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Q5IJ48

- CRUM2_HUMAN

UniProt

Q5IJ48 - CRUM2_HUMAN

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Protein
Protein crumbs homolog 2
Gene
CRB2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in polarized cells morphogenesis.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. enzyme binding Source: UniProt

GO - Biological processi

  1. cardiovascular system development Source: UniProt
  2. maintenance of epithelial cell apical/basal polarity Source: UniProt
  3. mesoderm formation Source: UniProt
  4. negative regulation of endopeptidase activity Source: UniProt
  5. notochord formation Source: UniProt
  6. positive regulation of BMP signaling pathway Source: UniProt
  7. positive regulation of epithelial to mesenchymal transition Source: UniProt
  8. somitogenesis Source: UniProt
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein crumbs homolog 2
Alternative name(s):
Crumbs-like protein 2
Gene namesi
Name:CRB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:18688. CRB2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 12241196Extracellular Reviewed prediction
Add
BLAST
Transmembranei1225 – 124521Helical; Reviewed prediction
Add
BLAST
Topological domaini1246 – 128540Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane raft Source: UniProt
  4. plasma membrane Source: UniProtKB-SubCell
  5. protein complex Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910460.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed prediction
Add
BLAST
Chaini29 – 12851257Protein crumbs homolog 2
PRO_0000007502Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi71 ↔ 82 By similarity
Disulfide bondi76 ↔ 94 By similarity
Disulfide bondi96 ↔ 105 By similarity
Disulfide bondi112 ↔ 123 By similarity
Disulfide bondi117 ↔ 132 By similarity
Disulfide bondi134 ↔ 143 By similarity
Disulfide bondi150 ↔ 161 By similarity
Disulfide bondi155 ↔ 170 By similarity
Disulfide bondi172 ↔ 181 By similarity
Disulfide bondi188 ↔ 199 By similarity
Disulfide bondi193 ↔ 208 By similarity
Disulfide bondi210 ↔ 220 By similarity
Disulfide bondi227 ↔ 238 By similarity
Disulfide bondi232 ↔ 247 By similarity
Glycosylationi235 – 2351N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi249 ↔ 258 By similarity
Disulfide bondi265 ↔ 276 By similarity
Disulfide bondi270 ↔ 306 By similarity
Disulfide bondi308 ↔ 317 By similarity
Disulfide bondi324 ↔ 335 By similarity
Disulfide bondi329 ↔ 344 By similarity
Disulfide bondi346 ↔ 355 By similarity
Disulfide bondi362 ↔ 373 By similarity
Disulfide bondi367 ↔ 382 By similarity
Disulfide bondi384 ↔ 393 By similarity
Disulfide bondi400 ↔ 411 By similarity
Disulfide bondi405 ↔ 424 By similarity
Disulfide bondi426 ↔ 435 By similarity
Glycosylationi438 – 4381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi478 – 4781N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi579 ↔ 603 By similarity
Disulfide bondi609 ↔ 620 By similarity
Disulfide bondi614 ↔ 629 By similarity
Disulfide bondi631 ↔ 640 By similarity
Glycosylationi669 – 6691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi690 – 6901N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi766 ↔ 805 By similarity
Glycosylationi786 – 7861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi800 – 8001N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi811 ↔ 822 By similarity
Disulfide bondi816 ↔ 831 By similarity
Disulfide bondi833 ↔ 842 By similarity
Glycosylationi836 – 8361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi886 – 8861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi926 – 9261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1009 – 10091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1013 ↔ 1054 By similarity
Disulfide bondi1060 ↔ 1071 By similarity
Disulfide bondi1065 ↔ 1080 By similarity
Disulfide bondi1082 ↔ 1091 By similarity
Disulfide bondi1098 ↔ 1108 By similarity
Disulfide bondi1103 ↔ 1118 By similarity
Disulfide bondi1120 ↔ 1129 By similarity
Disulfide bondi1138 ↔ 1150 By similarity
Glycosylationi1141 – 11411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1144 ↔ 1159 By similarity
Glycosylationi1158 – 11581N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1161 ↔ 1170 By similarity
Disulfide bondi1177 ↔ 1188 By similarity
Disulfide bondi1182 ↔ 1197 By similarity
Disulfide bondi1199 ↔ 1208 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5IJ48.
PRIDEiQ5IJ48.

