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Q5IS48

- DVL1_PANTR

UniProt

Q5IS48 - DVL1_PANTR

Protein

Segment polarity protein dishevelled homolog DVL-1

Gene

DVL1

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) By similarity.By similarity

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome
    2. protein kinase binding Source: RefGenome
    3. Rac GTPase binding Source: RefGenome
    4. signal transducer activity Source: InterPro

    GO - Biological processi

    1. axon extension Source: RefGenome
    2. axon guidance Source: RefGenome
    3. canonical Wnt signaling pathway Source: RefGenome
    4. cochlea morphogenesis Source: RefGenome
    5. collateral sprouting Source: RefGenome
    6. convergent extension Source: RefGenome
    7. convergent extension involved in neural plate elongation Source: Ensembl
    8. cytoplasmic microtubule organization Source: Ensembl
    9. dendrite morphogenesis Source: RefGenome
    10. intracellular signal transduction Source: InterPro
    11. negative regulation of protein binding Source: Ensembl
    12. negative regulation of protein kinase activity Source: Ensembl
    13. neural tube development Source: Ensembl
    14. neurotransmitter secretion Source: Ensembl
    15. planar cell polarity pathway involved in neural tube closure Source: RefGenome
    16. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    17. positive regulation of neuron projection development Source: Ensembl
    18. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
    19. positive regulation of transcription, DNA-templated Source: RefGenome
    20. prepulse inhibition Source: Ensembl
    21. protein localization to microtubule Source: Ensembl
    22. protein localization to nucleus Source: Ensembl
    23. regulation of signaling Source: RefGenome
    24. skeletal muscle acetylcholine-gated channel clustering Source: RefGenome
    25. social behavior Source: Ensembl
    26. transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Segment polarity protein dishevelled homolog DVL-1
    Short name:
    Dishevelled-1
    Alternative name(s):
    DSH homolog 1
    Gene namesi
    Name:DVL1
    OrganismiPan troglodytes (Chimpanzee)
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Unplaced

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmcytosol By similarity. Cytoplasmic vesicle By similarity
    Note: Localizes at the cell membrane upon interaction with frizzled family members.By similarity

    GO - Cellular componenti

    1. axon Source: RefGenome
    2. cell cortex Source: RefGenome
    3. clathrin-coated vesicle Source: RefGenome
    4. cytosol Source: UniProtKB-SubCell
    5. dendrite Source: RefGenome
    6. growth cone Source: RefGenome
    7. lateral plasma membrane Source: Ensembl
    8. microtubule Source: RefGenome
    9. neuronal cell body Source: RefGenome
    10. synapse Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 670670Segment polarity protein dishevelled homolog DVL-1PRO_0000145744Add
    BLAST

    Post-translational modificationi

    Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains By similarity.By similarity

    Keywords - PTMi

    Ubl conjugation

    Interactioni

    Subunit structurei

    Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts with CXXC4. Interacts (via PDZ domain) with NXN. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1. Interacts with CYLD. Interacts (via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site. Interacts (via DEP domain) with MUSK; the interaction is direct and mediates the formation a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering. Interacts (via PDZ domain) with TMEM88 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9598.ENSPTRP00000052962.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5IS48.
    SMRiQ5IS48. Positions 251-345, 381-474.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8585DIXPROSITE-ProRule annotationAdd
    BLAST
    Domaini251 – 32373PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini400 – 47475DEPPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi221 – 2244Poly-Arg

    Domaini

    The DIX domain promotes homooligomerization.By similarity
    The DEP domain mediates interaction with the cell membrane.By similarity

