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Q5IJ48

- CRUM2_HUMAN

UniProt

Q5IJ48 - CRUM2_HUMAN

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Protein

Protein crumbs homolog 2

Gene

CRB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in polarized cells morphogenesis.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. enzyme binding Source: UniProt

GO - Biological processi

  1. cardiovascular system development Source: UniProt
  2. maintenance of epithelial cell apical/basal polarity Source: UniProt
  3. mesoderm formation Source: UniProt
  4. negative regulation of endopeptidase activity Source: UniProt
  5. notochord formation Source: UniProt
  6. positive regulation of BMP signaling pathway Source: UniProt
  7. positive regulation of epithelial to mesenchymal transition Source: UniProt
  8. somitogenesis Source: UniProt
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein crumbs homolog 2
Alternative name(s):
Crumbs-like protein 2
Gene namesi
Name:CRB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:18688. CRB2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 12241196ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1225 – 124521HelicalSequence AnalysisAdd
BLAST
Topological domaini1246 – 128540CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane raft Source: UniProt
  4. plasma membrane Source: UniProtKB-KW
  5. protein complex Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910460.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 12851257Protein crumbs homolog 2PRO_0000007502Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi71 ↔ 82By similarity
Disulfide bondi76 ↔ 94By similarity
Disulfide bondi96 ↔ 105By similarity
Disulfide bondi112 ↔ 123By similarity
Disulfide bondi117 ↔ 132By similarity
Disulfide bondi134 ↔ 143By similarity
Disulfide bondi150 ↔ 161By similarity
Disulfide bondi155 ↔ 170By similarity
Disulfide bondi172 ↔ 181By similarity
Disulfide bondi188 ↔ 199By similarity
Disulfide bondi193 ↔ 208By similarity
Disulfide bondi210 ↔ 220By similarity
Disulfide bondi227 ↔ 238By similarity
Disulfide bondi232 ↔ 247By similarity
Glycosylationi235 – 2351N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi249 ↔ 258By similarity
Disulfide bondi265 ↔ 276By similarity
Disulfide bondi270 ↔ 306By similarity
Disulfide bondi308 ↔ 317By similarity
Disulfide bondi324 ↔ 335By similarity
Disulfide bondi329 ↔ 344By similarity
Disulfide bondi346 ↔ 355By similarity
Disulfide bondi362 ↔ 373By similarity
Disulfide bondi367 ↔ 382By similarity
Disulfide bondi384 ↔ 393By similarity
Disulfide bondi400 ↔ 411By similarity
Disulfide bondi405 ↔ 424By similarity
Disulfide bondi426 ↔ 435By similarity
Glycosylationi438 – 4381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi579 ↔ 603By similarity
Disulfide bondi609 ↔ 620By similarity
Disulfide bondi614 ↔ 629By similarity
Disulfide bondi631 ↔ 640By similarity
Glycosylationi669 – 6691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi690 – 6901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi766 ↔ 805By similarity
Glycosylationi786 – 7861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi800 – 8001N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi811 ↔ 822By similarity
Disulfide bondi816 ↔ 831By similarity
Disulfide bondi833 ↔ 842By similarity
Glycosylationi836 – 8361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi886 – 8861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi926 – 9261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1009 – 10091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1013 ↔ 1054By similarity
Disulfide bondi1060 ↔ 1071By similarity
Disulfide bondi1065 ↔ 1080By similarity
Disulfide bondi1082 ↔ 1091By similarity
Disulfide bondi1098 ↔ 1108By similarity
Disulfide bondi1103 ↔ 1118By similarity
Disulfide bondi1120 ↔ 1129By similarity
Disulfide bondi1138 ↔ 1150By similarity
Glycosylationi1141 – 11411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1144 ↔ 1159By similarity
Glycosylationi1158 – 11581N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1161 ↔ 1170By similarity
Disulfide bondi1177 ↔ 1188By similarity
Disulfide bondi1182 ↔ 1197By similarity
Disulfide bondi1199 ↔ 1208By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ5IJ48.
PaxDbiQ5IJ48.
PRIDEiQ5IJ48.