PTM databases

PhosphoSiteiQ5IJ48.

Expressioni

Tissue specificityi

Expressed in retina, fetal eye and brain. Also expressed in kidney, ARPE-19 and RPE/choroid cell lines, and at low levels in lung, placenta, and heart.1 Publication

Gene expression databases

BgeeiQ5IJ48.
CleanExiHS_CRB2.
GenevestigatoriQ5IJ48.

Organism-specific databases

HPAiHPA043674.

Interactioni

Protein-protein interaction databases

BioGridi130332. 2 interactions.
STRINGi9606.ENSP00000362734.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WO6X-ray2.50C4-9[»]
ProteinModelPortaliQ5IJ48.
SMRiQ5IJ48. Positions 37-438, 440-705, 828-881, 1060-1210.

Miscellaneous databases

EvolutionaryTraceiQ5IJ48.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 10640EGF-like 1
Add
BLAST
Domaini108 – 14437EGF-like 2; calcium-binding Reviewed prediction
Add
BLAST
Domaini146 – 18237EGF-like 3; calcium-binding Reviewed prediction
Add
BLAST
Domaini184 – 22138EGF-like 4; calcium-binding Reviewed prediction
Add
BLAST
Domaini223 – 25937EGF-like 5
Add
BLAST
Domaini261 – 31858EGF-like 6
Add
BLAST
Domaini320 – 35637EGF-like 7; calcium-binding Reviewed prediction
Add
BLAST
Domaini358 – 39437EGF-like 8; calcium-binding Reviewed prediction
Add
BLAST
Domaini396 – 43641EGF-like 9
Add
BLAST
Domaini431 – 603173Laminin G-like 1
Add
BLAST
Domaini605 – 64137EGF-like 10
Add
BLAST
Domaini647 – 805159Laminin G-like 2
Add
BLAST
Domaini807 – 84337EGF-like 11
Add
BLAST
Domaini871 – 1054184Laminin G-like 3
Add
BLAST
Domaini1056 – 109237EGF-like 12
Add
BLAST
Domaini1094 – 113037EGF-like 13
Add
BLAST
Domaini1134 – 117138EGF-like 14
Add
BLAST
Domaini1173 – 120937EGF-like 15
Add
BLAST

Sequence similaritiesi

Belongs to the Crumbs protein family.
Contains 15 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
HOVERGENiHBG080001.
InParanoidiQ5IJ48.
KOiK16681.
OMAiGACVDLW.
OrthoDBiEOG7PVWNH.
PhylomeDBiQ5IJ48.
TreeFamiTF316224.

