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Q5I6M2 (HOG1_SETTU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase HOG1

Short name=MAP kinase HOG1
EC=2.7.11.24
Alternative name(s):
MAP kinase STK1
Gene names
Name:HOG1
Synonyms:STK1
OrganismSetosphaeria turcica (Northern leaf blight fungus) (Exserohilum turcicum)
Taxonomic identifier93612 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeSetosphaeria

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by tyrosine and threonine phosphorylation By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-144 and Tyr-146, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.

Contains 1 protein kinase domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 329329Mitogen-activated protein kinase HOG1
PRO_0000289701

Regions

Domain1 – 272272Protein kinase
Nucleotide binding1 – 77ATP By similarity
Motif144 – 1463TXY

Sites

Active site1141Proton acceptor By similarity
Binding site221ATP By similarity

Amino acid modifications

Modified residue1441Phosphothreonine By similarity
Modified residue1461Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5I6M2 [UniParc].

Last modified October 31, 2006. Version 2.
Checksum: 0AD4C21C0BA4E346

FASTA32937,743
        10         20         30         40         50         60 
MGAFGLVCSA KDQLTNQAVA VKKIMKPFST PVLSKRTYRE LKLLKHLRHE NIISLSDIFI 

        70         80         90        100        110        120 
SPLEDIYFVT ELLGTDLHRL LTSRPLEKQF IQYFLYQILR GLKYIHSAGV VHRDLKPSNI 

       130        140        150        160        170        180 
LVNENCDLKI CDFGLARIQD PQVTGYVSTR YYRAPEIMLT WQKYDVEVDI WSAGCIFAEM 

       190        200        210        220        230        240 
LEGKPLFPGK DHVNQFSIIT ELLGTPPDDV IQTICSENTL RFVQPLPKRE RQPLANKFKN 

       250        260        270        280        290        300 
AEPEAVDLLE NMLVFDPRKR VRAEQALAHP YLAPYHDPTD EPIAEEKFDW SFNDADLPVD 

       310        320 
TWKIMMYSEI LDYHNVDAAA QDAPESNGS 

« Hide

References

[1]Gu S., Fan Y., Dong J.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY849317 mRNA. Translation: AAW55999.2.

3D structure databases

ProteinModelPortalQ5I6M2.
SMRQ5I6M2. Positions 1-316.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR01773. P38MAPKINASE.
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHOG1_SETTU
AccessionPrimary (citable) accession number: Q5I6M2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 31, 2006
Last modified: April 16, 2014
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families