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Q5I6F9

- Q5I6F9_HUMAN

UniProt

Q5I6F9 - Q5I6F9_HUMAN

Protein
Submitted name:

Cystic fibrosis transmembrane conductance regulator ATP-binding cassette subfamily C member 7

Gene

CFTR

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. bicarbonate transmembrane transporter activity Source: Ensembl
    4. chloride transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. cellular response to cAMP Source: Ensembl
    2. cellular response to hormone stimulus Source: Ensembl
    3. cholesterol biosynthetic process Source: Ensembl
    4. cholesterol transport Source: Ensembl
    5. intracellular pH elevation Source: Ensembl
    6. iodide transport Source: Ensembl
    7. lung development Source: Ensembl
    8. membrane hyperpolarization Source: Ensembl
    9. positive regulation of vasodilation Source: Ensembl
    10. response to cytokine Source: Ensembl
    11. response to drug Source: Ensembl
    12. response to estrogen Source: Ensembl
    13. response to peptide hormone Source: Ensembl
    14. sperm capacitation Source: Ensembl
    15. transepithelial chloride transport Source: Ensembl
    16. vasodilation Source: Ensembl
    17. water transport Source: Ensembl

    Keywords - Ligandi

    ATP-bindingImported, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cystic fibrosis transmembrane conductance regulator ATP-binding cassette subfamily C member 7Imported
    Submitted name:
    Cystic fibrosis transmembrane conductance regulator/ATP-binding cassette sub-family C member 7Imported
    Gene namesi
    Name:CFTRImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basolateral plasma membrane Source: Ensembl
    3. cytoplasmic vesicle membrane Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW
    5. microvillus Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiQ5I6F9.
    BgeeiQ5I6F9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5I6F9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    TransmembraneImported

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003439. ABC_transporter-like.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00005. ABC_tran. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q5I6F9-1 [UniParc]FASTAAdd to Basket

    « Hide

    VGLRSVIEQF PGKLDFVLVD GGCVLSHGHK QLMCLARSVL SKAKILLLDE    50
    PSAHLDPVTY QIIRRTLKQA FADCTVILCE HRIEAMLECQ QFLVIEENKV 100
    RQYDSIQKLL NERSLFRQAI SPSDRVKLFP HRNSSKCKSK PQIAALKEET 150
    EEEVQDTRL 159
    Length:159
    Mass (Da):18,157
    Last modified:February 15, 2005 - v1
    Checksum:iF9470470FBC047AF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY848828 Genomic DNA. Translation: AAW33655.1.
    AY849794 Genomic DNA. Translation: AAW33782.1.
    UniGeneiHs.489786.
    Hs.621460.
    Hs.661104.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY848828 Genomic DNA. Translation: AAW33655.1 .
    AY849794 Genomic DNA. Translation: AAW33782.1 .
    UniGenei Hs.489786.
    Hs.621460.
    Hs.661104.

    3D structure databases

    ProteinModelPortali Q5I6F9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    ArrayExpressi Q5I6F9.
    Bgeei Q5I6F9.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003439. ABC_transporter-like.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Fa0458Imported.

    Entry informationi

    Entry nameiQ5I6F9_HUMAN
    AccessioniPrimary (citable) accession number: Q5I6F9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 15, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.