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Q5IJ48

- CRUM2_HUMAN

UniProt

Q5IJ48 - CRUM2_HUMAN

Protein

Protein crumbs homolog 2

Gene

CRB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    May play a role in polarized cells morphogenesis.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. enzyme binding Source: UniProt

    GO - Biological processi

    1. cardiovascular system development Source: UniProt
    2. maintenance of epithelial cell apical/basal polarity Source: UniProt
    3. mesoderm formation Source: UniProt
    4. negative regulation of endopeptidase activity Source: UniProt
    5. notochord formation Source: UniProt
    6. positive regulation of BMP signaling pathway Source: UniProt
    7. positive regulation of epithelial to mesenchymal transition Source: UniProt
    8. somitogenesis Source: UniProt

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein crumbs homolog 2
    Alternative name(s):
    Crumbs-like protein 2
    Gene namesi
    Name:CRB2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:18688. CRB2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane raft Source: UniProt
    4. plasma membrane Source: UniProtKB-SubCell
    5. protein complex Source: UniProt

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134910460.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 12851257Protein crumbs homolog 2PRO_0000007502Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi71 ↔ 82By similarity
    Disulfide bondi76 ↔ 94By similarity
    Disulfide bondi96 ↔ 105By similarity
    Disulfide bondi112 ↔ 123By similarity
    Disulfide bondi117 ↔ 132By similarity
    Disulfide bondi134 ↔ 143By similarity
    Disulfide bondi150 ↔ 161By similarity
    Disulfide bondi155 ↔ 170By similarity
    Disulfide bondi172 ↔ 181By similarity
    Disulfide bondi188 ↔ 199By similarity
    Disulfide bondi193 ↔ 208By similarity
    Disulfide bondi210 ↔ 220By similarity
    Disulfide bondi227 ↔ 238By similarity
    Disulfide bondi232 ↔ 247By similarity
    Glycosylationi235 – 2351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi249 ↔ 258By similarity
    Disulfide bondi265 ↔ 276By similarity
    Disulfide bondi270 ↔ 306By similarity
    Disulfide bondi308 ↔ 317By similarity
    Disulfide bondi324 ↔ 335By similarity
    Disulfide bondi329 ↔ 344By similarity
    Disulfide bondi346 ↔ 355By similarity
    Disulfide bondi362 ↔ 373By similarity
    Disulfide bondi367 ↔ 382By similarity
    Disulfide bondi384 ↔ 393By similarity
    Disulfide bondi400 ↔ 411By similarity
    Disulfide bondi405 ↔ 424By similarity
    Disulfide bondi426 ↔ 435By similarity
    Glycosylationi438 – 4381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi579 ↔ 603By similarity
    Disulfide bondi609 ↔ 620By similarity
    Disulfide bondi614 ↔ 629By similarity
    Disulfide bondi631 ↔ 640By similarity
    Glycosylationi669 – 6691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi690 – 6901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi766 ↔ 805By similarity
    Glycosylationi786 – 7861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi800 – 8001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi811 ↔ 822By similarity
    Disulfide bondi816 ↔ 831By similarity
    Disulfide bondi833 ↔ 842By similarity
    Glycosylationi836 – 8361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi886 – 8861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi926 – 9261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1009 – 10091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1013 ↔ 1054By similarity
    Disulfide bondi1060 ↔ 1071By similarity
    Disulfide bondi1065 ↔ 1080By similarity
    Disulfide bondi1082 ↔ 1091By similarity
    Disulfide bondi1098 ↔ 1108By similarity
    Disulfide bondi1103 ↔ 1118By similarity
    Disulfide bondi1120 ↔ 1129By similarity
    Disulfide bondi1138 ↔ 1150By similarity
    Glycosylationi1141 – 11411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1144 ↔ 1159By similarity
    Glycosylationi1158 – 11581N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1161 ↔ 1170By similarity
    Disulfide bondi1177 ↔ 1188By similarity
    Disulfide bondi1182 ↔ 1197By similarity
    Disulfide bondi1199 ↔ 1208By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ5IJ48.
    PRIDEiQ5IJ48.

