UniProtKB - Q5IS48 (DVL1_PANTR)
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Protein
Segment polarity protein dishevelled homolog DVL-1
Gene
DVL1
Organism
Pan troglodytes (Chimpanzee)
Status
Functioni
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity).By similarity
GO - Molecular functioni
- frizzled binding Source: GO_Central
GO - Biological processi
- canonical Wnt signaling pathway Source: GO_Central
- intracellular signal transduction Source: InterPro
- planar cell polarity pathway involved in neural tube closure Source: GO_Central
Keywordsi
Molecular function | Developmental protein |
Biological process | Wnt signaling pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Segment polarity protein dishevelled homolog DVL-1Short name: Dishevelled-1 Alternative name(s): DSH homolog 1 |
Gene namesi | Name:DVL1 |
Organismi | Pan troglodytes (Chimpanzee) |
Taxonomic identifieri | 9598 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan |
Proteomesi |
|
Subcellular locationi
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoplasmic vesicle, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000145744 | 1 – 670 | Segment polarity protein dishevelled homolog DVL-1Add BLAST | 670 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 194 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains (By similarity).By similarity
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q5IS48. |
Interactioni
Subunit structurei
Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts with CXXC4. Interacts (via PDZ domain) with NXN. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1. Interacts with CYLD. Interacts (via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site. Interacts (via DEP domain) with MUSK; the interaction is direct and mediates the formation a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering. Interacts (via PDZ domain) with TMEM88 (By similarity). Interacts with DCDC2. Interacts with FOXK2 (By similarity).By similarity
GO - Molecular functioni
- frizzled binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9598.ENSPTRP00000055553. |
Structurei
3D structure databases
ProteinModelPortali | Q5IS48. |
SMRi | Q5IS48. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 85 | DIXPROSITE-ProRule annotationAdd BLAST | 85 | |
Domaini | 251 – 323 | PDZPROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 400 – 474 | DEPPROSITE-ProRule annotationAdd BLAST | 75 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 221 – 224 | Poly-Arg | 4 |
Domaini
The DIX domain promotes homooligomerization.By similarity
The DEP domain mediates interaction with the cell membrane.By similarity
Sequence similaritiesi
Belongs to the DSH family.Curated
Phylogenomic databases
eggNOGi | KOG3571. Eukaryota. ENOG410Y5G4. LUCA. |
HOGENOMi | HOG000017084. |
HOVERGENi | HBG005542. |
InParanoidi | Q5IS48. |
KOi | K02353. |
Family and domain databases
Gene3Di | 1.10.10.10. 1 hit. 3.10.20.380. 1 hit. |
InterProi | View protein in InterPro IPR000591. DEP_dom. IPR024580. Dishevelled_C-dom. IPR008339. Dishevelled_fam. IPR003351. Dishevelled_protein_dom. IPR001158. DIX. IPR038207. DIX_dom_sf. IPR015506. Dsh/Dvl-rel. IPR008340. DVL-1. IPR001478. PDZ. IPR036034. PDZ_sf. IPR029071. Ubiquitin-like_domsf. IPR036388. WH-like_DNA-bd_sf. IPR036390. WH_DNA-bd_sf. |
PANTHERi | PTHR10878. PTHR10878. 1 hit. PTHR10878:SF5. PTHR10878:SF5. 1 hit. |
Pfami | View protein in Pfam PF00610. DEP. 1 hit. PF02377. Dishevelled. 1 hit. PF00778. DIX. 1 hit. PF12316. Dsh_C. 1 hit. PF00595. PDZ. 1 hit. |
PRINTSi | PR01760. DISHEVELLED. |
SMARTi | View protein in SMART SM00021. DAX. 1 hit. SM00049. DEP. 1 hit. SM00228. PDZ. 1 hit. |
SUPFAMi | SSF46785. SSF46785. 1 hit. SSF50156. SSF50156. 1 hit. SSF54236. SSF54236. 1 hit. |
PROSITEi | View protein in PROSITE PS50186. DEP. 1 hit. PS50841. DIX. 1 hit. PS50106. PDZ. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q5IS48-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK
60 70 80 90 100
SMDQDFGVVK EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT
110 120 130 140 150
DLPPPLERTG GIGDSRPPSF HPNVASSRDG MDNETGTESM VSHRRERARR
160 170 180 190 200
RNREEAARTN GHPRGDRRRD VGLPPDSAST ALSSELESSS FVDSDEDGST
210 220 230 240 250
SRLSSSTEQS TSSRLIRKHK RRRRKQRLRQ ADRASSFSSI TDSTMSLNIV
260 270 280 290 300
TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM
310 320 330 340 350
LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTVP
360 370 380 390 400
RADPVRPIDP AAWLSHTAAL TGALPRYELE EAPLTVKSDM SAVVRVMQLP
410 420 430 440 450
DSGLEIRDRM WLKITIANAV IGADVVDWLY THVEGFKERR EARKYASSLL
460 470 480 490 500
KHGFLRHTVN KITFSEQCYY VFGDLCSNLA TLNLNSGSSG ASDQDTLAPL
510 520 530 540 550
PHPAAPWPLG QGYPYQYPGP PPCFPPAYQD PGFSYGSGST GSQQSEGSKS
560 570 580 590 600
SGSTRSSRRA PGREKERRAA GAGGSGSESD HTAPSGVGSS WRERPAGQLS
610 620 630 640 650
RGSSPRSQAS ATAPGLPPPH PTTKAYTVVG GPPGGPPVRE LAAVPPELTG
660 670
SRQSFQKAMG NPCEFFVDIM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY665280 mRNA. Translation: AAV74318.1. |
RefSeqi | NP_001012432.1. NM_001012430.1. |
UniGenei | Ptr.6576. |
Genome annotation databases
GeneIDi | 457191. |
KEGGi | ptr:457191. |
Similar proteinsi
Entry informationi
Entry namei | DVL1_PANTR | |
Accessioni | Q5IS48Primary (citable) accession number: Q5IS48 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2005 |
Last sequence update: | February 15, 2005 | |
Last modified: | March 28, 2018 | |
This is version 98 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |