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Q5I6N4

- Q5I6N4_HUMAN

UniProt

Q5I6N4 - Q5I6N4_HUMAN

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Protein
Submitted name: Cystic fibrosis transmembrane conductance regulator ATP-binding cassette subfamily C member 7
Gene
CFTR
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  3. bicarbonate transmembrane transporter activity Source: Ensembl
  4. chloride channel activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cellular response to cAMP Source: Ensembl
  2. cellular response to hormone stimulus Source: Ensembl
  3. cholesterol biosynthetic process Source: Ensembl
  4. cholesterol transport Source: Ensembl
  5. intracellular pH elevation Source: Ensembl
  6. iodide transport Source: Ensembl
  7. lung development Source: Ensembl
  8. membrane hyperpolarization Source: Ensembl
  9. positive regulation of vasodilation Source: Ensembl
  10. response to cytokine Source: Ensembl
  11. response to drug Source: Ensembl
  12. response to estrogen Source: Ensembl
  13. response to peptide hormone Source: Ensembl
  14. sperm capacitation Source: Ensembl
  15. transepithelial chloride transport Source: Ensembl
  16. vasodilation Source: Ensembl
  17. water transport Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

ATP-bindingImported, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Cystic fibrosis transmembrane conductance regulator ATP-binding cassette subfamily C member 7Imported
Gene namesi
Name:CFTRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basolateral plasma membrane Source: Ensembl
  3. cytoplasmic vesicle membrane Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. microvillus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ArrayExpressiQ5I6N4.
BgeeiQ5I6N4.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ5I6N4.

Family & Domainsi

Keywords - Domaini

TransmembraneImported

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR001140. ABC_transptr_TM_dom.
IPR009147. CysFib_conduc_TM.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
PRINTSiPR01851. CYSFIBREGLTR.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5I6N4-1 [UniParc]FASTAAdd to Basket

« Hide

VAASLVVLWL LGNTPLQDKG NSTHSRNNSY AVIITSTSSY YVFYIYVGVA    50
DTLLAMGFFR GLPLVHTLIT VSKILHHKML HSVLQAPMST LNTLKAGGIL 100
NRFSKDIAIL DDLLPLTIFD FIQLLLIVIG AIAVVAVLQP YIFVATVPVI 150
VAFIMLRAYF LQTSQQLKQL ESEGRSPIFT HLVTSLKGLW TLRAFGRQPY 200
FETLFHKALN LHTANWFLYL STLRWFQMRI EMIFVIFFIA VTFISILTTG 250
EGEGRVGIIL TLAMNIMSTL QWAVNSSIDV DSLMRSVSRV FKFIDMPTEG 300
KPTKSTKPYK NGQLSKVMII ENSHVKKDDI WPSGGQMTVK DLTAKYTEGG 350
NAILENISFS ISPGQRVGLL GRTGSGKSTL LSAFLRLLNT EGEIQIDGVS 400
WDSITLQQWR KAFGVIPQ 418
Length:418
Mass (Da):46,572
Last modified:February 15, 2005 - v1
Checksum:i7D8ED8FA01B52196
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei418 – 4181Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY848832 Genomic DNA. Translation: AAW33659.1.
UniGeneiHs.489786.
Hs.621460.
Hs.661104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY848832 Genomic DNA. Translation: AAW33659.1 .
UniGenei Hs.489786.
Hs.621460.
Hs.661104.

3D structure databases

ProteinModelPortali Q5I6N4.
ModBasei Search...

Chemistry

BindingDBi Q5I6N4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

H-InvDB HIX0033689.

Gene expression databases

ArrayExpressi Q5I6N4.
Bgeei Q5I6N4.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR001140. ABC_transptr_TM_dom.
IPR009147. CysFib_conduc_TM.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view ]
PRINTSi PR01851. CYSFIBREGLTR.
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEi PS50929. ABC_TM1F. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Fa0322Imported.

Entry informationi

Entry nameiQ5I6N4_HUMAN
AccessioniPrimary (citable) accession number: Q5I6N4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: July 9, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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