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Q5I6N7

- Q5I6N7_HUMAN

UniProt

Q5I6N7 - Q5I6N7_HUMAN

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Protein
Submitted name: Cystic fibrosis transmembrane conductance regulator ATP-binding cassette subfamily C member 7
Gene
CFTR
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity Source: InterPro
  3. bicarbonate transmembrane transporter activity Source: Ensembl
  4. chloride transmembrane transporter activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. cellular response to cAMP Source: Ensembl
  2. cellular response to hormone stimulus Source: Ensembl
  3. cholesterol biosynthetic process Source: Ensembl
  4. cholesterol transport Source: Ensembl
  5. intracellular pH elevation Source: Ensembl
  6. iodide transport Source: Ensembl
  7. lung development Source: Ensembl
  8. membrane hyperpolarization Source: Ensembl
  9. positive regulation of vasodilation Source: Ensembl
  10. response to cytokine Source: Ensembl
  11. response to drug Source: Ensembl
  12. response to estrogen Source: Ensembl
  13. response to peptide hormone Source: Ensembl
  14. sperm capacitation Source: Ensembl
  15. transepithelial chloride transport Source: Ensembl
  16. vasodilation Source: Ensembl
  17. water transport Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotationImported, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Cystic fibrosis transmembrane conductance regulator ATP-binding cassette subfamily C member 7Imported
Gene namesi
Name:CFTRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basolateral plasma membrane Source: Ensembl
  3. cytoplasmic vesicle membrane Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. microvillus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ5I6N7.

Expressioni

Gene expression databases

ArrayExpressiQ5I6N7.
BgeeiQ5I6N7.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ5I6N7.

Family & Domainsi

Keywords - Domaini

TransmembraneImported

Phylogenomic databases

HOVERGENiHBG078977.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5I6N7-1 [UniParc]FASTAAdd to Basket

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MRSVSRVFKF IDMPTEGKPT KSTKPYKNGQ LSKVMIIENS HVKKDDIWPS    50
GGQMTVKDLT AKYTEGGNAI LENISFSISP GQRVGLLGRT GSGKSTLLSA 100
FLRLLNTEGE IQIDGVSWDS ITLQQWRKAF GVIPQKVFIF SGTFRKNLDP 150
YEQWSDQEIW KVADEVGLRS VIEQFPGKLD FVLVDGGCVL SHGHKQLMCL 200
ARSVLSKAKI LLLDEPSAHL DPVTYQIIRR TLKQAFADCT VILCEHRIEA 250
MLECQQFL 258
Length:258
Mass (Da):28,948
Last modified:February 15, 2005 - v1
Checksum:iD6BF6F1ABF3A8C16
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei258 – 2581Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY848829 Genomic DNA. Translation: AAW33656.1.
UniGeneiHs.489786.
Hs.621460.
Hs.661104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY848829 Genomic DNA. Translation: AAW33656.1 .
UniGenei Hs.489786.
Hs.621460.
Hs.661104.

3D structure databases

ProteinModelPortali Q5I6N7.
ModBasei Search...

Chemistry

BindingDBi Q5I6N7.

Proteomic databases

PRIDEi Q5I6N7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG078977.

Gene expression databases

ArrayExpressi Q5I6N7.
Bgeei Q5I6N7.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00005. ABC_tran. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Fa0427Imported.

Entry informationi

Entry nameiQ5I6N7_HUMAN
AccessioniPrimary (citable) accession number: Q5I6N7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: July 9, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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