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Q5I146

- PTPH2_MDBVW

UniProt

Q5I146 - PTPH2_MDBVW

Protein

Tyrosine phosphatase H2

Gene

H2

Organism
Microplitis demolitor bracovirus (isolate Webb) (MdBV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Suppresses host immune cell adhesion and phagocytosis. Triggers host mitochondrial membrane depolarization and caspase-dependent apoptosis.2 Publications

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei236 – 2361Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB-KW
    2. suppression by virus of host innate immune response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Activation of host caspases by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Modulation of host cell apoptosis by virus, Viral immunoevasion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine phosphatase H2 (EC:3.1.3.48)
    Short name:
    PTP-H2
    Gene namesi
    Name:H2
    OrganismiMicroplitis demolitor bracovirus (isolate Webb) (MdBV)
    Taxonomic identifieri654919 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePolydnaviridaeBracovirus
    Virus hostiMicroplitis demolitor [TaxID: 69319]
    ProteomesiUP000008168: Genome

    Subcellular locationi

    Host cytoplasm 1 Publication

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325Tyrosine phosphatase H2PRO_0000405352Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ5I146.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 295269Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5I146-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRCKFRSLN YSEFLNLVEK SDFEEVVTRE HEKIMAQKVD GTFNESMKLE    50
    NRKLNRYLDM LCFDHTRVTL PAEKNRGDYI NANYVDGYEY KKKFICTQAP 100
    LQQTAYDFWR TVWMHHTRII VMMCKKKENR KQCFAYWNDI EGGDIVFGKF 150
    KITTTQIETH LSYIETTLLV TDGTSAIQEV THFVFTQWPD YGVPNDVMNL 200
    LNFILTVKSA QKDVIRQLAQ ERFKIGDNPP PIVVHCSAGV GRTGAYCLLD 250
    SAISEFDACA TISIPSTLIN IRNQRYYCIF ILPQYFFCYR VMERYVNLTV 300
    NKVSKKLIAN VATALFNKVL HLKDN 325
    Length:325
    Mass (Da):37,876
    Last modified:February 15, 2005 - v1
    Checksum:iD83B669F822005CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY875685 Genomic DNA. Translation: AAW51786.1.
    RefSeqiYP_239382.1. NC_007035.1.

    Genome annotation databases

    GeneIDi5075819.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY875685 Genomic DNA. Translation: AAW51786.1 .
    RefSeqi YP_239382.1. NC_007035.1.

    3D structure databases

    ProteinModelPortali Q5I146.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5075819.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "PTP-H2 and PTP-H3 from Microplitis demolitor Bracovirus localize to focal adhesions and are antiphagocytic in insect immune cells."
      Pruijssers A.J., Strand M.R.
      J. Virol. 81:1209-1219(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    3. "Protein tyrosine phosphatase-H2 from a polydnavirus induces apoptosis of insect cells."
      Suderman R.J., Pruijssers A.J., Strand M.R.
      J. Gen. Virol. 89:1411-1420(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Characterization and kinetic analysis of protein tyrosine phosphatase-H2 from Microplitis demolitor bracovirus."
      Eum J.H., Bottjen R.C., Pruijssers A.J., Clark K.D., Strand M.R.
      Insect Biochem. Mol. Biol. 40:690-698(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiPTPH2_MDBVW
    AccessioniPrimary (citable) accession number: Q5I146
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 8, 2011
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3