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Q5I6N5

- Q5I6N5_HUMAN

UniProt

Q5I6N5 - Q5I6N5_HUMAN

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Protein
Submitted name: Cystic fibrosis transmembrane conductance regulator ATP-binding cassette subfamily C member 7
Gene
CFTR
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  3. bicarbonate transmembrane transporter activity Source: Ensembl
  4. chloride channel activity Source: InterPro

GO - Biological processi

  1. cellular response to cAMP Source: Ensembl
  2. cellular response to hormone stimulus Source: Ensembl
  3. cholesterol biosynthetic process Source: Ensembl
  4. cholesterol transport Source: Ensembl
  5. intracellular pH elevation Source: Ensembl
  6. iodide transport Source: Ensembl
  7. lung development Source: Ensembl
  8. membrane hyperpolarization Source: Ensembl
  9. positive regulation of vasodilation Source: Ensembl
  10. response to cytokine Source: Ensembl
  11. response to drug Source: Ensembl
  12. response to estrogen Source: Ensembl
  13. response to peptide hormone Source: Ensembl
  14. sperm capacitation Source: Ensembl
  15. transepithelial chloride transport Source: Ensembl
  16. vasodilation Source: Ensembl
  17. water transport Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

ATP-bindingImported, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Cystic fibrosis transmembrane conductance regulator ATP-binding cassette subfamily C member 7Imported
Gene namesi
Name:CFTRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basolateral plasma membrane Source: Ensembl
  3. cytoplasmic vesicle membrane Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. microvillus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ArrayExpressiQ5I6N5.
BgeeiQ5I6N5.

Structurei

3D structure databases

ProteinModelPortaliQ5I6N5.

Family & Domainsi

Keywords - Domaini

TransmembraneImported

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR001140. ABC_transptr_TM_dom.
IPR009147. CysFib_conduc_TM.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
PRINTSiPR01851. CYSFIBREGLTR.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5I6N5-1 [UniParc]FASTAAdd to Basket

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TPLQDKGNST HSRNNSYAVI ITSTSSYYVF YIYVGVADTL LAMGFFRGLP    50
LVHTLITVSK ILHHKMLHSV LQAPMSTLNT LKAGGILNRF SKDIAILDDL 100
LPLTIFDFIQ LLLIVIGAIA VVAVLQPYIF VATVPVIVAF IMLRAYFLQT 150
SQQLKQLESE GRSPIFTHLV TSLKGLWTLR AFGRQPYFET LFHKALNLHT 200
ANWFLYLSTL RWFQMRIEMI FVIFFIAVTF ISILTTGEGE GRVGIILTLA 250
MNIMSTLQWA VNSSIDVDSL MRSVSRVFKF IDMPTEGKPT KSTKPYKNGQ 300
LSKVMIIENS HVKKDDIWPS GGQMTVKDLT AKYTEGGNAI LENISFSISP 350
GQRVGLLGRT GSGKSTLLSA FLRLLNTEGE IQIDGVSWDS ITLQQWRKAF 400
GVIPQ 405
Length:405
Mass (Da):45,235
Last modified:February 15, 2005 - v1
Checksum:i4B10DD73A99C27D0
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei405 – 4051Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY848831 Genomic DNA. Translation: AAW33658.1.
UniGeneiHs.489786.
Hs.621460.
Hs.661104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY848831 Genomic DNA. Translation: AAW33658.1 .
UniGenei Hs.489786.
Hs.621460.
Hs.661104.

3D structure databases

ProteinModelPortali Q5I6N5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

ArrayExpressi Q5I6N5.
Bgeei Q5I6N5.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR001140. ABC_transptr_TM_dom.
IPR009147. CysFib_conduc_TM.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view ]
PRINTSi PR01851. CYSFIBREGLTR.
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEi PS50929. ABC_TM1F. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Fa0428Imported.

Entry informationi

Entry nameiQ5I6N5_HUMAN
AccessioniPrimary (citable) accession number: Q5I6N5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: July 9, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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