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Q5IGR6

- EXT1C_DANRE

UniProt

Q5IGR6 - EXT1C_DANRE

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Protein
Exostosin-1c
Gene
ext1c
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Glycosyltransferase required for the biosynthesis of heparan-sulfate By similarity.

Catalytic activityi

UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan = UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan.
UDP-alpha-D-glucuronate + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan.

Pathwayi

GO - Molecular functioni

  1. N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity Source: UniProtKB
  2. glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. heparan sulfate proteoglycan biosynthetic process Source: UniProtKB
  2. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT47. Glycosyltransferase Family 47.
GT64. Glycosyltransferase Family 64.

Names & Taxonomyi

Protein namesi
Recommended name:
Exostosin-1c (EC:2.4.1.224, EC:2.4.1.225)
Alternative name(s):
Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase 1c
Multiple exostoses protein 1 homolog c
Gene namesi
Name:ext1c
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-050211-5. ext1c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66Cytoplasmic Reviewed prediction
Transmembranei7 – 2721Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini28 – 737710Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of endoplasmic reticulum membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 737737Exostosin-1c
PRO_0000149661Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi194 – 1941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi322 – 3221N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5IGR6.

Expressioni

Developmental stagei

Expressed zygotically. First detected at the beginning of somatogenesis. At the 16-somite stage, restricted to posterior adaxial cells and, in the anterior, to cells adjacent to the neural tube and to ventromedial reigons of the somites. At 24 hours-post-fertilization (hpf), expressed in the ventral rhombomeres, telencephalon and olfactory bulbs. At 48 hpf, expressed in the brain, retina and fin buds.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ5IGR6.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG269038.
HOVERGENiHBG003459.
PhylomeDBiQ5IGR6.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR004263. Exostosin.
IPR015338. HexNAc_Trfase_a.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR11062. PTHR11062. 1 hit.
PfamiPF03016. Exostosin. 1 hit.
PF09258. Glyco_transf_64. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5IGR6-1 [UniParc]FASTAAdd to Basket

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MQARKKYVLL GLCTCCWILL YYWAGLQERL LGLITHRRGE VPRPWPDWLD    50
RALLPNFAEQ LDLQNGGGPG DSPRQRKQAW SSIYKDSRCR MDTCFDFGRC 100
QTQSGFRVYI YPPEKGERVS EGYRKILTSV SESRYYTSDP REACLFVLGI 150
DTLDRDQLSQ QFVPNVDERI RGYPLWNDGR NHVIFNLYSG TWPNYTEDLG 200
FNVGQAILAK ASLNTEHFRP GFDISIPLFS KEHPQKGGKR GWLVRNSVPP 250
RRKYLLMFKG KRYLTGIGSD TRNALHHIHN GKDIVSLTTC RHGKDWEKHK 300
DARCDHDNQE YERFDYQELL HNSTFCLVPR GRRLGSFRFL ESLQAACIPV 350
LLSNGWELPF SDVIQWNQAV VEGDERLLLQ VPSTVRAVGI DRVLALRQQT 400
QTLWDAYFSS VDKIVLTTLE IIKDRVYSHI SRNKLMWNAL PGGLLVLPEF 450
STHLAHYPFY YLHLGISPGL EFTAVIHATS PLVSQSQPIM KLLQVVSKSK 500
YCSQIIILWN SEKSPPQRSK WPPMPVPLTV TDGRRKTSSR FLPHAAIETE 550
AVLSLDEDTV LLTSEINFAF HVWRSFPDRI VGYPPRSHFW DPVKKAWGYT 600
SKWTNEYSII LTGAAFYHRY YHHLFSHYLP SSLRALVDHS CNCEDILMNF 650
LVSSVAHLPP VKVAQRKQYK EMPSLQGTKM APWANPEHFT QRQECVNTFS 700
SWFGYMPLEH SQFRLDPVLF KDHVSVLRKR YKDLERV 737
Length:737
Mass (Da):85,389
Last modified:February 15, 2005 - v1
Checksum:i349EB644FB7AADB4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY734457 mRNA. Translation: AAW29035.1.
UniGeneiDr.38024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY734457 mRNA. Translation: AAW29035.1 .
UniGenei Dr.38024.

3D structure databases

ProteinModelPortali Q5IGR6.
ModBasei Search...

Protein family/group databases

CAZyi GT47. Glycosyltransferase Family 47.
GT64. Glycosyltransferase Family 64.

Proteomic databases

PRIDEi Q5IGR6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ZFINi ZDB-GENE-050211-5. ext1c.

Phylogenomic databases

eggNOGi NOG269038.
HOVERGENi HBG003459.
PhylomeDBi Q5IGR6.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR004263. Exostosin.
IPR015338. HexNAc_Trfase_a.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
PANTHERi PTHR11062. PTHR11062. 1 hit.
Pfami PF03016. Exostosin. 1 hit.
PF09258. Glyco_transf_64. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Distinct tissue-specificity of three zebrafish ext1 genes encoding proteoglycan modifying enzymes and their relationship to somitic Sonic hedgehog signaling."
    Siekmann A.F., Brand M.
    Dev. Dyn. 232:498-505(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiEXT1C_DANRE
AccessioniPrimary (citable) accession number: Q5IGR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: February 15, 2005
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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