Q5IJ48 (CRUM2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein crumbs homolog 2

Alternative name(s):
Crumbs-like protein 2

Gene names

Name:

CRB2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1285 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in polarized cells morphogenesis.
Subcellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.
Tissue specificity	Expressed in retina, fetal eye and brain. Also expressed in kidney, ARPE-19 and RPE/choroid cell lines, and at low levels in lung, placenta, and heart. Ref.1
Sequence similarities	Belongs to the Crumbs protein family. Contains 15 EGF-like domains. Contains 3 laminin G-like domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5IJ48-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5IJ48-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1131-1176: LPVPSKECSL...GQRCQVPTLP → WDGWAGGWAA...VLICDMRRTV
     1177-1285: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q5IJ48-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.
     333-351: GHCQDLPNGFQCHCPDGYA → MAMEPGALWTFLGHLWLLA

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 1285	1257	Protein crumbs homolog 2		PRO_0000007502
Regions
	Topological domain	29 – 1224	1196	Extracellular Potential
	Transmembrane	1225 – 1245	21	Helical; Potential
	Topological domain	1246 – 1285	40	Cytoplasmic Potential
	Domain	67 – 106	40	EGF-like 1
	Domain	108 – 144	37	EGF-like 2; calcium-binding Potential
	Domain	146 – 182	37	EGF-like 3; calcium-binding Potential
	Domain	184 – 221	38	EGF-like 4; calcium-binding Potential
	Domain	223 – 259	37	EGF-like 5
	Domain	261 – 318	58	EGF-like 6
	Domain	320 – 356	37	EGF-like 7; calcium-binding Potential
	Domain	358 – 394	37	EGF-like 8; calcium-binding Potential
	Domain	396 – 436	41	EGF-like 9
	Domain	431 – 603	173	Laminin G-like 1
	Domain	605 – 641	37	EGF-like 10
	Domain	647 – 805	159	Laminin G-like 2
	Domain	807 – 843	37	EGF-like 11
	Domain	871 – 1054	184	Laminin G-like 3
	Domain	1056 – 1092	37	EGF-like 12
	Domain	1094 – 1130	37	EGF-like 13
	Domain	1134 – 1171	38	EGF-like 14
	Domain	1173 – 1209	37	EGF-like 15
Amino acid modifications
	Glycosylation	235	1	N-linked (GlcNAc...) Potential
	Glycosylation	438	1	N-linked (GlcNAc...) Potential
	Glycosylation	478	1	N-linked (GlcNAc...) Potential
	Glycosylation	669	1	N-linked (GlcNAc...) Potential
	Glycosylation	690	1	N-linked (GlcNAc...) Potential
	Glycosylation	786	1	N-linked (GlcNAc...) Potential
	Glycosylation	800	1	N-linked (GlcNAc...) Potential
	Glycosylation	836	1	N-linked (GlcNAc...) Potential
	Glycosylation	886	1	N-linked (GlcNAc...) Potential
	Glycosylation	926	1	N-linked (GlcNAc...) Potential
	Glycosylation	1009	1	N-linked (GlcNAc...) Potential
	Glycosylation	1141	1	N-linked (GlcNAc...) Potential
	Glycosylation	1158	1	N-linked (GlcNAc...) Potential
	Disulfide bond	71 ↔ 82		By similarity
	Disulfide bond	76 ↔ 94		By similarity
	Disulfide bond	96 ↔ 105		By similarity
	Disulfide bond	112 ↔ 123		By similarity
	Disulfide bond	117 ↔ 132		By similarity
	Disulfide bond	134 ↔ 143		By similarity
	Disulfide bond	150 ↔ 161		By similarity
	Disulfide bond	155 ↔ 170		By similarity
	Disulfide bond	172 ↔ 181		By similarity
	Disulfide bond	188 ↔ 199		By similarity
	Disulfide bond	193 ↔ 208		By similarity
	Disulfide bond	210 ↔ 220		By similarity
