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Q5I146 (PTPH2_MDBVW) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine phosphatase H2

Short name=PTP-H2
EC=3.1.3.48
Gene names
Name:H2
OrganismMicroplitis demolitor bracovirus (isolate Webb) (MdBV) [Reference proteome]
Taxonomic identifier654919 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePolydnaviridaeBracovirus
Virus hostMicroplitis demolitor [TaxID: 69319]

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Suppresses host immune cell adhesion and phagocytosis. Triggers host mitochondrial membrane depolarization and caspase-dependent apoptosis. Ref.2 Ref.3

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Host cytoplasm Ref.4.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Tyrosine phosphatase H2
PRO_0000405352

Regions

Domain27 – 295269Tyrosine-protein phosphatase

Sites

Active site2361Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5I146 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: D83B669F822005CF

FASTA32537,876
        10         20         30         40         50         60 
MSRCKFRSLN YSEFLNLVEK SDFEEVVTRE HEKIMAQKVD GTFNESMKLE NRKLNRYLDM 

        70         80         90        100        110        120 
LCFDHTRVTL PAEKNRGDYI NANYVDGYEY KKKFICTQAP LQQTAYDFWR TVWMHHTRII 

       130        140        150        160        170        180 
VMMCKKKENR KQCFAYWNDI EGGDIVFGKF KITTTQIETH LSYIETTLLV TDGTSAIQEV 

       190        200        210        220        230        240 
THFVFTQWPD YGVPNDVMNL LNFILTVKSA QKDVIRQLAQ ERFKIGDNPP PIVVHCSAGV 

       250        260        270        280        290        300 
GRTGAYCLLD SAISEFDACA TISIPSTLIN IRNQRYYCIF ILPQYFFCYR VMERYVNLTV 

       310        320 
NKVSKKLIAN VATALFNKVL HLKDN 

« Hide

References

[1]"Polydnavirus genomes reflect their dual roles as mutualists and pathogens."
Webb B.A., Strand M.R., Dickey S.E., Beck M.H., Hilgarth R.S., Barney W.E., Kadash K., Kroemer J.A., Lindstrom K.G., Rattanadechakul W., Shelby K.S., Thoetkiattikul H., Turnbull M.W., Witherell R.A.
Virology 347:160-174(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"PTP-H2 and PTP-H3 from Microplitis demolitor Bracovirus localize to focal adhesions and are antiphagocytic in insect immune cells."
Pruijssers A.J., Strand M.R.
J. Virol. 81:1209-1219(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[3]"Protein tyrosine phosphatase-H2 from a polydnavirus induces apoptosis of insect cells."
Suderman R.J., Pruijssers A.J., Strand M.R.
J. Gen. Virol. 89:1411-1420(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Characterization and kinetic analysis of protein tyrosine phosphatase-H2 from Microplitis demolitor bracovirus."
Eum J.H., Bottjen R.C., Pruijssers A.J., Clark K.D., Strand M.R.
Insect Biochem. Mol. Biol. 40:690-698(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY875685 Genomic DNA. Translation: AAW51786.1.
RefSeqYP_239382.1. NC_007035.1.

3D structure databases

ProteinModelPortalQ5I146.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5075819.

Phylogenomic databases

ProtClustDBPHA2738.

Family and domain databases

InterProIPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00194. PTPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePTPH2_MDBVW
AccessionPrimary (citable) accession number: Q5I146
Entry history
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: February 15, 2005
Last modified: April 16, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families