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Q5IGR6 (EXT1C_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Exostosin-1c

EC=2.4.1.224
EC=2.4.1.225
Alternative name(s):
Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase 1c
Multiple exostoses protein 1 homolog c
Gene names
Name:ext1c
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length737 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Glycosyltransferase required for the biosynthesis of heparan-sulfate By similarity.

Catalytic activity

UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan = UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan.

UDP-alpha-D-glucuronate + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity.

Developmental stage

Expressed zygotically. First detected at the beginning of somatogenesis. At the 16-somite stage, restricted to posterior adaxial cells and, in the anterior, to cells adjacent to the neural tube and to ventromedial reigons of the somites. At 24 hours-post-fertilization (hpf), expressed in the ventral rhombomeres, telencephalon and olfactory bulbs. At 48 hpf, expressed in the brain, retina and fin buds. Ref.1

Sequence similarities

Belongs to the glycosyltransferase 47 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 737737Exostosin-1c
PRO_0000149661

Regions

Topological domain1 – 66Cytoplasmic Potential
Transmembrane7 – 2721Helical; Signal-anchor for type II membrane protein; Potential
Topological domain28 – 737710Lumenal Potential

Amino acid modifications

Glycosylation1941N-linked (GlcNAc...) Potential
Glycosylation3221N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5IGR6 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 349EB644FB7AADB4

FASTA73785,389
        10         20         30         40         50         60 
MQARKKYVLL GLCTCCWILL YYWAGLQERL LGLITHRRGE VPRPWPDWLD RALLPNFAEQ 

        70         80         90        100        110        120 
LDLQNGGGPG DSPRQRKQAW SSIYKDSRCR MDTCFDFGRC QTQSGFRVYI YPPEKGERVS 

       130        140        150        160        170        180 
EGYRKILTSV SESRYYTSDP REACLFVLGI DTLDRDQLSQ QFVPNVDERI RGYPLWNDGR 

       190        200        210        220        230        240 
NHVIFNLYSG TWPNYTEDLG FNVGQAILAK ASLNTEHFRP GFDISIPLFS KEHPQKGGKR 

       250        260        270        280        290        300 
GWLVRNSVPP RRKYLLMFKG KRYLTGIGSD TRNALHHIHN GKDIVSLTTC RHGKDWEKHK 

       310        320        330        340        350        360 
DARCDHDNQE YERFDYQELL HNSTFCLVPR GRRLGSFRFL ESLQAACIPV LLSNGWELPF 

       370        380        390        400        410        420 
SDVIQWNQAV VEGDERLLLQ VPSTVRAVGI DRVLALRQQT QTLWDAYFSS VDKIVLTTLE 

       430        440        450        460        470        480 
IIKDRVYSHI SRNKLMWNAL PGGLLVLPEF STHLAHYPFY YLHLGISPGL EFTAVIHATS 

       490        500        510        520        530        540 
PLVSQSQPIM KLLQVVSKSK YCSQIIILWN SEKSPPQRSK WPPMPVPLTV TDGRRKTSSR 

       550        560        570        580        590        600 
FLPHAAIETE AVLSLDEDTV LLTSEINFAF HVWRSFPDRI VGYPPRSHFW DPVKKAWGYT 

       610        620        630        640        650        660 
SKWTNEYSII LTGAAFYHRY YHHLFSHYLP SSLRALVDHS CNCEDILMNF LVSSVAHLPP 

       670        680        690        700        710        720 
VKVAQRKQYK EMPSLQGTKM APWANPEHFT QRQECVNTFS SWFGYMPLEH SQFRLDPVLF 

       730 
KDHVSVLRKR YKDLERV 

« Hide

References

[1]"Distinct tissue-specificity of three zebrafish ext1 genes encoding proteoglycan modifying enzymes and their relationship to somitic Sonic hedgehog signaling."
Siekmann A.F., Brand M.
Dev. Dyn. 232:498-505(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY734457 mRNA. Translation: AAW29035.1.
UniGeneDr.38024.

3D structure databases

ProteinModelPortalQ5IGR6.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT47. Glycosyltransferase Family 47.
GT64. Glycosyltransferase Family 64.

Proteomic databases

PRIDEQ5IGR6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ZFINZDB-GENE-050211-5. ext1c.

Phylogenomic databases

eggNOGNOG269038.
HOVERGENHBG003459.
PhylomeDBQ5IGR6.

Enzyme and pathway databases

UniPathwayUPA00378.

Family and domain databases

Gene3D3.90.550.10. 1 hit.
InterProIPR004263. Exostosin.
IPR015338. HexNAc_Trfase_a.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERPTHR11062. PTHR11062. 1 hit.
PfamPF03016. Exostosin. 1 hit.
PF09258. Glyco_transf_64. 1 hit.
[Graphical view]
SUPFAMSSF53448. SSF53448. 1 hit.
ProtoNetSearch...

Entry information

Entry nameEXT1C_DANRE
AccessionPrimary (citable) accession number: Q5IGR6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: February 15, 2005
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways