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Protein

Tetratricopeptide repeat protein 32

Gene

TTC32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 32
Short name:
TPR repeat protein 32
Gene namesi
Name:TTC32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:32954. TTC32.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145147867.

Polymorphism and mutation databases

BioMutaiTTC32.
DMDMi74755518.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 151151Tetratricopeptide repeat protein 32PRO_0000263100Add
BLAST

Proteomic databases

EPDiQ5I0X7.
MaxQBiQ5I0X7.
PaxDbiQ5I0X7.
PeptideAtlasiQ5I0X7.
PRIDEiQ5I0X7.

PTM databases

iPTMnetiQ5I0X7.
PhosphoSiteiQ5I0X7.

Expressioni

Gene expression databases

BgeeiQ5I0X7.
CleanExiHS_TTC32.
ExpressionAtlasiQ5I0X7. baseline and differential.
GenevisibleiQ5I0X7. HS.

Organism-specific databases

HPAiHPA036024.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ARID3AQ998563EBI-8636434,EBI-5458244
FBF1Q8TES7-63EBI-8636434,EBI-10244131
MAGED1Q9Y5V33EBI-8636434,EBI-716006
PRDM14Q9GZV83EBI-8636434,EBI-3957793
TRIM39Q9HCM93EBI-8636434,EBI-739510
ZNF18P170223EBI-8636434,EBI-8648067
ZNF219Q9P2Y43EBI-8636434,EBI-3937106

Protein-protein interaction databases

BioGridi126236. 10 interactions.
IntActiQ5I0X7. 8 interactions.
STRINGi9606.ENSP00000333018.

Structurei

3D structure databases

ProteinModelPortaliQ5I0X7.
SMRiQ5I0X7. Positions 1-143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati8 – 4134TPR 1Add
BLAST
Repeati58 – 9134TPR 2Add
BLAST
Repeati92 – 12534TPR 3Add
BLAST

Sequence similaritiesi

Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000011905.
HOGENOMiHOG000068047.
HOVERGENiHBG056063.
InParanoidiQ5I0X7.
OMAiYIRQCAC.
PhylomeDBiQ5I0X7.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 2 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5I0X7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGQRQESHA TLTLAQAHFN NGEYAEAEAL YSAYIRRCAC AASSDESPGS
60 70 80 90 100
KCSPEDLATA YNNRGQIKYF RVDFYEAMDD YTSAIEVQPN FEVPYYNRGL
110 120 130 140 150
ILYRLGYFDD ALEDFKKVLD LNPGFQDATL SLKQTILDKE EKQRRNVAKN

Y
Length:151
Mass (Da):17,296
Last modified:February 15, 2005 - v1
Checksum:i81BE35CDA095B2D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057850 mRNA. Translation: AAH57850.1.
CCDSiCCDS33151.1.
RefSeqiNP_001008238.1. NM_001008237.2.
UniGeneiHs.591547.

Genome annotation databases

EnsembliENST00000333610; ENSP00000333018; ENSG00000183891.
GeneIDi130502.
KEGGihsa:130502.
UCSCiuc002rdg.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057850 mRNA. Translation: AAH57850.1.
CCDSiCCDS33151.1.
RefSeqiNP_001008238.1. NM_001008237.2.
UniGeneiHs.591547.

3D structure databases

ProteinModelPortaliQ5I0X7.
SMRiQ5I0X7. Positions 1-143.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126236. 10 interactions.
IntActiQ5I0X7. 8 interactions.
STRINGi9606.ENSP00000333018.

PTM databases

iPTMnetiQ5I0X7.
PhosphoSiteiQ5I0X7.

Polymorphism and mutation databases

BioMutaiTTC32.
DMDMi74755518.

Proteomic databases

EPDiQ5I0X7.
MaxQBiQ5I0X7.
PaxDbiQ5I0X7.
PeptideAtlasiQ5I0X7.
PRIDEiQ5I0X7.

Protocols and materials databases

DNASUi130502.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333610; ENSP00000333018; ENSG00000183891.
GeneIDi130502.
KEGGihsa:130502.
UCSCiuc002rdg.4. human.

Organism-specific databases

CTDi130502.
GeneCardsiTTC32.
HGNCiHGNC:32954. TTC32.
HPAiHPA036024.
neXtProtiNX_Q5I0X7.
PharmGKBiPA145147867.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000011905.
HOGENOMiHOG000068047.
HOVERGENiHBG056063.
InParanoidiQ5I0X7.
OMAiYIRQCAC.
PhylomeDBiQ5I0X7.

Miscellaneous databases

GenomeRNAii130502.
PROiQ5I0X7.

Gene expression databases

BgeeiQ5I0X7.
CleanExiHS_TTC32.
ExpressionAtlasiQ5I0X7. baseline and differential.
GenevisibleiQ5I0X7. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 2 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiTTC32_HUMAN
AccessioniPrimary (citable) accession number: Q5I0X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: February 15, 2005
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.