMVI 500
    DRIFLWLFII VCFLGTIGLF LPPFLAGMI 529
    Length:529
    Mass (Da):59,773
    Last modified:February 15, 2005 - v1
    Checksum:iDCE98F58DC06EDDC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY665276 mRNA. Translation: AAV74314.1.
    RefSeqiNP_001029107.1. NM_001033935.1.
    UniGeneiPtr.6123.

    Genome annotation databases

    EnsembliENSPTRT00000037245; ENSPTRP00000034420; ENSPTRG00000020105.
    GeneIDi472725.
    KEGGiptr:472725.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY665276 mRNA. Translation: AAV74314.1 .
    RefSeqi NP_001029107.1. NM_001033935.1.
    UniGenei Ptr.6123.

    3D structure databases

    ProteinModelPortali Q5IS52.
    SMRi Q5IS52. Positions 265-356.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9598.ENSPTRP00000034420.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPTRT00000037245 ; ENSPTRP00000034420 ; ENSPTRG00000020105 .
    GeneIDi 472725.
    KEGGi ptr:472725.

    Organism-specific databases

    CTDi 1135.

    Phylogenomic databases

    eggNOGi NOG290206.
    GeneTreei ENSGT00750000117277.
    HOGENOMi HOG000006756.
    HOVERGENi HBG003756.
    InParanoidi Q5IS52.
    KOi K04804.
    OMAi ACAGHVA.
    OrthoDBi EOG72JWGV.
    TreeFami TF315605.

    Miscellaneous databases

    NextBioi 20849390.

    Family and domain databases

    Gene3Di 1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProi IPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Accelerated evolution of nervous system genes in the origin of Homo sapiens."
      Dorus S., Vallender E.J., Evans P.D., Anderson J.R., Gilbert S.L., Mahowald M., Wyckoff G.J., Malcom C.M., Lahn B.T.
      Cell 119:1027-1040(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiACHA2_PANTR
    AccessioniPrimary (citable) accession number: Q5IS52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3