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Protein

C-C motif chemokine 3

Gene

CCL3

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 3
Alternative name(s):
Macrophage inflammatory protein 1-alpha
Short name:
MIP-1-alpha
Small-inducible cytokine A3
Gene namesi
Name:CCL3
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000000515924 – 92C-C motif chemokine 3Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ5I1Z0

Expressioni

Gene expression databases

BgeeiENSPTRG00000030906

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000053003

Structurei

3D structure databases

ProteinModelPortaliQ5I1Z0
SMRiQ5I1Z0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4I9 Eukaryota
ENOG410YXJU LUCA
GeneTreeiENSGT00900000140870
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiQ5I1Z0
KOiK05408
OMAiMALCNQV
OrthoDBiEOG091G14Y2
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5I1Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVSTAALAV LLCTMALCNQ FSASLAADTP TACCFSYISR QIPQNFIADY
60 70 80 90
FETSSQCSKP SVIFLTKRGR QVCADPSEEW VQKYVSDLEL SA
Length:92
Mass (Da):10,098
Last modified:February 15, 2005 - v1
Checksum:i3DF0B8D5D6777821
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY864054 mRNA Translation: AAW57434.1
RefSeqiNP_001029254.1, NM_001034082.1
UniGeneiPtr.6150

Genome annotation databases

EnsembliENSPTRT00000065443; ENSPTRP00000057009; ENSPTRG00000009039
GeneIDi454592
KEGGiptr:454592

Similar proteinsi

Entry informationi

Entry nameiCCL3_PANTR
AccessioniPrimary (citable) accession number: Q5I1Z0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: February 15, 2005
Last modified: April 25, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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