PTM databases

PhosphoSiteiQ5IJ48.

Expressioni

Tissue specificityi

Expressed in retina, fetal eye and brain. Also expressed in kidney, ARPE-19 and RPE/choroid cell lines, and at low levels in lung, placenta, and heart.1 Publication

Gene expression databases

BgeeiQ5IJ48.
CleanExiHS_CRB2.
GenevestigatoriQ5IJ48.

Organism-specific databases

HPAiHPA043674.

Interactioni

Protein-protein interaction databases

BioGridi130332. 2 interactions.
STRINGi9606.ENSP00000362734.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WO6X-ray2.50C4-9[»]
ProteinModelPortaliQ5IJ48.
SMRiQ5IJ48. Positions 37-435, 440-705, 1060-1210.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5IJ48.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 10640EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini108 – 14437EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini146 – 18237EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini184 – 22138EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini223 – 25937EGF-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini261 – 31858EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini320 – 35637EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini358 – 39437EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini396 – 43641EGF-like 9PROSITE-ProRule annotationAdd
BLAST
Domaini431 – 603173Laminin G-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini605 – 64137EGF-like 10PROSITE-ProRule annotationAdd
BLAST
Domaini647 – 805159Laminin G-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini807 – 84337EGF-like 11PROSITE-ProRule annotationAdd
BLAST
Domaini871 – 1054184Laminin G-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini1056 – 109237EGF-like 12PROSITE-ProRule annotationAdd
BLAST
Domaini1094 – 113037EGF-like 13PROSITE-ProRule annotationAdd
BLAST
Domaini1134 – 117138EGF-like 14PROSITE-ProRule annotationAdd
BLAST
Domaini1173 – 120937EGF-like 15PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Crumbs protein family.Curated
Contains 15 EGF-like domains.PROSITE-ProRule annotation
Contains 3 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00760000118786.
HOVERGENiHBG080001.
InParanoidiQ5IJ48.
KOiK16681.
OMAiGACVDLW.
OrthoDBiEOG7PVWNH.
PhylomeDBiQ5IJ48.
TreeFamiTF316224.

