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Q5I1Z0

- CCL3_PANTR

UniProt

Q5I1Z0 - CCL3_PANTR

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Protein

C-C motif chemokine 3

Gene

CCL3

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity).By similarity

GO - Molecular functioni

  1. calcium-dependent protein kinase C activity Source: UniProtKB
  2. chemoattractant activity Source: UniProtKB
  3. chemokine activity Source: UniProtKB
  4. kinase activity Source: UniProtKB
  5. phospholipase activator activity Source: UniProtKB
  6. protein kinase activity Source: UniProtKB

GO - Biological processi

  1. astrocyte cell migration Source: UniProtKB
  2. behavior Source: UniProtKB
  3. calcium ion transport Source: UniProtKB
  4. calcium-mediated signaling Source: UniProtKB
  5. cell activation Source: UniProtKB
  6. cell-cell signaling Source: UniProtKB
  7. cellular calcium ion homeostasis Source: UniProtKB
  8. cellular response to interferon-gamma Source: Ensembl
  9. cellular response to interleukin-1 Source: Ensembl
  10. cellular response to organic cyclic compound Source: UniProtKB
  11. cellular response to tumor necrosis factor Source: Ensembl
  12. chemotaxis Source: UniProtKB
  13. cytoskeleton organization Source: UniProtKB
  14. eosinophil chemotaxis Source: UniProtKB
  15. eosinophil degranulation Source: UniProtKB
  16. exocytosis Source: UniProtKB
  17. granulocyte chemotaxis Source: UniProtKB
  18. inflammatory response Source: UniProtKB
  19. lipopolysaccharide-mediated signaling pathway Source: UniProtKB
  20. lymphocyte chemotaxis Source: UniProtKB
  21. macrophage chemotaxis Source: UniProtKB
  22. MAPK cascade Source: UniProtKB
  23. monocyte chemotaxis Source: UniProtKB
  24. negative regulation by host of viral transcription Source: UniProtKB
  25. negative regulation of bone mineralization Source: Ensembl
  26. negative regulation of gene expression Source: UniProtKB
  27. negative regulation of osteoclast differentiation Source: UniProtKB
  28. neutrophil chemotaxis Source: UniProtKB
  29. osteoblast differentiation Source: UniProtKB
  30. positive regulation of calcium ion transport Source: UniProtKB
  31. positive regulation of calcium-mediated signaling Source: UniProtKB
  32. positive regulation of cell migration Source: UniProtKB
  33. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  34. positive regulation of gene expression Source: UniProtKB
  35. positive regulation of inflammatory response Source: UniProtKB
  36. positive regulation of interleukin-1 beta secretion Source: UniProtKB
  37. positive regulation of natural killer cell chemotaxis Source: UniProtKB
  38. positive regulation of neuron apoptotic process Source: UniProtKB
  39. positive regulation of protein kinase B signaling Source: Ensembl
  40. positive regulation of tumor necrosis factor production Source: UniProtKB
  41. protein kinase B signaling Source: UniProtKB
  42. protein phosphorylation Source: UniProtKB
  43. regulation of cell shape Source: UniProtKB
  44. regulation of sensory perception of pain Source: UniProtKB
  45. release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: UniProtKB
  46. response to cholesterol Source: UniProtKB
  47. response to toxic substance Source: UniProtKB
  48. signaling Source: UniProtKB
  49. T cell chemotaxis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 3
Alternative name(s):
Macrophage inflammatory protein 1-alpha
Short name:
MIP-1-alpha
Small-inducible cytokine A3
Gene namesi
Name:CCL3
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Chromosome 17

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: UniProtKB
  3. extracellular space Source: UniProtKB
  4. intracellular Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9269C-C motif chemokine 3PRO_0000005159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000053003.

Structurei

3D structure databases

ProteinModelPortaliQ5I1Z0.
SMRiQ5I1Z0. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGieuNOG10545.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ5I1Z0.
KOiK05408.
OMAiLCAMALC.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5I1Z0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQVSTAALAV LLCTMALCNQ FSASLAADTP TACCFSYISR QIPQNFIADY
60 70 80 90
FETSSQCSKP SVIFLTKRGR QVCADPSEEW VQKYVSDLEL SA
Length:92
Mass (Da):10,098
Last modified:February 15, 2005 - v1
Checksum:i3DF0B8D5D6777821
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY864054 mRNA. Translation: AAW57434.1.
RefSeqiNP_001029254.1. NM_001034082.1.
UniGeneiPtr.6150.

Genome annotation databases

EnsembliENSPTRT00000059770; ENSPTRP00000053003; ENSPTRG00000030906.
GeneIDi454592.
KEGGiptr:454592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY864054 mRNA. Translation: AAW57434.1 .
RefSeqi NP_001029254.1. NM_001034082.1.
UniGenei Ptr.6150.

3D structure databases

ProteinModelPortali Q5I1Z0.
SMRi Q5I1Z0. Positions 24-92.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9598.ENSPTRP00000053003.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPTRT00000059770 ; ENSPTRP00000053003 ; ENSPTRG00000030906 .
GeneIDi 454592.
KEGGi ptr:454592.

Organism-specific databases

CTDi 6348.

Phylogenomic databases

eggNOGi euNOG10545.
GeneTreei ENSGT00730000110278.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi Q5I1Z0.
KOi K05408.
OMAi LCAMALC.
OrthoDBi EOG7CVQ1F.
TreeFami TF334888.

Miscellaneous databases

NextBioi 20836206.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL3_PANTR
AccessioniPrimary (citable) accession number: Q5I1Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: February 15, 2005
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3