	Disulfide bond	227 ↔ 238		By similarity
	Disulfide bond	232 ↔ 247		By similarity
	Disulfide bond	249 ↔ 258		By similarity
	Disulfide bond	265 ↔ 276		By similarity
	Disulfide bond	270 ↔ 306		By similarity
	Disulfide bond	308 ↔ 317		By similarity
	Disulfide bond	324 ↔ 335		By similarity
	Disulfide bond	329 ↔ 344		By similarity
	Disulfide bond	346 ↔ 355		By similarity
	Disulfide bond	362 ↔ 373		By similarity
	Disulfide bond	367 ↔ 382		By similarity
	Disulfide bond	384 ↔ 393		By similarity
	Disulfide bond	400 ↔ 411		By similarity
	Disulfide bond	405 ↔ 424		By similarity
	Disulfide bond	426 ↔ 435		By similarity
	Disulfide bond	579 ↔ 603		By similarity
	Disulfide bond	609 ↔ 620		By similarity
	Disulfide bond	614 ↔ 629		By similarity
	Disulfide bond	631 ↔ 640		By similarity
	Disulfide bond	766 ↔ 805		By similarity
	Disulfide bond	811 ↔ 822		By similarity
	Disulfide bond	816 ↔ 831		By similarity
	Disulfide bond	833 ↔ 842		By similarity
	Disulfide bond	1013 ↔ 1054		By similarity
	Disulfide bond	1060 ↔ 1071		By similarity
	Disulfide bond	1065 ↔ 1080		By similarity
	Disulfide bond	1082 ↔ 1091		By similarity
	Disulfide bond	1098 ↔ 1108		By similarity
	Disulfide bond	1103 ↔ 1118		By similarity
	Disulfide bond	1120 ↔ 1129		By similarity
	Disulfide bond	1138 ↔ 1150		By similarity
	Disulfide bond	1144 ↔ 1159		By similarity
	Disulfide bond	1161 ↔ 1170		By similarity
	Disulfide bond	1177 ↔ 1188		By similarity
	Disulfide bond	1182 ↔ 1197		By similarity
	Disulfide bond	1199 ↔ 1208		By similarity
Natural variations
	Alternative sequence	1 – 332	332	Missing in isoform 3.		VSP_014737
	Alternative sequence	333 – 351	19	GHCQD…PDGYA → MAMEPGALWTFLGHLWLLA in isoform 3.		VSP_014738
	Alternative sequence	1131 – 1176	46	LPVPS…VPTLP → WDGWAGGWAANAPWGYGGAE KSARSVDESLPFPGPHVLIC DMRRTV in isoform 2.		VSP_014739
	Alternative sequence	1177 – 1285	109	Missing in isoform 2.		VSP_014740
	Natural variant	46	1	P → L. Ref.1		VAR_022984
	Natural variant	90	1	T → N. Ref.2 Corresponds to variant rs2808415 [ dbSNP | Ensembl ].		VAR_048974
	Natural variant	97	1	V → L. Ref.1		VAR_022985
	Natural variant	116	1	P → L. Ref.1		VAR_022986
	Natural variant	145	1	M → T. Ref.1 Ref.2 Corresponds to variant rs1105223 [ dbSNP | Ensembl ].		VAR_022987
	Natural variant	159	1	G → A. Ref.1 Ref.2 Corresponds to variant rs1105222 [ dbSNP | Ensembl ].		VAR_022988
	Natural variant	187	1	E → D. Ref.1		VAR_022989
	Natural variant	351	1	A → T. Ref.1		VAR_022990
	Natural variant	534	1	R → Q. Ref.1		VAR_022991
	Natural variant	610	1	R → W. Ref.1		VAR_022992
	Natural variant	709	1	V → A. Ref.1 Ref.2 Corresponds to variant rs2488602 [ dbSNP | Ensembl ].		VAR_061153
	Natural variant	746	1	H → Q. Ref.1		VAR_022993
	Natural variant	1110	1	T → M. Ref.1		VAR_022994
Experimental info
	Sequence conflict	430	1	T → A in BAC86684. Ref.2
	Sequence conflict	969	1	T → A in AK123000. Ref.2
	Sequence conflict	969	1	T → A in BAC86684. Ref.2
	Sequence conflict	1153	1	G → R in BAC86684. Ref.2
	Sequence conflict	1239	1	Missing in BAC86684. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: C5B7E9D7A91CD703	FASTA	1,285	134,265
