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Q5I146

- PTPH2_MDBVW

UniProt

Q5I146 - PTPH2_MDBVW

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Protein
Tyrosine phosphatase H2
Gene
H2
Organism
Microplitis demolitor bracovirus (isolate Webb) (MdBV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Suppresses host immune cell adhesion and phagocytosis. Triggers host mitochondrial membrane depolarization and caspase-dependent apoptosis.2 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei236 – 2361Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB-KW
  2. suppression by virus of host innate immune response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Activation of host caspases by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Modulation of host cell apoptosis by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine phosphatase H2 (EC:3.1.3.48)
Short name:
PTP-H2
Gene namesi
Name:H2
OrganismiMicroplitis demolitor bracovirus (isolate Webb) (MdBV)
Taxonomic identifieri654919 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePolydnaviridaeBracovirus
Virus hostiMicroplitis demolitor [TaxID: 69319]
ProteomesiUP000008168: Genome

Subcellular locationi

Host cytoplasm 1 Publication

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Tyrosine phosphatase H2
PRO_0000405352Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5I146.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 295269Tyrosine-protein phosphatase
Add
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5I146-1 [UniParc]FASTAAdd to Basket

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MSRCKFRSLN YSEFLNLVEK SDFEEVVTRE HEKIMAQKVD GTFNESMKLE    50
NRKLNRYLDM LCFDHTRVTL PAEKNRGDYI NANYVDGYEY KKKFICTQAP 100
LQQTAYDFWR TVWMHHTRII VMMCKKKENR KQCFAYWNDI EGGDIVFGKF 150
KITTTQIETH LSYIETTLLV TDGTSAIQEV THFVFTQWPD YGVPNDVMNL 200
LNFILTVKSA QKDVIRQLAQ ERFKIGDNPP PIVVHCSAGV GRTGAYCLLD 250
SAISEFDACA TISIPSTLIN IRNQRYYCIF ILPQYFFCYR VMERYVNLTV 300
NKVSKKLIAN VATALFNKVL HLKDN 325
Length:325
Mass (Da):37,876
Last modified:February 15, 2005 - v1
Checksum:iD83B669F822005CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY875685 Genomic DNA. Translation: AAW51786.1.
RefSeqiYP_239382.1. NC_007035.1.

Genome annotation databases

GeneIDi5075819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY875685 Genomic DNA. Translation: AAW51786.1 .
RefSeqi YP_239382.1. NC_007035.1.

3D structure databases

ProteinModelPortali Q5I146.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5075819.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "PTP-H2 and PTP-H3 from Microplitis demolitor Bracovirus localize to focal adhesions and are antiphagocytic in insect immune cells."
    Pruijssers A.J., Strand M.R.
    J. Virol. 81:1209-1219(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "Protein tyrosine phosphatase-H2 from a polydnavirus induces apoptosis of insect cells."
    Suderman R.J., Pruijssers A.J., Strand M.R.
    J. Gen. Virol. 89:1411-1420(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Characterization and kinetic analysis of protein tyrosine phosphatase-H2 from Microplitis demolitor bracovirus."
    Eum J.H., Bottjen R.C., Pruijssers A.J., Clark K.D., Strand M.R.
    Insect Biochem. Mol. Biol. 40:690-698(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPTPH2_MDBVW
AccessioniPrimary (citable) accession number: Q5I146
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: February 15, 2005
Last modified: June 11, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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