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Protein

Tyrosine phosphatase H3

Gene

H3

Organism
Microplitis demolitor bracovirus (isolate Webb) (MdBV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Suppresses host immune cell adhesion and phagocytosis.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei250 – 2501Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine phosphatase H3 (EC:3.1.3.48)
Short name:
PTP-H3
Gene namesi
Name:H3
OrganismiMicroplitis demolitor bracovirus (isolate Webb) (MdBV)
Taxonomic identifieri654919 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePolydnaviridaeBracovirus
Virus hostiMicroplitis demolitor [TaxID: 69319]
ProteomesiUP000008168 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Tyrosine phosphatase H3PRO_0000405353Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5I145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 309288Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

KOiK18038.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5I145-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGYCFEIFN VFDFFDKTNK ANFWEFVRLE HAQVMDIPIS GTVNHFLKPE
60 70 80 90 100
NLRKNRYHDV TCWDNSRVVL SSHGSKMYDY GDSDGKKIIV TSQDSDSTYI
110 120 130 140 150
HASFVNGFKE ANKFICCQGP KESTSGDFWK MVSEHNSSVI VSLTETDDED
160 170 180 190 200
QVCYEYWVKE EDYELAFGRY VVKTLEIIEE SSFTRTRLRL TDVSSDTSRE
210 220 230 240 250
IHHFWYPHWS DYGNPTNPAE ILNLISKVNQ KRKEMKKTAD SQPGPIVVHC
260 270 280 290 300
SAGIGRTGTF CTIDNALSQL RKEQTVCLPQ TVLKIRKQRH SSVFLPEQYA
310 320
FCYKAVRYAL IREIKKKFFY
Length:320
Mass (Da):37,219
Last modified:February 15, 2005 - v1
Checksum:iC029D5041E9A9D23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY875685 Genomic DNA. Translation: AAW51787.1.
RefSeqiYP_239383.1. NC_007035.1.

Genome annotation databases

GeneIDi5075818.
KEGGivg:5075818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY875685 Genomic DNA. Translation: AAW51787.1.
RefSeqiYP_239383.1. NC_007035.1.

3D structure databases

ProteinModelPortaliQ5I145.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5075818.
KEGGivg:5075818.

Phylogenomic databases

KOiK18038.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "PTP-H2 and PTP-H3 from Microplitis demolitor Bracovirus localize to focal adhesions and are antiphagocytic in insect immune cells."
    Pruijssers A.J., Strand M.R.
    J. Virol. 81:1209-1219(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiPTPH3_MDBVW
AccessioniPrimary (citable) accession number: Q5I145
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: February 15, 2005
Last modified: April 1, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.