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Reviewed, UniProtKB/Swiss-Prot Q5IFP1 (3BHS_CANFA)

Last modified November 25, 2008. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
      Short name=3-beta-HSD
Including the following 2 domains:
    1- Recommended name:
            3-beta-hydroxy-Delta(5)-steroid dehydrogenase
              EC=1.1.1.145
        Alternative name(s):
            3-beta-hydroxy-5-ene steroid dehydrogenase
            Progesterone reductase
    2- Recommended name:
            Steroid Delta-isomerase
              EC=5.3.3.1
        Alternative name(s):
            Delta-5-3-ketosteroid isomerase
Gene names
Name: HSD3B
OrganismCanis familiaris (Dog)
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids By similarity.

Catalytic activity

A 3-beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)-steroid + NADH.

A 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid.

Pathway

Lipid metabolism; steroid biosynthesis.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane proteinBy similarity. Mitochondrion membrane; Single-pass membrane proteinBy similarity.

Sequence similarities

Belongs to the 3-beta-HSD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 3733723 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
PRO_0000087772

Regions

Transmembrane288 – 30821 Potential

Sequences

Sequence LengthMass (Da)Tools
Q5IFP1-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: EB12CB016D650A5B

FASTA37342,378
        10         20         30         40         50         60 
MAGWSCLVTG AGGFLGQRIV HLLAEEKELQ EIRALDKAFR PELLEEFSKL QSKTKLTMVE 

        70         80         90        100        110        120 
GDILDEQCLK RACQGTSVVI HTASVIDVMN VIHRETIMNV NLKGTQLLLE ACAQASVPIF 

       130        140        150        160        170        180 
IYTSTIEVAG PNSYRDIIQN AHEEEHLEST WSAPYPYSKK LAEKAVLAAN GWALKNGGTL 

       190        200        210        220        230        240 
HTCALRPMYI YGEGSIFLYN YIYKALRNNG ILTHHSKFSI VNPVYVGNVA WAHILALRAL 

       250        260        270        280        290        300 
QDPKKAPSVQ GQFYYISDDT PHQSYDDLNY NLSKEWGFSL DSRMSLPISL EYWLAFLLEI 

       310        320        330        340        350        360 
VSFLLSPIYK YQPPFNRHMV TLSNSIFTFS YKKAQRDLGY KPLFSWEEAK QKTTEWIGSL 

       370 
VKQHKETLKT KTH 

« Hide

References

[1]"Expression of 3-beta-hydroxysteroid dehydrogenase in canine corpus luteum during dioestrus."
Kowalewski M.P., Taubert A., Hoffmann B.
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Corpus luteum.

Cross-references

Sequence databases

AY739720 mRNA. Translation: AAW31741.1.
RefSeqNP_001010954.1.
UniGeneCfa.13172

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSCAFG00000010039. Canis familiaris. [Contig view]
GeneID483146.
KEGGcfa:483146.

Phylogenomic databases

HOVERGENQ5IFP1.

Family and domain databases

InterProIPR002225. 3Beta_OHSteriod_DHase/Estase.
IPR016040. NAD(P)-bd.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF01073. 3Beta_HSD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry name3BHS_CANFA
AccessionPrimary (citable) accession number: Q5IFP1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 23, 2007
Last modified: November 25, 2008
This is version 31 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents