SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5IS48

- DVL1_PANTR

UniProt

Q5IS48 - DVL1_PANTR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Segment polarity protein dishevelled homolog DVL-1
Gene
DVL1
Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) By similarity.

GO - Molecular functioni

  1. Rac GTPase binding Source: RefGenome
  2. frizzled binding Source: RefGenome
  3. protein kinase binding Source: RefGenome
  4. signal transducer activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. axon extension Source: RefGenome
  2. axon guidance Source: RefGenome
  3. canonical Wnt signaling pathway Source: RefGenome
  4. cochlea morphogenesis Source: RefGenome
  5. collateral sprouting Source: RefGenome
  6. convergent extension Source: RefGenome
  7. convergent extension involved in neural plate elongation Source: Ensembl
  8. cytoplasmic microtubule organization Source: Ensembl
  9. dendrite morphogenesis Source: RefGenome
  10. intracellular signal transduction Source: InterPro
  11. negative regulation of protein binding Source: Ensembl
  12. negative regulation of protein kinase activity Source: Ensembl
  13. neural tube development Source: Ensembl
  14. neurotransmitter secretion Source: Ensembl
  15. planar cell polarity pathway involved in neural tube closure Source: RefGenome
  16. positive regulation of canonical Wnt signaling pathway Source: Ensembl
  17. positive regulation of neuron projection development Source: Ensembl
  18. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
  19. positive regulation of transcription, DNA-templated Source: RefGenome
  20. prepulse inhibition Source: Ensembl
  21. protein localization to microtubule Source: Ensembl
  22. protein localization to nucleus Source: Ensembl
  23. regulation of signaling Source: RefGenome
  24. skeletal muscle acetylcholine-gated channel clustering Source: RefGenome
  25. social behavior Source: Ensembl
  26. transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Segment polarity protein dishevelled homolog DVL-1
Short name:
Dishevelled-1
Alternative name(s):
DSH homolog 1
Gene namesi
Name:DVL1
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Unplaced

Subcellular locationi

Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasmcytosol By similarity. Cytoplasmic vesicle By similarity
Note: Localizes at the cell membrane upon interaction with frizzled family members By similarity.

GO - Cellular componenti

  1. axon Source: RefGenome
  2. cell cortex Source: RefGenome
  3. clathrin-coated vesicle Source: RefGenome
  4. cytosol Source: UniProtKB-SubCell
  5. dendrite Source: RefGenome
  6. growth cone Source: RefGenome
  7. lateral plasma membrane Source: Ensembl
  8. microtubule Source: RefGenome
  9. neuronal cell body Source: RefGenome
  10. synapse Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Segment polarity protein dishevelled homolog DVL-1
PRO_0000145744Add
BLAST

Post-translational modificationi

Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains By similarity.

Keywords - PTMi

Ubl conjugation

Interactioni

Subunit structurei

Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts with CXXC4. Interacts (via PDZ domain) with NXN. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1. Interacts with CYLD. Interacts (via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site. Interacts (via DEP domain) with MUSK; the interaction is direct and mediates the formation a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering. Interacts (via PDZ domain) with TMEM88 By similarity.

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000052962.

Structurei

3D structure databases

ProteinModelPortaliQ5IS48.
SMRiQ5IS48. Positions 251-345, 381-474.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8585DIX
Add
BLAST
Domaini251 – 32373PDZ
Add
BLAST
Domaini400 – 47475DEP
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi221 – 2244Poly-Arg

Domaini

The DIX domain promotes homooligomerization By similarity.
The DEP domain mediates interaction with the cell membrane By similarity.

Sequence similaritiesi

Belongs to the DSH family.
Contains 1 DEP domain.
Contains 1 DIX domain.
Contains 1 PDZ (DHR) domain.

Phylogenomic databases

eggNOGiNOG322275.
HOGENOMiHOG000017084.
HOVERGENiHBG005542.
KOiK02353.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR008340. Dishevelled_1.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF5. PTHR10878:SF5. 1 hit.
PfamiPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR01760. DISHEVELLED.
SMARTiSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5IS48-1 [UniParc]FASTAAdd to Basket

« Hide

MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK    50
SMDQDFGVVK EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT 100
DLPPPLERTG GIGDSRPPSF HPNVASSRDG MDNETGTESM VSHRRERARR 150
RNREEAARTN GHPRGDRRRD VGLPPDSAST ALSSELESSS FVDSDEDGST 200
SRLSSSTEQS TSSRLIRKHK RRRRKQRLRQ ADRASSFSSI TDSTMSLNIV 250
TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM 300
LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTVP 350
RADPVRPIDP AAWLSHTAAL TGALPRYELE EAPLTVKSDM SAVVRVMQLP 400
DSGLEIRDRM WLKITIANAV IGADVVDWLY THVEGFKERR EARKYASSLL 450
KHGFLRHTVN KITFSEQCYY VFGDLCSNLA TLNLNSGSSG ASDQDTLAPL 500
PHPAAPWPLG QGYPYQYPGP PPCFPPAYQD PGFSYGSGST GSQQSEGSKS 550
SGSTRSSRRA PGREKERRAA GAGGSGSESD HTAPSGVGSS WRERPAGQLS 600
RGSSPRSQAS ATAPGLPPPH PTTKAYTVVG GPPGGPPVRE LAAVPPELTG 650
SRQSFQKAMG NPCEFFVDIM 670
Length:670
Mass (Da):72,851
Last modified:February 15, 2005 - v1
Checksum:iDA314641C8453F07
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY665280 mRNA. Translation: AAV74318.1.
RefSeqiNP_001012432.1. NM_001012430.1.
UniGeneiPtr.6576.

Genome annotation databases

GeneIDi457191.
KEGGiptr:457191.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY665280 mRNA. Translation: AAV74318.1 .
RefSeqi NP_001012432.1. NM_001012430.1.
UniGenei Ptr.6576.

3D structure databases

ProteinModelPortali Q5IS48.
SMRi Q5IS48. Positions 251-345, 381-474.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9598.ENSPTRP00000052962.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 457191.
KEGGi ptr:457191.

Organism-specific databases

CTDi 1855.

Phylogenomic databases

eggNOGi NOG322275.
HOGENOMi HOG000017084.
HOVERGENi HBG005542.
KOi K02353.

Miscellaneous databases

NextBioi 20838055.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR000591. DEP_dom.
IPR008340. Dishevelled_1.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10878. PTHR10878. 1 hit.
PTHR10878:SF5. PTHR10878:SF5. 1 hit.
Pfami PF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view ]
PRINTSi PR01760. DISHEVELLED.
SMARTi SM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Accelerated evolution of nervous system genes in the origin of Homo sapiens."
    Dorus S., Vallender E.J., Evans P.D., Anderson J.R., Gilbert S.L., Mahowald M., Wyckoff G.J., Malcom C.M., Lahn B.T.
    Cell 119:1027-1040(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiDVL1_PANTR
AccessioniPrimary (citable) accession number: Q5IS48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: February 15, 2005
Last modified: June 11, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi