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Protein

Toll-like receptor 9

Gene

TLR9

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-SSC-109704. PI3K Cascade.
R-SSC-1679131. Trafficking and processing of endosomal TLR.
R-SSC-168138. Toll Like Receptor 9 (TLR9) Cascade.
R-SSC-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-SSC-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-SSC-975155. MyD88 dependent cascade initiated on endosome.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 9
Alternative name(s):
CD_antigen: CD289
Gene namesi
Name:TLR9
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 13

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 816ExtracellularSequence analysisAdd BLAST792
Transmembranei817 – 837HelicalSequence analysisAdd BLAST21
Topological domaini838 – 1030CytoplasmicSequence analysisAdd BLAST193

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000022700925 – 1030Toll-like receptor 9Add BLAST1006

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi63N-linked (GlcNAc...)Sequence analysis1
Glycosylationi128N-linked (GlcNAc...)Sequence analysis1
Glycosylationi199N-linked (GlcNAc...)Sequence analysis1
Glycosylationi209N-linked (GlcNAc...)Sequence analysis1
Glycosylationi241N-linked (GlcNAc...)Sequence analysis1
Glycosylationi339N-linked (GlcNAc...)Sequence analysis1
Glycosylationi512N-linked (GlcNAc...)Sequence analysis1
Glycosylationi566N-linked (GlcNAc...)Sequence analysis1
Glycosylationi668N-linked (GlcNAc...)Sequence analysis1
Glycosylationi693N-linked (GlcNAc...)Sequence analysis1
Glycosylationi730N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5I2M3.
PRIDEiQ5I2M3.

Expressioni

Gene expression databases

BgeeiENSSSCG00000011436.
GenevisibleiQ5I2M3. SS.

Interactioni

Subunit structurei

Interacts with MYD88 via their respective TIR domains. Interacts with BTK. Interacts (via transmembrane domain) with UNC93B1. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Interacts with SMPDL3B.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000012188.

Structurei

3D structure databases

ProteinModelPortaliQ5I2M3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati61 – 84LRR 1Add BLAST24
Repeati86 – 109LRR 2Add BLAST24
Repeati121 – 146LRR 3Add BLAST26
Repeati149 – 165LRR 4Add BLAST17
Repeati166 – 189LRR 5Add BLAST24
Repeati197 – 220LRR 6Add BLAST24
Repeati222 – 241LRR 7Add BLAST20
Repeati242 – 267LRR 8Add BLAST26
Repeati282 – 305LRR 9Add BLAST24
Repeati307 – 331LRR 10Add BLAST25
Repeati332 – 355LRR 11Add BLAST24
Repeati362 – 385LRR 12Add BLAST24
Repeati389 – 412LRR 13Add BLAST24
Repeati414 – 439LRR 14Add BLAST26
Repeati469 – 493LRR 15Add BLAST25
Repeati495 – 518LRR 16Add BLAST24
Repeati519 – 542LRR 17Add BLAST24
Repeati544 – 571LRR 18Add BLAST28
Repeati573 – 597LRR 19Add BLAST25
Repeati599 – 621LRR 20Add BLAST23
Repeati626 – 649LRR 21Add BLAST24
Repeati651 – 674LRR 22Add BLAST24
Repeati675 – 698LRR 23Add BLAST24
Repeati700 – 722LRR 24Add BLAST23
Repeati723 – 746LRR 25Add BLAST24
Repeati748 – 771LRR 26Add BLAST24
Domaini865 – 1013TIRPROSITE-ProRule annotationAdd BLAST149