Family and domain databases

Gene3Di2.60.120.200. 4 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00008. EGF. 7 hits.
PF12661. hEGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 9 hits.
SM00179. EGF_CA. 6 hits.
SM00282. LamG. 3 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 3 hits.
PROSITEiPS00010. ASX_HYDROXYL. 7 hits.
PS00022. EGF_1. 14 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 5 hits.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5IJ48-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALARPGTPD PQALASVLLL LLWAPALSLL AGTVPSEPPS ACASDPCAPG
60 70 80 90 100
TECQATESGG YTCGPMEPRG CATQPCHHGA LCVPQGPDPT GFRCYCVPGF
110 120 130 140 150
QGPRCELDID ECASRPCHHG ATCRNLADRY ECHCPLGYAG VTCEMEVDEC
160 170 180 190 200
ASAPCLHGGS CLDGVGSFRC VCAPGYGGTR CQLDLDECQS QPCAHGGTCH
210 220 230 240 250
DLVNGFRCDC AGTGYEGTHC EREVLECASA PCEHNASCLE GLGSFRCLCW
260 270 280 290 300
PGYSGELCEV DEDECASSPC QHGGRCLQRS DPALYGGVQA AFPGAFSFRH
310 320 330 340 350
AAGFLCHCPP GFEGADCGVE VDECASRPCL NGGHCQDLPN GFQCHCPDGY
360 370 380 390 400
AGPTCEEDVD ECLSDPCLHG GTCSDTVAGY ICRCPETWGG RDCSVQLTGC
410 420 430 440 450
QGHTCPLAAT CIPIFESGVH SYVCHCPPGT HGPFCGQNTT FSVMAGSPIQ
460 470 480 490 500
ASVPAGGPLG LALRFRTTLP AGTLATRNDT KESLELALVA ATLQATLWSY
510 520 530 540 550
STTVLVLRLP DLALNDGHWH QVEVVLHLAT LELRLWHEGC PARLCVASGP
560 570 580 590 600
VALASTASAT PLPAGISSAQ LGDATFAGCL QDVRVDGHLL LPEDLGENVL
610 620 630 640 650
LGCERREQCR PLPCVHGGSC VDLWTHFRCD CARPHRGPTC ADEIPAATFG
660 670 680 690 700
LGGAPSSASF LLQELPGPNL TVSFLLRTRE SAGLLLQFAN DSAAGLTVFL
710 720 730 740 750
SEGRIRAEVP GSPAVVLPGR WDDGLRHLVM LSFGPDQLQD LGQHVHVGGR
760 770 780 790 800
LLAADSQPWG GPFRGCLQDL RLDGCHLPFF PLPLDNSSQP SELGGRQSWN
810 820 830 840 850
LTAGCVSEDM CSPDPCFNGG TCLVTWNDFH CTCPANFTGP TCAQQLWCPG
860 870 880 890 900
QPCLPPATCE EVPDGFVCVA EATFREGPPA AFSGHNASSG RLLGGLSLAF
910 920 930 940 950
RTRDSEAWLL RAAAGALEGV WLAVRNGSLA GGVRGGHGLP GAVLPIPGPR
960 970 980 990 1000
VADGAWHRVR LAMERPAATT SRWLLWLDGA ATPVALRGLA SDLGFLQGPG
1010 1020 1030 1040 1050
AVRILLAENF TGCLGRVALG GLPLPLARPR PGAAPGAREH FASWPGTPAP
1060 1070 1080 1090 1100
ILGCRGAPVC APSPCLHDGA CRDLFDAFAC ACGPGWEGPR CEAHVDPCHS
1110 1120 1130 1140 1150
APCARGRCHT HPDGRFECRC PPGFGGPRCR LPVPSKECSL NVTCLDGSPC
1160 1170 1180 1190 1200
EGGSPAANCS CLEGLAGQRC QVPTLPCEAN PCLNGGTCRA AGGVSECICN
1210 1220 1230 1240 1250
ARFSGQFCEV AKGLPLPLPF PLLEVAVPAA CACLLLLLLG LLSGILAARK
1260 1270 1280
RRQSEGTYSP SQQEVAGARL EMDSVLKVPP EERLI
Length:1,285
Mass (Da):134,265
Last modified:October 17, 2006 - v2
Checksum:iC5B7E9D7A91CD703
GO
Isoform 2 (identifier: Q5IJ48-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1131-1176: LPVPSKECSL...GQRCQVPTLP → WDGWAGGWAA...VLICDMRRTV
     1177-1285: Missing.

Note: No experimental confirmation available.

Show »
Length:1,176
Mass (Da):123,213
Checksum:iA33CB9D605EDE5A0
GO
Isoform 3 (identifier: Q5IJ48-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.
     333-351: GHCQDLPNGFQCHCPDGYA → MAMEPGALWTFLGHLWLLA

Note: No experimental confirmation available.

