DVL1

Functionⁱ

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity).By similarity

GO - Molecular functionⁱ

frizzled binding Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

canonical Wnt signaling pathway Source: GO_Central
intracellular signal transduction Source: InterPro
planar cell polarity pathway involved in neural tube closure Source: GO_Central

Complete GO annotation...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Wnt signaling pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Segment polarity protein dishevelled homolog DVL-1 Short name: Dishevelled-1 Alternative name(s): DSH homolog 1
Gene namesⁱ	Name:DVL1
Organismⁱ	Pan troglodytes (Chimpanzee)
Taxonomic identifierⁱ	9598 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Pan
Proteomesⁱ	UP000002277 Componentⁱ: Unplaced

Subcellular locationⁱ

Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Cytoplasm › cytosol By similarity
Cytoplasmic vesicle By similarity

Note:

Localizes at the cell membrane upon interaction with frizzled family members.By similarity

GO - Cellular componentⁱ

cytoplasmic vesicle Source: UniProtKB-KW
cytosol Source: GO_Central
plasma membrane Source: UniProtKB

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000145744	1 – 670	Segment polarity protein dishevelled homolog DVL-1Add BLAST		670

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	194	PhosphoserineBy similarity		1

Post-translational modificationⁱ

Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains (By similarity).By similarity

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q5IS48.

PaxDbⁱ

Q5IS48.

Interactionⁱ

Subunit structureⁱ

Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts with CXXC4. Interacts (via PDZ domain) with NXN. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1. Interacts with CYLD. Interacts (via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site. Interacts (via DEP domain) with MUSK; the interaction is direct and mediates the formation a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering. Interacts (via PDZ domain) with TMEM88 (By similarity). Interacts with DCDC2. Interacts with FOXK2 (By similarity).By similarity

GO - Molecular functionⁱ

frizzled binding Source: GO_Central

Complete GO annotation...

Protein-protein interaction databases

STRINGⁱ	9598.ENSPTRP00000055553.

STRINGⁱ

9598.ENSPTRP00000055553.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5IS48.
SMRⁱ	Q5IS48.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 85	DIXPROSITE-ProRule annotationAdd BLAST	85
Domainⁱ	251 – 323	PDZPROSITE-ProRule annotationAdd BLAST	73
Domainⁱ	400 – 474	DEPPROSITE-ProRule annotationAdd BLAST	75

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	221 – 224	Poly-Arg		4

Domainⁱ

The DIX domain promotes homooligomerization.By similarity

The DEP domain mediates interaction with the cell membrane.By similarity

Sequence similaritiesⁱ

Belongs to the DSH family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3571. Eukaryota. ENOG410Y5G4. LUCA.
HOGENOMⁱ	HOG000017084.
HOVERGENⁱ	HBG005542.
InParanoidⁱ	Q5IS48.
KEGG Orthology (KO) More...KOⁱ	K02353.

Family and domain databases

Gene3Dⁱ	1.10.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000591. DEP_dom. IPR024580. Dishevelled_C-dom. IPR008339. Dishevelled_fam. IPR003351. Dishevelled_protein_dom. IPR001158. DIX. IPR015506. Dsh/Dvl-rel. IPR008340. DVL-1. IPR001478. PDZ. IPR029071. Ubiquitin-rel_dom. IPR011991. WHTH_DNA-bd_dom.
PANTHERⁱ	PTHR10878. PTHR10878. 1 hit. PTHR10878:SF30. PTHR10878:SF30. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00610. DEP. 1 hit. PF02377. Dishevelled. 1 hit. PF00778. DIX. 1 hit. PF12316. Dsh_C. 1 hit. PF00595. PDZ. 1 hit.
PRINTSⁱ	PR01760. DISHEVELLED.
SMARTⁱ	View protein in SMART SM00021. DAX. 1 hit. SM00049. DEP. 1 hit. SM00228. PDZ. 1 hit.
SUPFAMⁱ	SSF46785. SSF46785. 1 hit. SSF50156. SSF50156. 1 hit. SSF54236. SSF54236. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50186. DEP. 1 hit. PS50841. DIX. 1 hit. PS50106. PDZ. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5IS48-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK 
        60         70         80         90        100
SMDQDFGVVK EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT 
       110        120        130        140        150
DLPPPLERTG GIGDSRPPSF HPNVASSRDG MDNETGTESM VSHRRERARR 
       160        170        180        190        200
RNREEAARTN GHPRGDRRRD VGLPPDSAST ALSSELESSS FVDSDEDGST 
       210        220        230        240        250
SRLSSSTEQS TSSRLIRKHK RRRRKQRLRQ ADRASSFSSI TDSTMSLNIV 
       260        270        280        290        300
TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM 
       310        320        330        340        350
LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTVP 
       360        370        380        390        400
RADPVRPIDP AAWLSHTAAL TGALPRYELE EAPLTVKSDM SAVVRVMQLP 
       410        420        430        440        450
DSGLEIRDRM WLKITIANAV IGADVVDWLY THVEGFKERR EARKYASSLL 
       460        470        480        490        500
KHGFLRHTVN KITFSEQCYY VFGDLCSNLA TLNLNSGSSG ASDQDTLAPL 
       510        520        530        540        550
PHPAAPWPLG QGYPYQYPGP PPCFPPAYQD PGFSYGSGST GSQQSEGSKS 
       560        570        580        590        600
SGSTRSSRRA PGREKERRAA GAGGSGSESD HTAPSGVGSS WRERPAGQLS 
       610        620        630        640        650
RGSSPRSQAS ATAPGLPPPH PTTKAYTVVG GPPGGPPVRE LAAVPPELTG 
       660        670
SRQSFQKAMG NPCEFFVDIM

Length:670

Mass (Da):72,851

Last modified:February 15, 2005 - v1

Checksum:ⁱDA314641C8453F07

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY665280 mRNA. Translation: AAV74318.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001012432.1. NM_001012430.1.
UniGeneⁱ	Ptr.6576.