Family and domain databases

Gene3Di2.60.120.200. 4 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00008. EGF. 7 hits.
PF12661. hEGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 9 hits.
SM00179. EGF_CA. 6 hits.
SM00282. LamG. 3 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 3 hits.
PROSITEiPS00010. ASX_HYDROXYL. 7 hits.
PS00022. EGF_1. 14 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 5 hits.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5IJ48-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MALARPGTPD PQALASVLLL LLWAPALSLL AGTVPSEPPS ACASDPCAPG     50
TECQATESGG YTCGPMEPRG CATQPCHHGA LCVPQGPDPT GFRCYCVPGF 100
QGPRCELDID ECASRPCHHG ATCRNLADRY ECHCPLGYAG VTCEMEVDEC 150
ASAPCLHGGS CLDGVGSFRC VCAPGYGGTR CQLDLDECQS QPCAHGGTCH 200
DLVNGFRCDC AGTGYEGTHC EREVLECASA PCEHNASCLE GLGSFRCLCW 250
PGYSGELCEV DEDECASSPC QHGGRCLQRS DPALYGGVQA AFPGAFSFRH 300
AAGFLCHCPP GFEGADCGVE VDECASRPCL NGGHCQDLPN GFQCHCPDGY 350
AGPTCEEDVD ECLSDPCLHG GTCSDTVAGY ICRCPETWGG RDCSVQLTGC 400
QGHTCPLAAT CIPIFESGVH SYVCHCPPGT HGPFCGQNTT FSVMAGSPIQ 450
ASVPAGGPLG LALRFRTTLP AGTLATRNDT KESLELALVA ATLQATLWSY 500
STTVLVLRLP DLALNDGHWH QVEVVLHLAT LELRLWHEGC PARLCVASGP 550
VALASTASAT PLPAGISSAQ LGDATFAGCL QDVRVDGHLL LPEDLGENVL 600
LGCERREQCR PLPCVHGGSC VDLWTHFRCD CARPHRGPTC ADEIPAATFG 650
LGGAPSSASF LLQELPGPNL TVSFLLRTRE SAGLLLQFAN DSAAGLTVFL 700
SEGRIRAEVP GSPAVVLPGR WDDGLRHLVM LSFGPDQLQD LGQHVHVGGR 750
LLAADSQPWG GPFRGCLQDL RLDGCHLPFF PLPLDNSSQP SELGGRQSWN 800
LTAGCVSEDM CSPDPCFNGG TCLVTWNDFH CTCPANFTGP TCAQQLWCPG 850
QPCLPPATCE EVPDGFVCVA EATFREGPPA AFSGHNASSG RLLGGLSLAF 900
RTRDSEAWLL RAAAGALEGV WLAVRNGSLA GGVRGGHGLP GAVLPIPGPR 950
VADGAWHRVR LAMERPAATT SRWLLWLDGA ATPVALRGLA SDLGFLQGPG 1000
AVRILLAENF TGCLGRVALG GLPLPLARPR PGAAPGAREH FASWPGTPAP 1050
ILGCRGAPVC APSPCLHDGA CRDLFDAFAC ACGPGWEGPR CEAHVDPCHS 1100
APCARGRCHT HPDGRFECRC PPGFGGPRCR LPVPSKECSL NVTCLDGSPC 1150
EGGSPAANCS CLEGLAGQRC QVPTLPCEAN PCLNGGTCRA AGGVSECICN 1200
ARFSGQFCEV AKGLPLPLPF PLLEVAVPAA CACLLLLLLG LLSGILAARK 1250
RRQSEGTYSP SQQEVAGARL EMDSVLKVPP EERLI 1285
Length:1,285
Mass (Da):134,265
Last modified:October 17, 2006 - v2
Checksum:iC5B7E9D7A91CD703
GO
Isoform 2 (identifier: Q5IJ48-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1131-1176: LPVPSKECSL...GQRCQVPTLP → WDGWAGGWAA...VLICDMRRTV
     1177-1285: Missing.

Note: No experimental confirmation available.

Show »
Length:1,176
Mass (Da):123,213
Checksum:iA33CB9D605EDE5A0
GO
Isoform 3 (identifier: Q5IJ48-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.
     333-351: GHCQDLPNGFQCHCPDGYA → MAMEPGALWTFLGHLWLLA

Note: No experimental confirmation available.

