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Q5I145 (PTPH3_MDBVW) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine phosphatase H3

Short name=PTP-H3
EC=3.1.3.48
Gene names
Name:H3
OrganismMicroplitis demolitor bracovirus (isolate Webb) (MdBV) [Reference proteome]
Taxonomic identifier654919 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePolydnaviridaeBracovirus
Virus hostMicroplitis demolitor [TaxID: 69319]

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Suppresses host immune cell adhesion and phagocytosis. Ref.2

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Tyrosine phosphatase H3
PRO_0000405353

Regions

Domain22 – 309288Tyrosine-protein phosphatase

Sites

Active site2501Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5I145 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: C029D5041E9A9D23

FASTA32037,219
        10         20         30         40         50         60 
MPGYCFEIFN VFDFFDKTNK ANFWEFVRLE HAQVMDIPIS GTVNHFLKPE NLRKNRYHDV 

        70         80         90        100        110        120 
TCWDNSRVVL SSHGSKMYDY GDSDGKKIIV TSQDSDSTYI HASFVNGFKE ANKFICCQGP 

       130        140        150        160        170        180 
KESTSGDFWK MVSEHNSSVI VSLTETDDED QVCYEYWVKE EDYELAFGRY VVKTLEIIEE 

       190        200        210        220        230        240 
SSFTRTRLRL TDVSSDTSRE IHHFWYPHWS DYGNPTNPAE ILNLISKVNQ KRKEMKKTAD 

       250        260        270        280        290        300 
SQPGPIVVHC SAGIGRTGTF CTIDNALSQL RKEQTVCLPQ TVLKIRKQRH SSVFLPEQYA 

       310        320 
FCYKAVRYAL IREIKKKFFY 

« Hide

References

[1]"Polydnavirus genomes reflect their dual roles as mutualists and pathogens."
Webb B.A., Strand M.R., Dickey S.E., Beck M.H., Hilgarth R.S., Barney W.E., Kadash K., Kroemer J.A., Lindstrom K.G., Rattanadechakul W., Shelby K.S., Thoetkiattikul H., Turnbull M.W., Witherell R.A.
Virology 347:160-174(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"PTP-H2 and PTP-H3 from Microplitis demolitor Bracovirus localize to focal adhesions and are antiphagocytic in insect immune cells."
Pruijssers A.J., Strand M.R.
J. Virol. 81:1209-1219(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY875685 Genomic DNA. Translation: AAW51787.1.
RefSeqYP_239383.1. NC_007035.1.

3D structure databases

ProteinModelPortalQ5I145.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5075818.

Family and domain databases

Gene3D3.90.190.10. 1 hit.
InterProIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePTPH3_MDBVW
AccessionPrimary (citable) accession number: Q5I145
Entry history
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: February 15, 2005
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families