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Protein

Melanin-concentrating hormone receptor 1

Gene

MCHR1

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melanin-concentrating hormone receptor 1
Short name:
MCH receptor 1
Short name:
MCH-R1
Short name:
MCHR-1
Alternative name(s):
G-protein coupled receptor 24
MCH-1R
Short name:
MCH1R
Short name:
MCHR
Gene namesi
Name:MCHR1
Synonyms:GPR24
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 113113ExtracellularSequence analysisAdd
BLAST
Transmembranei114 – 13623Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini137 – 14812CytoplasmicSequence analysisAdd
BLAST
Transmembranei149 – 17123Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini172 – 18514ExtracellularSequence analysisAdd
BLAST
Transmembranei186 – 20823Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini209 – 22719CytoplasmicSequence analysisAdd
BLAST
Transmembranei228 – 25023Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini251 – 27828ExtracellularSequence analysisAdd
BLAST
Transmembranei279 – 30123Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini302 – 32120CytoplasmicSequence analysisAdd
BLAST
Transmembranei322 – 34423Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini345 – 35814ExtracellularSequence analysisAdd
BLAST
Transmembranei359 – 38123Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini382 – 42241CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Melanin-concentrating hormone receptor 1PRO_0000069737Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence analysis
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence analysis
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5IJ49.
PRIDEiQ5IJ49.

Interactioni

Subunit structurei

Interacts with NCDN.By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000024831.

Structurei

3D structure databases

ProteinModelPortaliQ5IJ49.
SMRiQ5IJ49. Positions 97-389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000000704.
HOVERGENiHBG105726.
InParanoidiQ5IJ49.
KOiK04320.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
IPR008361. MCH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PR01783. MCHRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5IJ49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVGAMKKGV GRAVGLGGGS GCQATEEDPL PNCGACAPGQ GGRRWRLPQP
60 70 80 90 100
AWVEGSSARL WEQATGTGWM DLEASLLPTG PNASNTSDGP DNLTSAGSPP
110 120 130 140 150
RTGSISYINI IMPSVFGTIC LLGIIGNSTV IFAVVKKSKL HWCNNVPDIF
160 170 180 190 200
IINLSVVDLL FLLGMPFMIH QLMGNGVWHF GETMCTLITA MDANSQFTST
210 220 230 240 250
YILTAMAIDR YLATVHPISS TKFRKPSVAT LVICLLWALS FISITPVWLY
260 270 280 290 300
ARLIPFPGGA VGCGIRLPNP DTDLYWFTLY QFFLAFALPF VVITAAYVRI
310 320 330 340 350
LQRMTSSVAP ASQRSIRLRT KRVTRTAIAI CLVFFVCWAP YYVLQLTQLS
360 370 380 390 400
ISRPTLTFVY LYNAAISLGY ANSCLNPFVY IVLCETFRKR LVLSVKPAAQ
410 420
GQLRAVSNAQ TADEERTESK GT
Length:422
Mass (Da):45,963
Last modified:February 15, 2005 - v1
Checksum:i3986919A18183818
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY714489 mRNA. Translation: AAV98096.1.
RefSeqiNP_001012440.1. NM_001012438.1.
UniGeneiPtr.6179.

Genome annotation databases

GeneIDi470220.
KEGGiptr:470220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY714489 mRNA. Translation: AAV98096.1.
RefSeqiNP_001012440.1. NM_001012438.1.
UniGeneiPtr.6179.

3D structure databases

ProteinModelPortaliQ5IJ49.
SMRiQ5IJ49. Positions 97-389.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000024831.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ5IJ49.
PRIDEiQ5IJ49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi470220.
KEGGiptr:470220.

Organism-specific databases

CTDi2847.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000000704.
HOVERGENiHBG105726.
InParanoidiQ5IJ49.
KOiK04320.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
IPR008361. MCH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PR01783. MCHRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of Pan troglodytes G-protein coupled receptor 24 (GPR24) mRNA."
    Reichwald K., Petz U., Huse K., Enard W., Platzer M.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiMCHR1_PANTR
AccessioniPrimary (citable) accession number: Q5IJ49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: February 15, 2005
Last modified: June 8, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1, Met-6 or Met-70 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.