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Q5I145

- PTPH3_MDBVW

UniProt

Q5I145 - PTPH3_MDBVW

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Protein

Tyrosine phosphatase H3

Gene
H3
Organism
Microplitis demolitor bracovirus (isolate Webb) (MdBV)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Suppresses host immune cell adhesion and phagocytosis.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei250 – 2501Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. suppression by virus of host innate immune response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine phosphatase H3 (EC:3.1.3.48)
Short name:
PTP-H3
Gene namesi
Name:H3
OrganismiMicroplitis demolitor bracovirus (isolate Webb) (MdBV)
Taxonomic identifieri654919 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePolydnaviridaeBracovirus
Virus hostiMicroplitis demolitor [TaxID: 69319]
ProteomesiUP000008168: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Tyrosine phosphatase H3PRO_0000405353Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5I145.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 309288Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5I145-1 [UniParc]FASTAAdd to Basket

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MPGYCFEIFN VFDFFDKTNK ANFWEFVRLE HAQVMDIPIS GTVNHFLKPE    50
NLRKNRYHDV TCWDNSRVVL SSHGSKMYDY GDSDGKKIIV TSQDSDSTYI 100
HASFVNGFKE ANKFICCQGP KESTSGDFWK MVSEHNSSVI VSLTETDDED 150
QVCYEYWVKE EDYELAFGRY VVKTLEIIEE SSFTRTRLRL TDVSSDTSRE 200
IHHFWYPHWS DYGNPTNPAE ILNLISKVNQ KRKEMKKTAD SQPGPIVVHC 250
SAGIGRTGTF CTIDNALSQL RKEQTVCLPQ TVLKIRKQRH SSVFLPEQYA 300
FCYKAVRYAL IREIKKKFFY 320
Length:320
Mass (Da):37,219
Last modified:February 15, 2005 - v1
Checksum:iC029D5041E9A9D23
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY875685 Genomic DNA. Translation: AAW51787.1.
RefSeqiYP_239383.1. NC_007035.1.

Genome annotation databases

GeneIDi5075818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY875685 Genomic DNA. Translation: AAW51787.1 .
RefSeqi YP_239383.1. NC_007035.1.

3D structure databases

ProteinModelPortali Q5I145.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5075818.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "PTP-H2 and PTP-H3 from Microplitis demolitor Bracovirus localize to focal adhesions and are antiphagocytic in insect immune cells."
    Pruijssers A.J., Strand M.R.
    J. Virol. 81:1209-1219(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiPTPH3_MDBVW
AccessioniPrimary (citable) accession number: Q5I145
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: February 15, 2005
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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