Q5IS48 (DVL1_PANTR) Reviewed, UniProtKB/Swiss-Prot
Last modified November 13, 2013. Version 69. History...
Names and origin
|Protein names||Recommended name:|
Segment polarity protein dishevelled homolog DVL-1
DSH homolog 1
|Organism||Pan troglodytes (Chimpanzee) [Reference proteome]|
|Taxonomic identifier||9598 [NCBI]|
|Taxonomic lineage||Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan|
|Sequence length||670 AA.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) By similarity.
Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts with CXXC4. Interacts (via PDZ domain) with NXN. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1. Interacts with CYLD. Interacts (via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site. Interacts (via DEP domain) with MUSK; the interaction is direct and mediates the formation a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering. Interacts (via PDZ domain) with TMEM88 By similarity.
Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm › cytosol By similarity. Cytoplasmic vesicle By similarity. Note: Localizes at the cell membrane upon interaction with frizzled family members By similarity.
The DIX domain promotes homooligomerization By similarity.
The DEP domain mediates interaction with the cell membrane By similarity.
Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains By similarity.
Belongs to the DSH family.
Contains 1 DEP domain.
Contains 1 DIX domain.
Contains 1 PDZ (DHR) domain.
Sequence annotation (Features)
|AY665280 mRNA. Translation: AAV74318.1.|
|RefSeq||NP_001012432.1. NM_001012430.1. |
3D structure databases
|SMR||Q5IS48. Positions 251-345, 381-474. |
Protein-protein interaction databases
Protocols and materials databases
Genome annotation databases
Family and domain databases
|Gene3D||184.108.40.206. 1 hit. |
|InterPro||IPR000591. DEP_dom. |
|PANTHER||PTHR10878. PTHR10878. 1 hit. |
PTHR10878:SF5. PTHR10878:SF5. 1 hit.
|Pfam||PF00610. DEP. 1 hit. |
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
|PRINTS||PR01760. DISHEVELLED. |
|SMART||SM00021. DAX. 1 hit. |
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
|SUPFAM||SSF50156. SSF50156. 1 hit. |
|PROSITE||PS50186. DEP. 1 hit. |
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
|Accession||Primary (citable) accession number: Q5IS48|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Chordata Protein Annotation Program|
Index of protein domains and families