	10 20 30 40 50 60 MALARPGTPD PQALASVLLL LLWAPALSLL AGTVPSEPPS ACASDPCAPG TECQATESGG 70 80 90 100 110 120 YTCGPMEPRG CATQPCHHGA LCVPQGPDPT GFRCYCVPGF QGPRCELDID ECASRPCHHG 130 140 150 160 170 180 ATCRNLADRY ECHCPLGYAG VTCEMEVDEC ASAPCLHGGS CLDGVGSFRC VCAPGYGGTR 190 200 210 220 230 240 CQLDLDECQS QPCAHGGTCH DLVNGFRCDC AGTGYEGTHC EREVLECASA PCEHNASCLE 250 260 270 280 290 300 GLGSFRCLCW PGYSGELCEV DEDECASSPC QHGGRCLQRS DPALYGGVQA AFPGAFSFRH 310 320 330 340 350 360 AAGFLCHCPP GFEGADCGVE VDECASRPCL NGGHCQDLPN GFQCHCPDGY AGPTCEEDVD 370 380 390 400 410 420 ECLSDPCLHG GTCSDTVAGY ICRCPETWGG RDCSVQLTGC QGHTCPLAAT CIPIFESGVH 430 440 450 460 470 480 SYVCHCPPGT HGPFCGQNTT FSVMAGSPIQ ASVPAGGPLG LALRFRTTLP AGTLATRNDT 490 500 510 520 530 540 KESLELALVA ATLQATLWSY STTVLVLRLP DLALNDGHWH QVEVVLHLAT LELRLWHEGC 550 560 570 580 590 600 PARLCVASGP VALASTASAT PLPAGISSAQ LGDATFAGCL QDVRVDGHLL LPEDLGENVL 610 620 630 640 650 660 LGCERREQCR PLPCVHGGSC VDLWTHFRCD CARPHRGPTC ADEIPAATFG LGGAPSSASF 670 680 690 700 710 720 LLQELPGPNL TVSFLLRTRE SAGLLLQFAN DSAAGLTVFL SEGRIRAEVP GSPAVVLPGR 730 740 750 760 770 780 WDDGLRHLVM LSFGPDQLQD LGQHVHVGGR LLAADSQPWG GPFRGCLQDL RLDGCHLPFF 790 800 810 820 830 840 PLPLDNSSQP SELGGRQSWN LTAGCVSEDM CSPDPCFNGG TCLVTWNDFH CTCPANFTGP 850 860 870 880 890 900 TCAQQLWCPG QPCLPPATCE EVPDGFVCVA EATFREGPPA AFSGHNASSG RLLGGLSLAF 910 920 930 940 950 960 RTRDSEAWLL RAAAGALEGV WLAVRNGSLA GGVRGGHGLP GAVLPIPGPR VADGAWHRVR 970 980 990 1000 1010 1020 LAMERPAATT SRWLLWLDGA ATPVALRGLA SDLGFLQGPG AVRILLAENF TGCLGRVALG 1030 1040 1050 1060 1070 1080 GLPLPLARPR PGAAPGAREH FASWPGTPAP ILGCRGAPVC APSPCLHDGA CRDLFDAFAC 1090 1100 1110 1120 1130 1140 ACGPGWEGPR CEAHVDPCHS APCARGRCHT HPDGRFECRC PPGFGGPRCR LPVPSKECSL 1150 1160 1170 1180 1190 1200 NVTCLDGSPC EGGSPAANCS CLEGLAGQRC QVPTLPCEAN PCLNGGTCRA AGGVSECICN 1210 1220 1230 1240 1250 1260 ARFSGQFCEV AKGLPLPLPF PLLEVAVPAA CACLLLLLLG LLSGILAARK RRQSEGTYSP 1270 1280 SQQEVAGARL EMDSVLKVPP EERLI
	Isoform 2 [UniParc]. Checksum: A33CB9D605EDE5A0	FASTA	1,176	123,213
	10 20 30 40 50 60 MALARPGTPD PQALASVLLL LLWAPALSLL AGTVPSEPPS ACASDPCAPG TECQATESGG 70 80 90 100 110 120 YTCGPMEPRG CATQPCHHGA LCVPQGPDPT GFRCYCVPGF QGPRCELDID ECASRPCHHG 130 140 150 160 170 180 ATCRNLADRY ECHCPLGYAG VTCEMEVDEC ASAPCLHGGS CLDGVGSFRC VCAPGYGGTR 190 200 210 220 230 240 CQLDLDECQS QPCAHGGTCH DLVNGFRCDC AGTGYEGTHC EREVLECASA PCEHNASCLE 250 260 270 280 290 300 GLGSFRCLCW PGYSGELCEV DEDECASSPC QHGGRCLQRS DPALYGGVQA AFPGAFSFRH 310 320 330 340 350 360 AAGFLCHCPP GFEGADCGVE VDECASRPCL NGGHCQDLPN GFQCHCPDGY AGPTCEEDVD 370 380 390 400 410 420 ECLSDPCLHG GTCSDTVAGY ICRCPETWGG RDCSVQLTGC QGHTCPLAAT CIPIFESGVH 430 440 450 460 470 480 SYVCHCPPGT HGPFCGQNTT FSVMAGSPIQ ASVPAGGPLG LALRFRTTLP AGTLATRNDT 490 500 510 520 530 540 KESLELALVA ATLQATLWSY STTVLVLRLP DLALNDGHWH QVEVVLHLAT LELRLWHEGC 550 560 570 580 590 600 PARLCVASGP VALASTASAT PLPAGISSAQ LGDATFAGCL QDVRVDGHLL LPEDLGENVL 610 620 630 640 650 660 LGCERREQCR PLPCVHGGSC VDLWTHFRCD CARPHRGPTC ADEIPAATFG LGGAPSSASF 670 680 690 700 710 720 LLQELPGPNL TVSFLLRTRE SAGLLLQFAN DSAAGLTVFL SEGRIRAEVP GSPAVVLPGR 730 740 750 760 770 780 WDDGLRHLVM LSFGPDQLQD LGQHVHVGGR LLAADSQPWG GPFRGCLQDL RLDGCHLPFF 790 800 810 820 830 840 PLPLDNSSQP SELGGRQSWN LTAGCVSEDM CSPDPCFNGG TCLVTWNDFH CTCPANFTGP 850 860 870 880 890 900 TCAQQLWCPG QPCLPPATCE EVPDGFVCVA EATFREGPPA AFSGHNASSG RLLGGLSLAF 910 920 930 940 950 960 RTRDSEAWLL RAAAGALEGV WLAVRNGSLA GGVRGGHGLP GAVLPIPGPR VADGAWHRVR 970 980 990 1000 1010 1020 LAMERPAATT SRWLLWLDGA ATPVALRGLA SDLGFLQGPG AVRILLAENF TGCLGRVALG 1030 1040 1050 1060 1070 1080 GLPLPLARPR PGAAPGAREH FASWPGTPAP ILGCRGAPVC APSPCLHDGA CRDLFDAFAC 1090 1100 1110 1120 1130 1140 ACGPGWEGPR CEAHVDPCHS APCARGRCHT HPDGRFECRC PPGFGGPRCR WDGWAGGWAA 1150 1160 1170 NAPWGYGGAE KSARSVDESL PFPGPHVLIC DMRRTV