    PTM databases

    PhosphoSiteiQ5IJ48.

    Expressioni

    Tissue specificityi

    Expressed in retina, fetal eye and brain. Also expressed in kidney, ARPE-19 and RPE/choroid cell lines, and at low levels in lung, placenta, and heart.1 Publication

    Gene expression databases

    BgeeiQ5IJ48.
    CleanExiHS_CRB2.
    GenevestigatoriQ5IJ48.

    Organism-specific databases

    HPAiHPA043674.

    Interactioni

    Protein-protein interaction databases

    BioGridi130332. 2 interactions.
    STRINGi9606.ENSP00000362734.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2WO6X-ray2.50C4-9[»]
    ProteinModelPortaliQ5IJ48.
    SMRiQ5IJ48. Positions 37-438, 440-705, 828-881, 1060-1210.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5IJ48.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 12241196ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1246 – 128540CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1225 – 124521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini67 – 10640EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini108 – 14437EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini146 – 18237EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini184 – 22138EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini223 – 25937EGF-like 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini261 – 31858EGF-like 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini320 – 35637EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini358 – 39437EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini396 – 43641EGF-like 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini431 – 603173Laminin G-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini605 – 64137EGF-like 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini647 – 805159Laminin G-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini807 – 84337EGF-like 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini871 – 1054184Laminin G-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1056 – 109237EGF-like 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini1094 – 113037EGF-like 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini1134 – 117138EGF-like 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini1173 – 120937EGF-like 15PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Crumbs protein family.Curated
    Contains 15 EGF-like domains.PROSITE-ProRule annotation
    Contains 3 laminin G-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    HOVERGENiHBG080001.
    InParanoidiQ5IJ48.
    KOiK16681.
    OMAiGACVDLW.
    OrthoDBiEOG7PVWNH.
    PhylomeDBiQ5IJ48.
    TreeFamiTF316224.

