Q5I145 (PTPH3_MDBVW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine phosphatase H3
Short name=PTP-H3
EC=3.1.3.48

Gene names

Name:

H3

Organism

Microplitis demolitor bracovirus (isolate Webb) (MdBV) [Reference proteome]

Taxonomic identifier

654919 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Polydnaviridae › Bracovirus › Microplitis demolitor bracovirus

Virus host

Microplitis demolitor [TaxID: 69319]

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Suppresses host immune cell adhesion and phagocytosis. Ref.2
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Biological process	Host-virus interaction Inhibition of host innate immune response by virus Viral immunoevasion
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC suppression by virus of host innate immune response Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 320	320	Tyrosine phosphatase H3		PRO_0000405353
Regions
	Domain	22 – 309	288	Tyrosine-protein phosphatase
Sites
	Active site	250	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5I145 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: C029D5041E9A9D23	FASTA	320	37,219
	10 20 30 40 50 60 MPGYCFEIFN VFDFFDKTNK ANFWEFVRLE HAQVMDIPIS GTVNHFLKPE NLRKNRYHDV 70 80 90 100 110 120 TCWDNSRVVL SSHGSKMYDY GDSDGKKIIV TSQDSDSTYI HASFVNGFKE ANKFICCQGP 130 140 150 160 170 180 KESTSGDFWK MVSEHNSSVI VSLTETDDED QVCYEYWVKE EDYELAFGRY VVKTLEIIEE 190 200 210 220 230 240 SSFTRTRLRL TDVSSDTSRE IHHFWYPHWS DYGNPTNPAE ILNLISKVNQ KRKEMKKTAD 250 260 270 280 290 300 SQPGPIVVHC SAGIGRTGTF CTIDNALSQL RKEQTVCLPQ TVLKIRKQRH SSVFLPEQYA 310 320 FCYKAVRYAL IREIKKKFFY

References

[1]	"Polydnavirus genomes reflect their dual roles as mutualists and pathogens." Webb B.A., Strand M.R., Dickey S.E., Beck M.H., Hilgarth R.S., Barney W.E., Kadash K., Kroemer J.A., Lindstrom K.G., Rattanadechakul W., Shelby K.S., Thoetkiattikul H., Turnbull M.W., Witherell R.A. Virology 347:160-174(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"PTP-H2 and PTP-H3 from Microplitis demolitor Bracovirus localize to focal adhesions and are antiphagocytic in insect immune cells." Pruijssers A.J., Strand M.R. J. Virol. 81:1209-1219(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY875685 Genomic DNA. Translation: AAW51787.1.
RefSeq	YP_239383.1. NC_007035.1.
3D structure databases
ProteinModelPortal	Q5I145.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5075818.
Phylogenomic databases
ProtClustDB	PHA2746.
Family and domain databases
InterPro	IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Pfam	PF00102. Y_phosphatase. 1 hit. [Graphical view]
PRINTS	PR00700. PRTYPHPHTASE.
SMART	SM00194. PTPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTPH3_MDBVW

Accession

Primary (citable) accession number: Q5I145

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 8, 2011
Last sequence update:	February 15, 2005
Last modified:	March 6, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program