    Sequence similaritiesi

    Belongs to the DSH family.Curated
    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 1 DIX domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG322275.
    HOGENOMiHOG000017084.
    HOVERGENiHBG005542.
    KOiK02353.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR000591. DEP_dom.
    IPR008340. Dishevelled_1.
    IPR024580. Dishevelled_C-dom.
    IPR008339. Dishevelled_fam.
    IPR003351. Dishevelled_protein_dom.
    IPR001158. DIX.
    IPR015506. Dsh/Dvl-rel.
    IPR001478. PDZ.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PANTHERiPTHR10878. PTHR10878. 1 hit.
    PTHR10878:SF5. PTHR10878:SF5. 1 hit.
    PfamiPF00610. DEP. 1 hit.
    PF02377. Dishevelled. 1 hit.
    PF00778. DIX. 1 hit.
    PF12316. Dsh_C. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view]
    PRINTSiPR01760. DISHEVELLED.
    SMARTiSM00021. DAX. 1 hit.
    SM00049. DEP. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50186. DEP. 1 hit.
    PS50841. DIX. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5IS48-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK    50
    SMDQDFGVVK EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT 100
    DLPPPLERTG GIGDSRPPSF HPNVASSRDG MDNETGTESM VSHRRERARR 150
    RNREEAARTN GHPRGDRRRD VGLPPDSAST ALSSELESSS FVDSDEDGST 200
    SRLSSSTEQS TSSRLIRKHK RRRRKQRLRQ ADRASSFSSI TDSTMSLNIV 250
    TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM 300
    LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTVP 350
    RADPVRPIDP AAWLSHTAAL TGALPRYELE EAPLTVKSDM SAVVRVMQLP 400
    DSGLEIRDRM WLKITIANAV IGADVVDWLY THVEGFKERR EARKYASSLL 450
    KHGFLRHTVN KITFSEQCYY VFGDLCSNLA TLNLNSGSSG ASDQDTLAPL 500
    PHPAAPWPLG QGYPYQYPGP PPCFPPAYQD PGFSYGSGST GSQQSEGSKS 550
    SGSTRSSRRA PGREKERRAA GAGGSGSESD HTAPSGVGSS WRERPAGQLS 600
    RGSSPRSQAS ATAPGLPPPH PTTKAYTVVG GPPGGPPVRE LAAVPPELTG 650
    SRQSFQKAMG NPCEFFVDIM 670
    Length:670
    Mass (Da):72,851
    Last modified:February 15, 2005 - v1
    Checksum:iDA314641C8453F07
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY665280 mRNA. Translation: AAV74318.1.
    RefSeqiNP_001012432.1. NM_001012430.1.
    UniGeneiPtr.6576.

    Genome annotation databases

    GeneIDi457191.
    KEGGiptr:457191.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY665280 mRNA. Translation: AAV74318.1 .
    RefSeqi NP_001012432.1. NM_001012430.1.
    UniGenei Ptr.6576.

    3D structure databases

    ProteinModelPortali Q5IS48.
    SMRi Q5IS48. Positions 251-345, 381-474.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9598.ENSPTRP00000052962.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 457191.
    KEGGi ptr:457191.

    Organism-specific databases

    CTDi 1855.

    Phylogenomic databases

    eggNOGi NOG322275.
    HOGENOMi HOG000017084.
    HOVERGENi HBG005542.
    KOi K02353.

    Miscellaneous databases

    NextBioi 20838055.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR000591. DEP_dom.
    IPR008340. Dishevelled_1.
    IPR024580. Dishevelled_C-dom.
    IPR008339. Dishevelled_fam.
    IPR003351. Dishevelled_protein_dom.
    IPR001158. DIX.
    IPR015506. Dsh/Dvl-rel.
    IPR001478. PDZ.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10878. PTHR10878. 1 hit.
    PTHR10878:SF5. PTHR10878:SF5. 1 hit.
    Pfami PF00610. DEP. 1 hit.
    PF02377. Dishevelled. 1 hit.
    PF00778. DIX. 1 hit.
    PF12316. Dsh_C. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view ]
    PRINTSi PR01760. DISHEVELLED.
    SMARTi SM00021. DAX. 1 hit.
    SM00049. DEP. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50186. DEP. 1 hit.
    PS50841. DIX. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Accelerated evolution of nervous system genes in the origin of Homo sapiens."
      Dorus S., Vallender E.J., Evans P.D., Anderson J.R., Gilbert S.L., Mahowald M., Wyckoff G.J., Malcom C.M., Lahn B.T.
      Cell 119:1027-1040(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiDVL1_PANTR
    AccessioniPrimary (citable) accession number: Q5IS48
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3