    Family and domain databases

    Gene3Di2.60.120.200. 4 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR001791. Laminin_G.
    [Graphical view]
    PfamiPF00008. EGF. 7 hits.
    PF12661. hEGF. 1 hit.
    PF02210. Laminin_G_2. 2 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 9 hits.
    SM00179. EGF_CA. 6 hits.
    SM00282. LamG. 3 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 3 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 7 hits.
    PS00022. EGF_1. 14 hits.
    PS01186. EGF_2. 8 hits.
    PS50026. EGF_3. 15 hits.
    PS01187. EGF_CA. 5 hits.
    PS50025. LAM_G_DOMAIN. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5IJ48-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALARPGTPD PQALASVLLL LLWAPALSLL AGTVPSEPPS ACASDPCAPG     50
    TECQATESGG YTCGPMEPRG CATQPCHHGA LCVPQGPDPT GFRCYCVPGF 100
    QGPRCELDID ECASRPCHHG ATCRNLADRY ECHCPLGYAG VTCEMEVDEC 150
    ASAPCLHGGS CLDGVGSFRC VCAPGYGGTR CQLDLDECQS QPCAHGGTCH 200
    DLVNGFRCDC AGTGYEGTHC EREVLECASA PCEHNASCLE GLGSFRCLCW 250
    PGYSGELCEV DEDECASSPC QHGGRCLQRS DPALYGGVQA AFPGAFSFRH 300
    AAGFLCHCPP GFEGADCGVE VDECASRPCL NGGHCQDLPN GFQCHCPDGY 350
    AGPTCEEDVD ECLSDPCLHG GTCSDTVAGY ICRCPETWGG RDCSVQLTGC 400
    QGHTCPLAAT CIPIFESGVH SYVCHCPPGT HGPFCGQNTT FSVMAGSPIQ 450
    ASVPAGGPLG LALRFRTTLP AGTLATRNDT KESLELALVA ATLQATLWSY 500
    STTVLVLRLP DLALNDGHWH QVEVVLHLAT LELRLWHEGC PARLCVASGP 550
    VALASTASAT PLPAGISSAQ LGDATFAGCL QDVRVDGHLL LPEDLGENVL 600
    LGCERREQCR PLPCVHGGSC VDLWTHFRCD CARPHRGPTC ADEIPAATFG 650
    LGGAPSSASF LLQELPGPNL TVSFLLRTRE SAGLLLQFAN DSAAGLTVFL 700
    SEGRIRAEVP GSPAVVLPGR WDDGLRHLVM LSFGPDQLQD LGQHVHVGGR 750
    LLAADSQPWG GPFRGCLQDL RLDGCHLPFF PLPLDNSSQP SELGGRQSWN 800
    LTAGCVSEDM CSPDPCFNGG TCLVTWNDFH CTCPANFTGP TCAQQLWCPG 850
    QPCLPPATCE EVPDGFVCVA EATFREGPPA AFSGHNASSG RLLGGLSLAF 900
    RTRDSEAWLL RAAAGALEGV WLAVRNGSLA GGVRGGHGLP GAVLPIPGPR 950
    VADGAWHRVR LAMERPAATT SRWLLWLDGA ATPVALRGLA SDLGFLQGPG 1000
    AVRILLAENF TGCLGRVALG GLPLPLARPR PGAAPGAREH FASWPGTPAP 1050
    ILGCRGAPVC APSPCLHDGA CRDLFDAFAC ACGPGWEGPR CEAHVDPCHS 1100
    APCARGRCHT HPDGRFECRC PPGFGGPRCR LPVPSKECSL NVTCLDGSPC 1150
    EGGSPAANCS CLEGLAGQRC QVPTLPCEAN PCLNGGTCRA AGGVSECICN 1200
    ARFSGQFCEV AKGLPLPLPF PLLEVAVPAA CACLLLLLLG LLSGILAARK 1250
    RRQSEGTYSP SQQEVAGARL EMDSVLKVPP EERLI 1285
    Length:1,285
    Mass (Da):134,265
    Last modified:October 17, 2006 - v2
    Checksum:iC5B7E9D7A91CD703
    GO
    Isoform 2 (identifier: Q5IJ48-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1131-1176: LPVPSKECSL...GQRCQVPTLP → WDGWAGGWAA...VLICDMRRTV
         1177-1285: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,176
    Mass (Da):123,213
    Checksum:iA33CB9D605EDE5A0
    GO
    Isoform 3 (identifier: Q5IJ48-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-332: Missing.
         333-351: GHCQDLPNGFQCHCPDGYA → MAMEPGALWTFLGHLWLLA

    Note: No experimental confirmation available.

    Show »
    Length:953
    Mass (Da):99,830
    Checksum:i277A62189E3BEC0D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti430 – 4301T → A in BAC86684. (PubMed:14702039)Curated
    Sequence conflicti969 – 9691T → A in AK123000. (PubMed:14702039)Curated
    Sequence conflicti969 – 9691T → A in BAC86684. (PubMed:14702039)Curated
    Sequence conflicti1153 – 11531G → R in BAC86684. (PubMed:14702039)Curated
    Sequence conflicti1239 – 12391Missing in BAC86684. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti46 – 461P → L.1 Publication
    Corresponds to variant rs73571404 [ dbSNP | Ensembl ].
    VAR_022984
    Natural varianti90 – 901T → N.1 Publication
    Corresponds to variant rs2808415 [ dbSNP | Ensembl ].
    VAR_048974
    Natural varianti97 – 971V → L.1 Publication
    VAR_022985
    Natural varianti116 – 1161P → L.1 Publication
    VAR_022986
    Natural varianti145 – 1451M → T.2 Publications
    Corresponds to variant rs1105223 [ dbSNP | Ensembl ].
    VAR_022987
    Natural varianti159 – 1591G → A.2 Publications
    Corresponds to variant rs1105222 [ dbSNP | Ensembl ].
    VAR_022988
    Natural varianti187 – 1871E → D.1 Publication
    VAR_022989
    Natural varianti351 – 3511A → T.1 Publication
    VAR_022990
    Natural varianti534 – 5341R → Q.1 Publication
    VAR_022991
    Natural varianti610 – 6101R → W.1 Publication
    Corresponds to variant rs145286619 [ dbSNP | Ensembl ].
    VAR_022992
    Natural varianti709 – 7091V → A.2 Publications
    Corresponds to variant rs2488602 [ dbSNP | Ensembl ].
    VAR_061153
    Natural varianti746 – 7461H → Q.1 Publication
    VAR_022993
    Natural varianti1110 – 11101T → M.1 Publication
    Corresponds to variant rs73571431 [ dbSNP | Ensembl ].
    VAR_022994

