Q5IGR8EXT1A_DANREExostosin-1a2.4.1.2242.4.1.225Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase 1aMultiple exostoses protein 1 homolog aext1aDanio rerioZebrafishBrachydanio rerioEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanioDistinct tissue-specificity of three zebrafish ext1 genes encoding proteoglycan modifying enzymes and their relationship to somitic Sonic hedgehog signaling.NUCLEOTIDE SEQUENCE [MRNA]DEVELOPMENTAL STAGEGlycosyltransferase required for the biosynthesis of heparan-sulfate.3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDPMn(2+)Protein modification; protein glycosylation.Endoplasmic reticulum membraneSingle-pass type II membrane proteinExpressed both maternally and zygotically. During gastrulation, expressed in the neuroectoderm. At the 3-somite stage, expressed in the prospective forebrain, hindbrain and tailbud. From the 5-somite stage, expressed in the somitic mesoderm. At the 16-somite stage, also expressed in the dorsal neural tube, the eye and the Kupffer's vesicle. At 48 hours-post-fertilization (hpf), expression continues in the dorsal diencephalon and cerebellum and is observed in the otic vesicle.Belongs to the glycosyltransferase 47 family.Disulfide bondEndoplasmic reticulumGlycoproteinGlycosyltransferaseManganeseMembraneMetal-bindingReference proteomeSignal-anchorTransferaseTransmembraneTransmembrane helixUDP-N-acetyl-alpha-D-glucosamineUDP-N-acetyl-alpha-D-glucosamineUDP-N-acetyl-alpha-D-glucosamineMn(2+)catalyticUDP-N-acetyl-alpha-D-glucosamineUDP-N-acetyl-alpha-D-glucosamineUDP-N-acetyl-alpha-D-glucosamineUDP-N-acetyl-alpha-D-glucosamineMQAKKRYLILFSAGVCLILLFYLQGPASRRTPKRGDDPHPHWPHFSDPLRAFIPWDQTETEDYNVRASPRHKRDDSTGADKCRMDSCFDFELCKRNGFKVYVYPQQKGEKISESYQNILSSIEGSRFYTSDPGQACLFVLNLDTLDRDQLSPQYVHNLKTKIQNLNLWNNGRNHLIFNLYSGTWPDYTEDLGFDIGQAMLAKASISTESFRPNFDISIPLFSKDHPRTGGERGFLKYNTIPPFRKYMLVFKGKRYLTGIGSDTRNALYHIHNAEDVVLLTTCKHGKDWQKHKDARCDKDNAEYDRYDYKEMLHNSTFCLVPRGRRLGSFRFLEALQAACVPVMLSNGWELPFSEIIDWRTAAVIGDERLLLQIPSTVRSIHQDRILSLRQQTQFLWEAYFSSVEKIVLTTLEIIQDRVLQHSAHSTLMWNRLPGGLFTLPQYSSYLGDFPFFYALLGIKPHQKFTAVIHAVTPLVSQSQPIFKLLVAVAKSQFCAQIMVLWNCDKPLPSKHRWPATSVPVIVIEGESKVMSSRFLPYENIITDAVLSLDEDTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWDSNKERWGYTSKWTNDYSMVLTGAAFYHRYYNYLYTHYLPGSLKGLVDQLSNCEDILMNFLVSAVTKMPPIKVTQKKQYKETMMGQTSRASRWADPDHFAQRQTCMNKFASWFGTMPLVHSQMRLDPVLFRDQVSILRKKYRDIERL
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