Show »
Length:953
Mass (Da):99,830
Checksum:i277A62189E3BEC0D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461P → L.1 Publication
Corresponds to variant rs73571404 [ dbSNP | Ensembl ].
VAR_022984
Natural varianti90 – 901T → N.1 Publication
Corresponds to variant rs2808415 [ dbSNP | Ensembl ].
VAR_048974
Natural varianti97 – 971V → L.1 Publication
VAR_022985
Natural varianti116 – 1161P → L.1 Publication
VAR_022986
Natural varianti145 – 1451M → T.2 Publications
Corresponds to variant rs1105223 [ dbSNP | Ensembl ].
VAR_022987
Natural varianti159 – 1591G → A.2 Publications
Corresponds to variant rs1105222 [ dbSNP | Ensembl ].
VAR_022988
Natural varianti187 – 1871E → D.1 Publication
VAR_022989
Natural varianti351 – 3511A → T.1 Publication
VAR_022990
Natural varianti534 – 5341R → Q.1 Publication
VAR_022991
Natural varianti610 – 6101R → W.1 Publication
Corresponds to variant rs145286619 [ dbSNP | Ensembl ].
VAR_022992
Natural varianti709 – 7091V → A.2 Publications
Corresponds to variant rs2488602 [ dbSNP | Ensembl ].
VAR_061153
Natural varianti746 – 7461H → Q.1 Publication
VAR_022993
Natural varianti1110 – 11101T → M.1 Publication
Corresponds to variant rs73571431 [ dbSNP | Ensembl ].
VAR_022994

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 332332Missing in isoform 3.
VSP_014737Add
BLAST
Alternative sequencei333 – 35119GHCQD…PDGYA → MAMEPGALWTFLGHLWLLA in isoform 3.
VSP_014738Add
BLAST
Alternative sequencei1131 – 117646LPVPS…VPTLP → WDGWAGGWAANAPWGYGGAE KSARSVDESLPFPGPHVLIC DMRRTV in isoform 2.
VSP_014739Add
BLAST
Alternative sequencei1177 – 1285109Missing in isoform 2.
VSP_014740Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti430 – 4301T → A in BAC86684. 1 Publication
Sequence conflicti969 – 9691T → A in AK123000. 1 Publication
Sequence conflicti969 – 9691T → A in BAC86684. 1 Publication
Sequence conflicti1153 – 11531G → R in BAC86684. 1 Publication
Sequence conflicti1239 – 12391Missing in BAC86684. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY720432 mRNA. Translation: AAU14134.1.
AK123000 mRNA. No translation available.
AK126775 mRNA. Translation: BAC86684.1.
AL445489, AL365504 Genomic DNA. Translation: CAI39793.1.
AL365504, AL445489 Genomic DNA. Translation: CAI41011.1.
AL445489, AL365504 Genomic DNA. Translation: CAM14433.1.
AL365504, AL445489 Genomic DNA. Translation: CAM21391.1.
DQ426866 mRNA. Translation: ABD90532.1.
CCDSiCCDS6852.2. [Q5IJ48-1]
RefSeqiNP_775960.4. NM_173689.6. [Q5IJ48-1]
XP_005251991.1. XM_005251934.1. [Q5IJ48-3]
UniGeneiHs.568340.
Hs.710092.

Genome annotation databases

EnsembliENST00000359999; ENSP00000353092; ENSG00000148204. [Q5IJ48-2]
ENST00000373629; ENSP00000362732; ENSG00000148204. [Q5IJ48-3]
ENST00000373631; ENSP00000362734; ENSG00000148204. [Q5IJ48-1]
ENST00000460253; ENSP00000435279; ENSG00000148204. [Q5IJ48-3]
GeneIDi286204.
KEGGihsa:286204.
UCSCiuc004bnw.1. human. [Q5IJ48-2]
uc004bnx.1. human. [Q5IJ48-1]

Polymorphism databases

DMDMi116241316.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY720432 mRNA. Translation: AAU14134.1 .
AK123000 mRNA. No translation available.
AK126775 mRNA. Translation: BAC86684.1 .
AL445489 , AL365504 Genomic DNA. Translation: CAI39793.1 .
AL365504 , AL445489 Genomic DNA. Translation: CAI41011.1 .
AL445489 , AL365504 Genomic DNA. Translation: CAM14433.1 .
AL365504 , AL445489 Genomic DNA. Translation: CAM21391.1 .
DQ426866 mRNA. Translation: ABD90532.1 .
CCDSi CCDS6852.2. [Q5IJ48-1 ]
RefSeqi NP_775960.4. NM_173689.6. [Q5IJ48-1 ]
XP_005251991.1. XM_005251934.1. [Q5IJ48-3 ]
UniGenei Hs.568340.
Hs.710092.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2WO6 X-ray 2.50 C 4-9 [» ]
ProteinModelPortali Q5IJ48.
SMRi Q5IJ48. Positions 37-438, 440-705, 828-881, 1060-1210.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 130332. 2 interactions.
STRINGi 9606.ENSP00000362734.