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 332332Missing in isoform 3. 1 PublicationVSP_014737Add
    BLAST
    Alternative sequencei333 – 35119GHCQD…PDGYA → MAMEPGALWTFLGHLWLLA in isoform 3. 1 PublicationVSP_014738Add
    BLAST
    Alternative sequencei1131 – 117646LPVPS…VPTLP → WDGWAGGWAANAPWGYGGAE KSARSVDESLPFPGPHVLIC DMRRTV in isoform 2. 1 PublicationVSP_014739Add
    BLAST
    Alternative sequencei1177 – 1285109Missing in isoform 2. 1 PublicationVSP_014740Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY720432 mRNA. Translation: AAU14134.1.
    AK123000 mRNA. No translation available.
    AK126775 mRNA. Translation: BAC86684.1.
    AL445489, AL365504 Genomic DNA. Translation: CAI39793.1.
    AL365504, AL445489 Genomic DNA. Translation: CAI41011.1.
    AL445489, AL365504 Genomic DNA. Translation: CAM14433.1.
    AL365504, AL445489 Genomic DNA. Translation: CAM21391.1.
    DQ426866 mRNA. Translation: ABD90532.1.
    CCDSiCCDS6852.2. [Q5IJ48-1]
    RefSeqiNP_775960.4. NM_173689.6. [Q5IJ48-1]
    XP_005251991.1. XM_005251934.1. [Q5IJ48-3]
    UniGeneiHs.568340.
    Hs.710092.

    Genome annotation databases

    EnsembliENST00000359999; ENSP00000353092; ENSG00000148204. [Q5IJ48-2]
    ENST00000373631; ENSP00000362734; ENSG00000148204. [Q5IJ48-1]
    ENST00000460253; ENSP00000435279; ENSG00000148204. [Q5IJ48-3]
    GeneIDi286204.
    KEGGihsa:286204.
    UCSCiuc004bnw.1. human. [Q5IJ48-2]
    uc004bnx.1. human. [Q5IJ48-1]

    Polymorphism databases

    DMDMi116241316.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY720432 mRNA. Translation: AAU14134.1 .
    AK123000 mRNA. No translation available.
    AK126775 mRNA. Translation: BAC86684.1 .
    AL445489 , AL365504 Genomic DNA. Translation: CAI39793.1 .
    AL365504 , AL445489 Genomic DNA. Translation: CAI41011.1 .
    AL445489 , AL365504 Genomic DNA. Translation: CAM14433.1 .
    AL365504 , AL445489 Genomic DNA. Translation: CAM21391.1 .
    DQ426866 mRNA. Translation: ABD90532.1 .
    CCDSi CCDS6852.2. [Q5IJ48-1 ]
    RefSeqi NP_775960.4. NM_173689.6. [Q5IJ48-1 ]
    XP_005251991.1. XM_005251934.1. [Q5IJ48-3 ]
    UniGenei Hs.568340.
    Hs.710092.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2WO6 X-ray 2.50 C 4-9 [» ]
    ProteinModelPortali Q5IJ48.
    SMRi Q5IJ48. Positions 37-438, 440-705, 828-881, 1060-1210.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130332. 2 interactions.
    STRINGi 9606.ENSP00000362734.

