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Q5IS52 (ACHA2_PANTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuronal acetylcholine receptor subunit alpha-2
Gene names
Name:CHRNA2
OrganismPan troglodytes (Chimpanzee) [Reference proteome]
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane By similarity.

Subunit structure

Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Alpha-2 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors By similarity.

Subcellular location

Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein By similarity. Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-2/CHRNA2 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 529503Neuronal acetylcholine receptor subunit alpha-2
PRO_0000000342

Regions

Topological domain27 – 264238Extracellular
Transmembrane265 – 28925Helical; Potential
Transmembrane297 – 31519Helical; Potential
Transmembrane331 – 35222Helical; Potential
Topological domain353 – 502150Cytoplasmic
Transmembrane503 – 52119Helical; Potential

Amino acid modifications

Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation1291N-linked (GlcNAc...) Potential
Glycosylation2351N-linked (GlcNAc...) Potential
Disulfide bond183 ↔ 197 By similarity
Disulfide bond247 ↔ 248Associated with receptor activation By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5IS52 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: DCE98F58DC06EDDC

FASTA52959,773
        10         20         30         40         50         60 
MGPSCPVFLS FTKLSLWWLL LTPAGGEEAK RPPPRAPGDP LSSPSPTALP QGGSHTETED 

        70         80         90        100        110        120 
RLFKHLFRGY NRWARPVPNT SDVVIVRFGL SIAQLIDVDE KNQMMTTNVW LKQEWSDYKL 

       130        140        150        160        170        180 
RWNPADFGNI TSLRVPSEMI WIPDIVLYNN ADGEFAVTHM TKAHLFSTGT VHWVPPAIYK 

       190        200        210        220        230        240 
SSCSIDVTFF PFDQQNCKMK FGSWTYDKAK IDLEQMEQTV DLKDYWESGE WAIVNATGTY 

       250        260        270        280        290        300 
NSKKYDCCAE IYPDVTYAFI IRRLPLFYTI NLIIPCLLIS CLTVLVFYLP SNCGEKITLC 

       310        320        330        340        350        360 
ISVLLSLTVF LLLITEIIPS TSLVIPLIGE YLLFTMIFVT LSIVITVFVL NVHHRSPSTH 

       370        380        390        400        410        420 
TMPHWVRGTL LGCVPRWLLM NRPPPPLELC HPLHLKLSPS YHWLESNVDA EEREVVVEEE 

       430        440        450        460        470        480 
DRWACAGHVA PSVGTLCSHG HLHSGASGPK AEALLQEGEL LLSPHMQKAL EGVHYIADHL 

       490        500        510        520 
RSEDADSSVK EDWKYVAMVI DRIFLWLFII VCFLGTIGLF LPPFLAGMI 

« Hide

References

[1]"Accelerated evolution of nervous system genes in the origin of Homo sapiens."
Dorus S., Vallender E.J., Evans P.D., Anderson J.R., Gilbert S.L., Mahowald M., Wyckoff G.J., Malcom C.M., Lahn B.T.
Cell 119:1027-1040(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY665276 mRNA. Translation: AAV74314.1.
RefSeqNP_001029107.1. NM_001033935.1.
UniGenePtr.6123.

3D structure databases

ProteinModelPortalQ5IS52.
SMRQ5IS52. Positions 265-356.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9598.ENSPTRP00000034420.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPTRT00000037245; ENSPTRP00000034420; ENSPTRG00000020105.
GeneID472725.
KEGGptr:472725.

Organism-specific databases

CTD1135.

Phylogenomic databases

eggNOGNOG290206.
GeneTreeENSGT00750000117277.
HOGENOMHOG000006756.
HOVERGENHBG003756.
InParanoidQ5IS52.
KOK04804.
OMAACAGHVA.
OrthoDBEOG72JWGV.
TreeFamTF315605.

Family and domain databases

Gene3D1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERPTHR18945. PTHR18945. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsTIGR00860. LIC. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20849390.

Entry information

Entry nameACHA2_PANTR
AccessionPrimary (citable) accession number: Q5IS52
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: February 15, 2005
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families