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated
Contains 26 LRR (leucine-rich) repeats.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000230468.
HOVERGENiHBG018601.
InParanoidiQ5I2M3.
OMAiVNCNWLF.
OrthoDBiEOG091G0BWK.
TreeFamiTF325595.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 4 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027181. TLR9.
[Graphical view]
PANTHERiPTHR24373:SF37. PTHR24373:SF37. 3 hits.
PfamiPF13516. LRR_6. 1 hit.
PF13855. LRR_8. 4 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 16 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 17 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5I2M3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPRCTLHPL SLLVQVTALA AALAQGRLPA FLPCELQPHG LVNCNWLFLK
60 70 80 90 100
SVPHFSAAAP RANVTSLSLL SNRIHHLHDS DFVHLSSLRT LNLKWNCPPA
110 120 130 140 150
GLSPMHFPCH MTIEPNTFLA VPTLEELNLS YNSITTVPAL PDSLVSLSLS
160 170 180 190 200
RTNILVLDPT HLTGLHALRY LYMDGNCYYK NPCQGALEVV PGALLGLGNL
210 220 230 240 250
THLSLKYNNL TEVPRSLPPS LETLLLSYNH IVTLTPEDLA NLTALRVLDV
260 270 280 290 300
GGNCRRCDHA RNPCRECPKD HPKLHSDTFS HLSRLEGLVL KDSSLYNLDT
310 320 330 340 350
RWFRGLDRLQ VLDLSENFLY DCITKTTAFQ GLARLRSLNL SFNYHKKVSF
360 370 380 390 400
AHLHLAPSFG HLRSLKELDM HGIFFRSLSE TTLQPLVQLP MLQTLRLQMN
410 420 430 440 450
FINQAQLSIF GAFPGLLYVD LSDNRISGAA RPVAITREVD GRERVWLPSR
460 470 480 490 500
NLAPRPLDTL RSEDFMPNCK AFSFTLDLSR NNLVTIQSEM FARLSRLECL
510 520 530 540 550
RLSHNSISQA VNGSQFVPLT SLRVLDLSHN KLDLYHGRSF TELPRLEALD
560 570 580 590 600
LSYNSQPFTM QGVGHNLSFV AQLPALRYLS LAHNDIHSRV SQQLCSASLC
610 620 630 640 650
ALDFSGNDLS RMWAEGDLYL RFFQGLRSLV WLDLSQNHLH TLLPRALDNL
660 670 680 690 700
PKSLKHLHLR DNNLAFFNWS SLTLLPKLET LDLAGNQLKA LSNGSLPSGT
710 720 730 740 750
QLRRLDLSGN SIGFVNPGFF ALAKQLEELN LSANALKTVE PSWFGSMVGN
760 770 780 790 800
LKVLDVSANP LHCACGATFV GFLLEVQAAV PGLPSRVKCG SPGQLQGHSI
810 820 830 840 850
FAQDLRLCLD ETLSWNCFGI SLLAMALGLV VPMLHHLCGW DLWYCFHLCL
860 870 880 890 900
AWLPHRGQRR GADALFYDAF VVFDKAQSAV ADWVYNELRV QLEERRGRRA
910 920 930 940 950
LRLCLEERDW LPGKTLFENL WASVYSSRKT LFVLAHTDRV SGLLRASFLL
960 970 980 990 1000
AQQRLLEDRK DVVVLVILRP DAYRSRYVRL RQRLCRQSVL LWPHQPRGQG
1010 1020 1030
SFWAQLGTAL TRDNHHFYNR NFCRGPTTAE
Length:1,030
Mass (Da):115,883
Last modified:February 15, 2005 - v1
Checksum:i5D81A7DC80EE4D32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY859728 mRNA. Translation: AAW50956.1.
UniGeneiSsc.16634.

Genome annotation databases

EnsembliENSSSCT00000012516; ENSSSCP00000012188; ENSSSCG00000011436.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY859728 mRNA. Translation: AAW50956.1.
UniGeneiSsc.16634.

3D structure databases

ProteinModelPortaliQ5I2M3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000012188.

Proteomic databases

PaxDbiQ5I2M3.
PRIDEiQ5I2M3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000012516; ENSSSCP00000012188; ENSSSCG00000011436.

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000230468.
HOVERGENiHBG018601.
InParanoidiQ5I2M3.
OMAiVNCNWLF.
OrthoDBiEOG091G0BWK.
TreeFamiTF325595.

Enzyme and pathway databases

ReactomeiR-SSC-109704. PI3K Cascade.
R-SSC-1679131. Trafficking and processing of endosomal TLR.
R-SSC-168138. Toll Like Receptor 9 (TLR9) Cascade.
R-SSC-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-SSC-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-SSC-975155. MyD88 dependent cascade initiated on endosome.

Gene expression databases

BgeeiENSSSCG00000011436.
GenevisibleiQ5I2M3. SS.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 4 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027181. TLR9.
[Graphical view]
PANTHERiPTHR24373:SF37. PTHR24373:SF37. 3 hits.
PfamiPF13516. LRR_6. 1 hit.
PF13855. LRR_8. 4 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 16 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 17 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTLR9_PIG
AccessioniPrimary (citable) accession number: Q5I2M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: February 15, 2005
Last modified: October 5, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.