    PTM databases

    PhosphoSitei Q5IJ48.

    Polymorphism databases

    DMDMi 116241316.

    Proteomic databases

    PaxDbi Q5IJ48.
    PRIDEi Q5IJ48.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359999 ; ENSP00000353092 ; ENSG00000148204 . [Q5IJ48-2 ]
    ENST00000373631 ; ENSP00000362734 ; ENSG00000148204 . [Q5IJ48-1 ]
    ENST00000460253 ; ENSP00000435279 ; ENSG00000148204 . [Q5IJ48-3 ]
    GeneIDi 286204.
    KEGGi hsa:286204.
    UCSCi uc004bnw.1. human. [Q5IJ48-2 ]
    uc004bnx.1. human. [Q5IJ48-1 ]

    Organism-specific databases

    CTDi 286204.
    GeneCardsi GC09P126118.
    H-InvDB HIX0008365.
    HGNCi HGNC:18688. CRB2.
    HPAi HPA043674.
    MIMi 609720. gene.
    neXtProti NX_Q5IJ48.
    PharmGKBi PA134910460.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOVERGENi HBG080001.
    InParanoidi Q5IJ48.
    KOi K16681.
    OMAi GACVDLW.
    OrthoDBi EOG7PVWNH.
    PhylomeDBi Q5IJ48.
    TreeFami TF316224.

    Miscellaneous databases

    EvolutionaryTracei Q5IJ48.
    GenomeRNAii 286204.
    NextBioi 96074.
    PROi Q5IJ48.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5IJ48.
    CleanExi HS_CRB2.
    Genevestigatori Q5IJ48.

    Family and domain databases

    Gene3Di 2.60.120.200. 4 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR001791. Laminin_G.
    [Graphical view ]
    Pfami PF00008. EGF. 7 hits.
    PF12661. hEGF. 1 hit.
    PF02210. Laminin_G_2. 2 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 9 hits.
    SM00179. EGF_CA. 6 hits.
    SM00282. LamG. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 3 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 7 hits.
    PS00022. EGF_1. 14 hits.
    PS01186. EGF_2. 8 hits.
    PS50026. EGF_3. 15 hits.
    PS01187. EGF_CA. 5 hits.
    PS50025. LAM_G_DOMAIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the crumbs homolog 2 (CRB2) gene and analysis of its role in retinitis pigmentosa and Leber congenital amaurosis."
      van den Hurk J.A.J.M., Rashbass P., Roepman R., Davis J., Voesenek K.E.J., Arends M.L., Zonneveld M.N., van Roekel M.H.G., Cameron K., Rohrschneider K., Heckenlively J.R., Koenekoop R.K., Hoyng C.B., Cremers F.P.M., den Hollander A.I.
      Mol. Vis. 11:263-273(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS LEU-46; LEU-97; LEU-116; THR-145; ALA-159; ASP-187; THR-351; GLN-534; TRP-610; ALA-709; GLN-746 AND MET-1110.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANTS ASN-90; THR-145; ALA-159 AND ALA-709.
      Tissue: Cerebellum.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Roni V., Carpio R., Wissinger B.
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-22.
      Tissue: Retina.
    5. "The crystal structure of the human dual specificity tyrosine-phosphorylation-regulated kinase 1A."
      Structural genomics consortium (SGC)
      Submitted (AUG-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 4-9 IN COMPLEX WITH DYRK1A.

    Entry informationi

    Entry nameiCRUM2_HUMAN
    AccessioniPrimary (citable) accession number: Q5IJ48
    Secondary accession number(s): A2A3N4
    , Q0QD46, Q5JS41, Q5JS43, Q6ZTA9, Q6ZWI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3