Show »
Length:953
Mass (Da):99,830
Checksum:i277A62189E3BEC0D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti430 – 4301T → A in BAC86684. (PubMed:14702039)Curated
Sequence conflicti969 – 9691T → A in AK123000. (PubMed:14702039)Curated
Sequence conflicti969 – 9691T → A in BAC86684. (PubMed:14702039)Curated
Sequence conflicti1153 – 11531G → R in BAC86684. (PubMed:14702039)Curated
Sequence conflicti1239 – 12391Missing in BAC86684. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461P → L.1 Publication
Corresponds to variant rs73571404 [ dbSNP | Ensembl ].
VAR_022984
Natural varianti90 – 901T → N.1 Publication
Corresponds to variant rs2808415 [ dbSNP | Ensembl ].
VAR_048974
Natural varianti97 – 971V → L.1 Publication
VAR_022985
Natural varianti116 – 1161P → L.1 Publication
VAR_022986
Natural varianti145 – 1451M → T.2 Publications
Corresponds to variant rs1105223 [ dbSNP | Ensembl ].
VAR_022987
Natural varianti159 – 1591G → A.2 Publications
Corresponds to variant rs1105222 [ dbSNP | Ensembl ].
VAR_022988
Natural varianti187 – 1871E → D.1 Publication
VAR_022989
Natural varianti351 – 3511A → T.1 Publication
VAR_022990
Natural varianti534 – 5341R → Q.1 Publication
VAR_022991
Natural varianti610 – 6101R → W.1 Publication
Corresponds to variant rs145286619 [ dbSNP | Ensembl ].
VAR_022992
Natural varianti709 – 7091V → A.2 Publications
Corresponds to variant rs2488602 [ dbSNP | Ensembl ].
VAR_061153
Natural varianti746 – 7461H → Q.1 Publication
VAR_022993
Natural varianti1110 – 11101T → M.1 Publication
Corresponds to variant rs73571431 [ dbSNP | Ensembl ].
VAR_022994

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 332332Missing in isoform 3. 1 PublicationVSP_014737Add
BLAST
Alternative sequencei333 – 35119GHCQD…PDGYA → MAMEPGALWTFLGHLWLLA in isoform 3. 1 PublicationVSP_014738Add
BLAST
Alternative sequencei1131 – 117646LPVPS…VPTLP → WDGWAGGWAANAPWGYGGAE KSARSVDESLPFPGPHVLIC DMRRTV in isoform 2. 1 PublicationVSP_014739Add
BLAST
Alternative sequencei1177 – 1285109Missing in isoform 2. 1 PublicationVSP_014740Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY720432 mRNA. Translation: AAU14134.1.
AK123000 mRNA. No translation available.
AK126775 mRNA. Translation: BAC86684.1.
AL445489, AL365504 Genomic DNA. Translation: CAI39793.1.
AL365504, AL445489 Genomic DNA. Translation: CAI41011.1.
AL445489, AL365504 Genomic DNA. Translation: CAM14433.1.
AL365504, AL445489 Genomic DNA. Translation: CAM21391.1.
DQ426866 mRNA. Translation: ABD90532.1.
CCDSiCCDS6852.2. [Q5IJ48-1]
RefSeqiNP_775960.4. NM_173689.6. [Q5IJ48-1]
XP_005251991.1. XM_005251934.1. [Q5IJ48-3]
UniGeneiHs.568340.
Hs.710092.

Genome annotation databases

EnsembliENST00000359999; ENSP00000353092; ENSG00000148204. [Q5IJ48-2]
ENST00000373631; ENSP00000362734; ENSG00000148204. [Q5IJ48-1]
ENST00000460253; ENSP00000435279; ENSG00000148204. [Q5IJ48-3]
GeneIDi286204.
KEGGihsa:286204.
UCSCiuc004bnw.1. human. [Q5IJ48-2]
uc004bnx.1. human. [Q5IJ48-1]

Polymorphism databases

DMDMi116241316.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY720432 mRNA. Translation: AAU14134.1 .
AK123000 mRNA. No translation available.
AK126775 mRNA. Translation: BAC86684.1 .
AL445489 , AL365504 Genomic DNA. Translation: CAI39793.1 .
AL365504 , AL445489 Genomic DNA. Translation: CAI41011.1 .
AL445489 , AL365504 Genomic DNA. Translation: CAM14433.1 .
AL365504 , AL445489 Genomic DNA. Translation: CAM21391.1 .
DQ426866 mRNA. Translation: ABD90532.1 .
CCDSi CCDS6852.2. [Q5IJ48-1 ]
RefSeqi NP_775960.4. NM_173689.6. [Q5IJ48-1 ]
XP_005251991.1. XM_005251934.1. [Q5IJ48-3 ]
UniGenei Hs.568340.
Hs.710092.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2WO6 X-ray 2.50 C 4-9 [» ]
ProteinModelPortali Q5IJ48.
SMRi Q5IJ48. Positions 37-435, 440-705, 1060-1210.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 130332. 2 interactions.
STRINGi 9606.ENSP00000362734.

PTM databases

PhosphoSitei Q5IJ48.

Polymorphism databases

DMDMi 116241316.

Proteomic databases

MaxQBi Q5IJ48.
PaxDbi Q5IJ48.
PRIDEi Q5IJ48.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359999 ; ENSP00000353092 ; ENSG00000148204 . [Q5IJ48-2 ]
ENST00000373631 ; ENSP00000362734 ; ENSG00000148204 . [Q5IJ48-1 ]
ENST00000460253 ; ENSP00000435279 ; ENSG00000148204 . [Q5IJ48-3 ]
GeneIDi 286204.
KEGGi hsa:286204.
UCSCi uc004bnw.1. human. [Q5IJ48-2 ]
uc004bnx.1. human. [Q5IJ48-1 ]

Organism-specific databases

CTDi 286204.
GeneCardsi GC09P126118.
H-InvDB HIX0008365.
HGNCi HGNC:18688. CRB2.
HPAi HPA043674.
MIMi 609720. gene.
neXtProti NX_Q5IJ48.
PharmGKBi PA134910460.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00760000118786.
HOVERGENi HBG080001.
InParanoidi Q5IJ48.
KOi K16681.
OMAi GACVDLW.
OrthoDBi EOG7PVWNH.
PhylomeDBi Q5IJ48.
TreeFami TF316224.

Miscellaneous databases

EvolutionaryTracei Q5IJ48.
GenomeRNAii 286204.
NextBioi 96074.
PROi Q5IJ48.
SOURCEi Search...

Gene expression databases

Bgeei Q5IJ48.
CleanExi HS_CRB2.
Genevestigatori Q5IJ48.

Family and domain databases

Gene3Di 2.60.120.200. 4 hits.
InterProi IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF00008. EGF. 7 hits.
PF12661. hEGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 9 hits.
SM00179. EGF_CA. 6 hits.
SM00282. LamG. 3 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 3 hits.
PROSITEi PS00010. ASX_HYDROXYL. 7 hits.
PS00022. EGF_1. 14 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 5 hits.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the crumbs homolog 2 (CRB2) gene and analysis of its role in retinitis pigmentosa and Leber congenital amaurosis."
    van den Hurk J.A.J.M., Rashbass P., Roepman R., Davis J., Voesenek K.E.J., Arends M.L., Zonneveld M.N., van Roekel M.H.G., Cameron K., Rohrschneider K., Heckenlively J.R., Koenekoop R.K., Hoyng C.B., Cremers F.P.M., den Hollander A.I.
    Mol. Vis. 11:263-273(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS LEU-46; LEU-97; LEU-116; THR-145; ALA-159; ASP-187; THR-351; GLN-534; TRP-610; ALA-709; GLN-746 AND MET-1110.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANTS ASN-90; THR-145; ALA-159 AND ALA-709.
    Tissue: Cerebellum.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Roni V., Carpio R., Wissinger B.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-22.
    Tissue: Retina.
  5. "The crystal structure of the human dual specificity tyrosine-phosphorylation-regulated kinase 1A."
    Structural genomics consortium (SGC)
    Submitted (AUG-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 4-9 IN COMPLEX WITH DYRK1A.

Entry informationi

Entry nameiCRUM2_HUMAN
AccessioniPrimary (citable) accession number: Q5IJ48
Secondary accession number(s): A2A3N4
, Q0QD46, Q5JS41, Q5JS43, Q6ZTA9, Q6ZWI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 17, 2006
Last modified: November 26, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3