	Isoform 3 [UniParc]. Checksum: 277A62189E3BEC0D	FASTA	953	99,830
	10 20 30 40 50 60 MAMEPGALWT FLGHLWLLAG PTCEEDVDEC LSDPCLHGGT CSDTVAGYIC RCPETWGGRD 70 80 90 100 110 120 CSVQLTGCQG HTCPLAATCI PIFESGVHSY VCHCPPGTHG PFCGQNTTFS VMAGSPIQAS 130 140 150 160 170 180 VPAGGPLGLA LRFRTTLPAG TLATRNDTKE SLELALVAAT LQATLWSYST TVLVLRLPDL 190 200 210 220 230 240 ALNDGHWHQV EVVLHLATLE LRLWHEGCPA RLCVASGPVA LASTASATPL PAGISSAQLG 250 260 270 280 290 300 DATFAGCLQD VRVDGHLLLP EDLGENVLLG CERREQCRPL PCVHGGSCVD LWTHFRCDCA 310 320 330 340 350 360 RPHRGPTCAD EIPAATFGLG GAPSSASFLL QELPGPNLTV SFLLRTRESA GLLLQFANDS 370 380 390 400 410 420 AAGLTVFLSE GRIRAEVPGS PAVVLPGRWD DGLRHLVMLS FGPDQLQDLG QHVHVGGRLL 430 440 450 460 470 480 AADSQPWGGP FRGCLQDLRL DGCHLPFFPL PLDNSSQPSE LGGRQSWNLT AGCVSEDMCS 490 500 510 520 530 540 PDPCFNGGTC LVTWNDFHCT CPANFTGPTC AQQLWCPGQP CLPPATCEEV PDGFVCVAEA 550 560 570 580 590 600 TFREGPPAAF SGHNASSGRL LGGLSLAFRT RDSEAWLLRA AAGALEGVWL AVRNGSLAGG 610 620 630 640 650 660 VRGGHGLPGA VLPIPGPRVA DGAWHRVRLA MERPAATTSR WLLWLDGAAT PVALRGLASD 670 680 690 700 710 720 LGFLQGPGAV RILLAENFTG CLGRVALGGL PLPLARPRPG AAPGAREHFA SWPGTPAPIL 730 740 750 760 770 780 GCRGAPVCAP SPCLHDGACR DLFDAFACAC GPGWEGPRCE AHVDPCHSAP CARGRCHTHP 790 800 810 820 830 840 DGRFECRCPP GFGGPRCRLP VPSKECSLNV TCLDGSPCEG GSPAANCSCL EGLAGQRCQV 850 860 870 880 890 900 PTLPCEANPC LNGGTCRAAG GVSECICNAR FSGQFCEVAK GLPLPLPFPL LEVAVPAACA 910 920 930 940 950 CLLLLLLGLL SGILAARKRR QSEGTYSPSQ QEVAGARLEM DSVLKVPPEE RLI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the crumbs homolog 2 (CRB2) gene and analysis of its role in retinitis pigmentosa and Leber congenital amaurosis." van den Hurk J.A.J.M., Rashbass P., Roepman R., Davis J., Voesenek K.E.J., Arends M.L., Zonneveld M.N., van Roekel M.H.G., Cameron K., Rohrschneider K., Heckenlively J.R., Koenekoop R.K., Hoyng C.B., Cremers F.P.M., den Hollander A.I. Mol. Vis. 11:263-273(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS LEU-46; LEU-97; LEU-116; THR-145; ALA-159; ASP-187; THR-351; GLN-534; TRP-610; ALA-709; GLN-746 AND MET-1110.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANTS ASN-90; THR-145; ALA-159 AND ALA-709. Tissue: Cerebellum.
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Roni V., Carpio R., Wissinger B. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-22. Tissue: Retina.
[5]	"The crystal structure of the human dual specificity tyrosine-phosphorylation-regulated kinase 1A." Structural genomics consortium (SGC) Submitted (AUG-2009) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 4-9 IN COMPLEX WITH DYRK1A.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY720432 mRNA. Translation: AAU14134.1.
AK123000 mRNA. No translation available.
AK126775 mRNA. Translation: BAC86684.1.
AL445489, AL365504 Genomic DNA. Translation: CAI39793.1.
AL365504, AL445489 Genomic DNA. Translation: CAI41011.1.
AL445489, AL365504 Genomic DNA. Translation: CAM14433.1.
AL365504, AL445489 Genomic DNA. Translation: CAM21391.1.
DQ426866 mRNA. Translation: ABD90532.1.

