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Protein

T-box transcription factor TBX5

Gene

Tbx5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi58 – 238T-boxPROSITE-ProRule annotationAdd BLAST181

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX5
Short name:
T-box protein 5
Gene namesi
Name:Tbx5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305702. Tbx5.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844371 – 517T-box transcription factor TBX5Add BLAST517

Proteomic databases

PaxDbiQ5I2P1.

Interactioni

Subunit structurei

Monomer. Interacts with GATA4.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001893.

Structurei

3D structure databases

ProteinModelPortaliQ5I2P1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3585. Eukaryota.
ENOG410XSTS. LUCA.
HOGENOMiHOG000286001.
HOVERGENiHBG007310.
InParanoidiQ5I2P1.
KOiK10179.
PhylomeDBiQ5I2P1.

Family and domain databases

CDDicd00182. TBOX. 1 hit.
Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5I2P1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADADEGFGL ARTPLEPDSK DRSCDSKPES ALGAPSKSPS SPQAAFTQQG
60 70 80 90 100
MEGIKVFLHE RELWLKFHEV GTEMIITKAG RQMFPSYKVK VTGLNPKTKY
110 120 130 140 150
ILLMDIVPAD DHRYKFADNK WSVTGKAEPA MPGRLYVHPD SPATGAHWMR
160 170 180 190 200
QLVSFQKLKL TNNHLDPFGH IILNSMHKYQ PRLHIVKADE NNGFGSKNTA
210 220 230 240 250
FCTHVFPETA FIAVTSYQNH KITQLKIENN PFAKGFRGSD DLELHRMSRM
260 270 280 290 300
RSKEYPVVPR STVRHKVANH SPFSSETRAL STSSNLGSQY QCENGVSGPS
310 320 330 340 350
QDLLPPPNPY PLAQEHSQIY HCTKRKDEEC SSTEHPYKKP YMETSPSEED
360 370 380 390 400
TFYRSGYPQQ QGLSTSYRTE SAQRQACMYA SSAPPSEPVP SLEDISCNTW
410 420 430 440 450
PSMPSYSSCT VTTVQPMDRL PYQHFSAHFT SGPLVPRLAG MANHGSPQLG
460 470 480 490 500
EGMFQHQTSV THQPVVRQCG PQTGLQSPGS LQPPEFLYTH GVPRTLSPHQ
510
YHSVHGVGMV PEWSENS
Length:517
Mass (Da):57,745
Last modified:February 15, 2005 - v1
Checksum:i24F233DE80FAD872
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY859491 mRNA. Translation: AAW33688.1.
RefSeqiNP_001009964.1. NM_001009964.1.
UniGeneiRn.6327.

Genome annotation databases

GeneIDi304514.
KEGGirno:304514.
UCSCiRGD:1305702. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY859491 mRNA. Translation: AAW33688.1.
RefSeqiNP_001009964.1. NM_001009964.1.
UniGeneiRn.6327.

3D structure databases

ProteinModelPortaliQ5I2P1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001893.

Proteomic databases

PaxDbiQ5I2P1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi304514.
KEGGirno:304514.
UCSCiRGD:1305702. rat.

Organism-specific databases

CTDi6910.
RGDi1305702. Tbx5.

Phylogenomic databases

eggNOGiKOG3585. Eukaryota.
ENOG410XSTS. LUCA.
HOGENOMiHOG000286001.
HOVERGENiHBG007310.
InParanoidiQ5I2P1.
KOiK10179.
PhylomeDBiQ5I2P1.

Miscellaneous databases

PROiQ5I2P1.

Family and domain databases

CDDicd00182. TBOX. 1 hit.
Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBX5_RAT
AccessioniPrimary (citable) accession number: Q5I2P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: February 15, 2005
Last modified: November 30, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.