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Protein
Submitted name:

Lamin A/C transcript variant 1

Gene

LMNA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Lamin A/C transcript variant 1Imported
Gene namesi
Name:LMNAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filamentUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ5I6Y5.
PeptideAtlasiQ5I6Y5.
PRIDEiQ5I6Y5.

Structurei

3D structure databases

ProteinModelPortaliQ5I6Y5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili28 – 69Sequence analysisAdd BLAST42
Coiled coili78 – 221Sequence analysisAdd BLAST144
Coiled coili242 – 269Sequence analysisAdd BLAST28
Coiled coili292 – 369Sequence analysisAdd BLAST78

Sequence similaritiesi

Belongs to the intermediate filament family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0977. Eukaryota.
ENOG410Y2H6. LUCA.
HOGENOMiHOG000007711.
HOVERGENiHBG013015.

Family and domain databases

Gene3Di2.60.40.1260. 1 hit.
InterProiView protein in InterPro
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR036415. Lamin_tail_dom_sf.
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiView protein in Pfam
PF00038. Filament. 1 hit.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.
SUPFAMiSSF74853. SSF74853. 1 hit.
PROSITEiView protein in PROSITE
PS00226. IF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5I6Y5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR
60 70 80 90 100
SLETENAGLR LRITESEEVV SREVSGIKAA YEAELGDARK TLDSVAKERA
110 120 130 140 150
RLQLELSKVR EEFKELKARN TKKEGDLIAA QARLKDLEAL LNSKEAALST
160 170 180 190 200
ALSEKRTLEG ELHDLRGQVA KLEAALGEAK KQLQDEMLRR VDAENRLQTM
210 220 230 240 250
KEELDFQKNI YSEELRETKR RHETRLVEID NGKQREFESR LADALQELRA
260 270 280 290 300
QHEDQVEQYK KELEKTYSAK LDNARQSAER NSNLVGAAHE ELQQSRIRID
310 320 330 340 350
SLSAQLSQLQ KQLAAKEAKL RDLEDSLARE RDTSRRLLAE KEREMAEMRA
360 370 380 390 400
RMQQQLDEYQ ELLDIKLALD MEIHAYRKLL EGEEERLRLS PSPTSQRSRG
410 420 430 440 450
RASSHSSQTQ GGGSVTKKRK LESTESRSSF SQHARTSGRV AVEEVDEEGK
460 470 480
FVRLRNKSNE DQSMGNWQIK RQNGDDPLLT
Length:480
Mass (Da):55,044
Last modified:February 15, 2005 - v1
Checksum:iFDB7A651202DF037
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY847596 mRNA. Translation: AAW32539.1.
UniGeneiHs.594444.
Hs.706897.
Hs.733671.

Similar proteinsi

Entry informationi

Entry nameiQ5I6Y5_HUMAN
AccessioniPrimary (citable) accession number: Q5I6Y5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: November 22, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.