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Protein

Tyrosine phosphatase H3

Gene

H3

Organism
Microplitis demolitor bracovirus (isolate Webb) (MdBV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Suppresses host immune cell adhesion and phagocytosis.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei250Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine phosphatase H3 (EC:3.1.3.48)
Short name:
PTP-H3
Gene namesi
Name:H3
OrganismiMicroplitis demolitor bracovirus (isolate Webb) (MdBV)
Taxonomic identifieri654919 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePolydnaviridaeBracovirus
Virus hostiMicroplitis demolitor [TaxID: 69319]
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004053531 – 320Tyrosine phosphatase H3Add BLAST320

Proteomic databases

PRIDEiQ5I145

Structurei

3D structure databases

ProteinModelPortaliQ5I145
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 309Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST288

Sequence similaritiesi

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

Q5I145-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGYCFEIFN VFDFFDKTNK ANFWEFVRLE HAQVMDIPIS GTVNHFLKPE
60 70 80 90 100
NLRKNRYHDV TCWDNSRVVL SSHGSKMYDY GDSDGKKIIV TSQDSDSTYI
110 120 130 140 150
HASFVNGFKE ANKFICCQGP KESTSGDFWK MVSEHNSSVI VSLTETDDED
160 170 180 190 200
QVCYEYWVKE EDYELAFGRY VVKTLEIIEE SSFTRTRLRL TDVSSDTSRE
210 220 230 240 250
IHHFWYPHWS DYGNPTNPAE ILNLISKVNQ KRKEMKKTAD SQPGPIVVHC
260 270 280 290 300
SAGIGRTGTF CTIDNALSQL RKEQTVCLPQ TVLKIRKQRH SSVFLPEQYA
310 320
FCYKAVRYAL IREIKKKFFY
Length:320
Mass (Da):37,219
Last modified:February 15, 2005 - v1
Checksum:iC029D5041E9A9D23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY875685 Genomic DNA Translation: AAW51787.1
RefSeqiYP_239383.1, NC_007035.1

Genome annotation databases

GeneIDi5075818
KEGGivg:5075818

Entry informationi

Entry nameiPTPH3_MDBVW
AccessioniPrimary (citable) accession number: Q5I145
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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