PTM databases

PhosphoSitei Q5IJ48.

Polymorphism databases

DMDMi 116241316.

Proteomic databases

PaxDbi Q5IJ48.
PRIDEi Q5IJ48.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359999 ; ENSP00000353092 ; ENSG00000148204 . [Q5IJ48-2 ]
ENST00000373629 ; ENSP00000362732 ; ENSG00000148204 . [Q5IJ48-3 ]
ENST00000373631 ; ENSP00000362734 ; ENSG00000148204 . [Q5IJ48-1 ]
ENST00000460253 ; ENSP00000435279 ; ENSG00000148204 . [Q5IJ48-3 ]
GeneIDi 286204.
KEGGi hsa:286204.
UCSCi uc004bnw.1. human. [Q5IJ48-2 ]
uc004bnx.1. human. [Q5IJ48-1 ]

Organism-specific databases

CTDi 286204.
GeneCardsi GC09P126118.
H-InvDB HIX0008365.
HGNCi HGNC:18688. CRB2.
HPAi HPA043674.
MIMi 609720. gene.
neXtProti NX_Q5IJ48.
PharmGKBi PA134910460.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOVERGENi HBG080001.
InParanoidi Q5IJ48.
KOi K16681.
OMAi GACVDLW.
OrthoDBi EOG7PVWNH.
PhylomeDBi Q5IJ48.
TreeFami TF316224.

Miscellaneous databases

EvolutionaryTracei Q5IJ48.
GenomeRNAii 286204.
NextBioi 96074.
PROi Q5IJ48.
SOURCEi Search...

Gene expression databases

Bgeei Q5IJ48.
CleanExi HS_CRB2.
Genevestigatori Q5IJ48.

Family and domain databases

Gene3Di 2.60.120.200. 4 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF00008. EGF. 7 hits.
PF12661. hEGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 9 hits.
SM00179. EGF_CA. 6 hits.
SM00282. LamG. 3 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 3 hits.
PROSITEi PS00010. ASX_HYDROXYL. 7 hits.
PS00022. EGF_1. 14 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 5 hits.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the crumbs homolog 2 (CRB2) gene and analysis of its role in retinitis pigmentosa and Leber congenital amaurosis."
    van den Hurk J.A.J.M., Rashbass P., Roepman R., Davis J., Voesenek K.E.J., Arends M.L., Zonneveld M.N., van Roekel M.H.G., Cameron K., Rohrschneider K., Heckenlively J.R., Koenekoop R.K., Hoyng C.B., Cremers F.P.M., den Hollander A.I.
    Mol. Vis. 11:263-273(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS LEU-46; LEU-97; LEU-116; THR-145; ALA-159; ASP-187; THR-351; GLN-534; TRP-610; ALA-709; GLN-746 AND MET-1110.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANTS ASN-90; THR-145; ALA-159 AND ALA-709.
    Tissue: Cerebellum.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Roni V., Carpio R., Wissinger B.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-22.
    Tissue: Retina.
  5. "The crystal structure of the human dual specificity tyrosine-phosphorylation-regulated kinase 1A."
    Structural genomics consortium (SGC)
    Submitted (AUG-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 4-9 IN COMPLEX WITH DYRK1A.

Entry informationi

Entry nameiCRUM2_HUMAN
AccessioniPrimary (citable) accession number: Q5IJ48
Secondary accession number(s): A2A3N4
, Q0QD46, Q5JS41, Q5JS43, Q6ZTA9, Q6ZWI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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