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Protein

C-C motif chemokine 3

Gene

CCL3

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity).By similarity

GO - Molecular functioni

  1. calcium-dependent protein kinase C activity Source: UniProtKB
  2. chemoattractant activity Source: UniProtKB
  3. chemokine activity Source: UniProtKB
  4. kinase activity Source: UniProtKB
  5. phospholipase activator activity Source: UniProtKB
  6. protein kinase activity Source: UniProtKB

GO - Biological processi

  1. astrocyte cell migration Source: UniProtKB
  2. behavior Source: UniProtKB
  3. calcium ion transport Source: UniProtKB
  4. calcium-mediated signaling Source: UniProtKB
  5. cell activation Source: UniProtKB
  6. cell-cell signaling Source: UniProtKB
  7. cellular calcium ion homeostasis Source: UniProtKB
  8. cellular response to organic cyclic compound Source: UniProtKB
  9. chemotaxis Source: UniProtKB
  10. cytoskeleton organization Source: UniProtKB
  11. eosinophil chemotaxis Source: UniProtKB
  12. eosinophil degranulation Source: UniProtKB
  13. exocytosis Source: UniProtKB
  14. granulocyte chemotaxis Source: UniProtKB
  15. inflammatory response Source: UniProtKB
  16. lipopolysaccharide-mediated signaling pathway Source: UniProtKB
  17. lymphocyte chemotaxis Source: UniProtKB
  18. macrophage chemotaxis Source: UniProtKB
  19. MAPK cascade Source: UniProtKB
  20. monocyte chemotaxis Source: UniProtKB
  21. negative regulation by host of viral transcription Source: UniProtKB
  22. negative regulation of gene expression Source: UniProtKB
  23. negative regulation of osteoclast differentiation Source: UniProtKB
  24. neutrophil chemotaxis Source: UniProtKB
  25. osteoblast differentiation Source: UniProtKB
  26. positive chemotaxis Source: GOC
  27. positive regulation of calcium ion transport Source: UniProtKB
  28. positive regulation of calcium-mediated signaling Source: UniProtKB
  29. positive regulation of catalytic activity Source: GOC
  30. positive regulation of cell migration Source: UniProtKB
  31. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  32. positive regulation of gene expression Source: UniProtKB
  33. positive regulation of inflammatory response Source: UniProtKB
  34. positive regulation of interleukin-1 beta secretion Source: UniProtKB
  35. positive regulation of natural killer cell chemotaxis Source: UniProtKB
  36. positive regulation of neuron apoptotic process Source: UniProtKB
  37. positive regulation of tumor necrosis factor production Source: UniProtKB
  38. protein kinase B signaling Source: UniProtKB
  39. protein phosphorylation Source: UniProtKB
  40. regulation of cell shape Source: UniProtKB
  41. regulation of sensory perception of pain Source: UniProtKB
  42. release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: UniProtKB
  43. response to cholesterol Source: UniProtKB
  44. response to toxic substance Source: UniProtKB
  45. signaling Source: UniProtKB
  46. T cell chemotaxis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 3
Alternative name(s):
Macrophage inflammatory protein 1-alpha
Short name:
MIP-1-alpha
Small-inducible cytokine A3
Gene namesi
Name:CCL3
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Chromosome 17

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: UniProtKB
  3. extracellular space Source: UniProtKB
  4. intracellular Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9269C-C motif chemokine 3PRO_0000005159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000053003.

Structurei

3D structure databases

ProteinModelPortaliQ5I1Z0.
SMRiQ5I1Z0. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGieuNOG10545.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ5I1Z0.
KOiK05408.
OMAiSAPFGAD.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5I1Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVSTAALAV LLCTMALCNQ FSASLAADTP TACCFSYISR QIPQNFIADY
60 70 80 90
FETSSQCSKP SVIFLTKRGR QVCADPSEEW VQKYVSDLEL SA
Length:92
Mass (Da):10,098
Last modified:February 15, 2005 - v1
Checksum:i3DF0B8D5D6777821
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY864054 mRNA. Translation: AAW57434.1.
RefSeqiNP_001029254.1. NM_001034082.1.
UniGeneiPtr.6150.

Genome annotation databases

EnsembliENSPTRT00000059770; ENSPTRP00000053003; ENSPTRG00000030906.
GeneIDi454592.
KEGGiptr:454592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY864054 mRNA. Translation: AAW57434.1.
RefSeqiNP_001029254.1. NM_001034082.1.
UniGeneiPtr.6150.

3D structure databases

ProteinModelPortaliQ5I1Z0.
SMRiQ5I1Z0. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000053003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000059770; ENSPTRP00000053003; ENSPTRG00000030906.
GeneIDi454592.
KEGGiptr:454592.

Organism-specific databases

CTDi6348.

Phylogenomic databases

eggNOGieuNOG10545.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ5I1Z0.
KOiK05408.
OMAiSAPFGAD.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Miscellaneous databases

NextBioi20836206.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL3_PANTR
AccessioniPrimary (citable) accession number: Q5I1Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: February 15, 2005
Last modified: March 4, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.