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Q5I145

- PTPH3_MDBVW

UniProt

Q5I145 - PTPH3_MDBVW

Protein

Tyrosine phosphatase H3

Gene

H3

Organism
Microplitis demolitor bracovirus (isolate Webb) (MdBV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Suppresses host immune cell adhesion and phagocytosis.1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei250 – 2501Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. suppression by virus of host innate immune response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Host-virus interaction, Inhibition of host innate immune response by virus, Viral immunoevasion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine phosphatase H3 (EC:3.1.3.48)
    Short name:
    PTP-H3
    Gene namesi
    Name:H3
    OrganismiMicroplitis demolitor bracovirus (isolate Webb) (MdBV)
    Taxonomic identifieri654919 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePolydnaviridaeBracovirus
    Virus hostiMicroplitis demolitor [TaxID: 69319]
    ProteomesiUP000008168: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Tyrosine phosphatase H3PRO_0000405353Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ5I145.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 309288Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5I145-1 [UniParc]FASTAAdd to Basket

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    MPGYCFEIFN VFDFFDKTNK ANFWEFVRLE HAQVMDIPIS GTVNHFLKPE    50
    NLRKNRYHDV TCWDNSRVVL SSHGSKMYDY GDSDGKKIIV TSQDSDSTYI 100
    HASFVNGFKE ANKFICCQGP KESTSGDFWK MVSEHNSSVI VSLTETDDED 150
    QVCYEYWVKE EDYELAFGRY VVKTLEIIEE SSFTRTRLRL TDVSSDTSRE 200
    IHHFWYPHWS DYGNPTNPAE ILNLISKVNQ KRKEMKKTAD SQPGPIVVHC 250
    SAGIGRTGTF CTIDNALSQL RKEQTVCLPQ TVLKIRKQRH SSVFLPEQYA 300
    FCYKAVRYAL IREIKKKFFY 320
    Length:320
    Mass (Da):37,219
    Last modified:February 15, 2005 - v1
    Checksum:iC029D5041E9A9D23
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY875685 Genomic DNA. Translation: AAW51787.1.
    RefSeqiYP_239383.1. NC_007035.1.

    Genome annotation databases

    GeneIDi5075818.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY875685 Genomic DNA. Translation: AAW51787.1 .
    RefSeqi YP_239383.1. NC_007035.1.

    3D structure databases

    ProteinModelPortali Q5I145.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5075818.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "PTP-H2 and PTP-H3 from Microplitis demolitor Bracovirus localize to focal adhesions and are antiphagocytic in insect immune cells."
      Pruijssers A.J., Strand M.R.
      J. Virol. 81:1209-1219(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiPTPH3_MDBVW
    AccessioniPrimary (citable) accession number: Q5I145
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 8, 2011
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3