Genome annotation databases

GeneIDⁱ	457191.
KEGGⁱ	ptr:457191.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q5IS48	K7ANK8 H2RBE2	Pan troglodytes (Chimpanzee)	670	UniRef100_Q5IS48	Cluster: Segment polarity protein dishevelled homolog DVL-1	3

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q5IS48	P54792 UPI000719549D UPI000719EE11 UPI00005A0CD7 UPI0002BD1577 UPI0003F0D899 UPI0003F17721 UPI00042CFF7A UPI0004BDF3FC UPI0005AC9674 +68	Homo sapiens (Human) Ceratotherium simum simum (southern white rhinoceros) Equus asinus (Donkey) (Equus africanus asinus) Canis lupus familiaris (Dog) (Canis familiaris) Orcinus orca (Killer whale) Elephantulus edwardii (Cape long-eared elephant shrew) Chrysochloris asiatica (Cape golden mole) Bubalus bubalis (Domestic water buffalo) Equus przewalskii (Przewalski's horse) (Equus caballus przewalskii) Felis catus (Cat) (Felis silvestris catus) And more	670	UniRef90_P54792	Cluster: Putative segment polarity protein dishevelled homolog DVL1P1	79

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q5IS48	P54792 UPI000719549D UPI000719EE11 UPI0005FB0C86 UPI000A1B9D4A UPI0005AC9674 UPI00071982FD UPI00042CFF7A UPI000A2B03E5 UPI0003F0D899 +103	Homo sapiens (Human) Ceratotherium simum simum (southern white rhinoceros) Equus asinus (Donkey) (Equus africanus asinus) Ovis aries musimon (Mouflon) Odocoileus virginianus texanus Felis catus (Cat) (Felis silvestris catus) Bubalus bubalis (Domestic water buffalo) Sus scrofa (Pig) Elephantulus edwardii (Cape long-eared elephant shrew) Chrysochloris asiatica (Cape golden mole) And more	670	UniRef50_P54792	Cluster: Putative segment polarity protein dishevelled homolog DVL1P1	114

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY665280 mRNA. Translation: AAV74318.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001012432.1. NM_001012430.1.
UniGeneⁱ	Ptr.6576.

3D structure databases

ProteinModelPortalⁱ	Q5IS48.
SMRⁱ	Q5IS48.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9598.ENSPTRP00000055553.

STRINGⁱ

9598.ENSPTRP00000055553.

Proteomic databases

PaxDbⁱ	Q5IS48.

PaxDbⁱ

Q5IS48.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	457191.
KEGGⁱ	ptr:457191.

Organism-specific databases

CTDⁱ	1855.

CTDⁱ

1855.

Phylogenomic databases

eggNOGⁱ	KOG3571. Eukaryota. ENOG410Y5G4. LUCA.
HOGENOMⁱ	HOG000017084.
HOVERGENⁱ	HBG005542.
InParanoidⁱ	Q5IS48.
KEGG Orthology (KO) More...KOⁱ	K02353.

Family and domain databases

Gene3Dⁱ	1.10.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000591. DEP_dom. IPR024580. Dishevelled_C-dom. IPR008339. Dishevelled_fam. IPR003351. Dishevelled_protein_dom. IPR001158. DIX. IPR015506. Dsh/Dvl-rel. IPR008340. DVL-1. IPR001478. PDZ. IPR029071. Ubiquitin-rel_dom. IPR011991. WHTH_DNA-bd_dom.
PANTHERⁱ	PTHR10878. PTHR10878. 1 hit. PTHR10878:SF30. PTHR10878:SF30. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00610. DEP. 1 hit. PF02377. Dishevelled. 1 hit. PF00778. DIX. 1 hit. PF12316. Dsh_C. 1 hit. PF00595. PDZ. 1 hit.
PRINTSⁱ	PR01760. DISHEVELLED.
SMARTⁱ	View protein in SMART SM00021. DAX. 1 hit. SM00049. DEP. 1 hit. SM00228. PDZ. 1 hit.
SUPFAMⁱ	SSF46785. SSF46785. 1 hit. SSF50156. SSF50156. 1 hit. SSF54236. SSF54236. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50186. DEP. 1 hit. PS50841. DIX. 1 hit. PS50106. PDZ. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DVL1_PANTR
Accessionⁱ	Q5IS48Primary (citable) accession number: Q5IS48
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
	Last sequence update:	February 15, 2005
	Last modified:	August 30, 2017
	This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniProtKB - Q5IS48 (DVL1_PANTR)

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Segment polarity protein dishevelled homolog DVL-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