IPI

IPI00410585.
IPI00607804.
IPI00607881.

RefSeq

NP_775960.4. NM_173689.5.

UniGene

Hs.710092.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2WO6	X-ray	2.50	C	4-9	[»]

ProteinModelPortal

Q5IJ48.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000362734.

PTM databases

PhosphoSite

Q5IJ48.

Polymorphism databases

DMDM

116241316.

Proteomic databases

PaxDb

Q5IJ48.

PRIDE

Q5IJ48.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000359999; ENSP00000353092; ENSG00000148204.
ENST00000373629; ENSP00000362732; ENSG00000148204.
ENST00000373631; ENSP00000362734; ENSG00000148204.
ENST00000460253; ENSP00000435279; ENSG00000148204.

GeneID

286204.

KEGG

hsa:286204.

UCSC

uc004bnw.1. human.
uc004bnx.1. human.

Organism-specific databases

CTD

286204.

GeneCards

GC09P126118.

H-InvDB

HIX0008365.

HGNC

HGNC:18688. CRB2.

HPA

HPA043674.

MIM

609720. gene.

neXtProt

NX_Q5IJ48.

PharmGKB

PA134910460.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG12793.

HOVERGEN

HBG080001.

InParanoid

Q5IJ48.

KO

K16681.

OMA

GVTCEAE.

OrthoDB

EOG4XWFX3.

Gene expression databases

Bgee

Q5IJ48.

CleanEx

HS_CRB2.

Genevestigator

Q5IJ48.

GermOnline

ENSG00000148204. Homo sapiens.

Family and domain databases

Gene3D

2.60.120.200. 4 hits.

InterPro

IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
[Graphical view]

Pfam

PF00008. EGF. 7 hits.
PF12661. hEGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]

SMART

SM00181. EGF. 9 hits.
SM00179. EGF_CA. 6 hits.
SM00282. LamG. 3 hits.
[Graphical view]

SUPFAM

SSF49899. ConA_like_lec_gl. 3 hits.

PROSITE

PS00010. ASX_HYDROXYL. 7 hits.
PS00022. EGF_1. 14 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 5 hits.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q5IJ48.

GenomeRNAi

286204.

NextBio

96074.

SOURCE

Search...

Entry information

Entry name

CRUM2_HUMAN

Accession

Primary (citable) accession number: Q5IJ48
Secondary accession number(s): A2A3N4 , Q0QD46, Q5JS41, Q5JS43, Q6ZTA9, Q6ZWI6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.